Is cancer gene therapy an empty suit?

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

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Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia

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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

Brentjens, R. J., Davila, M. L., Riviere, I., Park, J., Wang, X., Cowell, L. G., Bartido, S., Stefanski, J., Taylor, C., Olszewska, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005930 · Cited by 2,063 · see citing works

Principles and Practice of Pediatric Oncology

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

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Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

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Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

Kochenderfer, J. N., Dudley, M. E., Feldman, S. A., Wilson, W. H., Spaner, D., Marić, I., Stetler‐Stevenson, M., Phan, G. Q., Hughes, M. S., Sherry, R. M., et al. (2011) · Blood · doi:10.1182/blood-2011-10-384388 · Cited by 1,441 · see citing works

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

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The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

Brentjens, R. J., Rivière, I., Park, J. H., Davila, M. L., Wang, X., Stefanski, J., Taylor, C., Yeh, R., Bartido, S. M., Bórquez-Ojeda, O., et al. (2011) · Blood · doi:10.1182/blood-2011-04-348540 · Cited by 1,287 · see citing works

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

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Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

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Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

Morgan, R. A., Chinnasamy, N., Abate‐Daga, D., Gros, A., Robbins, P. F., Zheng, Z., Dudley, M. E., Feldman, S. A., Yang, J. C., Sherry, R. M., et al. (2013) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3182829903 · Cited by 1,155 · see citing works

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Khuri, F. R., Nemunaitis, J. J., Ganly, I., Arseneau, J. C., Tannock, I. F., Romel, L., Gore, M. E., Ironside, J. A. D., MacDougall, R. H., Heise, C. C., et al. (2000) · Nature Medicine · doi:10.1038/78638 · Cited by 1,099 · see citing works

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

Parkhurst, M. R., Yang, J. C.-H., Langan, R. C., Dudley, M. E., Nathan, D.-A. N., Feldman, S. A., Davis, J. L., Morgan, R. A., Merino, M. J., Sherry, R. M., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.272 · Cited by 1,025 · see citing works

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

Savoldo, B., Ramos, C. A., Liu, E., Mims, M. P., Keating, M. J., Carrum, G., Kamble, R. T., Bollard, C. M., Gee, A. P., Mei, Z., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46110 · Cited by 1,023 · see citing works

Principles and Practice of Pediatric Oncology

Labotka, R. J. (2002) · JAMA · doi:10.1001/jama.288.7.894-a · Cited by 1,019 · see citing works

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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Intratumor Heterogeneity: Evolution through Space and Time

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Treatment of Metastatic Renal Cell Carcinoma With Autologous T-Lymphocytes Genetically Retargeted Against Carbonic Anhydrase IX: First Clinical Experience

Lamers, C. H. J., Sleijfer, S., Vulto, A. G., Kruit, W. H. J., Kliffen, M., Debets, R., Gratama, J. W., Stoter, G., & Oosterwijk, E. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.9964 · Cited by 915 · see citing works

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

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Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Heo, J., Reid, T. R., Ruo, L., Breitbach, C. J., Rose, S. C., Bloomston, M., Cho, M., Lim, H. Y., Chung, H. C., Kim, C. W., et al. (2013) · Nature Medicine · doi:10.1038/nm.3089 · Cited by 781 · see citing works

An inducible caspase 9 safety switch for T-cell therapy

Straathof, K. C. M., Pulè, M. A., Yotnda, P., Dotti, G., Vanin, E. F., Brenner, M. K., Heslop, H. E., Spencer, D. M., & Rooney, C. M. (2005) · Blood · doi:10.1182/blood-2004-11-4564 · Cited by 745 · see citing works

Evolution of the cancer genome

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DNA vaccines: an historical perspective and view to the future

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Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress

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Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

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Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity

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Oncolytic viruses

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The First 1000 Dendritic Cell Vaccinees

Ridgway, D. (2003) · Cancer Investigation · doi:10.1081/cnv-120025091 · Cited by 278 · see citing works

Clinical Trials with Oncolytic Adenovirus in China

Yu, W., & Fang, H. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780058817 · Cited by 274 · see citing works

Progress on new vaccine strategies for the immunotherapy and prevention of cancer

Berzofsky, J. A., Terabe, M., Oh, S., Belyakov, I. M., Ahlers, J. D., Janik, J. E., & Morris, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21926 · Cited by 256 · see citing works

Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial

Westphal, M., Ylä‐Herttuala, S., Martin, J. F., Warnke, P. C., Meneï, P., Eckland, D. J. A., Kinley, J., Kay, R., & Ram, Z. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70274-2 · Cited by 239 · see citing works

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

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Combined chemokine and cytokine gene transfer enhances antitumor immunity

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The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies

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Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies

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Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma.

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The cancer vaccine roller coaster

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Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation

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Report on consensus conference on cervical cancer screening and management

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Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy

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Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients.

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Phase I study of intranodal delivery of a plasmid DNA vaccine for patients with Stage IV melanoma

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Oncolytic viral therapies

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Transgenic mice with a diverse human T cell antigen receptor repertoire

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Antiangiogenic gene therapy of cancer: recent developments

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Oncolytic virus therapy for cancer: the first wave of translational clinical trials

Patel, M. R., & Kratzke, R. A. (2013) · Translational research · doi:10.1016/j.trsl.2012.12.010 · Cited by 104 · see citing works

Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy

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Gene therapy for primary immunodeficiencies: part 1

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The use of dendritic cells in cancer immunotherapy

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Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy

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MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors

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In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma

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Enhancing the clinical activity of granulocyte‐macrophage colony‐stimulating factor‐secreting tumor cell vaccines

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Responses to Human CD40 Ligand/Human Interleukin-2 Autologous Cell Vaccine in Patients with B-Cell Chronic Lymphocytic Leukemia

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Adenovirus CD40 Ligand Gene Therapy Counteracts Immune Escape Mechanisms in the Tumor Microenvironment

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Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy

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Safer CARS

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Modulation of GvHD by suicide-gene transduced donor T lymphocytes: clinical applications in mismatched transplantation

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Monoclonal T-cell receptors: new reagents for cancer therapy.

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Dendritoma vaccination combined with low dose interleukin-2 in metastatic melanoma patients induced immunological and clinical responses

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A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors

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Do CARs Need a Driver's License? Adoptive Cell Therapy with Chimeric Antigen Receptor-Redirected T Cells Has Caused Serious Adverse Events

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DNA fusion vaccines enter the clinic

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Cell and Gene Therapy

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Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: Presentation of MART1 to CD8+ T cells

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Chimeric T Cells for Adoptive Immunotherapy of Cancer: Using What Have We Learned to Plan for the Future

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54. Administration of TGFβ-Resistant Tumor-Specific Cytotoxic T Lymphocytes (CTL) to Patients with EBV-Associated Hodgkin's Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL)

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59. Cardiovascular Toxicity and Titin Cross-Reactivity of Affinity-Enhanced TCR-Engineered T Cells Against HLA-A1 Restricted MAGE-A3 Antigen

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CRISPR-Cas9: a new and promising player in gene therapy

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Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

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Advance in treatment of rheumatoid arthritis.

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The Applications of Gene-Transfer Therapy in Rheumatoid Arthritis

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Cystic fibrosis: gene therapy or preventive gene transfer?

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NIDDK Workshop on AAV Vectors: Gene Transfer into Quiescent Cells

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Gene Therapy for Myocardial Infarction

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