The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries
Open accessAbstract
Background As cancer survival improves, the long-term risks from treatments including the risk of developing a second cancer after radiotherapy become more important. The proportion of second cancers that may be related to radiotherapy is unknown. Methods We used the U.S. Surveillance, Epidemiology and End Results cancer registries to conduct a systematic analysis of 15 cancer sites that are treated routinely with radiotherapy. Relative risks (RR) for patients receiving radiotherapy versus patients not receiving radiotherapy were estimated using Poisson regression adjusted for age, stage and other potential confounders. Findings The cohort included 647,672 five-year adult survivors followed-up for an average of 7 additional years; 60,271 (9%) developed a second solid cancer. For each of the first cancer sites the RR of developing a second cancer associated with radiotherapy exceeded one, and varied from 1.08 (95%CI:0.79–1.46) after eye/orbit cancers to 1.43 (95%CI:1.13–1.84) after testicular cancer. In general the RR was highest for organs likely to have received >5Gy, decreased with increasing age at diagnosis and increased with time since diagnosis. We estimated a total of 3266 (95%CI:2862–3670) excess second solid cancers that could be related to radiation; 8% (95%CI:7%–9%) of the total in all radiotherapy patients (1+yr survivors) and 5 excess cancers/1,000 patients treated with radiotherapy by 15 years after diagnosis. Approximately half (54%) the excess cancers were in organs likely to have received >5Gy. Interpretation A relatively small proportion of second cancers are related to radiotherapy in adults, suggesting that most are due to other factors, such as lifestyle or genetics.
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Metadata
- Authors
- de Gonzalez, A. B., Curtis, R. E., Kry, S. F., Gilbert, E., Lamart, S., Berg, C. D., Stovall, M., & Ron, E.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 12
- Issue
- 4
- Pages
- 353-360
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2140430330
- Cited by
- 481
- References
- 31
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- green
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- de Gonzalez, A. B., Curtis, R. E., Kry, S. F., Gilbert, E., Lamart, S., Berg, C. D., Stovall, M., & Ron, E. (2011). Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(11)70061-4
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