Bone tissue engineering: from bench to bedside

Tissue engineering

Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893

Scaffolds in tissue engineering bone and cartilage

Hutmacher, D. W. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00121-6 · Cited by 5,061

The return of a forgotten polymer—Polycaprolactone in the 21st century

Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666

Tissue Engineering--Current Challenges and Expanding Opportunities

Griffith, L. G., & Naughton, G. K. (2002) · Science · doi:10.1126/science.1069210 · Cited by 2,348

Fused deposition modeling of novel scaffold architectures for tissue engineering applications

Zein, I., Hutmacher, D. W., Tan, K. C., & Teoh, S. H. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00232-0 · Cited by 1,874

Progress in polymer science

Gee, G. (1972) · Polymer · doi:10.1016/0032-3861(72)90025-0 · Cited by 1,367

Animal models for implant biomaterial research in bone: A review

AO Research Institute, A. F., Pearce, A., Richards, R., Milz, S., Schneider, E., & Pearce, S. (2007) · European Cells and Materials · doi:10.22203/ecm.v013a01 · Cited by 1,289

Additive manufacturing of tissues and organs

Melchels, F. P. W., Domingos, M. A. N., Klein, T. J., Malda, J., Bártolo, P., & Hutmacher, D. W. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.11.007 · Cited by 1,223

State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective

Hutmacher, D. W., Schantz, J. T., Lam, C. X. F., Tan, K. C., & Lim, T. C. (2007) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.24 · Cited by 1,007

Materials design for bone-tissue engineering

Koons, G. L., Diba, M., & Mikos, A. G. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0204-2 · Cited by 1,769

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Henkel, J., Woodruff, M. A., Epari, D. R., Steck, R., Glatt, V., Dickinson, I. C., Choong, P., Schuetz, M., & Hutmacher, D. W. (2013) · Bone Research · doi:10.4248/br201303002 · Cited by 910

Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering

Liu, Y., Luo, D., & Wang, T. (2016) · Small · doi:10.1002/smll.201600626 · Cited by 482

Hierarchically designed bone scaffolds: From internal cues to external stimuli

Du, Y., Guo, J. L., Wang, J., Mikos, A. G., & Zhang, S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119334 · Cited by 253

Melt Electrospinning and Its Technologization in Tissue Engineering

Muerza-Cascante, M. L., Haylock, D. N., Hutmacher, D. W., & Dalton, P. D. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0347 · Cited by 215

Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering

Akbarzadeh, R., & Yousefi, A. (2014) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.33101 · Cited by 208

Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects

Wu, J., Zheng, K., Huang, X., Liu, J., Liu, H., Boccaccini, A. R., Wan, Y., Guo, X., & Shao, Z. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.023 · Cited by 201

3D printing of biomaterials

Bandyopadhyay, A. K., Bose, S., & Das, S. (2015) · MRS Bulletin · doi:10.1557/mrs.2015.3 · Cited by 198

The horizon of bone organoid: A perspective on construction and application

Chen, S., Chen, X., Geng, Z., & Su, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.048 · Cited by 197

Prospect of Stem Cells in Bone Tissue Engineering: A Review

Yousefi, A., James, P. F., Akbarzadeh, R., Subramanian, A., Flavin, C., & Oudadesse, H. (2016) · Stem Cells International · doi:10.1155/2016/6180487 · Cited by 192

Biodegradable Polymers for Biomedical Additive Manufacturing

Puppi, D., & Chiellini, E. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2020.100700 · Cited by 197

Additive manufacturing of polymer melts for implantable medical devices and scaffolds

Youssef, A., Hollister, S. J., & Dalton, P. D. (2017) · Biofabrication · doi:10.1088/1758-5090/aa5766 · Cited by 191

Hierarchically Staggered Nanostructure of Mineralized Collagen as a Bone‐Grafting Scaffold

Liu, Y., Liu, S., Luo, D., Xue, Z., Yang, X., Gu, L., Zhou, Y.-H., & Wang, T. (2016) · Advanced Materials · doi:10.1002/adma.201602628 · Cited by 170

Bone remodelling in vitro: Where are we headed?

Kohli, N., Ho, S., Brown, S. J., Sawadkar, P., Sharma, V., Snow, M., & García‐Gareta, E. (2018) · Bone · doi:10.1016/j.bone.2018.01.015 · Cited by 157

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

Shah, N. J., Hyder, M. N., Quadir, M., Courchesne, N. D., Seeherman, H. J., Nevins, M., Spector, M., & Hammond, P. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408035111 · Cited by 148

The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective

Laubach, M., Hildebrand, F., Suresh, S., Wagels, M., Kobbe, P., Gilbert, F., Kneser, U., Holzapfel, B. M., & Hutmacher, D. W. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14070341 · Cited by 137

Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae

Cipitria, A., Reichert, J. C., Epari, D. R., Saifzadeh, S., Berner, A., Schell, H., Mehta, M., Schuetz, M., Duda, G. N., & Hutmacher, D. W. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.011 · Cited by 133

Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration

Li, Z., He, D., Guo, B., Wang, Z., Yu, H., Wang, Y., Jin, S., Yu, M., Zhu, L., Chen, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42598-4 · Cited by 143

Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing

Chhaya, M. P., Melchels, F. P. W., Holzapfel, B. M., Baldwin, J., & Hutmacher, D. W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.025 · Cited by 119

Evaluation of BMP-2 and VEGF loaded 3D printed hydroxyapatite composite scaffolds with enhanced osteogenic capacity in vitro and in vivo

Chen, S., Shi, Y., Zhang, X., & Ma, J. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110893 · Cited by 117

Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering

Carvalho, M. S., Silva, J. C., Udangawa, R. N., Cabral, J. M. S., Ferreira, F. C., da Silva, C. L., Linhardt, R. J., & Vashishth, D. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.127 · Cited by 111

Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms

Li, P., Dai, J., Li, Y., Alexander, D., Čapek, J., Geis‐Gerstorfer, J., Wan, G., Han, J., Yu, Z., & Li, A. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100932 · Cited by 114

Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering

Mouriño, V., Cattalini, J. P., Roether, J. A., Dubey, P., Roy, I., & Boccaccini, A. R. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.808183 · Cited by 105

Mechanical Properties of Compact Bone Defined by the Stress-Strain Curve Measured Using Uniaxial Tensile Test: A Concise Review and Practical Guide

Lin, C.-Y., & Kang, J. (2021) · Materials · doi:10.3390/ma14154224 · Cited by 105

In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization

Felfel, R. M., Poocza, L., Gimeno-Fabra, M., Milde, T., Hildebrand, G., Ahmed, I., Scotchford, C., Sottile, V., Grant, D. M., & Liefeith, K. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/1/015011 · Cited by 106

Composite PLA/PEG/nHA/Dexamethasone Scaffold Prepared by 3D Printing for Bone Regeneration

Li, X., Wang, Y., Wang, Z., Qi, Y., Li, L., Zhang, P., Chen, X., & Huang, Y. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800068 · Cited by 101

Advances in the Fabrication of Scaffold and 3D Printing of Biomimetic Bone Graft

Bisht, B., Hope, A., Mukherjee, A., & Paul, M. K. (2021) · Annals of Biomedical Engineering · doi:10.1007/s10439-021-02752-9 · Cited by 100

Clinical translation of a patient-specific scaffold-guided bone regeneration concept in four cases with large long bone defects

Laubach, M., Suresh, S., Herath, B., Wille, M., Delbrück, H., Alabdulrahman, H., Hutmacher, D. W., & Hildebrand, F. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.04.004 · Cited by 99

Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

Hao, J., Bai, B., Ci, Z., Tang, J., Hu, G., Dai, C., Yu, M., Li, M., Zhang, W., Zhang, Y., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.013 · Cited by 99

Injectable hydrogels for cartilage and bone tissue regeneration: A review

Ghandforoushan, P., Alehosseini, M., Golafshan, N., Castilho, M. D., Dolatshahi‐Pirouz, A., Hanaee, J., Davaran, S., & Orive, G. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125674 · Cited by 105

Permeability and fluid flow-induced wall shear stress of bone tissue scaffolds: Computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow models

Ali, D., & Şen, S. (2018) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2018.06.017 · Cited by 91

Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

Xu, C. W., Liu, Z., Chen, X., Gao, Y., Wang, W., Zhuang, X., Zhang, H., & Dong, X. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109197 · Cited by 90

3D printed hybrid bone constructs of PCL and dental pulp stem cells loaded GelMA

Büyüksungur, S., Hasırcı, V., & Hasırcı, N. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37235 · Cited by 84

Biomimetic Ultralight, Highly Porous, Shape‐Adjustable, and Biocompatible 3D Graphene Minerals via Incorporation of Self‐Assembled Peptide Nanosheets

Li, K., Zhang, Z., Li, D., Zhang, W., Yu, X., Liu, W., Gong, C., Wei, G., & Su, Z. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801056 · Cited by 83

Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

Fayyazbakhsh, F., Solati‐Hashjin, M., Keshtkar, A., Shokrgozar, M. A., Dehghan, M. M., & Larijani, B. A. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.02.172 · Cited by 83

Study on the properties of PLA/PBAT composite modified by nanohydroxyapatite

Yan, D., Wang, Z., Guo, Z., Ma, Y., Wang, C., Tan, H., & Zhang, Y. (2020) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2020.08.062 · Cited by 81

Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications

Cinici, B., Yaba, S., Kurt, M., Yalcin, H. C., Duta, L., & Gündüz, O. (2024) · Biomimetics · doi:10.3390/biomimetics9070409 · Cited by 81

Biomimetic self-assembly of apatite hybrid materials: From a single molecular template to bi-/multi-molecular templates

Ma, J., Wang, J., Ai, X. P., & Zhang, S. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.10.014 · Cited by 78

From Nature to Technology: Exploring the Potential of Plant-Based Materials and Modified Plants in Biomimetics, Bionics, and Green Innovations

Barbinta-Patrascu, M. E., Bita, B. I., & Neguț, I. (2024) · Biomimetics · doi:10.3390/biomimetics9070390 · Cited by 84

The Potential Impact of Bone Tissue Engineering in the Clinic

Mishra, R., Bishop, T. J., Valerio, I. L., Fisher, J. P., & Dean, D. (2016) · Regenerative Medicine · doi:10.2217/rme-2016-0042 · Cited by 72

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

Cipitria, A., Wagermaier, W., Zaslansky, P., Schell, H., Reichert, J. C., Fratzl, P., Hutmacher, D. W., & Duda, G. N. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.05.015 · Cited by 72

Biomimetic synthesis of Mg‐substituted hydroxyapatite nanocomposites and three‐dimensional printing of composite scaffolds for bone regeneration

Chen, S., Shi, Y., Zhang, X., & Ma, J. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36757 · Cited by 73

3D printed hydroxyapatite composite scaffolds with enhanced mechanical properties

Chen, S., Shi, Y., Zhang, X., & Ma, J. (2019) · Ceramics International · doi:10.1016/j.ceramint.2019.02.182 · Cited by 70

Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly( d , l ‑lactide) Composite Inducing Formation of Anisotropic Collagen Matrix

Zhang, Y., Li, J., Mouser, V. H. M., Roumans, N. J. T., Moroni, L., & Habibović, P. (2021) · ACS Nano · doi:10.1021/acsnano.1c03905 · Cited by 69

Melt Electrospinning of Nanofibers from Medical‐Grade Poly(ε‐Caprolactone) with a Modified Nozzle

Großhaus, C., Bakırcı, E., Berthel, M., Hrynevich, A., Kade, J. C., Hochleitner, G., Gröll, J., & Dalton, P. D. (2020) · Small · doi:10.1002/smll.202003471 · Cited by 68

Dynamic Nanocomposite Microgel Assembly with Microporosity, Injectability, Tissue‐Adhesion, and Sustained Drug Release Promotes Articular Cartilage Repair and Regeneration

Feng, Q., Li, D., Li, Q., Li, S., Huang, H., Li, H., Dong, H., & Cao, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202102395 · Cited by 67

Coculture of Peripheral Blood-Derived Mesenchymal Stem Cells and Endothelial Progenitor Cells on Strontium-Doped Calcium Polyphosphate Scaffolds to Generate Vascularized Engineered Bone

Fu, W., Xiang, Z., Huang, F., Gu, Z., Yu, X., Cen, S., Zhong, G., Duan, X., & Liu, M. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0267 · Cited by 66

The future of bone regeneration: integrating AI into tissue engineering

MacKay, B., Marshall, K. M., Grant‐Jacob, J. A., Kanczler, J. M., Eason, R. W., Oreffo, R. O. C., & Mills, B. (2021) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ac154f · Cited by 68

Additive manufacturing pertaining to bone: Hopes, reality and future challenges for clinical applications

Charbonnier, B., Hadida, M., & Marchat, D. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.039 · Cited by 68

Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations.

Cao, C., Huang, P., Prasopthum, A., Parsons, A. J., Ai, F., & Yang, J. (2022) · Biomaterials Science · doi:10.1039/d1bm01645h · Cited by 65

Breast Augmentation and Reconstruction from a Regenerative Medicine Point of View: State of the Art and Future Perspectives

Visscher, L. E., Cheng, M., Chhaya, M. P., Hintz, M. L., Schantz, J., Tran, P. A., Ung, O., Wong, C., & Hutmacher, D. W. (2017) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0303 · Cited by 58

3D-Printed Hydroxyapatite and Tricalcium Phosphates-Based Scaffolds for Alveolar Bone Regeneration in Animal Models: A Scoping Review

Mohd, N., Razali, M., Ghazali, M. J., & Kasim, N. H. A. (2022) · Materials · doi:10.3390/ma15072621 · Cited by 61

Bone tissue engineering gelatin–hydroxyapatite/graphene oxide scaffolds with the ability to release vitamin D: fabrication, characterization, and in vitro study

Mahdavi, R., Belgheisi, G., Nazarpak, M. H., Omidi, M., Khojasteh, A., & Solati‐Hashjin, M. (2020) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-020-06430-5 · Cited by 56

3D printing of strontium-doped hydroxyapatite based composite scaffolds for repairing critical-sized rabbit calvarial defects

Luo, Y. H., Chen, S., Shi, Y., & Ma, J. (2018) · Biomedical Materials · doi:10.1088/1748-605x/aad923 · Cited by 55

Engineering bone regeneration with novel cell-laden hydrogel microfiber-injectable calcium phosphate scaffold

Song, Y., Zhang, C., Wang, P., Wang, L., Bao, C., Weir, M. D., Reynolds, M. A., Ren, K., Zhao, L., & Xu, H. H. K. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.02.158 · Cited by 55

Hydrothermal fabrication of magnetic mesoporous carbonated hydroxyapatite microspheres: biocompatibility, osteoinductivity, drug delivery property and bactericidal property

Guo, Y., Long, T., Tang, S., Guo, Y., & Zhu, Z. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21829e · Cited by 53

Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle

Zheng, Y., Liu, X., Shen, D., Li, W., Cheng, Y., Yang, M., Kou, Y., & Jiang, B. (2022) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2022.12.004 · Cited by 51

Polymeric microgels for bone tissue engineering applications – a review

Meena, L. K., Rather, H., Kedaria, D., & Vasita, R. (2019) · International Journal of Polymeric Materials · doi:10.1080/00914037.2019.1570512 · Cited by 51

Perspectives on Synthetic Materials to Guide Tissue Regeneration for Osteochondral Defect Repair

Frassica, M. T., & Grunlan, M. A. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00753 · Cited by 50

Textile cell-free scaffolds for in situ tissue engineering applications

Aibibu, D., Hild, M., Wöltje, M., & Cherif, C. (2016) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5656-3 · Cited by 50

Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/poly(ε-caprolactone) Blend Scaffolds for Tissue Engineering

Puppi, D., Morelli, A., & Chiellini, E. (2017) · Bioengineering · doi:10.3390/bioengineering4020049 · Cited by 48

Gerüstträgerbasiertes Knochen-Tissue-Engineering

Holzapfel, B. M., Rudert, M., & Hutmacher, D. W. (2017) · Der Orthopäde · doi:10.1007/s00132-017-3444-0 · Cited by 48

3D-printed scaffold combined to 2D osteoinductive coatings to repair a critical-size mandibular bone defect

Bouyer, M., Garot, C., Machillot, P., Vollaire, J., Fitzpatrick, V., Morand, S., Boutonnât, J., Josserand, V., Bettega, G., & Picart, C. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100113 · Cited by 48

Biomimetic porous hydrogel scaffolds enabled vascular ingrowth and osteogenic differentiation for vascularized tissue-engineered bone regeneration

Wu, X., Huo, Y., Ci, Z., Wang, Y., Xu, W., Bai, B., Hao, J., Hu, G., Yu, M., Ren, W., et al. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101478 · Cited by 49

Graphene-reinforced mechanical properties of calcium silicate scaffolds by laser sintering

Shuai, C., Gao, C., Feng, P., & Peng, S. (2014) · RSC Advances · doi:10.1039/c3ra47862a · Cited by 45

Current Concepts and Methods in Tissue Interface Scaffold Fabrication

Vesvoranan, O., Anup, A., & Hixon, K. R. (2022) · Biomimetics · doi:10.3390/biomimetics7040151 · Cited by 48

Scaffold for bone tissue engineering

Tariverdian, T., Sefat, F., Gelinsky, M., & Mozafari, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102563-5.00010-1 · Cited by 44

3D-Printing of Hierarchically Designed and Osteoconductive Bone Tissue Engineering Scaffolds

Söhling, N., Neijhoft, J., Nienhaus, V., Valentin, A., Harbig, J., Menz, F., Ochs, J., Verboket, R. D., Ritz, U., Blaeser, A., et al. (2020) · Materials · doi:10.3390/ma13081836 · Cited by 46

Design and fabrication of scaffold-based tissue engineering

Henkel, J., & Hutmacher, D. W. (2013) · BioNanoMaterials · doi:10.1515/bnm-2013-0021 · Cited by 43

Introduction to 3D printing in medicine

Roopavath, U. K., & Kalaskar, D. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100717-4.00001-6 · Cited by 43

Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae

Li, J. J., Roohani‐Esfahani, S., Dunstan, C. R., Quach, T., Steck, R., Saifzadeh, S., Pivonka, P., & Zreiqat, H. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/1/015016 · Cited by 42

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Deng, X., Zhuang, Y., Cui, J., Wang, L., Zhan, H., Wang, X., Lin, K., & Yuan, C. (2025) · Advanced Science · doi:10.1002/advs.202510349 · Cited by 45

Genipin‐crosslinked gelatin hydrogel incorporated with PLLA‐nanocylinders as a bone scaffold: Synthesis, characterization, and mechanical properties evaluation

Oustadi, F., Imani, R., Nazarpak, M. H., & Sharifi, A. M. (2020) · Polymers for Advanced Technologies · doi:10.1002/pat.4905 · Cited by 39

Future Directions and Requirements for Tissue Engineering Biomaterials

Arjunan, A., Baroutaji, A., Robinson, J., Praveen, A. S., Pollard, A., & Wang, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815732-9.00068-1 · Cited by 38

Characterization of a composite polylactic acid-hydroxyapatite 3D-printing filament for bone-regeneration

Orozco-Diaz, C. A., Moorehead, R., Reilly, G. C., Gilchrist, F., & Miller, C. A. (2020) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ab73f8 · Cited by 37

Photopolymerization-based additive manufacturing for the development of 3D porous scaffolds

Husár, B., Hatzenbichler, M., Mironov, V. A., Liska, R., Stampfl, J., & Ovsianikov, A. (2014) · Elsevier eBooks · doi:10.1533/9780857098104.2.149 · Cited by 39

Multimodal‐3D imaging based on μMRI and μCT techniques bridges the gap with histology in visualization of the bone regeneration process

Sinibaldi, R., Conti, A., Sinjari, B., Spadone, S., Pecci, R., Palombo, M., Комлев, В. С., Ortore, M. G., Tromba, G., Capuani, S., et al. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2494 · Cited by 36

Nanocomposites for the delivery of bioactive molecules in tissue repair: vital structural features, application mechanisms, updated progress and future perspectives

Du, Z., Cao, G., Li, K., Zhang, R., & Li, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01670e · Cited by 35

Preparation and stability of dexamethasone-loaded polymeric scaffolds for bone regeneration processed by compressed CO2 foaming

Goimil, L., Jaeger, P. T., Ardao, I., Gómez-Amoza, J. L., Concheiro, Á., Alvarez‐Lorenzo, C., & García‐González, C. A. (2017) · Journal of CO2 Utilization · doi:10.1016/j.jcou.2017.12.012 · Cited by 35

Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering

Nulty, J. M., Burdis, R., & Kelly, D. J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.661989 · Cited by 34

Recent Advances in Bone Tissue Engineering: Enhancing the Potential of Mesenchymal Stem Cells for Regenerative Therapies

Kostadinova, M., Raykovska, M., Simeonov, R., Lolov, S. R., & Mourdjeva, M. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47040287 · Cited by 33

Evaluation of Preclinical Models for the Testing of Bone Tissue-Engineered Constructs

Zeiter, S., Koschitzki, K., Alini, M., Franz, J., Rudert, M., & Herrmann, M. (2019) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2019.0213 · Cited by 32

3D printing of bioactive macro/microporous continuous carbon fibre reinforced hydroxyapatite composite scaffolds with synchronously enhanced strength and toughness

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Jahani, B., Wang, X., & Brooks, A. E. (2020) · Recent Progress in Materials · doi:10.21926/rpm.2003021 · Cited by 31

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Li, C., Zhang, Y., Du, Y., Hou, Z., Zhang, Y., Cui, W., & Chen, W. (2023) · Small Science · doi:10.1002/smsc.202300027 · Cited by 30

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Poocza, L., Gottschaldt, M., Markweg, E., Hauptmann, N., Hildebrand, G., Pretzel, D., Hartlieb, M., Reichardt, C. L., Kübel, J., Schubert, U. S., et al. (2017) · Advanced Engineering Materials · doi:10.1002/adem.201600686 · Cited by 27

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Sekaran, S., Vimalraj, S., Lakshmanan, G., Jindal, A., Sundaramurthi, D., & Bhattacharya, J. (2019) · Springer series in biomaterials science and engineering · doi:10.1007/978-981-13-8855-2_18 · Cited by 21

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Woodruff, M. A., Lange, C., Reichert, J. C., Berner, A., Chen, F., Fratzl, P., Schantz, J., & Hutmacher, D. W. (2012) · QUT ePrints (Queensland University of Technology)

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Zhan, G. Z., He, L., 陈富林, & 易飞舟 (2003) · doi:10.3760/cma.j.issn.1673-4181.2003.05.007

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