Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009)

Espinel-Ingroff, Ana

doi:10.1016/s1130-1406(09)70004-x

Cited by 105Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009)

Espinel-Ingroff, Ana·2009·Revista Iberoamericana de Micología

DOI 10.1016/s1130-1406(09)70004-x

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Abstract

Background The incidence and prevalence of serious mycoses continues to be a public health problem. Despite aggressive treatment with new or more established licensed antifungal agents, these infections are an important cause of morbidity and mortality, especially in immunocompromised patients.Aims To critically review the literature regarding important new developments in the field of antifungal therapy both in the English and Spanish versions.Methods The search of the literature focused on different antifungal targets or mechanisms of action as well as new agents or strategies that could improve antifungal therapy.Results The review produced a huge amount of information on the use of virulent factors such as growth, filamentation, pathogen tissue clearance, among others, as putative targets of antifungal activity. More recently, the chemical-genetic relationships for licensed agents as well as for other compounds have been provided by the identification of the genes related to the mechanism of action.Conclusions Although the antifungal activity of numerous compounds has been examined, most of them are at the in vitro or animal models of efficacy stages. Therefore, further investigation should be carried out to realize the true clinical utility of these compounds.

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Extensive use of some antifungal drugs has led to increased selective pressure and the development of antifungal resistance.
“Unfortunately, some of these antifungal drugs have been extensively used and led to an increased selective pressure and the development of antifungal resistance [36].”
From CandidaInfections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [36]

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CandidaInfections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
Spampinato, C., & Leonardi, D. (2013) · BioMed Research International · doi:10.1155/2013/204237 · Cited by 411 · see citing works
Extracellular DNA Release Acts as an Antifungal Resistance Mechanism in Mature Aspergillus fumigatus Biofilms
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Pravastatin inhibits farnesol production inCandida albicansand improves survival in a mouse model of systemic candidiasis
Tashiro, M., Kimura, S., Tateda, K., Saga, T., Ohno, A., Ishii, Y., Izumikawa, K., Tashiro, T., Kohno, S., & Yamaguchi, K. (2012) · Medical Mycology · doi:10.3109/13693786.2011.610037 · Cited by 36 · see citing works

Authors: Espinel-Ingroff, A.
Venue: Revista Iberoamericana de Micología
Publisher: Elsevier BV
Published: 2009-03
Volume: 26
Issue: 1
Pages: 15-22
ISSN: 1130-1406 (ISSN-L)
DOI: 10.1016/s1130-1406(09)70004-x
OpenAlex: W2161143301
Cited by: 105
References: 115
Citations by year: 2026: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 11 · 2013: 13 · 2012: 18
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Revista Iberoamericana de Micología (publishedVersion)
PubMed (publishedVersion)
Hispana (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: antifungal agents, invasive fungal infections, antifungal drug targets, mechanism of action, virulence factors, filamentation, chemical genetics, immunocompromised patients, antifungal therapy
MeSH terms: Animals, Antifungal Agents, Candida albicans, Clinical Trials as Topic, Cryptococcus neoformans, Drug Evaluation, Preclinical, Drug Synergism, Enzyme Inhibitors, Fatty Acids, Fungal Proteins, Humans, Mycoses, Peptides, Drugs, Investigational, Drug Delivery Systems, Drug Monitoring, Biofilms, Drug Discovery

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Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009)

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