Cited by 185Sleep and related disordersRestless Legs Syndrome ResearchSleep and Wakefulness Research

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Amnestic sleep-related eating disorder associated with zolpidem

Morgenthaler, Timothy I, Silber, Michael H·2002·Sleep Medicine

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Abstract

Objective To describe the association of amnestic nocturnal eating behavior with use of zolpidem for insomnia.Background Sleep-related eating disorder is increasingly recognized in relationship to other diagnosable sleep disorders. Many of these disorders, like restless legs syndrome (RLS), give rise to complaints of insomnia. Zolpidem is the most commonly prescribed drug for insomnia complaints, and although it has sometimes been associated with side effects of transient amnesia and sleep walking, an association with sleep-related eating has not been previously emphasized.Methods Consecutive case series of five patients who were using zolpidem and evaluated with nocturnal eating behaviors.Results We evaluated five patients over 11 months with problematic amnestic nocturnal eating associated with zolpidem used for complaints of insomnia. All five patients had RLS, three had obstructive sleep apnea syndrome, two had sleep walking, and one had psychophysiologic insomnia. With discontinuation of zolpidem and effective treatment of their sleep disorders, nocturnal eating resolved.Conclusions Zolpidem, at least in patients with underlying sleep disorders that cause frequent arousals, may cause or augment sleep-related eating behavior. This report demonstrates the importance of arriving at a specific diagnosis for insomnia complaints, and alerts the sleep practitioner to this unusual side effect of zolpidem.

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Authors: Morgenthaler, T. I., & Silber, M. H.
Affiliations: Mayo Clinic (US)
Corresponding author: Morgenthaler, Timothy I
ORCID: Morgenthaler, Timothy I
Silber, Michael H
Venue: Sleep Medicine
Publisher: Elsevier BV
Published: 2002-07
Volume: 3
Issue: 4
Pages: 323-327
ISSN: 1389-9457 (ISSN-L)
DOI: 10.1016/s1389-9457(02)00007-2
OpenAlex: W2162977548
Cited by: 185
References: 33
Citations by year: 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 9 · 2015: 4 · 2014: 11 · 2013: 17 · 2012: 10
FWCI: 5.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: sleep-related eating disorder, zolpidem, drug-induced amnesia, insomnia, restless legs syndrome, obstructive sleep apnea, sleepwalking, hypnotic side effects

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Amnestic sleep-related eating disorder associated with zolpidem

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