The DOI matches its Crossref record; 68 of the 70 references it cites were found in a registry or an index.
Alcohol and cancer
Abstract
A causal association has been established between alcohol consumption and cancers of the oral cavity, pharynx, larynx, oesophagus, liver, colon, rectum, and, in women, breast; an association is suspected for cancers of the pancreas and lung. Evidence suggests that the effect of alcohol is modulated by polymorphisms in genes encoding enzymes for ethanol metabolism (eg, alcohol dehydrogenases, aldehyde dehydrogenases, and cytochrome P450 2E1), folate metabolism, and DNA repair. The mechanisms by which alcohol consumption exerts its carcinogenic effect have not been defined fully, although plausible events include: a genotoxic effect of acetaldehyde, the main metabolite of ethanol; increased oestrogen concentration, which is important for breast carcinogenesis; a role as solvent for tobacco carcinogens; production of reactive oxygen species and nitrogen species; and changes in folate metabolism. Alcohol consumption is increasing in many countries and is an important cause of cancer worldwide.
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“The risk relationship between alcohol consumption and the development of cancer has been shown to be modified by genetic variations in the carbon metabolism pathway and the ethanol–acetaldehyde metabolic pathways 181, 182.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [182]
Citations
Cites
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Collaborative Group on Hormonal Factors in Breast Cancer (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600596 · Cited by 1,135
A meta-analysis of alcohol consumption and the risk of 15 diseases
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Alcohol and Breast Cancer in Women
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Alcohol Consumption and Risk of Stroke
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Alcohol and coronary heart disease: a meta-analysis.
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A meta-analysis of alcohol drinking and cancer risk
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Characteristics of binge drinkers in Europe
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Research works printed but not linked: 1
- Singletary, 2001, Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms, JAMA, 286, 2143, 10.1001/jama.286.17.2143 · DOI
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Sorted by citations
Shared Risk Factors in Cardiovascular Disease and Cancer
Koene, R. J., Prizment, A. E., Blaes, A. H., & Konety, S. (2016) · Circulation · doi:10.1161/circulationaha.115.020406 · Cited by 1,512
Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis
Bagnardi, V, Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V, Scotti, L., Jenab, M., Turati, F., Pasquali, E., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.579 · Cited by 1,342
Self-citationAmerican Cancer Society guidelines on nutrition and physical activity for cancer prevention
Kushi, L. H., Doyle, C., McCullough, M. L., Rock, C. L., Demark‐Wahnefried, W., Bandera, E. V., Gapstur, S. M., Patel, A. V., Andrews, K. S., & Gansler, T. S. (2012) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20140 · Cited by 1,399
The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174
Metadata
- Authors
- Boffetta, P., & Hashibe, M.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Boffetta, Paolo
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 7
- Issue
- 2
- Pages
- 149-156
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W4241577617
- Cited by
- 877
- References
- 70
- Citations by year
- 2026: 19 · 2025: 45 · 2024: 36 · 2023: 47 · 2022: 66 · 2021: 58 · 2020: 54 · 2019: 37 · 2018: 44 · 2017: 48 · 2016: 45 · 2015: 51 · 2014: 42 · 2013: 43 · 2012: 52
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- alcohol consumption, alcohol-related cancer, oral cancer, pharyngeal cancer, laryngeal cancer, esophageal cancer, liver cancer, colorectal cancer, breast cancer, pancreatic cancer, lung cancer, alcohol metabolism, alcohol dehydrogenase, aldehyde dehydrogenase, CYP2E1, folate metabolism, DNA repair, acetaldehyde, genotoxicity, estrogen, tobacco carcinogens, reactive oxygen species, carcinogenesis mechanisms
- MeSH terms
- Alcohol Drinking, Ethanol, Female, Humans, Male, Neoplasms, Genetic Predisposition to Disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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