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Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?
Abstract
The discovery of somatic mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) in glioblastomas was remarkable because the enzyme was not previously identified with any known oncogenic pathway. IDH1 is mutated in up to 75% of grade II and grade III diffuse gliomas. Apart from acute myeloid leukaemia, other tumour types do not carry IDH1 mutations. Mutations in a homologous gene, IDH2, have also been identified, although they are much rarer. Although TP53 mutations and 1p/19q codeletions are mutually exclusive in gliomas, in both of these genotypes IDH1 mutations are common. IDH1 and IDH2 mutations are early events in the development of gliomas. Moreover, IDH1 and IDH2 mutations are a major prognostic marker for overall and progression-free survival in grade II-IV gliomas. Mutated IDH1 has an altered catalytic activity that results in the accumulation of 2-hydroxyglutarate. Molecularly, IDH1 and IDH2 mutations are heterozygous, affect only a single codon, and rarely occur together. Because IDH1 does not belong to a traditional oncogenic pathway and is specifically and commonly mutated in gliomas, the altered enzymatic activity of IDH1 may provide a fundamentally new understanding of diffuse glioma.
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“One of the key molecular differences between primary and secondary glioblastoma is the presence of isocitrate dehydrogenase-1 (IDH1) mutations which are found in approximately 75% of secondary GBM but are rare in primary GBM [13].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [13]
In the citing paper
“In contrast to wt-p53, GOF mut-p53 exhibits interactions with distinct transcription factors (e.g., NF-ɣ, SREBP, VDR, Sp1, ETS2, NFR2, p73, p63) that promote tumor initiation and progression [13,72,73,74,75,76,77].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [13]
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
Global Cancer Statistics, 2002
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,710
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143
Recurring mutations found by sequencing an acute myeloid leukemia genome
Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903840 · Cited by 2,219
Weinberg, R. A., & Weinberg, R. A. (2006) · W.W. Norton eBooks · doi:10.1201/9780203852569 · Cited by 1,806
Genetic Pathways to Primary and Secondary Glioblastoma
Ohgaki, H., & Kleihues, P. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070011 · Cited by 1,487
Epidemiology and etiology of gliomas
Ohgaki, H., & Kleihues, P. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-0991-y · Cited by 1,285
Hartmann, C. J., Meyer, J., Balß, J., Capper, D., Mueller, W. C., Christians, A., Felsberg, J., Wolter, M., Mawrin, C., Wick, W., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0561-9 · Cited by 1,163
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., et al. (2009) · Science · doi:10.1126/science.1170944 · Cited by 1,119
Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas
Sanson, M., Marie, Y., Paris, S., Idbaïh, A., Laffaire, J., Ducray, F., Hallani, S. E., Boisselier, B., Mokhtari, K., Hoang‐Xuan, K., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.21.9832 · Cited by 1,049
Analysis of the IDH1 codon 132 mutation in brain tumors
Balss, J., Meyer, J., Mueller, W., Korshunov, A., Hartmann, C., & von Deimling, A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0455-2 · Cited by 1,036
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
Watanabe, T., Nobusawa, S., Kleihues, P., & Ohgaki, H. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080958 · Cited by 1,027
HIF-1 and human disease: one highly involved factor
Semenza, G. L. (2000) · Genes & Development · doi:10.1101/gad.14.16.1983 · Cited by 909
Wick, W., Hartmann, C. J., Engel, C., Stoffels, M., Felsberg, J., Stockhammer, F., Sabel, M., Koeppen, S., Ketter, R., Meyermann, R., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.6497 · Cited by 803
IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
Nobusawa, S., Watanabe, T., Kleihues, P., & Ohgaki, H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0715 · Cited by 707
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Gravendeel, L. A. M., Kouwenhoven, M. C. M., Gevaert, O., de Rooi, J. J., Stubbs, A., Duijm, J. E., Daemen, A., Bleeker, F. E., Bralten, L. B. C., Kloosterhof, N. K., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2307 · Cited by 678
Self-citationWeller, M., Felsberg, J., Hartmann, C. J., Berger, H., Steinbach, J. P., Schramm, J., Westphal, M., Schackert, G., Simon, M., Tonn, J. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.0805 · Cited by 629
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
Ichimura, K., Pearson, D. M., Kocialkowski, S., Bäcklund, L. M., Chan, R., Jones, D., & Collins, V. P. (2009) · Neuro-Oncology · doi:10.1215/15228517-2009-025 · Cited by 593
van Nederveen, F. H., Gaal, J., Favier, J., Korpershoek, E., Oldenburg, R. A., de Bruyn, E. M., Sleddens, H. F. B. M., Derkx, P., Rivière, J., Dannenberg, H., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70164-0 · Cited by 554
Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors
Capper, D., Weißert, S., Balß, J., Habel, A., Meyer, J., Jaeger, D., Ackermann, U., Tessmer, C., Korshunov, A., Zentgraf, H., et al. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00352.x · Cited by 534
Lee, S., Nakamura, E., Yang, H., Wei, W., Linggi, M. S., Sajan, M. P., Farese, R. V., Freeman, R. S., Carter, B. D., Kaelin, W. G., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.015 · Cited by 527
Monoclonal antibody specific for IDH1 R132H mutation
Capper, D., Zentgraf, H., Balß, J., Hartmann, C. J., & von Deimling, A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0595-z · Cited by 438
Hunter, C., Smith, R., Cahill, D. P., Stephens, P., Stevens, C., Teague, J. W., Greenman, C., Edkins, S., Bignell, G. R., Davies, H. R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0127 · Cited by 431
van den Bent, M. J., Dubbink, H. J., Marie, Y., Brandes, A. A., TAPHOORN, M. J. B., Wesseling, P., Frénay, M., Tijssen, C. C., Lacombe, D. A., Idbaïh, A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2902 · Cited by 384
Self-citationBleeker, F. E., Lamba, S., Leenstra, S., Troost, D., Hulsebos, T. J. M., Vandertop, W. P., Frattini, M., Molinari, F., Knowles, M. A., Cerrato, A., et al. (2009) · Human Mutation · doi:10.1002/humu.20937 · Cited by 365
Genetic alterations and signaling pathways in the evolution of gliomas
Ohgaki, H., & Kleihues, P. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01308.x · Cited by 355
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Kang, M. R., Kim, M. S., Oh, J. E., Kim, Y. R., Song, S. Y., Seo, S. I., Lee, J. Y., Yoo, N. J., & Lee, S. H. (2009) · International Journal of Cancer · doi:10.1002/ijc.24379 · Cited by 312
Mitochondria in cancer: Not just innocent bystanders
Frezza, C., & Gottlieb, E. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.008 · Cited by 275
Korshunov, A., Meyer, J., Capper, D., Christians, A., Remke, M., Witt, H., Pfister, S. M., von Deimling, A., & Hartmann, C. J. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0550-z · Cited by 274
Cytosolic NADP+-dependent Isocitrate Dehydrogenase Plays a Key Role in Lipid Metabolism
Koh, H., Lee, S., Son, B.-G., Lee, S.-H., Ryoo, Z. Y., Chang, K., Park, J., Park, D., Song, B. J., Veech, R. L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402260200 · Cited by 258
Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2
Baumann, F., Leukel, P., Doerfelt, A., Beier, C. P., Dettmer, K., Oefner, P. J., Kastenberger, M., Kreutz, M. P., Nickl‐Jockschat, T., Bogdahn, U., et al. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-106 · Cited by 256
Ronnebaum, S. M., Ilkayeva, O., Burgess, S. C., Joseph, J. W., Lu, D., Stevens, R. D., Becker, T. C., Sherry, A. D., Newgard, C. B., & Jensen, M. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511908200 · Cited by 237
Metabolic enzymes as oncogenes or tumor suppressors
Thompson, C. B. (2009) · New England Journal of Medicine · doi:10.1056/nejme0810213 · Cited by 213
IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide
Dubbink, H. J., Taal, W., van Marion, R., Kros, J. M., van Heuvel, I., Bromberg, J. E. C., Zonnenberg, B. A., Zonnenberg, C. B. L., Postma, T. J., Gijtenbeek, J. M. M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c34ace · Cited by 186
Self-citationInsights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
Hartong, D. T., Dange, M., McGee, T. L., Berson, E. L., Dryja, T. P., & Colman, R. F. (2008) · Nature Genetics · doi:10.1038/ng.223 · Cited by 172
Brain tumours: classification and genes
Collins, V. P. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.040337 · Cited by 170
Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review
Aghili, M., Zahedi, F., & Rafiee, E. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9706-2 · Cited by 159
Kros, J. M., Gorlia, T., Kouwenhoven, M. C. M., Zheng, P., Collins, V. P., Figarella-Branger, D. F., Giangaspero, F., Giannini, C., Mokhtari, K., Mørk, S. J., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000263869.84188.72 · Cited by 156
Analysis of IDH1 and IDH2 mutations in Japanese glioma patients
Sonoda, Y., Kumabe, T., Nakamura, T., Saito, R., Kanamori, M., Yamashita, Y., Suzuki, H., & Tominaga, T. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01270.x · Cited by 140
l ‐2‐Hydroxyglutaric aciduria, a disorder of metabolite repair
SCHAFTINGEN, E. V., Rzem, R., & Veiga‐da‐Cunha, M. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-1042-3 · Cited by 133
Kölker, S., Pawlak, V., Ahlemeyer, B., Okun, J. G., Hörster, F., Mayatepek, E., Krieglstein, J., Hoffmann, G. F., & Köhr, G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02055.x · Cited by 133
Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas
Gaal, J., Burnichon, N., Korpershoek, E., Roncelin, I., Bertherat, J. Y., Plouin, P., de Krijger, R. R., Gimenez‐Roqueplo, A., & Dinjens, W. N. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2170 · Cited by 131
Mutagenesis and Laue Structures of Enzyme Intermediates: Isocitrate Dehydrogenase
Bolduc, J. M., Dyer, D. H., Scott, W. G., Singer, P., Sweet, R. M., Koshland, D. E., & Stoddard, B. L. (1995) · Science · doi:10.1126/science.7761851 · Cited by 123
Ceccarelli, C., Grodsky, N. B., Ariyaratne, N., Colman, R. F., & Bahnson, B. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207306200 · Cited by 116
Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase.
Ramachandran, N., & Colman, R. F. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43581-8 · Cited by 107
Kato, Y., Jin, G., Kuan, C.-T., McLendon, R. E., Yan, H., & Bigner, D. D. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.001 · Cited by 106
Shechter, I., Dai, P., Huo, L., & Guan, G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300285-jlr200 · Cited by 103
Segregation of non-p.R132H mutations inIDH1in distinct molecular subtypes of glioma
Gravendeel, L. A. M., Kloosterhof, N. K., Bralten, L. B. C., van Marion, R., Dubbink, H. J., Dinjens, W. N. M., Bleeker, F. E., Hoogenraad, C. C., Michiels, E. M. C., Kros, J. M., et al. (2010) · Human Mutation · doi:10.1002/humu.21201 · Cited by 101
Self-citationThe 2000 World Health Organization classification of tumours of the nervous system
Gonzales, M. F. (2001) · Journal of Clinical Neuroscience · doi:10.1054/jocn.2000.0829 · Cited by 97
Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
Watanabe, T., Vital, A., Nobusawa, S., Kleihues, P., & Ohgaki, H. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0528-x · Cited by 93
Lee, J. H., Kim, S. Y., Kil, I. S., & Park, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700303200 · Cited by 89
The Kinetics of Pig Heart Triphosphopyridine Nucleotide-Isocitrate Dehydrogenase
Uhr, M. L., Thompson, V. W., & Cleland, W. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42719-1 · Cited by 88
Colman, R. F. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45778-5 · Cited by 74
The Kinetics of Pig Heart Triphosphopyridine Nucleotide-Isocitrate Dehydrogenase
Northrop, D. B., & Cleland, W. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42720-8 · Cited by 71
PCR‐ and Restriction Endonuclease‐Based Detection of IDH1 Mutations
Meyer, J., Pusch, S., Balß, J., Capper, D., Mueller, W. C., Christians, A., Hartmann, C. J., & von Deimling, A. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00327.x · Cited by 59
Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster
Geer, B. W., Lindel, D. L., & Lindel, D. M. (1979) · Biochemical Genetics · doi:10.1007/bf00504310 · Cited by 53
Kil, I. S., Kim, S. Y., Lee, S. J., & Park, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.07.009 · Cited by 51
Kim, J., Kim, K. Y., Jang, H., Yoshida, T., Tsuchiya, K., Nitta, K., Park, J., Bonventre, J. V., & Park, K. M. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90566.2008 · Cited by 51
Antitumor effects of 2‐oxoglutarate through inhibition of angiogenesis in a murine tumor model
Matsumoto, K., Obara, N., Ema, M., Horie, M., Naka, A., Takahashi, S., & Imagawa, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01249.x · Cited by 48
Villafranca, J. J., & Colman, R. F. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45777-3 · Cited by 43
Soundar, S., Danek, B. L., & Colman, R. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5606 · Cited by 38
Quantifying Interactions Within the NADP(H) Enzyme Network in Drosophila melanogaster
Merritt, T. J. S., Kuczynski, C. A., Sezgın, E., Zhu, C.-T., Kumagai, S., & Eanes, W. F. (2009) · Genetics · doi:10.1534/genetics.109.100677 · Cited by 37
Schlisio, S. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00881.x · Cited by 33
Expression and Mutagenesis of Mammalian Cytosolic NADP+-Specific Isocitrate Dehydrogenase
Jennings, G. T., Minard, K. I., & McAlister-Henn, L. (1997) · Biochemistry · doi:10.1021/bi970916r · Cited by 32
Kelly, J. H., & Plaut, G. W. E. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70139-2 · Cited by 28
Testicular gene expression in male mice divergent for fertility after heat stress
Cammack, K. M., Antoniou, E., Hearne, L. B., & Lamberson, W. R. (2008) · Theriogenology · doi:10.1016/j.theriogenology.2008.09.029 · Cited by 28
Doyle, S. A., Beernink, P. T., & Koshland, D. E. (2001) · Biochemistry · doi:10.1021/bi002533q · Cited by 26
Redesigning the Substrate Specificity of an Enzyme: Isocitrate Dehydrogenase
Doyle, S. A., Fung, S.-Y. F., & Koshland, D. E. (2000) · Biochemistry · doi:10.1021/bi001458g · Cited by 23
Huang, Y. C., Grodsky, N. B., Kim, T., & Colman, R. F. (2004) · Biochemistry · doi:10.1021/bi030253f · Cited by 23
Kelly, J. H., & Plaut, G. W. E. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70140-9 · Cited by 20
Absence of IDH2 codon 172 mutation in common human cancers
Park, S. W., Chung, N. G., Han, J. Y., Eom, H., Lee, J. Y., Yoo, N. J., & Lee, S. H. (2009) · International Journal of Cancer · doi:10.1002/ijc.24647 · Cited by 19
Carlier, M., & Pantaloni, D. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12555.x · Cited by 18
Huang, Y. C., & Colman, R. F. (2002) · Biochemistry · doi:10.1021/bi0200716 · Cited by 15
Regulation of ethanol-induced toxicity by mitochondrial NADP+-dependent isocitrate dehydrogenase
Yang, E. S., & Park, J. (2009) · Biochimie · doi:10.1016/j.biochi.2009.05.008 · Cited by 15
Lee, P., & Colman, R. F. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00041-3 · Cited by 15
L-2-Hydroxyglutaric Aciduria and Brain Tumors
Yazıcı, N., Sarıalioğlu, F., Alkan, Ö., Kayaselçuk, F., & Erol, İ. (2009) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181b258c6 · Cited by 15
Gene expression of AGS cells stimulated with released proteins by Helicobacter pylori
Kim, N., Park, W., Kim, J. M., Park, J. H., Kim, J. S., Jung, H. C., & Song, I. S. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05241.x · Cited by 14
Bailey, J. M., & Colman, R. F. (1987) · Biochemistry · doi:10.1021/bi00389a042 · Cited by 13
Kim, T., & Colman, R. F. (2004) · Protein Science · doi:10.1110/ps.041091805 · Cited by 9
Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer
Holdhoff, M., Parsons, D. W., & Diaz, L. A. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9855-y · Cited by 8
Research works printed but not linked: 1
- Yan, 2009, IDH1 and IDH2 mutations play a fundamental role in glioma development, Neuro Oncol, 11, 608
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Metadata
- Authors
- Kloosterhof, N. K., Bralten, L. B., Dubbink, H. J., French, P. J., & van den Bent, M. J.
- Affiliations
- Erasmus MC - Sophia Children’s Hospital (NL)
- Daniel den Hoed Kliniek (NL)
- Erasmus MC (NL)
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 12
- Issue
- 1
- Pages
- 83-91
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2084945856
- Cited by
- 222
- References
- 86
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 21 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 19 · 2013: 20 · 2012: 17
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-10-01)
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- IDH1, IDH1 mutation, IDH2 mutation, diffuse glioma, glioblastoma, 2-hydroxyglutarate, TP53 mutation, 1p/19q codeletion, prognostic factors, tumor progression, oncogenic signaling
- MeSH terms
- Brain Neoplasms, Codon, Glioma, Humans, Isocitrate Dehydrogenase, Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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