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Bone tissue engineering: from bench to bedside
Open accessAbstract
The drive to develop bone grafts for the filling of major gaps in the skeletal structure has led to a major research thrust towards developing biomaterials for bone engineering. Unfortunately, from a clinical perspective, the promise of bone tissue engineering which was so vibrant a decade ago has so far failed to deliver the anticipated results of becoming a routine therapeutic application in reconstructive surgery. Here we describe our bench to bedside concept, the first clinical results and a detailed analysis of long-term bone regeneration studies in preclinical animal models, exploiting methods of micro- and nano analysis of biodegradable composite scaffolds.
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Metadata
- Authors
- Woodruff, M. A., Lange, C., Reichert, J., Berner, A., Chen, F., Fratzl, P., Schantz, J.-T., & Hutmacher, D. W.
- Affiliations
- Queensland University of Technology (AU)
- Max Planck Society (DE)
- University of Würzburg (DE)
- University of Regensburg (DE)
- Air Force Medical University (CN)
- TUM Klinikum (DE)
- Georgia Institute of Technology (US)
- Corresponding author
- Hutmacher, Dietmar W.
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 15
- Issue
- 10
- Pages
- 430-435
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W2089789987
- Cited by
- 182
- References
- 42
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 12 · 2018: 11 · 2017: 23 · 2016: 15 · 2015: 9 · 2014: 12 · 2013: 10
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Materials Today (publishedVersion, cc-by-nc-nd)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone tissue engineering, bone grafting, biomaterials, bone regeneration, preclinical animal models, clinical translation, reconstructive surgery
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