Clinical and epidemiological observations on individual radiation sensitivity and susceptibility
Open accessAbstract
Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility.Methods: The workshop reviewed the current evidence on this matter, to inform the MELODI Strategic Research Agenda (SRA), to determine social and scientific needs and to come up with recommendations for suitable and feasible future research initiatives to be taken for the benefit of an improved medical diagnosis and treatment as well as for radiation protection.Results: The present paper gives an overview of the current evidence in this field, including potential effect modifiers such as age, gender, genetic profile, and health status of the exposed population, based on clinical and epidemiological observations.Conclusion: The authors conclude with the following recommendations for the way forward in radiation research: (a) there is need for large (prospective) cohort studies; (b) build upon existing radiation research cohorts; (c) use data from well-defined cohorts with good exposure assessment and biological material already collected; (d) focus on study quality with standardized data collection and reporting; (e) improve statistical analysis; (f) cooperation between radiobiology and epidemiology; and (g) take consequences of radiosensitivity and radiosusceptibility into account.
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Some known inherited syndromes, such as ataxia telangiectasia, ataxia-telangiectasia-like disorder, radiosensitive severe combined immunodeficiency, Nijmegen breakage syndrome, and LIG4 deficiency, are associated with increased radiosensitivity.
“some of the known inherited syndromes, such as ataxia telangiectasia, ataxia-telangiectasia-like disorder, radiosensitive severe combined immunode fi ciency, Nijmegen breakage syndrome, and LIG4 de fi ciency are associated with increased radiosensitivity ( 96 , 107 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [107]
Sections 2.2 (Sensitivity) and 2.4 (Factors that may play a role in radiation sensitivity and susceptibility) identify ataxia telangiectasia and Nijmegen breakage syndrome as rare disorders with increased radiation sensitivity. The cited paper does not identify ataxia-telangiectasia-like disorder, radiosensitive severe combined immunodeficiency, or LIG4 deficiency in support of the rest of the list. Page numbers were not provided for these passages. (LLM, conf=0.88)
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Cites
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020 · see citing works
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005 · see citing works
Principles of Biomedical Ethics
(2012) · Thieves of Virtue · doi:10.7551/mitpress/9079.003.0009 · Cited by 13,453 · see citing works
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2014) · International Journal of Surgery · doi:10.1016/j.ijsu.2014.07.013 · Cited by 9,909 · see citing works
The functional assessment of cancer therapy scale: development and validation of the general measure
Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., Silberman, M., Yellen, S. B., Winicour, P., & Brannon, J. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.570 · Cited by 6,020 · see citing works
Cox, J. D., Stetz, J., & Pajak, T. F. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(95)00060-c · Cited by 4,811 · see citing works
Tolerance of normal tissue to therapeutic irradiation
Emami, B., Lyman, J., Brown, A., Cola, L., Goitein, M., Munzenrider, J. E., Shank, B., Solin, L. J., & Wesson, M. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90171-y · Cited by 4,488 · see citing works
The 2007 recommendations of the International Commission on Radiological Protection
Valentin, J. (2007) · Elsevier eBooks · Cited by 4,105 · see citing works
Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., Correa, C., Cutter, D., Gagliardi, G., Gigante, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209825 · Cited by 3,974 · see citing works
Pearce, M. S., Salotti, J. A., Little, M. P., McHugh, K., Lee, C., Kim, K. P., Howe, N. L., Ronckers, C. M., Rajaraman, P., Craft, A. W., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60815-0 · Cited by 3,735 · see citing works
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498 · see citing works
Improving the Quality of Reporting of Randomized Controlled Trials: The CONSORT Statement
Begg, C. (1996) · JAMA · doi:10.1001/jama.1996.03540080059030 · Cited by 3,127 · see citing works
Wild, C. P. (2005) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0456 · Cited by 2,562 · see citing works
Porta, M. (2026) · doi:10.1093/acref/9780197663639.001.0001 · Cited by 2,175 · see citing works
Mathews, J. D., Forsythe, A. V., Brady, Z., Butler, M. W., Goergen, S. K., Byrnes, G. B., Giles, G. G., Wallace, A. B., Anderson, P. R., Guiver, T. A., et al. (2013) · BMJ · doi:10.1136/bmj.f2360 · Cited by 2,029 · see citing works
Use of Normal Tissue Complication Probability Models in the Clinic
Marks, L. B., Yorke, E. D., Jackson, A., Ten Haken, R. K., Constine, L. S., Eisbruch, A., Bentzen, S. M., Nam, J., & Deasy, J. O. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.07.1754 · Cited by 1,826 · see citing works
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
Brenner, D. J., Doll, R., GOODHEAD, D. T., Hall, E. J., Land, C. E., Little, J. B., Lubin, J. H., Preston, D. L., Preston, R. J., Puskin, J. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235592100 · Cited by 1,765 · see citing works
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604 · see citing works
Wei, J. T., Dunn, R. L., Litwin, M. S., Sandler, H. M., & Sanda, M. G. (2000) · Urology · doi:10.1016/s0090-4295(00)00858-x · Cited by 1,520 · see citing works
Bentzen, S. M., Constine, L. S., Deasy, J. O., Eisbruch, A., Jackson, A., Marks, L. B., Haken, R. K. T., & Yorke, E. D. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.09.040 · Cited by 1,268 · see citing works
Reporting and analyzing dose distributions: A concept of equivalent uniform dose
Niemierko, A. (1997) · Medical Physics · doi:10.1118/1.598063 · Cited by 1,231 · see citing works
Complication Probability as Assessed from Dose-Volume Histograms
Lyman, J. T. (1985) · Radiation Research · doi:10.2307/3576626 · Cited by 1,160 · see citing works
Dueck, A. C., Mendoza, T. R., Mitchell, S. A., Reeve, B. B., Castro, K. M., Rogak, L. J., Atkinson, T. M., Bennett, A. V., Denicoff, A. M., O'Mara, A. M., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.2639 · Cited by 1,030 · see citing works
Bonassi, S., Znaor, A., Ceppi, M., Lando, C., Chang, W. P., Holland, N., Kirsch‐Volders, M., Zeiger, E., Ban, S., Barale, R., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl177 · Cited by 1,024 · see citing works
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity
Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., & Bridges, B. A. (1975) · Nature · doi:10.1038/258427a0 · Cited by 991 · see citing works
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype
Barnett, G. C., West, C., Dunning, A. M., Elliott, R. M., Coles, C. E., Pharoah, P. D. P., & Burnet, N. G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2587 · Cited by 771 · see citing works
Subsequent Neoplasms in 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor Study
Friedman, D. L., Whitton, J. A., Leisenring, W. M., Mertens, A. C., Hammond, S., Stovall, M., Donaldson, S. S., Meadows, A. T., Robison, L. L., & Neglia, J. P. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq238 · Cited by 700 · see citing works
Residential Radon and Risk of Lung Cancer
Krewski, D. R., Lubin, J. H., Zielinski, J. M., Alavanja, M. C. R., Catalan, V. S., Field, R. W., Klotz, J. B., tourneau, E. G. L., Lynch, C. F., Lyon, J. I., et al. (2005) · Epidemiology · doi:10.1097/01.ede.0000152522.80261.e3 · Cited by 697 · see citing works
Esper, P., Mo, F., Chodak, G., Sinner, M., Cella, D., & Pienta, K. J. (1997) · Urology · doi:10.1016/s0090-4295(97)00459-7 · Cited by 696 · cited 1× · see citing works
“For prostate cancer, for example, these include EPIC (Expanded prostate cancer index composite, Wei et al. 2000), FACT-P (Functional Assessment of Cancer Therapy – Prostate, Esper et al. 1997) or EORTC QLQ PR25 (van Andel et al. 2008) questionnaires.”
MethodRadiation-Related Heart Disease: Current Knowledge and Future Prospects
Darby, S. C., Cutter, D. J., Boerma, M., Constine, L. S., Fajardo, L. F., Kodama, K., Mabuchi, K., Marks, L. B., Mettler, F. A., Pierce, L. J., et al. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.09.064 · Cited by 621 · see citing works
Risk of Thyroid Cancer After Exposure to 131 I in Childhood
Cardis, E., Kesminiene, A., Ivanov, V. K., Malakhova, I. V., Shibata, Y., Khrouch, V., Drozdovitch, V., Maceika, E., Zvonova, I. A., Vlassov, O., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji129 · Cited by 591 · see citing works
Kutcher, G. J., Burman, C. M., Brewster, L. J., Goitein, M., & Mohan, R. (1991) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(91)90173-2 · Cited by 560 · see citing works
Radiobiology for the Radiologist
Malamud, H. (1995) · Clinical Nuclear Medicine · doi:10.1097/00003072-199501000-00029 · Cited by 549 · see citing works
Complication Probability as Assessed from Dose-Volume Histograms
Lyman, J. T. (1985) · Radiation Research Supplement · doi:10.2307/3583506 · Cited by 537 · see citing works
A Dictionary of Epidemiology (DRAFT)
(2014) · doi:10.1093/acref/9780199976720.001.0001 · Cited by 530 · see citing works
van Andel, G., Bottomley, A., Fosså, S. D., Efficace, F., Coens, C., Guerif, S. G., Kynaston, H., Gontero, P., Thalmann, G. N., Akdaş, A., et al. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.07.030 · Cited by 494 · see citing works
de González, A. B., Curtis, R. E., Kry, S. F., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70061-4 · Cited by 487 · see citing works
Genetic Susceptibility to Cancer
Dong, L. M., Potter, J. D., White, E., Ulrich, C. M., Cardon, L. R., & Peters, U. (2008) · JAMA · doi:10.1001/jama.299.20.2423 · Cited by 459 · see citing works
Leuraud, K., Richardson, D. B., Cardis, E., Daniels, R. D., Gillies, M., O'Hagan, J. A., Hamra, G. B., Haylock, R., Laurier, D., Moissonnier, M., et al. (2015) · The Lancet Haematology · doi:10.1016/s2352-3026(15)00094-0 · Cited by 442 · see citing works
Solid cancer incidence among the Life-span study of atomic-bomb survivors: 1958-2009
Grant, E. J., Brenner, A., Sugiyama, H., Sakata, R., Sadakane, A., Utada, M., Cahoon, E. K., Milder, C. M., Soda, M., Cullings, H. M., et al. (2017) · Radiation Research · doi:10.1667/rr14492.1 · Cited by 434 · see citing works
Muirhead, C. R., O'Hagan, J. A., Haylock, R., Phillipson, M. A., Willcock, T., Berridge, G. L. C., & ZHANG, W. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604825 · Cited by 423 · see citing works
Chodick, G., Bekiroğlu, N., Hauptmann, M., Alexander, B. H., Freedman, D. M., Doody, M. M., Cheung, L. C., Simon, S. L., Weinstock, R. M., Bouville, A. C., et al. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn171 · Cited by 408 · see citing works
Space Radiation and Cataracts in Astronauts
Cucinotta, F. A., Manuel, F. K., Jones, J., Iszard, G., Murrey, J., Djojonegro, B., & Wear, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)156[0460:sracia]2.0.co;2 · Cited by 391 · see citing works
Raemaekers, J. M. M., André, M. P. E., Federico, M., Girinsky, T., Reman, O., Brusamolino, E., Brice, P., Fermé, C., van der Maazen, R., Gotti, M., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.9298 · Cited by 387 · see citing works
Richardson, D. B., Cardis, E., Daniels, R. D., Gillies, M., O'Hagan, J. A., Hamra, G. B., Haylock, R., Laurier, D., Leuraud, K., Moissonnier, M., et al. (2015) · BMJ · doi:10.1136/bmj.h5359 · Cited by 379 · see citing works
Cataracts among Chernobyl Clean-up Workers: Implications Regarding Permissible Eye Exposures
Worgul, B. V., Kundiyev, Y. I., Sergiyenko, N. M., Chumak, V. V., Vitte, P. M., Medvedovsky, C., Bakhanova, E. V., Junk, A. K., Kyrychenko, O. Y., Musijachenko, N. V., et al. (2007) · Radiation Research · doi:10.1667/rr0298.1 · Cited by 371 · see citing works
Little, M. P., Azizova, T. V., Bazyka, D., Bouffler, S. D., Cardis, E., Chekin, S., Chumak, V. V., Cucinotta, F. A., de Vathaire, F., Hall, P., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1204982 · Cited by 367 · cited 1× · see citing works
“…associated with circulatory diseases (e.g. Darby et al. 2010; Kreuzer et al. 2015) with excess relative risks per Sv of 0.1–0.2 in a meta-analysis by Little et al. (2012) and Little (2016), although additional research better considering potential confounding factors such as hypertension or body…”
BackgroundInfluentialSelf-citationLyman, J. T., & Wolbarst, A. B. (1987) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(87)90266-5 · Cited by 365 · see citing works
Friedmann, H. (2000) · European Journal of Radiology · doi:10.1016/s0720-048x(99)00126-6 · Cited by 364 · see citing works
Radiation induced secondary malignancies: a review article
Dracham, C. B., Shankar, A., & Madan, R. (2018) · Radiation Oncology Journal · doi:10.3857/roj.2018.00290 · Cited by 351 · see citing works
Bonassi, S., Norppa, H., Ceppi, M., Stromberg, U., Vermeulen, R., Znaor, A., Cebulska-Wasilewska, A., Fabianova, E., Fucic, A., Gundy, S., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn075 · Cited by 336 · see citing works
Expanding research on the economics of occupational health
Leigh, J. P. (2006) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.969 · Cited by 334 · see citing works
Overview: Late effects of normal tissues (LENT) scoring system
Rubin, P., Constine, L. S., Fajardo, L. F., et al. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(95)00057-6 · Cited by 299 · see citing works
Tubiana, M. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2008.12.016 · Cited by 280 · see citing works
de González, A. B., Gilbert, E. S., Curtis, R. E., et al. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2012.09.001 · Cited by 279 · see citing works
Hawkins, M. M., Lancashire, E. R., Winter, D., Frobisher, C., Reulen, R. C., Taylor, A., Stevens, M. C. G., & Jenney, M. E. M. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21335 · Cited by 256 · see citing works
(2007) · Annals of the ICRP · doi:10.1016/j.icrp.2007.11.001 · Cited by 256 · see citing works
Suit, H. D., Goldberg, S. N., Niemierko, A., Ancukiewicz, M., Hall, E. J., Goitein, M., Wong, W. W., & Paganetti, H. (2007) · Radiation Research · doi:10.1667/rr0527.1 · Cited by 251 · see citing works
van Nimwegen, F. A., Ntentas, G., Darby, S. C., et al. (2017) · Blood · doi:10.1182/blood-2016-09-740332 · Cited by 242 · see citing works
Patient-to-patient variability in the expression of radiation-induced normal tissue injury
Bentzen, S. M., & Overgaard, J. (1994) · Seminars in Radiation Oncology · doi:10.1016/s1053-4296(05)80034-7 · Cited by 231 · see citing works
Pijpe, A., Andrieu, N., Easton, D., Kesminiene, A., Cardis, E., Noguès, C., Gauthier‐Villars, M., Lasset, C., Fricker, J., Peock, S., et al. (2012) · BMJ · doi:10.1136/bmj.e5660 · Cited by 228 · see citing works
Postoperative Cataract Cases among Atomic Bomb Survivors: Radiation Dose Response and Threshold
Neriishi, K., Nakashima, E., Minamoto, A., Fujiwara, S., Akahoshi, M., Mishima, H. K., Kitaoka, T., & Shore, R. E. (2007) · Radiation Research · doi:10.1667/rr0928.1 · Cited by 227 · see citing works
Teepen, J. C., van Leeuwen, F. E., Tissing, W. J. E., Broeder, E. V. D., van den Heuvel‐Eibrink, M. M., van der Pal, H. J. H., Loonen, J. J., Bresters, D., Versluys, B. A. B., Neggers, S. J. C. M. M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.6902 · Cited by 224 · see citing works
Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury.
Bentzen, S. M., & Overgaard, J. (1994) · PubMed · doi:10.1053/srao00400068 · Cited by 216 · see citing works
Kendall, G. M., Little, M. P., Wakeford, R., Bunch, K. J., Miles, J. C. H., Vincent, T. J., Meara, J. R., & Murphy, M. F. (2012) · Leukemia · doi:10.1038/leu.2012.151 · Cited by 204 · see citing works
Jackson, A., Marks, L. B., Bentzen, S. M., Eisbruch, A., Yorke, E. D., Haken, R. K. T., Constine, L. S., & Deasy, J. O. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.08.074 · Cited by 203 · see citing works
Individual response to ionizing radiation
Foray, N., Bourguignon, M., & Hamada, N. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.09.001 · Cited by 192 · see citing works
Self-citationPredictive factors for late normal tissue complications following radiotherapy for breast cancer
Lilla, C., Ambrosone, C. B., Kropp, S., Helmbold, I., Schmezer, P., von Fournier, D., Haase, W., Sautter‐Bihl, M., Wenz, F. K., & Chang-Claude, J. C. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9480-9 · Cited by 182 · see citing works
Genetic variants and normal tissue toxicity after radiotherapy: A systematic review
Andreassen, C. N., & Alsner, J. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.015 · Cited by 182 · see citing works
Liang, B., Yan, H., Tian, Y., Chen, X., Yan, L., Zhang, T., Zhou, Z., Wang, L., & Dai, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00269 · Cited by 178 · see citing works
Chylack, L. T., Peterson, L. E., Feiveson, A. H., Wear, M. L., Manuel, F. K., Tung, W. H., Hardy, D. S., Marak, L. J., & Cucinotta, F. A. (2009) · Radiation Research · doi:10.1667/rr1580.1 · Cited by 168 · see citing works
Fachal, L., Gómez‐Caamaño, A., Barnett, G. C., Peleteiro, P., Carballo, A. M., Calvo, P., Kerns, S. L., Sánchez-García, M., Lobato-Busto, R., Dorling, L., et al. (2014) · Nature Genetics · doi:10.1038/ng.3020 · Cited by 149 · see citing works
Schubauer‐Berigan, M. K., Daniels, R. D., & Pinkerton, L. E. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwn406 · Cited by 145 · see citing works
Andreassen, C. N., Rosenstein, B. S., Kerns, S. L., et al. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.06.017 · Cited by 145 · see citing works
Establishment of a Radiogenomics Consortium
West, C., & Rosenstein, B. S. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.12.017 · Cited by 141 · see citing works
Hoeller, U., Tribius, S., Kuhlmey, A., et al. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04202-5 · Cited by 141 · see citing works
Childhood cancer survivor cohorts in Europe
Winther, J. F., Kenborg, L., Byrne, J., et al. (2015) · Acta Oncologica · doi:10.3109/0284186x.2015.1008648 · Cited by 137 · see citing works
Radon and Lung Cancer in the American Cancer Society Cohort
Turner, M. C., Krewski, D. R., Chen, Y., Pope, C. A., Gapstur, S. M., & Thun, M. J. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-1153 · Cited by 137 · see citing works
ICRP Publication 138: Ethical Foundations of the System of Radiological Protection
Cho, K.-W., Cantone, M. C., Kurihara-Saio, C., et al. (2018) · Annals of the ICRP · doi:10.1177/0146645317746010 · Cited by 127 · see citing works
Azria, D., Riou, O., Castan, F., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.10.024 · Cited by 124 · see citing works
Granzotto, A., Benadjaoud, M. A., Vogin, G., Devic, C., Ferlazzo, M. L., Bodgi, L., Pereira, S., Sonzogni, L., Forcheron, F., Viau, M., et al. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.11.013 · Cited by 123 · see citing works
Self-citationLeuraud, K., Schnelzer, M., Tomášek, L., et al. (2011) · Radiation Research · doi:10.1667/rr2377.1 · Cited by 121 · see citing works
Appropriate Use of Effective Dose in Radiation Protection and Risk Assessment
Fisher, D. R., & Fahey, F. H. (2017) · Health Physics · doi:10.1097/hp.0000000000000674 · Cited by 121 · see citing works
Rugbjerg, K., Mellemkjær, L., Boice, J. D., Køber, L., Ewertz, M., & Olsen, J. H. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju110 · Cited by 120 · see citing works
Radiation and circulatory disease
Little, M. P. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.07.008 · Cited by 120 · see citing works
Radiogenomics: Radiobiology Enters the Era of Big Data and Team Science
Rosenstein, B. S., West, C., Bentzen, S. M., Alsner, J., Andreassen, C. N., Azria, D., Barnett, G. C., Baumann, M. A., Burnet, N. G., Chang‐Claude, J., et al. (2014) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2014.03.009 · Cited by 114 · see citing works
Seibold, P., Webb, A. J., Aguado-Barrera, M. E., Azria, D., Bourgier, C., Brengues, M., Briers, E., Bultijnck, R., Calvo, P., Carballo, A. M., et al. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.04.034 · Cited by 109 · see citing works
Self-citationLung Cancer Risks from Plutonium: An Updated Analysis of Data from the Mayak Worker Cohort
Gilbert, E. S., Sokolnikov, M. E., Preston, D. L., et al. (2013) · Radiation Research · doi:10.1667/rr3054.1 · Cited by 106 · see citing works
The risk of childhood leukaemia following exposure to ionising radiation—a review
Wakeford, R. (2013) · Journal of Radiological Protection · doi:10.1088/0952-4746/33/1/1 · Cited by 103 · see citing works
West, C., Azria, D., Chang-Claude, J. C., Davidson, S. E., Lambin, P., Rosenstein, B. S., Ruysscher, D. D., Talbot, C. J., Thierens, H. M., Valdagni, R., et al. (2014) · Clinical Oncology · doi:10.1016/j.clon.2014.09.008 · Cited by 99 · see citing works
Cahoon, E. K., Preston, D. L., Pierce, D. A., Grant, E. J., Brenner, A. V., Mabuchi, K., Utada, M., & Ozasa, K. (2017) · Radiation Research · doi:10.1667/rr14583.1 · Cited by 98 · see citing works
Solid Cancer Mortality in the Techa River Cohort (1950–2007)
Schonfeld, S. J., Krestinina, L. Y., Epifanova, S., et al. (2013) · Radiation Research · doi:10.1667/rr2932.1 · Cited by 92 · see citing works
Kerns, S. L., Dorling, L., Fachal, L., Bentzen, S. M., Pharoah, P. D. P., Barnes, D. R., Gómez‐Caamaño, A., Carballo, A. M., Dearnaley, D. P., Peleteiro, P., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.07.022 · Cited by 89 · see citing works
Little, M. P., Kitahara, C. M., Cahoon, E. K., Bernier, M., Velazquez‐Kronen, R., Doody, M. M., Borrego, D., Miller, J. S., Alexander, B. H., Simon, S. L., et al. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0435-3 · Cited by 89 · see citing works
Kreuzer, M., Auvinen, A., Cardis, E., Hall, J., Jourdain, J.-R., Laurier, D., Little, M. P., Peters, A., Raj, K., Russell, N. S., et al. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.03.002 · Cited by 86 · see citing works
Self-citationLittle, M. P. (2001) · International Journal of Radiation Biology · doi:10.1080/09553000010022634 · Cited by 79 · see citing works
Barnett, G. C., West, C., Coles, C. E., Pharoah, P. D. P., Talbot, C. J., Elliott, R. M., Tanteles, G. A., Symonds, R. P., Wilkinson, J. S., Dunning, A. M., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.03.015 · Cited by 70 · see citing works
Azizova, T. V., Hamada, N., Grigoryeva, E. S., & Bragin, E. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0450-4 · Cited by 69 · see citing works
Kreuzer, M., Auvinen, A. P., Cardis, E., Durante, M., Harms‐Ringdahl, M., Jourdain, J.-R., Madas, B. G., Ottolenghi, A., Pazzaglia, S., Prise, K. M., et al. (2017) · Radiation and Environmental Biophysics · doi:10.1007/s00411-017-0726-1 · Cited by 68 · see citing works
Self-citationKreuzer, M., Sobotzki, C., Schnelzer, M., et al. (2017) · Radiation Research · doi:10.1667/rr14889.1 · Cited by 67 · see citing works
Progress in low dose health risk research
Averbeck, D., Salomaa, S. I., Bouffler, S. D., Ottolenghi, A., Smyth, V., & Sabatier, L. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.04.001 · Cited by 67 · see citing works
Self-citationSTROGAR – STrengthening the Reporting Of Genetic Association studies in Radiogenomics
Kerns, S. L., Ruysscher, D. D., Andreassen, C. N., Azria, D., Barnett, G. C., Chang-Claude, J. C., Davidson, S. E., Deasy, J. O., Dunning, A. M., D, H. O. M., et al. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.07.011 · Cited by 66 · see citing works
The meaning of low dose and low dose-rate
Wakeford, R., & Tawn, E. J. (2010) · Journal of Radiological Protection · doi:10.1088/0952-4746/30/1/e02 · Cited by 66 · see citing works
Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland
Vienneau, D., de Hoogh, K., Hauri, D. D., Vicedo-Cabrera, A. M., Schindler, C., Huss, A., Röösli, M., & for the SNC Study Group (2017) · Environmental Health Perspectives · doi:10.1289/ehp825 · Cited by 64 · see citing works
Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure
Thome, C., Chambers, D. B., Hooker, A. M., Thompson, J. W., & Boreham, D. R. (2018) · Health Physics · doi:10.1097/hp.0000000000000810 · Cited by 63 · see citing works
Doses from radon and its decay products to children
Kendall, G. M., & Smith, T. J. (2005) · Journal of Radiological Protection · doi:10.1088/0952-4746/25/3/002 · Cited by 61 · see citing works
van der Laan, H. P., van den Bergh, A., Schilstra, C., et al. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.07.2363 · Cited by 59 · see citing works
Tse, L. A., Yu, I. T.-S., Qiu, H., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002790 · Cited by 59 · see citing works
Grabow, D., Kaiser, M., Hjorth, L., et al. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0370-3 · Cited by 59 · see citing works
Beyond the bombs: cancer risks of low-dose medical radiation
Einstein, A. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60897-6 · Cited by 56 · see citing works
The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics
Asdahl, P. H., Winther, J. F., Bonnesen, T. G., Licht, S. D. F., Guðmundsdóttir, Þ., Anderson, H., Madanat‐Harjuoja, L. M., Tryggvadóttír, L., Småstuen, M. C., Holmqvist, A. S., et al. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25661 · Cited by 55 · see citing works
The evolution and application of toxicity criteria
Trotti, A. (2002) · Seminars in Radiation Oncology · doi:10.1053/srao.2002.31353 · Cited by 52 · see citing works
Genetic susceptibility to cancer: ICRP Publication 79
Approved by the Commission in May 1997 (1998) · Annals of the ICRP · doi:10.1016/s0146-6435(98)00007-3 · Cited by 52 · see citing works
Sigurdson, A. J., Bhatti, P., Doody, M. M., Hauptmann, M., Bowen, L., Simon, S. L., Weinstock, R. M., Linet, M. S., Rosenstein, M., Stovall, M. A., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0282 · Cited by 46 · see citing works
100 Years of Individual Radiosensitivity: How We Have Forgotten the Evidence
Foray, N., Colin, C., & Bourguignon, M. (2012) · Radiology · doi:10.1148/radiol.12112560 · Cited by 46 · see citing works
Self-citationMh, S. (1998) · PubMed · Cited by 45 · see citing works
Pedersen, C., Bräuner, E. V., Rod, N. H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107096 · Cited by 42 · see citing works
Overdiagnosis and overimaging: an ethical issue for radiological protection
Salerno, S., Laghi, A., Cantone, M. C., et al. (2019) · La radiologia medica · doi:10.1007/s11547-019-01029-5 · Cited by 42 · see citing works
Residential radon and lung cancer incidence in a Danish cohort
Bräuner, E. V., Andersen, C. E., Sørensen, M., Andersen, Z. J., Gravesen, P., Ulbak, K., Hertel, O., Pedersen, C., Overvad, K., Tjønneland, A. M., et al. (2012) · Environmental Research · doi:10.1016/j.envres.2012.05.012 · Cited by 41 · see citing works
Gomolka, M., Blyth, B. J., Bourguignon, M., Badie, C., Schmitz, A., Talbot, C. J., Hoeschen, C., & Salomaa, S. I. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1642544 · Cited by 41 · see citing works
Self-citationRosenberger, A., Hung, R. J., Christiani, D. C., Caporaso, N. E., Liu, G., Bojesen, S. E., Marchand, L. L., Haiman, C. A., Albanes, D., Aldrich, M. C., et al. (2018) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-018-1334-3 · Cited by 39 · see citing works
Ethical and Legal Aspects of Cancer Genetic Testing
Offit, K., & Thom, P. (2007) · Seminars in Oncology · doi:10.1053/j.seminoncol.2007.07.007 · Cited by 38 · see citing works
A New Era of Low-Dose Radiation Epidemiology
Kitahara, C. M., Linet, M. S., Rajaraman, P., Ntowe, E., & de González, A. B. (2015) · Current Environmental Health Reports · doi:10.1007/s40572-015-0055-y · Cited by 37 · see citing works
Bhatti, P., Doody, M. M., Rajaraman, P., et al. (2010) · Radiation Research · doi:10.1667/rr1985.1 · Cited by 35 · see citing works
Risk of second bone sarcoma following childhood cancer: role of radiation therapy treatment
Schwartz, B., Benadjaoud, M. A., Cléro, É., Haddy, N., El‐Fayech, C., Guibout, C., Teinturier, C., Oberlin, O., Veres, C., Pacquement, H., et al. (2014) · Radiation and Environmental Biophysics · doi:10.1007/s00411-013-0510-9 · Cited by 33 · see citing works
Scholz-Kreisel, P., Spix, C., Blettner, M., Eckerle, S., Faber, J., Wild, P. S., Merzenich, H., & Hennewig, U. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26428 · Cited by 33 · see citing works
Self-citationThomas, J., Fermé, C., Noordijk, E. M., et al. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.10.015 · Cited by 33 · see citing works
Pragmatic ethical basis for radiation protection in diagnostic radiology
Malone, J., & Zölzer, F. (2016) · British Journal of Radiology · doi:10.1259/bjr.20150713 · Cited by 32 · see citing works
On prognostic estimates of radiation risk in medicine and radiation protection
Ulanowski, A., Kaiser, J. C., Schneider, U., & Walsh, L. (2019) · Radiation and Environmental Biophysics · doi:10.1007/s00411-019-00794-1 · Cited by 31 · see citing works
Cowley, L. (2016) · Bioethics · doi:10.1111/bioe.12272 · Cited by 30 · see citing works
Zvereva, A., Kamp, F., Schlattl, H., Zankl, M., & Parodi, K. (2018) · Medical Physics · doi:10.1002/mp.12984 · Cited by 28 · see citing works
Schwarz, G., & Dunning, D. E. (1982) · Health Physics · doi:10.1097/00004032-198211000-00001 · Cited by 26 · see citing works
Bräuner, E. V., Andersen, C. E., Andersen, H. P., et al. (2010) · Cancer Causes & Control · doi:10.1007/s10552-010-9608-4 · Cited by 26 · see citing works
Grant, E. J., Ozasa, K., Preston, D. L., Suyama, A., Shimizu, Y., Sakata, R., Sugiyama, H., Pham, T.-M., COLOGNE, J. B., Yamada, M., et al. (2012) · Radiation Research · doi:10.1667/rr2841.1 · Cited by 26 · see citing works
Towards a strategic research agenda for social sciences and humanities in radiological protection
Perko, T., Oudheusden, M. V., Turcanu, C., et al. (2019) · Journal of Radiological Protection · doi:10.1088/1361-6498/ab0f89 · Cited by 25 · see citing works
Radiation Carcinogenesis Risk Assessments for Never-smokers
Cucinotta, F. A., Chappell, L. J., Kim, M. Y., & Wang, M. (2012) · Health Physics · doi:10.1097/hp.0b013e318267b3ad · Cited by 24 · see citing works
Schofield, P. N., Kulka, U., Tapio, S., & Grosche, B. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1589026 · Cited by 24 · see citing works
Doses and lung cancer risks from exposure to radon and plutonium
Marsh, J. W., Harrison, J. D., Laurier, D., Birchall, A., Blanchardon, E., Paquet, F., & Tirmarche, M. (2014) · International Journal of Radiation Biology · doi:10.3109/09553002.2014.942919 · Cited by 23 · see citing works
Colin, C., Foray, N., Leo, G. D., & Sardanelli, F. (2017) · Radioprotection · doi:10.1051/radiopro/2017034 · Cited by 23 · see citing works
A quality index for equivalent uniform dose
Henríquez, F. C., & Castrillón, S. (2011) · Journal of Medical Physics · doi:10.4103/0971-6203.83466 · Cited by 21 · see citing works
Radiation effects: Modulating factors and risk assessment - an overview
Wakeford, R. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.06.036 · Cited by 19 · see citing works
On the shape of neutron dose-effect curves for radiogenic cancers and life shortening in mice
Storer, J. B., & Fry, R. J. (1995) · Radiation and Environmental Biophysics · doi:10.1007/bf01210541 · Cited by 17 · see citing works
Mossman, K. L. (2011) · Health Physics · doi:10.1097/hp.0b013e3182295960 · Cited by 15 · see citing works
Imaging practices and radiation doses from imaging in radiotherapy
Siiskonen, T., Kaijaluoto, S., & Florea, T. (2017) · Physica Medica · doi:10.1016/j.ejmp.2017.03.012 · Cited by 15 · see citing works
Chaikh, A., Calugaru, V., Bondiau, P., Thariat, J., & Balosso, J. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1486516 · Cited by 15 · see citing works
Aznar, M. C., Girinsky, T., Berthelsen, A. K., et al. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1279750 · Cited by 14 · see citing works
Suslova, K. G., Sokolova, A. B., Krahenbuhl, M. P., & Miller, S. C. (2009) · Radiation Research · doi:10.1667/0033-7587-171.3.302 · Cited by 13 · see citing works
Considerations on the use of the terms radiosensitivity and radiosusceptibility
Wójcik, A., Bouffler, S. D., Hauptmann, M., et al. (2018) · Journal of Radiological Protection · doi:10.1088/1361-6498/aacb03 · Cited by 12 · see citing works
Analyzing the usage of standards in radiation therapy clinical studies
Zhen, Y., Jiang, Y., Yuan, L., et al. (2017) · IEEE EMBS International Conference on Biomedical & Health Informatics (BHI) · doi:10.1109/bhi.2017.7897277 · Cited by 11 · see citing works
Ethical considerations related to radiosensitivity and radiosusceptibility
Kalman, C., & Oughton, D. H. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1665210 · Cited by 9 · see citing works
Klein, W., & Breustedt, B. (2013) · Radiation Protection Dosimetry · doi:10.1093/rpd/nct233 · Cited by 7 · see citing works
Professional ethics in radiological protection
Brandl, A., & Tschurlovits, M. (2018) · Journal of Radiological Protection · doi:10.1088/1361-6498/aadd23 · Cited by 6 · see citing works
Toward tailoring radiation protection strategies at an individual level
Hamada, N., Salomaa, S. I., & Dörr, W. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1513178 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Falk R, Farchi S, Figueiras A, et al. 2006. Residential radon and lung cancer-detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 per sons without lung cancer from 13 epidemiologic studies in Europe. Scand J Work Environ Health. 32(1):1-83.
- NRC. 1999. National Research Council, Committee on Health Risks of Exposure to Radon. Health effects of exposure to radon (BEIR VI). Washington, DC: National Academies Press.
- NRC. 2006. Health risks from exposures to low levels of ionizing radi ation (BEIR VII), phase 2. Board on radiation effects research. Washington, DC: National Academies Press.
- Rothman KJ, Greenland S, Lash TL. 2012. Modern epidemiology. Philadelphia, USA: Lippincott Wolters Kluwer.
- Teepen JC, van Leeuwen FE, Tissing WJ, van Dulmen-den Broeder E, van den Heuvel-Eibrink MM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, Neggers SJCMM, et al. 2017. Long-term risk of subse- quent malignant neoplasms after treatment of childhood cancer. JCO. 35(20):2288-2289.
Cited by
Sorted by citations
Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95 · see citing works
- Authors
- Seibold, P., Auvinen, A., Averbeck, D., Bourguignon, M., Hartikainen, J. M., Hoeschen, C., Laurent, O., Noël, G., Sabatier, L., Salomaa, S., & Blettner, M.
- Affiliations
- German Cancer Research Center (DE)
- Tampere University (FI)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- University of Eastern Finland (FI)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Institut de Radioprotection et de Sûreté Nucléaire (FR)
- Institut Strauss (FR)
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Seibold, Petra
- ORCID
- Venue
- International Journal of Radiation Biology
- Publisher
- Informa UK Limited
- Published
- 2019-09-20
- Volume
- 96
- Issue
- 3
- Pages
- 324-339
- ISSN
- 0955-3002 (ISSN-L)
- 1362-3095
- OpenAlex
- W2973453056
- Cited by
- 56
- References
- 155
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 5 · 2021: 14 · 2020: 8 · 2019: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Radiation Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Tampere University Institutional Repository (Tampere University) (submittedVersion, cc-by-nc-nd)
- Funders
- Bundesamt für Strahlenschutz
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiation Dose and Imaging
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- radiation exposure, effect modifiers, age, gender, genetic susceptibility, health status, radiation protection, radiation biology, radiation epidemiology, prospective cohort, research recommendations
- MeSH terms
- Radiation Exposure, Animals, Congresses as Topic, Europe, Humans, Radiation Dosage, Radiation Injuries, Radiation Monitoring, Radiation Protection, Radiation Tolerance, Radiobiology, Radiometry, Risk, Mice
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