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The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis

Open access
Eapen, Mary, Rocha, Vanderson, Sanz, Guillermo, Scaradavou, Andromachi, Zhang, Mei-Jie, Arcese, William, Sirvent, Anne, Champlin, Richard E, Chao, Nelson, Gee, Adrian P, Isola, Luis, Laughlin, Mary J, Marks, David I, Nabhan, Samir, Ruggeri, Annalisa, Soiffer, Robert, Horowitz, Mary M, Gluckman, Eliane, Wagner, John E·2010·The Lancet Oncology
DOI 10.1016/s1470-2045(10)70127-3
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Abstract

SUMMARY Background Umbilical cord blood (UCB) is increasingly considered as an alternative to peripheral blood progenitor cells (PBPC) or bone marrow (BM), especially when a HLA-matched adult unrelated donor is not available. Methods In order to establish the appropriateness of current graft selection practices, we retrospectively compared leukemia-free survival and other outcomes for each graft source in patients aged >16 years transplanted for acute leukemia using Cox regression. Data were available on 1525 patients transplanted between 2002 and 2006 using UCB (n=165), PBPC (n=888) and BM (n=472). UCB units were matched at HLA-A and B at antigen level and DRB1 at allele level (n=10) or mismatched at one (n=40) or two antigens (n=115). PBPC and BM grafts from unrelated adult donors were matched for allele-level HLA-A, B, C and DRB1 (n=632; n=332) or mismatched at one locus (n=256; n=140). Findings Leukemia-free survival after UCB transplantation was comparable to that observed after 8/8 and 7/8 allele-matched PBPC or BM transplantation. Transplant-related mortality, however, was higher after UCB transplantation compared to 8/8 allele-matched PBPC (HR 1.62, p<0.01) or BM (HR 1.69, p<0.01). Grades 2–4 acute and chronic graft-versus-host disease were lower in UCB recipients compared to allele-matched PBPC (HR 0.57, p<0.01 and HR 0.38, p<0.01, respectively), while chronic and not acute graft-versus-host disease was lower after UCB compared to allele-matched BM transplantation (HR 0.63, p=0.01). Interpretation Together, these data support the use of UCB for adults with acute leukemia when an HLA-matched unrelated adult donor is lacking and when transplant is urgently needed.

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Metadata

Authors
Eapen, M., Rocha, V., Sanz, G., Scaradavou, A., Zhang, M.-J., Arcese, W., Sirvent, A., Champlin, R. E., Chao, N., Gee, A. P., Isola, L., Laughlin, M. J., Marks, D. I., Nabhan, S., Ruggeri, A., Soiffer, R., Horowitz, M. M., Gluckman, E., & Wagner, J. E.
Venue
The Lancet Oncology
Publisher
Elsevier BV
Published
2010-07
Volume
11
Issue
7
Pages
653-660
ISSN
1470-2045 (ISSN-L)
DOI
10.1016/s1470-2045(10)70127-3
OpenAlex
W2141557403
Cited by
586
References
21
FWCI
29.45
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. https://app.cochat.ai/papers/10.1016/s1470-2045(10)70127-3
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Eapen, M., Rocha, V., Sanz, G., Scaradavou, A., Zhang, M.-J., Arcese, W., Sirvent, A., Champlin, R. E., Chao, N., Gee, A. P., Isola, L., Laughlin, M. J., Marks, D. I., Nabhan, S., Ruggeri, A., Soiffer, R., Horowitz, M. M., Gluckman, E., & Wagner, J. E. (2010). Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(10)70127-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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