Detection of 2-Hydroxyglutarate in IDH -Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy
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2-Hydroxyglutarate, a metabolite overproduced in IDH -mutated gliomas, can be detected noninvasively in patients with brain tumors by optimized magnetic resonance spectroscopy.
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1H magnetic resonance spectroscopy can be applied for 2HG detection in vivo for glioma.
“recent data have suggested that 1H magnetic resonance spectroscopy can be applied for 2HG detection in vivo for glioma (Andronesi et al., 2012; Choi et al., 2012; Gross et al., 2010; Pope et al., 2012)”
From Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (2012) · cites this paper as Andronesi et al., 2012
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- [6]Mardis ER Ding L Dooling DJ Larson DE McLellan MD Chen K Koboldt DC Fulton RS Delehaunty KD McGrath SD Fulton LA Locke DP Magrini VJ Abbott RM Vickery TL Reed JS Robinson JS Wylie T Smith SM Carmichael L Eldred JM Harris CC Walker J Peck JB Du FY Dukes AF Sanderson GE Brummett AM Clark E McMichael JF Meyer RJ Schindler JK Pohl CS Wallis JW Shi XQ Lin L Schmidt H Tang YZ Haipek C Wiechert ME Ivy JV Kalicki J Elliott G Ries RE Payton JE Westervelt P Tomasson MH Watson MA Baty J Heath S Shannon WD Nagarajan R Link DC Walter MJ Graubert TA DiPersio JF Wilson RK Ley TJ New England Journal of Medicine 9 2009 361 1058
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- [33]Smith SA Levante TO Meier BH Ernst RR Journal of Magnetic Resonance Series A 1 1994 106 75
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- Authors
- Andronesi, O. C., Kim, G. S., Gerstner, E., Batchelor, T., Tzika, A. A., Fantin, V. R., Vander Heiden, M. G., & Sorensen, A. G.
- Affiliations
- Harvard University (US)
- Agios Pharmaceuticals (United States) (US)
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- Corresponding author
- Andronesi, Ovidiu C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-01-11
- Volume
- 4
- Issue
- 116
- Pages
- 116ra4-116ra4
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3720836
- OpenAlex
- W2011526905
- Cited by
- 438
- References
- 37
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 13 · 2023: 22 · 2022: 27 · 2021: 24 · 2020: 33 · 2019: 39 · 2018: 48 · 2017: 45 · 2016: 46 · 2015: 32 · 2014: 28 · 2013: 25 · 2012: 15
- FWCI
- 24.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- University of Minnesota
- National Institutes of Health (1s10rr013026-01, 1s10rr021110-01a1)
- National Cancer Institute (P30CA014051)
- National Center for Research Resources (S10‐RR‐021110, S10RR023401)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- 2-hydroxyglutarate, IDH1 mutation, glioma, in vivo magnetic resonance spectroscopy, spectral editing, two-dimensional correlation spectroscopy, high-resolution magic angle spinning, non-invasive biomarkers, glioblastoma, treatment monitoring
- MeSH terms
- Adult, Aged, Biopsy, Brain Neoplasms, Epilepsy, Female, Glioma, Glutarates, Humans, Isocitrate Dehydrogenase, Male, Middle Aged, Mutation, Magnetic Resonance Spectroscopy, Phantoms, Imaging, Young Adult
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