Cited by 459Kruppel-like factors researchGenomics and Chromatin DynamicsConnective Tissue Growth Factor Research

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The biology of the mammalian Krüppel-like family of transcription factors

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Dang, Duyen T., Pevsner, Jonathan, Yang, Vincent W.·2000·The International Journal of Biochemistry & Cell Biology

DOI 10.1016/s1357-2725(00)00059-5PMC PMC2754176

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Abstract

Recent advances in molecular cloning have led to the identification of a large number of mammalian zinc finger-containing transcription factors that exhibit homology to the Drosophila melanogaster protein, Krüppel. Although the amino acid sequences in the zinc finger domains of these Krüppel-like factors (KLFs) are closely related to one another, the regions outside the zinc fingers of the proteins are usually unique. KLFs display seemingly different and broad biological properties with each functioning as an activator of transcription, a repressor or both. This review article provides a current phylogenetic classification of the identified KLFs to date. More importantly, the currently known biological activities of the KLFs in regulating transcription, cell proliferation, differentiation and development are summarized and compared. Further characterization of this interesting protein family should provide additional insights into the their respective regulatory role in various important biological processes.

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Authors: Dang, D. T., Pevsner, J., & Yang, V. W.
Affiliations: Johns Hopkins University (US)
Kennedy Krieger Institute (US)
Corresponding author: Yang, Vincent W.
ORCID: Pevsner, Jonathan
Yang, Vincent W.
Venue: The International Journal of Biochemistry & Cell Biology
Publisher: Elsevier BV
Published: 2000-12
Volume: 32
Issue: 11-12
Pages: 1103-1121
ISSN: 1357-2725 (ISSN-L)
DOI: 10.1016/s1357-2725(00)00059-5
PMC: PMC2754176
OpenAlex: W2133383018
Cited by: 458
References: 126
Citations by year: 2026: 6 · 2025: 8 · 2024: 16 · 2023: 22 · 2022: 7 · 2021: 12 · 2020: 15 · 2019: 17 · 2018: 29 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 21 · 2012: 18
FWCI: 1.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 385 d)
Locations: The International Journal of Biochemistry & Cell Biology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA 84197, R01CA084197)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK010020, DK 52230, DK10020, R01DK052230)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords: Krüppel-like factors, zinc finger transcription factor, transcriptional regulation, transcriptional activator, transcriptional repressor, phylogenetic classification, cell proliferation, cell differentiation, development (biology)
MeSH terms: Animals, DNA-Binding Proteins, Humans, Mammals, Phylogeny, Repressor Proteins, Transcription Factors, Transcription, Genetic, Zinc Fingers, Kruppel-Like Transcription Factors

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The biology of the mammalian Krüppel-like family of transcription factors

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