Cited by 459Kruppel-like factors researchGenomics and Chromatin DynamicsConnective Tissue Growth Factor Research

The DOI matches its Crossref record; 124 of the 126 references it cites were found in a registry or an index.

The biology of the mammalian Krüppel-like family of transcription factors

Open access

Dang, Duyen T., Pevsner, Jonathan, Yang, Vincent W.·2000·The International Journal of Biochemistry & Cell Biology

DOI 10.1016/s1357-2725(00)00059-5PMC PMC2754176

Open this paper in CoChat — free account

Abstract

Recent advances in molecular cloning have led to the identification of a large number of mammalian zinc finger-containing transcription factors that exhibit homology to the Drosophila melanogaster protein, Krüppel. Although the amino acid sequences in the zinc finger domains of these Krüppel-like factors (KLFs) are closely related to one another, the regions outside the zinc fingers of the proteins are usually unique. KLFs display seemingly different and broad biological properties with each functioning as an activator of transcription, a repressor or both. This review article provides a current phylogenetic classification of the identified KLFs to date. More importantly, the currently known biological activities of the KLFs in regulating transcription, cell proliferation, differentiation and development are summarized and compared. Further characterization of this interesting protein family should provide additional insights into the their respective regulatory role in various important biological processes.

Integrity signals

Registry

Crossref · 10.1016/s1357-2725(00)00059-5

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Berg, J. M., & Shi, Y. (1996) · Science · doi:10.1126/science.271.5252.1081 · Cited by 1,930
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
Kadonaga, J. T., Carner, K., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,614
The Sp-family of transcription factors
Suske, G. (1999) · Gene · doi:10.1016/s0378-1119(99)00357-1 · Cited by 1,112
Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex
Côté, J., Quinn, J., Workman, J. L., & Peterson, C. L. (1994) · Science · doi:10.1126/science.8016655 · Cited by 861
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C. R., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 810

Show all 126 references

Research works printed but not linked: 1

Perkins, 1997, Blood, 90, 575

Sorted by citations

Items 301–400 of 459

Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library
Gao, L., Sun, C., Qiu, H., Liu, H., Shao, H., Wang, J., & Li, W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.158 · Cited by 15
Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641
Qi, X., Li, Y., Xiao, J., Yuan, W., Yan, Y., Wang, Y., Liang, S., Zhu, C., Chen, Y., Liu, M., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.124 · Cited by 15
Induced pluripotent stem cells: From derivation to application in biochemical and biomedical research
Novosadova, E. V., & Grivennikov, I. A. (2014) · Biochemistry (Moscow) · doi:10.1134/s000629791413001x · Cited by 16
Monitoring methylation‑driven genes as prognostic biomarkers in patients with lung squamous cell cancer
Han, P., Liu, Q., & Xiang, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.11163 · Cited by 14
The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
Nagare, T., Sakaue, H., Takashima, M., Takahashi, K., Gomi, H., Matsuki, Y., Watanabe, E., Hiramatsu, R., Ogawa, W., & Kasuga, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.020 · Cited by 14
Growth Inhibitory Effect of Krueppel-like Factor 6 on Human Prostatic Carcinoma and Renal Carcinoma Cell Lines
Cheng, X., Li, D., Zhuang, M., Chen, Z.-Y., Lu, D.-X., & Hattori, T. (2008) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.216.35 · Cited by 14
Thymic output: influence factors and molecular mechanism.
Jin, R., Zhang, J., & Chen, W. (2006) · PubMed · Cited by 14
LH-induced Transcriptional Regulation of Klf4 Expression in Granulosa Cells Occurs via the cAMP/PKA Pathway and Requires a Putative Sp1 Binding Site
Choi, H., & Roh, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197385 · Cited by 14
Regulation of Angiotensin II-Induced Krueppel-Like Factor 5 Expression in Vascular Smooth Muscle Cells
Gao, D., Niu, X., Ning, N., & Hao, G. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2004 · Cited by 14
MED27 plays a tumor‐promoting role in breast cancer progression by targeting KLF4
Wang, R., Yu, W., Zhu, T., Lin, F., Hua, C., Ru, L., Guo, P., Wan, X., Xue, G., Guo, Z., et al. (2023) · Cancer Science · doi:10.1111/cas.15757 · Cited by 13
KLF4: a multifunctional nexus connecting tumor progression and immune regulation
Ju, Y., Xiao, W., Mathis, B. J., & Shi, Y. Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1514780 · Cited by 13
Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias
Buttar, N. S., Fernández-Zapico, M. E., & Urrutia, R. A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000239864.73962.db · Cited by 13
Expression, regulation and function of miR-126 in the mouse choroid vasculature
Zhao, F., Anderson, C. A., karnes, S., Zhou, Q., Ma, J., Jin, Z., Bhattacharjee, P. S., & Wang, S. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.02.026 · Cited by 13
Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer
Safi, S., Badshah, Y., Shabbir, M., Zahra, K., Khan, K., Dilshad, E., Afsar, T., Almajwal, A. M., Alruwaili, N. W., Aldisi, D. A., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.797007 · Cited by 13
A novel nomogram based on cell cycle-related genes for predicting overall survival in early-onset colorectal cancer
Xiang, M., Gao, Y., Zhou, Y., Wang, M., & Yao, X. (2023) · BMC Cancer · doi:10.1186/s12885-023-11075-y · Cited by 13
Loss of Heterozygosity Status of D9S105 Marker Is Associated with Downregulation of Krüppel-Like Factor 4 Expression in Pancreatic Ductal Adenocarcinoma and Pancreatic Intraepithelial Lesions
Funel, N., Morelli, M., Giovannetti, E., Chiaro, M. D., Pollina, L. E., Mosca, F., Boggi, U., Cavazzana, A. O., & Campani, D. (2011) · Pancreatology · doi:10.1159/000322990 · Cited by 13
Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel‐like factor4
Akthar, I. S. T., Pichiah, P. B. T., Arunachalam, S., & Raja, S. (2018) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22235 · Cited by 13
KLF5 is involved in regulation of IFITM1, 2, and 3 genes during H5N1 virus infection in A549 cells
Wang, H.-F., Chen, L., Luo, J., & He, H.-X. (2016) · Cellular and Molecular Biology · doi:10.14715/cmb/2016.62.13.12 · Cited by 13
Modeling dynamic functional relationship networks and application to ex vivo human erythroid differentiation
Zhu, F., Shi, L., Li, H., Eksi, R., Engel, J. D., & Guan, Y. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu542 · Cited by 12
Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer
Wang, L., Mao, Q., Zhou, S., & Ji, X. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s226121 · Cited by 12
Exposure to enriched environment ameliorated chronic unpredictable mild stress-induced depression-like symptoms in rats via regulating the miR-92a-3p/kruppel-like factor 2 (KLF2) pathway
Ji, X., & Zhao, Z. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.01.002 · Cited by 15
The transcriptional activator Klf5 recruits p300-mediated H3K27ac for maintaining trophoblast stem cell pluripotency
Dou, C., Wu, L., Zhang, J., He, H., Xu, T., Yu, Z., Su, P., Zhang, X., Wang, J., Miao, Y., et al. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad045 · Cited by 12
Acute molecular response of mouse hindlimb muscles to chronic stimulation
LaFramboise, W. A., Jayaraman, R., Bombach, K. L., Ankrapp, D. P., Krill-Burger, J. M., Sciulli, C., Petrosko, P., & Wiseman, R. W. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00046.2009 · Cited by 12
Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1→q13.4
Dai, J., Li, Y., Ji, C., Jin, F., Zheng, Z., Wang, X., Sun, X., Xu, X., Gu, S., Xie, Y., et al. (2003) · Cytogenetic and Genome Research · doi:10.1159/000076292 · Cited by 12
KLF12 transcriptionally regulates PD‐L1 expression in non‐small cell lung cancer
Pan, X., Zhang, W., Wang, L., Guo, H., Zheng, M., Wu, H., Weng, Q., He, Q., Ding, L., & Yang, B. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13512 · Cited by 13
Function of KLF4 in Stem Cell Biology
Shi, Y. Q., & Ai, W. (2013) · InTech eBooks · doi:10.5772/54370 · Cited by 11
Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1
Zhang, J. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.564 · Cited by 11
Meningioma Tumor Microenvironment
Negah, S. S., & Gorji, A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-59038-3_3 · Cited by 11
A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution
Moriano, J., Leonardi, O., Vitriolo, A., Testa, G., & Boeckx, C. A. (2024) · Development · doi:10.1242/dev.202390 · Cited by 12
Kruppel-Like Transcription Factor-4 Gene Expression and DNA Methylation Status in Type 2 Diabetes and Diabetic Nephropathy Patients
Coşkun, Z. M., Ersöz, M., Adaş, M., Hançer, V. S., Boysan, Ş. N., Gönen, M. S., & Acar, A. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.05.012 · Cited by 11
Krüppel-like Factors 4 and 5 in Colorectal Tumorigenesis
Lee, E., Cheung, J., & Bialkowska, A. B. (2023) · Cancers · doi:10.3390/cancers15092430 · Cited by 11
MZF6D, a Novel KRAB Zinc-Finger Gene Expressed Exclusively in Meiotic Male Germ Cells
Looman, C., Mark, C., Åbrink, M., & Hellman, L. (2003) · DNA and Cell Biology · doi:10.1089/10445490360708892 · Cited by 11
Conjunctival Goblet Cells
Hodges, R. R., & Dartt, D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374203-2.00053-1 · Cited by 11
Altered expression of zinc finger proteins, ADAMs, and integrin‐related proteins following treatment of cultured human cells with a low concentration of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine
Jin, J., Gao, Z., Guo, L., Yang, J. J., & Yu, Y. (2003) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10163 · Cited by 11
Comprehensive analysis of KLF family reveals KLF6 as a promising prognostic and immune biomarker in pancreatic ductal adenocarcinoma
Lin, J., Liu, P., Sun, K., Jiang, L., Liu, Y., Huang, Y., Liu, J., Shi, M., Zhang, J., Wang, T., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03369-3 · Cited by 10
Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
Chen, H., Li, L., & Du, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1115226 · Cited by 12
Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain
Duncan, J. W., Wang, N., Zhang, X., Johnson, S., Harris, S., Zheng, B., Zhang, Q., Rajkowska, G., Miguel-Hidalgo, J. J., Sittman, D. B., et al. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9524-1 · Cited by 10
Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation
Siddique, A., Malo, M. S., Ocuin, L. M., Hinnebusch, B. F., Abedrapo, M. A., Henderson, J. W., Zhang, W., Mozumder, M., Yang, V. W., & Hodin, R. A. (2003) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.09.006 · Cited by 10
Self-citation
KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma
Chen, X., Zhou, M., Ma, S., Wu, H., & Cai, H. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113645 · Cited by 9
Oxidative Stress Modulates KLF 6Full and Its Splice Variants
Urtasun, R., Cubero, F. J., & Nieto, N. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01798.x · Cited by 9
Cardiovascular proteomic analysis
Suzuki, T., & Nagai, R. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.043 · Cited by 9
Identification of Multiple Differentially Expressed Messenger RNAs in Normal and Pathological Trophoblast
Durand, S., Abadie, P., Angeletti, S., & Genti‐Raimondi, S. (2003) · Placenta · doi:10.1053/plac.2002.0885 · Cited by 9
Correction: Investigation of Susceptibility Genes Triggering Lachrymal/Salivary Gland Lesion Complications in Japanese Patients with Type 1 Autoimmune Pancreatitis
Oguchi, T., Ôta, M., Ito, T., Hamano, H., Arakura, N., Katsuyama, Y., Meguro, A., & Kawa, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146738 · Cited by 9
Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice
Ikuta, K., Hayashi, S., Kikuchi, K., Fujita, M., Anjiki, K., Onoi, Y., Tachibana, S., Suda, Y., Wada, K., Kuroda, Y., et al. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.08.009 · Cited by 8
Krüppel-like factor 2 is an endoprotective transcription factor in diabetic kidney disease
Min, L., Zhong, F., Gu, L., Lee, K., & He, C. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2024 · Cited by 8
Regulation of EPCs: The Gateway to Blood Vessel Formation
Parham, K. A., Pitson, S. M., & Bonder, C. S. (2014) · New Journal of Science · doi:10.1155/2014/972043 · Cited by 8
Expression of human Krüppel‐like factor 3 in peripheral blood as a promising biomarker for acute leukemia
Yan, M., Liu, H., Xu, J., Cen, X., Wang, Q., Xu, W., Wang, W., Qiu, Z.-X., Ou, J.-P., Dong, Y., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.2911 · Cited by 8
KLF4 signalling in carcinogenesis and epigenetic regulation of hTERT
Yadav, S. S., Nair, R. R., & Yadava, P. K. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.03.012 · Cited by 9
Krüppel-like factor/specificity protein evolution in the Spiralia and the implications for cephalopod visual system novelties
McCulloch, K. J., & Koenig, K. M. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2020.2055 · Cited by 8
Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches
Ellis, H. P., McInerney, C. E., Schrimpf, D., Sahm, F., Stupnikov, A., Wadsley, M. K., Wragg, C., White, P., Prise, K. M., McArt, D. G., et al. (2019) · Journal of Oncology · doi:10.1155/2019/4878547 · Cited by 8
Genome-wide identification, evolution of Krüppel-like factors (klfs) and their expressions during GCRV challenge in grass carp (Ctenopharyngodon idella)
Chen, L., Huang, R., Li, Y., Li, Y., Li, Y., Liao, L., He, L., Zhu, Z., & Wang, Y. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104062 · Cited by 7
Induction of Krüppel‐like factor 4 by high‐density lipoproteins promotes the expression of scavenger receptor class B type I
Yang, T., Chen, C., Zhang, B., Huang, H., Wu, G., Wen, J., & Liu, J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07779.x · Cited by 7
ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity
Deng, Y., Liu, B., Fan, X., Wang, Y., Tang, M., Mo, X., Li, Y., Ying, Z., Wan, Y., Luo, N., et al. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.3.193 · Cited by 7
Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene
Wang, G., Zuo, X.-X., Jiang, L., Wang, K., Wei, X., Zhang, B., & Xiao, X. (2009) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2009005000010 · Cited by 7
Vitamin D and Vascular Smooth Muscle Cells: Gene Modulation Following Exposure to a Diabetic-Like Environment
Zitman‐Gal, T., & Green, J. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000218 · Cited by 7
Cross‑validation of genes potentially associated with neoadjuvant chemotherapy and platinum‑based chemoresistance in epithelial ovarian carcinoma
Zhang, K., Wang, W., Chen, L., Liu, Y., Hu, J., Guo, F., Tian, W., Wang, Y., & Xue, F. (2020) · Oncology Reports · doi:10.3892/or.2020.7668 · Cited by 7
Expression pattern of Cubitus interruptus from the mulberry silkworm Bombyx mori in late developmental stages
Dhawan, S., & Gopinathan, K. P. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0314-z · Cited by 7
Gene structure and promoter analysis of the rat BTEB2 gene
Mori, D., Okuro, N., Fujii‐Kuriyama, Y., & Sogawa, K. (2003) · Gene · doi:10.1016/s0378-1119(02)01203-9 · Cited by 7
Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma
Chu, P., Hsu, N. C.-H., Liao, A. T., Yeh, K., Hou, M., & Ch, L. (2011) · BMC Veterinary Research · doi:10.1186/1746-6148-7-58 · Cited by 6
KLF5 , a Novel Therapeutic Target in Squamous Cell Carcinoma
Yang, S., Feng, T., & Li, H. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0674 · Cited by 6
The roles of zinc finger proteins in non-alcoholic fatty liver disease
Li, G., Ma, X., & Xu, L. (2020) · Liver Research · doi:10.1016/j.livres.2020.01.001 · Cited by 7
MicroRNA-145-5p modulates Krüppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma
Yuan, C., Hsu, W., Huang, A., Yuan, B., Chen, I.-H., Hsu, C.-A., Chen, R.-F., Chu, Y.-M., Lin, H., & Ke, H. (2022) · BMC Molecular and Cell Biology · doi:10.1186/s12860-022-00430-9 · Cited by 6
Nucleotide sequence and cell cycle-associated differential expression of ZF5128, a novel Kruppel type zinc finger protein gene
Rue, S. W., Kim, B. W., Jun, D. Y., & Kim, Y. H. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00337-2 · Cited by 6
Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor
Jung, H. G., Shin, J. H., Kim, K. W., Yu, J. Y., Kang, K. K., Ahn, B. O., Kwon, J. W., & Yoo, M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.10.022 · Cited by 6
Efecto de las estatinas más allá del colesterol
Álvarez, F. H., Duque, M. G., Vargas, J. C. O., Velázquez, B. S., Moreno, V. A., Villegas, E., Sánchez‐Reyes, L., & Fanghänel, G. (2006) · Revista de Endocrinología y Nutrición · Cited by 6
Transcriptional Regulation at the Chromatin Level in the Cardiovasculature Through Protein-protein Interactions and Chemical Modifications
Suzuki, T., MATSUMURA, T., & Nagai, R. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.04.003 · Cited by 6
Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases
Salmon-Cabrales, I., Kalife, D. A. D. L. G., García-González, G., Santoyo-Suárez, M. G., Rodríguez-Núñez, O., Estrada-Rodríguez, A. E., Jiménez-Gutiérrez, M. A., Garza-Treviño, E. N., Chao, D. F. B., Padilla-Rivas, G. R., et al. (2024) · Life · doi:10.3390/life14121671 · Cited by 5
KLF4 Genome: A double edged sword
Malik, D., & Kaul, D. (2015) · Journal of Solid Tumors · doi:10.5430/jst.v5n1p49 · Cited by 5
Characterization and expression analysis of Th-POK from the Japanese pufferfish, Takifugu rubripes
Nagamine, R., Korenaga, H., Sakai, M., Secombes, C. J., & Kono, T. (2012) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2012.11.006 · Cited by 5
TIEG1-null tenocytes display age-dependent differences in their gene expression, adhesion, spreading and proliferation properties
Haddad, O., Gumez, L., Hawse, J. R., Subramaniam, M., Spelsberg, T. C., & Bensamoun, S. F. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.05.007 · Cited by 5
Regulation of Yamanaka factors during H5N1 virus infection in A549 cells and HEK293T cells
Wang, H. F., & He, H. X. (2018) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2018.1541760 · Cited by 5
The (epi)genomic landscape of splenic marginal zone lymphoma, biological implications, clinical utility, and future questions
Oquendo, C. J., Parker, H., Oscier, D. G., Ennis, S., Gibson, J., & Strefford, J. C. (2021) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.04 · Cited by 6
Intrinsic determinants of optic nerve regeneration
Zhu, R., Cho, K., Guo, C., Chew, J., Chen, D., & Yang, L. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20130279 · Cited by 5
Adipose induces myoblast differentiation and mediates TNFα-regulated myogenesis
Wu, Y., Long, Q., Zheng, Z., Xia, Q., Wen, F., Zhu, X. A., Yu, X., & Yang, Z. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.07.018 · Cited by 5
Localization and Differential Expression of the Krüppel-Associated Box Zinc Finger Proteins 1 and 54 in Early Mouse Development
Albertsen, M., Teperek, M., Elholm, G., Füchtbauer, E., & Lykke-Hartmann, K. (2010) · DNA and Cell Biology · doi:10.1089/dna.2010.1040 · Cited by 6
Characterization and Spatiotemporal Expression of Klf4 in Large Yellow Croaker Larimichthys crocea
Jiang, Y., Han, K., Cai, M., Wang, Y., & Zhang, Z. (2017) · DNA and Cell Biology · doi:10.1089/dna.2017.3663 · Cited by 4
Gene Signatures and Associated Transcription Factors of Allergic Rhinitis: KLF4 Expression Is Associated with Immune Response
Jeon, Y., Kang, T. K., Lee, W., Jung, S. H., & Kim, Y. (2023) · BioMed Research International · doi:10.1155/2023/1317998 · Cited by 4
AhR signaling in joint homeostasis and disease
Brahmachary, P. P., Keim, E., Walk, S. T., McGee‐Lawrence, M. E., & June, R. K. (2026) · Biochimie · doi:10.1016/j.biochi.2026.03.003 · Cited by 4
MicroRNA-135b mainly functions as an oncogene during tumor progression
Ghasaban, F. T., Taghehchian, N., Zangouei, A. S., Keivany, M. R., & Moghbeli, M. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155547 · Cited by 4
Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer.
Fatourachi, P., Maragheh, B. F. A., Mohammadi, S. M., Valipour, B., Dehnad, A., & Charoudeh, H. N. (2018) · Gastroenterology and hepatology from bed to bench. · Cited by 3
Transcription factor Kruppel-like factor 5 positively regulates the expression of AarF domain containing kinase 4
Chen, X., Liu, S., Chen, J., Wang, X., & Zhou, G. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05882-w · Cited by 3
An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice
Muta, K., Nakazawa, Y., Obata, Y., Inoue, H., Torigoe, K., Nakazawa, M., Abe, K., Furusu, A., Miyazaki, M., Yamamoto, K., et al. (2021) · Peritoneal Dialysis International · doi:10.1177/0896860820981322 · Cited by 3
Krüppel-like Factors and the Liver
Narla, G., & Friedman, S. L. (2009) · Springer eBooks · doi:10.1007/978-4-431-87775-2_11 · Cited by 3
Molecular cloning and characterization of the anti-obesity gene adipose in pig
Wu, Y., Long, Q., Feng, B., Zhu, X. A., Zheng, Z., Gao, S., Gao, M., Gan, L., Zhou, L., & Yang, Z. (2012) · Gene · doi:10.1016/j.gene.2012.07.087 · Cited by 2
Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice
Ritter, M. L., Wagner, V. A., Balapattabi, K., Opichka, M. A., Lu, K., Wackman, K. K., Reho, J. J., Keen, H. L., Kwitek, A. E., Morselli, L. L., et al. (2023) · Physiological Genomics · doi:10.1152/physiolgenomics.00042.2023 · Cited by 2
Downregulation of Krüppel-like factor 15 expression delays endochondral bone ossification during fracture healing
Tachibana, S., Hayashi, S., Ikuta, K., Anjiki, K., Onoi, Y., Suda, Y., Wada, K., Maeda, T., Saito, A., Tsubosaka, M., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117302 · Cited by 2
Characterization of Transcription Factor Krüppel-Like Factor 3 Expression in Splenic T Lymphocytes and Association with Immune Status in Septic Mice
YAN, M., CHI, D., Wang, W., PEI, P., XIE, M., & LI, S. (2025) · Biocell · doi:10.32604/biocell.2025.063622 · Cited by 2
The Intrinsic Determinants of Axon Regeneration in the Central Nervous System
Cho, K., Guo, C., Chew, J., Yuan, J. C., Zhu, R., He, Z., & Chen, D. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00012-4 · Cited by 2
Notch Pathway Regulation of Intestinal Cell Fate
Dempsey, P. J., Bohin, N., & Samuelson, L. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00006-2 · Cited by 3
◾ Sourcing and Manipulating Stem Cells for Elastin Regeneration Applications
BALOG, A. R. B. M. (2018) · CRC Press eBooks · doi:10.1201/9781315370842-12 · Cited by 2
Notch Pathway Regulation of Intestinal Cell Fate
Dussen, K. L. V., Dempsey, P. J., & Samuelson, L. C. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00011-7 · Cited by 2
Krüppel-like Factors in Cancers
Yang, V. W. (2009) · Springer eBooks · doi:10.1007/978-4-431-87775-2_16 · Cited by 2
Self-citation
LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis
Xing, Z., Du, M., Zhen, Y., Chen, J., Li, D., Liu, R., & Zheng, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110907 · Cited by 2
GFP-linked zinc finger protein sp1
Matsushita, K., & Sugiura, Y. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00337-1 · Cited by 2
Emerging Evidence for Krüppel-Like Factor 4 (KLF4) as a Tumor Suppressor in Neuroblastoma
Ray, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812005-7.00016-3 · Cited by 1
Investigating the role of miR-87a-3p_1 in regulating spermatogenesis in the scallop, Chlamys farreri
Wang, J., Zhang, Z., Guo, X., Liu, F., Qin, Z., & Li, X. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742653 · Cited by 1
Genetic Predisposition for Type 2 Diabetes Mellitus in a Cameroonian Population: Contribution of rs4731702 (C/T) Polymorphism of Krüppel-Like Factor 14 Gene
Guewo‐Fokeng, M., Sobngwi, E., Atogho‐Tiedeu, B., Lontchi‐Yimagou, E., Chedjou, J.-P., Mbanya, J. C., & Mbacham, W. F. (2021) · Open Journal of Genetics · doi:10.4236/ojgen.2021.112002 · Cited by 2
INDUCED PLURIPOTENT STEM CELLS, CRISPR-CAS9 (KRISPER) GENOME EDITING SYSTEM AND PERSPECTIVES OF SOLVING THE PROBLEM OF GENE THERAPY OF HUMAN HEREDITARY DISEASES
Volotovski, I. D., & Poleshko, А. G. (2018) · Proceedings of the National Academy of Sciences of Belarus Biological Series · doi:10.29235/1029-8940-2018-63-1-113-125 · Cited by 1
Suppression of Krüppel-like factor 5 basal expression by CREB1 binding to far distal element
Mihara, N., & Imai, K. (2023) · Tumor Biology · doi:10.3233/tub-230017 · Cited by 1
KLF4 (Kruppel-like factor 4 (gut))
Ghaleb, A. M., & Yang, V. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44555 · Cited by 1
Self-citation

Authors: Dang, D. T., Pevsner, J., & Yang, V. W.
Affiliations: Johns Hopkins University (US)
Kennedy Krieger Institute (US)
Corresponding author: Yang, Vincent W.
ORCID: Pevsner, Jonathan
Yang, Vincent W.
Venue: The International Journal of Biochemistry & Cell Biology
Publisher: Elsevier BV
Published: 2000-12
Volume: 32
Issue: 11-12
Pages: 1103-1121
ISSN: 1357-2725 (ISSN-L)
DOI: 10.1016/s1357-2725(00)00059-5
PMC: PMC2754176
OpenAlex: W2133383018
Cited by: 458
References: 126
Citations by year: 2026: 6 · 2025: 8 · 2024: 16 · 2023: 22 · 2022: 7 · 2021: 12 · 2020: 15 · 2019: 17 · 2018: 29 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 21 · 2012: 18
FWCI: 1.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 385 d)
Locations: The International Journal of Biochemistry & Cell Biology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA 84197, R01CA084197)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK010020, DK 52230, DK10020, R01DK052230)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords: Krüppel-like factors, zinc finger transcription factor, transcriptional regulation, transcriptional activator, transcriptional repressor, phylogenetic classification, cell proliferation, cell differentiation, development (biology)
MeSH terms: Animals, DNA-Binding Proteins, Humans, Mammals, Phylogeny, Repressor Proteins, Transcription Factors, Transcription, Genetic, Zinc Fingers, Kruppel-Like Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The biology of the mammalian Krüppel-like family of transcription factors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks