Sticky DNA

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works

Molecular cloning: A laboratory manual

Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

Campuzano, V., Montermini, L., Moltò, M. D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Rodius, F., Duclos, F., Monticelli, A., et al. (1996) · Science · doi:10.1126/science.271.5254.1423 · Cited by 2,786 · see citing works

Supercoiling of the DNA template during transcription.

Liu, L. F., & Wang, J. C. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.20.7024 · Cited by 1,877 · see citing works

The locus of sequence-directed and protein-induced DNA bending

Wu, H., & Crothers, D. M. (1984) · Nature · doi:10.1038/308509a0 · Cited by 1,454 · see citing works

Clinical and Genetic Abnormalities in Patients with Friedreich's Ataxia

Dürr, A., Cossee, M., Agid, Y., Campuzano, V., Mignard, C., Penet, C., Mandel, J.-L., Brice, A., & Koenig, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351601 · Cited by 1,071 · see citing works

DNA Structure and Function

Coyle, H. M. (2004) · CRC Press eBooks · doi:10.1201/9780203484593-10 · Cited by 787 · see citing works

Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes

Campuzano, V., Montermini, L., Lutz, Y., Cova, L., Hindelang, C., Jiralerspong, S., Trottier, Y., Kish, S. J., Faucheux, B. A., Trouillas, P., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1771 · Cited by 739 · see citing works

Triplex DNA structures.

Frank-Kamenetskii, M., & Mirkin, S. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000433 · Cited by 695 · see citing works

ESCHERICHIA COLI SINGLE-STRANDED DNA-BINDING PROTEIN: Multiple DNA-Binding Modes and Cooperativities

Lohman, T. M., & Ferrari, M. E. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002523 · Cited by 608 · see citing works

The chemistry and biology of unusual DNA structures adopted by oligopurine · oligopyrimidine sequences

Wells, R. D., Collier, D. A., Hanvey, J. C., et al. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.14.3053307 · Cited by 541 · see citing works

SEQUENCE-DIRECTED CURVATURE OF DNA

Hagerman, P. J. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.003543 · Cited by 489 · see citing works

The relationship between trinucleotide (GAA) repeat length and clinical features in Friedreich ataxia.

Filla, A., Michele, G. D., Cavalcanti, F., Pianese, L., Monticelli, A., Campanella, G., & Cocozza, S. (1996) · PubMed Central · Cited by 487 · see citing works

The GAA Triplet-Repeat Expansion in Friedreich Ataxia Interferes with Transcription and May Be Associated with an Unusual DNA Structure

Bidichandani, S. I., Ashizawa, T., & Patel, P. I. (1998) · The American Journal of Human Genetics · doi:10.1086/301680 · Cited by 381 · see citing works

Triple-Helical Nucleic Acids

Soyfer, V. N., & Potaman, V. N. (1996) · Springer eBooks · doi:10.1007/978-1-4612-3972-7 · Cited by 361 · see citing works

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

Kang, S., Jaworski, A., Ohshima, K., & Wells, R. D. (1995) · Nature Genetics · doi:10.1038/ng0695-213 · Cited by 355 · see citing works

Evolution of the Friedreich’s ataxia trinucleotide repeat expansion: Founder effect and premutations

Cossée, M., Schmitt, M., Campuzano, V., Reutenauer, L., Moutou, C., Mandel, J., & Koenig, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7452 · Cited by 330 · see citing works

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

Kohwi, Y., & Kohwi-shigematsu, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3781 · Cited by 313 · see citing works

Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences

Morgan, A. R., & Wells, R. D. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90073-9 · Cited by 311 · see citing works

Inhibitory Effects of Expanded GAA·TTC Triplet Repeats from Intron I of the Friedreich Ataxia Gene on Transcription and Replicationin Vivo

Ohshima, K., Montermini, L., Wells, R. D., & Pandolfo, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14588 · Cited by 302 · see citing works

Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels.

Postel, E. H., Flint, S. J., Kessler, D. J., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8227 · Cited by 298 · see citing works

Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition.

Sternglanz, R., DiNardo, S., Voelkel, K., et al. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.2747 · Cited by 287 · see citing works

Phenotypic variability in friedreich ataxia: Role of the associated GAA triplet repeat expansion

Montermini, L., Richeter, A., Morgan, K. W., Justice, C. M., Julien, D., Castellotti, B., Mercier, J., Poirier, J., Capozzoli, F., Bouchard, J., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410410518 · Cited by 273 · see citing works

Genetic instabilities and hereditary neurological diseases

Wells, R. D., Warren, S. T., & Sarmiento, M. (1998) · Cited by 270 · see citing works

Genetic Instabilities and Hereditary Neurological Diseases

Opal, P., & Paulson, H. L. (1998) · The American Journal of Human Genetics · doi:10.1086/302134 · Cited by 250 · see citing works

Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates

Hardin, C. C., Henderson, E. A., Watson, T., & Prosser, J. K. (1991) · Biochemistry · doi:10.1021/bi00232a013 · Cited by 246 · see citing works

The Friedreich ataxia GAA triplet repeat: premutation and normal alleles

Montermini, L. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1261 · Cited by 207 · see citing works

Intramolecular DNA triplexes in supercoiled plasmids.

Hanvey, J. C., Shimizu, M., & Wells, R. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6292 · Cited by 197 · see citing works

Influence of DNA sequence on the formation of non-B right-handed helices in oligopurine.oligopyrimidine inserts in plasmids.

Hanvey, J. C., Kłysik, J., & Wells, R. D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68654-5 · Cited by 159 · see citing works

Problems and prospects in the theory of gel electrophoresis of DNA

Zimm, B. H., & Levene, S. D. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500004662 · Cited by 146 · see citing works

Atypical Friedreich ataxia caused by compound heterozygosity for a novel missense mutation and the GAA triplet-repeat expansion.

Bidichandani, S. I., Ashizawa, T., & Patel, P. I. (1997) · Europe PMC (PubMed Central) · Cited by 141 · see citing works

The facile generation of covalently closed, circular DNAs with defined negative superhelical densities

Singleton, C. K., & Wells, R. D. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90277-9 · Cited by 138 · see citing works

DNA bending induced by cruciform formation

Gough, G. W., & Lilley, D. M. J. (1985) · Nature · doi:10.1038/313154a0 · Cited by 133 · see citing works

Differential stability of the (GAA) n tract in the Friedreich ataxia (STM7) gene

Epplen, C., Epplen, J. T., Frank, G., Miterski, B., dos Santos, E. J. M., & Schöls, L. J. (1997) · Human Genetics · doi:10.1007/s004390050458 · Cited by 123 · see citing works

Cloning, Characterization, and Properties of Seven Triplet Repeat DNA Sequences

Ohshima, K., Kang, S., Larson, J. E., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16773 · Cited by 99 · see citing works

Cloning, Characterization and Properties of Plasmids Containing CGG Triplet Repeats from the FMR-1 Gene

Shimizu, M., Gellibolian, R., Oostra, B. A., & Wells, R. D. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0273 · Cited by 78 · see citing works

Cationic metals promote sequence-directed DNA bending

Laundon, C. H., & Griffith, J. D. (1987) · Biochemistry · doi:10.1021/bi00387a003 · Cited by 75 · see citing works

Intramolecular DNA Triplexes in Supercoiled Plasmids

Shimizu, M., Hanvey, J. C., & Wells, R. D. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83641-9 · Cited by 71 · see citing works

Escherichia coli single-strand binding protein stabilizes specific denatured sites in superhelical DNA

Glikin, G. C., Gargiulo, G., Rena-Descalzi, L., et al. (1983) · Nature · doi:10.1038/303770a0 · Cited by 68 · see citing works

Topoisomerase mutants and physiological conditions control supercoiling and Z-DNA formation in vivo

Jaworski, A., Higgins, N. P., Wells, R. D., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52284-5 · Cited by 63 · see citing works

Intramolecular DNA Triplexes in Supercoiled Plasmids

Hanvey, J. C., Shimizu, M., & Wells, R. D. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83642-0 · Cited by 61 · see citing works

Frataxin fracas

Cossée, M., Campuzano, V., Koutníková, H., Fischbeck, K., Mandel, J., Koenig, M., Bidichandani, S. I., Patel, P. I., Moltè, M. D., Cañizares, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-337 · Cited by 61 · see citing works

Effect of third strand composition on the triple helix formation: purine versus pyrimidine oligodeoxynucleotides

Faucon, B. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.16.3181 · Cited by 53 · see citing works

DNA triplet repeats and neurologic disease.

Rosenberg, R. N. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351609 · Cited by 46 · see citing works

Multiple non-B-DNA conformations of polypurine.cntdot.polypyrimidine sequences in plasmids

Shimizu, M., Hanvey, J. C., & Wells, R. D. (1990) · Biochemistry · doi:10.1021/bi00471a027 · Cited by 44 · see citing works

DNA Structure and function

(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90014-4 · Cited by 39 · see citing works

[24] Electron microscopic visualization of DNA and DNA-protein complexes as adjunct to biochemical studies

Thresher, R., & Griffith, J. D. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)11026-f · Cited by 38 · see citing works

Metal ions cause the isomerization of certain intramolecular triplexes.

Kang, S. M., Wohlrab, F., & Wells, R. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48423-2 · Cited by 33 · see citing works

Plasmid dimerization mediated by triplex formation between polypyrimidine-polypurine repeats

Hampel, K. J., Burkholder, G. D., & Lee, J. S. (1993) · Biochemistry · doi:10.1021/bi00055a012 · Cited by 27 · see citing works

Central non-Pur.Pyr sequences in oligo(dG.dC) tracts and metal ions influence the formation of intramolecular DNA triplex isomers.

Kang, S.-J., & Wells, R. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36770-5 · Cited by 18 · see citing works

Escherichia coli single‐stranded DNA‐binding protein alters the structure of intramolecular triplexes in plasmids

Kłysik, J., & Shimizu, M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80666-i · Cited by 5 · see citing works

Expandable DNA repeats and human disease

Mirkin, S. M. (2007) · Nature · doi:10.1038/nature05977 · Cited by 934 · see citing works

Intracellular iron transport and storage: from molecular mechanisms to health implications

Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works

Replication fork stalling at natural impediments

Mirkin, E. V., & Mirkin, S. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-06 · Cited by 482 · see citing works

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia

Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S. L., & Gottesfeld, J. M. (2006) · Nature Chemical Biology · doi:10.1038/nchembio815 · Cited by 442 · see citing works

Molecular mechanisms underlying nucleotide repeat expansion disorders

Malik, I., Kelley, C. P., Wang, E. T., & Todd, P. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00382-6 · Cited by 363 · see citing works

Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK Population

Beck, J., Poulter, M., Hensman, D., Rohrer, J. D., Mahoney, C. J., Adamson, G., Campbell, T., Uphill, J., Borg, A., Fratta, P., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.01.011 · Cited by 345 · see citing works

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

Khristich, A. N., & Mirkin, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007678 · Cited by 289 · see citing works

Crystal Structure of Human Frataxin

Dhe-Paganon, S., Shigeta, R., Chi, Y.-I., Ristow, M., & Shoelson, S. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000407200 · Cited by 226 · see citing works

The role of mitochondria in inherited neurodegenerative diseases

Kwong, J. Q., Beal, M. F., & Manfredi, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03990.x · Cited by 180 · see citing works

Frataxin knockin mouse

Miranda, C. J., Santos, M. M., Ohshima, K., Smith, J., Li, L., Bunting, M., Cossée, M., Koenig, M., Sequeiros, J., Kaplan, J., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02251-2 · Cited by 172 · see citing works

Friedreich Ataxia: From GAA Triplet–Repeat Expansion to Frataxin Deficiency

Patel, P. I., & Isaya, G. (2001) · The American Journal of Human Genetics · doi:10.1086/321283 · Cited by 126 · see citing works

Reduction in frataxin causes progressive accumulation of mitochondrial damage

Karthikeyan, G. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg349 · Cited by 102 · see citing works

Developments in RNA Splicing and Disease

Poulos, M. G., Batra, R., Charizanis, K., & Swanson, M. S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000778 · Cited by 98 · see citing works

Frataxin overexpressing mice

Miranda, C. J., Santos, M. M., Ohshima, K., Tessaro, M., Sequeiros, J., & Pandolfo, M. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.022 · Cited by 30 · see citing works

Molecular insights into nucleic acid triplexes: methodologies and biological applications

Klose, J. W., Urbina, G., & Pukala, T. L. (2025) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2025.2550728 · Cited by 1 · see citing works

Platinum(II) Complexes of Purine and Pyrimidine Bases and Their Nucleosides

Stetsenko, A. I., Yakovlev, K. I., & D’yachenko, S. A. (1987) · Russian Chemical Reviews · doi:10.1070/rc1987v056n09abeh003311 · Cited by 11 · see citing works

Synthesis and Biological Evaluation of Pyrimidine and Purine α-L-2′,3′-Dideoxy Nucleosides

DRAANEN, N. A. V., & Koszalka, G. W. (1994) · Nucleosides and Nucleotides · doi:10.1080/15257779408009473 · Cited by 19 · see citing works

Nucleoside free energy perturbation calculations: Mutation of purine‐to‐pyrimidine and pyrimidine‐to‐purine nucleosides

Wunz, T. P. (1992) · Journal of Computational Chemistry · doi:10.1002/jcc.540130517 · Cited by 5 · see citing works

Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives

Leškovskis, K., Zakis, J. M., Novosjolova, I., & Turks, M. (2021) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202100755 · Cited by 25 · see citing works

84. Experiments on the synthesis of purine nucleosides. Part V. The coupling of pyrimidine derivatives with diazonium salts. A method for the preparation of 5-aminopyrimidines

Lythgoe, B., Todd, A. R., & Topham, A. (1944) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9440000315 · Cited by 24 · see citing works