Cited by 877Alcohol Consumption and Health EffectsHead and Neck Cancer StudiesEsophageal Cancer Research and Treatment

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Alcohol and cancer

Boffetta, Paolo, Hashibe, Mia·2006·The Lancet Oncology

DOI 10.1016/s1470-2045(06)70577-0

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Abstract

A causal association has been established between alcohol consumption and cancers of the oral cavity, pharynx, larynx, oesophagus, liver, colon, rectum, and, in women, breast; an association is suspected for cancers of the pancreas and lung. Evidence suggests that the effect of alcohol is modulated by polymorphisms in genes encoding enzymes for ethanol metabolism (eg, alcohol dehydrogenases, aldehyde dehydrogenases, and cytochrome P450 2E1), folate metabolism, and DNA repair. The mechanisms by which alcohol consumption exerts its carcinogenic effect have not been defined fully, although plausible events include: a genotoxic effect of acetaldehyde, the main metabolite of ethanol; increased oestrogen concentration, which is important for breast carcinogenesis; a role as solvent for tobacco carcinogens; production of reactive oxygen species and nitrogen species; and changes in folate metabolism. Alcohol consumption is increasing in many countries and is an important cause of cancer worldwide.

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Authors: Boffetta, P., & Hashibe, M.
Affiliations: Centre international de recherche sur le cancer (FR)
Corresponding author: Boffetta, Paolo
ORCID: Boffetta, Paolo
Hashibe, Mia
Venue: The Lancet Oncology
Publisher: Elsevier BV
Published: 2006-02
Volume: 7
Issue: 2
Pages: 149-156
ISSN: 1470-2045 (ISSN-L)
DOI: 10.1016/s1470-2045(06)70577-0
OpenAlex: W4241577617
Cited by: 877
References: 70
Citations by year: 2026: 19 · 2025: 45 · 2024: 36 · 2023: 47 · 2022: 66 · 2021: 58 · 2020: 54 · 2019: 37 · 2018: 44 · 2017: 48 · 2016: 45 · 2015: 51 · 2014: 42 · 2013: 43 · 2012: 52
FWCI: 5.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Oncology (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords: alcohol consumption, alcohol-related cancer, oral cancer, pharyngeal cancer, laryngeal cancer, esophageal cancer, liver cancer, colorectal cancer, breast cancer, pancreatic cancer, lung cancer, alcohol metabolism, alcohol dehydrogenase, aldehyde dehydrogenase, CYP2E1, folate metabolism, DNA repair, acetaldehyde, genotoxicity, estrogen, tobacco carcinogens, reactive oxygen species, carcinogenesis mechanisms
MeSH terms: Alcohol Drinking, Ethanol, Female, Humans, Male, Neoplasms, Genetic Predisposition to Disease

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