Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives
Open accessAbstract
Human induced pluripotent stem cells (iPSCs) are promising in regenerative medicine. However, the risks of teratoma formation and the overgrowth of the transplanted cells continue to be major hurdles that must be overcome. Here, we examined the efficacy of the inducible caspase-9 (iCaspase9) gene as a fail-safe against undesired tumorigenic transformation of iPSC-derived somatic cells. We used a lentiviral vector to transduce iCaspase9 into two iPSC lines and assessed its efficacy in vitro and in vivo. In vitro, the iCaspase9 system induced apoptosis in approximately 95% of both iPSCs and iPSC-derived neural stem/progenitor cells (iPSC-NS/PCs). To determine in vivo function, we transplanted iPSC-NS/PCs into the injured spinal cord of NOD/SCID mice. All transplanted cells whose mass effect was hindering motor function recovery were ablated upon transduction of iCaspase9. Our results suggest that the iCaspase9 system may serve as an important countermeasure against post-transplantation adverse events in stem cell transplant therapies.
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Safety switches often take the form of an inducible gene encoding a protein that kills the cell, such as inducible Caspase9 or proliferation-induced constructs.
“These often take the form of an inducible gene to encoded for a protein that kills the cell, such as inducible Caspase9172 or proliferation-induced constructs.173”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [172]
The Introduction (page unavailable) describes HSV-TK as a suicide-gene system whose ablation is limited to cells with high proliferative potential, supporting the existence of proliferation-dependent safety switches. But this paper tests inducible caspase-9, not a proliferation-induced construct, so it does not support presenting its own system as the latter example. (LLM, conf=0.79)
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2007) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,781 · see citing works
Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
Di Stasi, A., Tey, S.-K., Dotti, G., Fujita, Y., Kennedy-Nasser, A., Martinez, C., Straathof, K., Liu, E., Durett, A. G., Grilley, B., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106152 · Cited by 1,512 · see citing works
Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.09.013 · Cited by 1,045 · see citing works
Nau, R., Sörgel, F., & Eiffert, H. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00007-10 · Cited by 1,031 · see citing works
Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108077108 · Cited by 546 · see citing works
Self-citationCiceri, F., Bonini, C., Stanghellini, M. T. L., Bondanza, A., Traversari, C., Salomoni, M., Turchetto, L., Colombi, S., Bernardi, M., Peccatori, J., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70074-9 · Cited by 485 · see citing works
Hentze, H., Soong, P., Wang, S. T., Phillips, B., Putti, T. C., & Dunn, N. R. (2009) · Stem Cell Research · doi:10.1016/j.scr.2009.02.002 · Cited by 474 · see citing works
Doi, D., Samata, B., Katsukawa, M., Kikuchi, T., Morizane, A., Ono, Y., Sekiguchi, K., Nakagawa, M., Parmar, M., & Takahashi, J. B. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.01.013 · Cited by 434 · see citing works
Nongenetic method for purifying stem cell–derived cardiomyocytes
Hattori, F., Chen, H., Yamashita, H., Tohyama, S., Satoh, Y.-S., Yuasa, S., Li, W., Yamakawa, H., Tanaka, T., Onitsuka, T., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1403 · Cited by 418 · see citing works
Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells
Okano, H., Nakamura, M., Yoshida, K., Okada, Y., Tsuji, O., Nori, S., Ikeda, E., Yamanaka, S., & Miura, K. (2013) · Circulation Research · doi:10.1161/circresaha.111.256149 · Cited by 413 · see citing works
Self-citationTransplantation of human neural stem cells for spinal cord injury in primates
Iwanami, A., Kaneko, S., Nakamura, M., Kanemura, Y., Mori, H., Kobayashi, S., Yamasaki, M., Momoshima, S., Ishii, H., Ando, K., et al. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20436 · Cited by 388 · see citing works
Self-citationKobayashi, Y., Okada, Y., Itakura, G., Iwai, H., Nishimura, S., Yasuda, A., Nori, S., Hikishima, K., Konomi, T., Fujiyoshi, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052787 · Cited by 315 · see citing works
Self-citationAbematsu, M., Tsujimura, K., Yamano, M., Saito, M., Kohno, K., Kohyama, J., Namihira, M., Komiya, S., & Nakashima, K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42957 · Cited by 299 · see citing works
Self-citationDenning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.014 · Cited by 293 · see citing works
Selective Ablation of Human Embryonic Stem Cells Expressing a “Suicide” Gene
Schuldiner, M., Itskovitz‐Eldor, J., & Benvenisty, N. (2003) · Stem Cells · doi:10.1634/stemcells.21-3-257 · Cited by 287 · see citing works
Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., Semi, K., Namihira, M., 節郎, 小., Smith, A. G., et al. (2012) · Stem Cells · doi:10.1002/stem.1083 · Cited by 245 · see citing works
iPS cell technologies: significance and applications to CNS regeneration and disease
Okano, H., & Yamanaka, S. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-22 · Cited by 232 · see citing works
Self-citationPruszak, J., Ludwig, W. W., Blak, A. A., Alavian, K. N., & Ole Isacson, A. (2009) · Stem Cells · doi:10.1002/stem.211 · Cited by 225 · see citing works
Sundberg, M., Bogetofte, H., Lawson, T., Jansson, J. P., Smith, G. A., Astradsson, A., Moore, M. A., Osborn, T. M., Cooper, O., Spealman, R. D., et al. (2013) · Stem Cells · doi:10.1002/stem.1415 · Cited by 223 · see citing works
Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu, A., Koya, I., Yoshida, R., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.01.006 · Cited by 223 · see citing works
Self-citationCell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells
Nakamura, M., & Okano, H. (2013) · Cell Research · doi:10.1038/cr.2012.171 · Cited by 214 · see citing works
Self-citationTraversari, C., Marktel, S., Magnani, Z. I., Mangia, P., Russo, V. E. A., Ciceri, F., Bonini, C., & Bordignon, C. (2007) · Blood · doi:10.1182/blood-2006-04-015230 · Cited by 206 · see citing works
祐介, 藤. (2012) · Medical Entomology and Zoology · Cited by 181 · see citing works
Kanemura, Y., Mori, H., Kobayashi, S., Islam, O., Kodama, E., Yamamoto, A., Nakanishi, Y., Arita, N., Yamasaki, M., Okano, H., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10377 · Cited by 153 · see citing works
Self-citationIntrona, M., Barbui, A. M., Bambacioni, F., Casati, C., Gaipa, G., Borleri, G., Bernasconi, S., Barbui, T., Golay, J., Biondi, A., et al. (2000) · Human Gene Therapy · doi:10.1089/10430340050015798 · Cited by 142 · see citing works
Cai, J., Yang, M., Poremsky, E., Kidd, S. K., Schneider, J. S., & Iacovitti, L. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0319 · Cited by 141 · see citing works
Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy
Griffioen, M., van Egmond, E. H. M., Kester, M. G. D., Willemze, R., Falkenburg, J. H. F., & Heemskerk, M. H. M. (2009) · Haematologica · doi:10.3324/haematol.2008.001677 · Cited by 137 · see citing works
Seminatore, C., Polentes, J., Ellman, D. G., Kozubenko, N., Itier, V., Tine, S., Tritschler, L., Brenot, M., Guidou, E., Blondeau, J., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.563015 · Cited by 129 · see citing works
Marin, V., Cribioli, E., Philip, B., Tettamanti, S., Pizzitola, I., Biondi, A., Biagi, E., & Pulè, M. A. (2012) · Human Gene Therapy Methods · doi:10.1089/hgtb.2012.050 · Cited by 122 · see citing works
Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy
Dachs, G. U., Hunt, M. A., Syddall, S. P., Singleton, D. C., & Patterson, A. V. (2009) · Molecules · doi:10.3390/molecules14114517 · Cited by 110 · see citing works
Okubo, T., Iwanami, A., Kohyama, J., Itakura, G., Kawabata, S., Nishiyama, Y., Sugai, K., Ozaki, M., Iida, T., Matsubayashi, K., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.015 · Cited by 99 · see citing works
Self-citationElimination of Tumorigenic Human Pluripotent Stem Cells by a Recombinant Lectin-Toxin Fusion Protein
Tateno, H., Onuma, Y., Ito, Y., Minoshima, F., Saito, S., Shimizu, M., Aiki, Y., Asashima, M., & Hirabayashi, J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.02.016 · Cited by 92 · see citing works
A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy
Ando, M., Nishimura, T., Yamazaki, S., Yamaguchi, T., Kawana-Tachikawa, A., Hayama, T., Nakauchi, Y., Ando, J., Ota, Y., Takahashi, S., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.07.011 · Cited by 82 · see citing works
Self-citationPfaff, N., Lachmann, N., Ackermann, M., Kohlscheen, S., Brendel, C., Maetzig, T., Niemann, H., Antoniou, M. N., Grez, M., Schambach, A., et al. (2013) · Stem Cells · doi:10.1002/stem.1316 · Cited by 82 · see citing works
Yanagida, A., Ito, K., Chikada, H., Nakauchi, H., & Kamiya, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067541 · Cited by 77 · see citing works
Self-citationProtecting against wayward human induced pluripotent stem cells with a suicide gene
Cheng, F., Ke, Q., Chen, F., Cai, B., Gao, Y., Ye, C., Wang, D., Zhang, L., Lahn, B. T., Li, W., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.023 · Cited by 76 · see citing works
Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies
Wu, C., Hong, S. G., Winkler, T., Spencer, D. M., Jares, A., Ichwan, B., Nicolae, A., Guo, V., Larochelle, A., & Dunbar, C. E. (2014) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2014.53 · Cited by 74 · see citing works
Bioluminescent system for dynamic imaging of cell and animal behavior
Hara‐Miyauchi, C., Tsuji, O., Hanyu, A., Okada, S., Yasuda, A., Fukano, T., Akazawa, C., Nakamura, M., Imamura, T., Matsuzaki, Y., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.141 · Cited by 73 · see citing works
Self-citationChen, H., Chuang, C.-Y., Lee, W.-C., Huang, H., Wu, H., Ho, H., Chen, Y., & Kuo, H. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9233-y · Cited by 60 · see citing works
Is cancer gene therapy an empty suit?
Brenner, M. K., Gottschalk, S., Leen, A. M., & Vera, J. F. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70173-6 · Cited by 52 · see citing works
Itakura, G., Kobayashi, Y., Nishimura, S., Iwai, H., Takano, M., Iwanami, A., Toyama, Y., Okano, H., & Nakamura, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116413 · Cited by 48 · see citing works
Self-citationKatsukawa, M., Nakajima, Y., Fukumoto, A., Doi, D., & Takahashi, J. B. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0394 · Cited by 48 · see citing works
Tumors Originating from Induced Pluripotent Stem Cells and Methods for Their Prevention
Duinsbergen, D., Salvatori, D., Eriksson, M., & Mikkers, H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04563.x · Cited by 45 · see citing works
Ando, M., Hoyos, V., Yagyu, S., Tao, W., Ramos, C. A., Dotti, G., Brenner, M. K., & Bouchier‐Hayes, L. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.53 · Cited by 43 · see citing works
Self-citationTateno, H., Onuma, Y., Ito, Y., Hiemori, K., Aiki, Y., Shimizu, M., Higuchi, K., Fukuda, M., Warashina, M., Honda, S., et al. (2014) · Scientific Reports · doi:10.1038/srep04069 · Cited by 42 · see citing works
Ogura, A., Morizane, A., Nakajima, Y., Miyamoto, S., & Takahashi, J. B. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0198 · Cited by 36 · see citing works
Barese, C. N., Felizardo, T. C., Sellers, S. E., Keyvanfar, K., Stasi, A. D., Metzger, M. E., Krouse, A. E., Donahue, R. E., Spencer, D. M., & Dunbar, C. E. (2014) · Stem Cells · doi:10.1002/stem.1869 · Cited by 33 · see citing works
Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells
Chen, F., Cai, B., Gao, Y., Yuan, X., Cheng, F., Wang, T., Meihua, J., Zhou, Y., Lahn, B. T., Li, W., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.018 · Cited by 32 · see citing works
Calderon, D., Planat‐Benard, V., Bellamy, V., Vanneaux, V., Kuhn, C., Peyrard, S., Larghero, J., Desnos, M., Casteilla, L., Pucéat, M., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01435.x · Cited by 24 · see citing works
Genetic modification of human T lymphocytes for the treatment of hematologic malignancies
Hoyos, V., Savoldo, B., & Dotti, G. (2012) · Haematologica · doi:10.3324/haematol.2012.064303 · Cited by 14 · see citing works
Kamada, M., Mitsui, Y., Matsuo, T., & Takahashi, T. (2015) · Human Cell · doi:10.1007/s13577-015-0119-1 · Cited by 10 · see citing works
Uno, N., Uno, K., Komoto, S., Suzuki, T., Hiratsuka, M., Osaki, M., Kazuki, Y., & Oshimura, M. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.45 · Cited by 8 · see citing works
Zhao, Q., Lu, B., George, S. K., Yoo, J. J., & Atala, A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.038 · Cited by 8 · see citing works
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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.002 · Cited by 210 · see citing works
Sato, Y., Bando, H., Piazza, M., Gowing, G., Herberts, C. A., Jackman, S. M., Leoni, G., Libertini, S., MacLachlan, T. K., McBlane, J. W., et al. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.10.001 · Cited by 169 · see citing works
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Devillard, C. D., & Marquette, C. A. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.721843 · Cited by 152 · see citing works
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Huang, L., Fu, C., Xiong, F., He, C., & Wei, Q. (2021) · Cell Transplantation · doi:10.1177/0963689721989266 · Cited by 137 · see citing works
Hosseini, S. M., Borys, B., & Karimi‐Abdolrezaee, S. (2023) · Brain · doi:10.1093/brain/awad392 · Cited by 134 · see citing works
Tsuji, O., Sugai, K., Yamaguchi, R., Tashiro, S., Nagoshi, N., Kohyama, J., Iida, T., Ohkubo, T., Itakura, G., Isoda, M., et al. (2018) · Stem Cells · doi:10.1002/stem.2926 · Cited by 128 · see citing works
Self-citationFoo, J. B., Looi, Q. H., Chong, P. P., Hassan, N. H., Yeo, G. E. C., Ng, C. Y., Koh, B., How, C. W., Lee, S. H., & Law, J. X. (2021) · Stem Cells International · doi:10.1155/2021/2616807 · Cited by 131 · see citing works
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Willis, C. M., Nicaise, A. M., Peruzzotti‐Jametti, L., & Pluchino, S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146615 · Cited by 117 · see citing works
Martin, R. M., Fowler, J. L., Cromer, M., Lesch, B., Ponce, E., Uchida, N., Nishimura, T., Porteus, M. H., & Loh, K. (2020) · Nature Communications · doi:10.1038/s41467-020-16455-7 · Cited by 100 · see citing works
Deng, J., Zhang, Y., Xie, Y., Zhang, L., & Tang, P. (2018) · Stem Cells International · doi:10.1155/2018/5653787 · Cited by 95 · see citing works
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Ashmore‐Harris, C., Iafrate, M., Saleem, A., & Fruhwirth, G. O. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.03.016 · Cited by 91 · see citing works
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
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Self-citationKojima, K., Miyoshi, H., Nagoshi, N., Kohyama, J., Itakura, G., Kawabata, S., Ozaki, M., Iida, T., Sugai, K., Ito, S., et al. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0096 · Cited by 86 · see citing works
Self-citationGuo, S., Wang, L., Xie, Y., Luo, X., Zhang, S., Xiong, L., Ai, H., Yuan, Z., & Wang, J. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.08.191 · Cited by 85 · see citing works
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Monaco, M. L., Merckx, G., Ratajczak, J., Gervois, P., Hilkens, P., Clegg, P., Bronckaers, A., Vandeweerd, J., & Lambrichts, I. (2018) · Stem Cells International · doi:10.1155/2018/9079538 · Cited by 85 · see citing works
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Lu, S., & Feng, Q. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.21-0135 · Cited by 40 · see citing works
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy
Kimura, Y., Shofuda, T., Higuchi, Y., Nagamori, I., Oda, M., Nakamori, M., Onodera, M., Kanematsu, D., Yamamoto, A., Katsuma, A., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0039 · Cited by 40 · see citing works
Remyelination in the central nervous system
Franklin, R. J. M., Bodini, B., & Goldman, S. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041371 · Cited by 40 · see citing works
Role of CD133 in human embryonic stem cell proliferation and teratoma formation
Wang, H., Gong, P., Li, J., Fu, Y., Zhou, Z., & Liu, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01729-0 · Cited by 39 · see citing works
Regenerative therapy for spinal cord injury using iPSC technology
Nagoshi, N., Okano, H., & Nakamura, M. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00149-0 · Cited by 39 · see citing works
Self-citationNiclis, J. C., Gantner, C. W., Hunt, C. J., Kauhausen, J. A., Durnall, J. C., Haynes, J. M., Pouton, C. W., Parish, C. L., & Thompson, L. H. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.002 · Cited by 38 · see citing works
Recapitulating kidney development: Progress and challenges
Little, M. H., Kumar, S. V. R., & Forbes, T. A. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.08.015 · Cited by 36 · see citing works
New trends in cellular therapy
Okano, H., & Sipp, D. (2020) · Development · doi:10.1242/dev.192567 · Cited by 37 · see citing works
Self-citationAttaluri, S., Gonzalez, J. J., Kirmani, M., Vogel, A. D., Upadhya, R., Kodali, M., Madhu, L. N., Rao, S., Shuai, B., Babu, R. S., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1200445 · Cited by 36 · see citing works
Predicting differentiation potential of human pluripotent stem cells: Possibilities and challenges
Liu, L., & Zheng, Y. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i7.375 · Cited by 31 · see citing works
Direct in vivo application of induced pluripotent stem cells is feasible and can be safe
Xiang, M., Lu, M., Quan, J., Xu, M., Meng, D., Cui, A., Li, N., Liu, Y., Lu, P., Kang, X., et al. (2018) · Theranostics · doi:10.7150/thno.28671 · Cited by 30 · see citing works
Tanimoto, Y., Yamasaki, T., Nagoshi, N., Nishiyama, Y., Nori, S., Nishimura, S., Iida, T., Ozaki, M., Tsuji, O., Ji, B., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0150 · Cited by 30 · see citing works
Self-citationKaewsaeng‐on, R., AL-Takhayneh, S. K., Jam, F. A., Chang, B.-L., Pradana, M., & Mahmood, S. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1028219 · Cited by 30 · see citing works
Stem cell-based approaches: Possible route to hearing restoration?
Alonso, M. B. D. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i6.422 · Cited by 29 · see citing works
Furukawa, Y., Hamano, Y., Shirane, S., Kinoshita, S., Azusawa, Y., Ando, J., Nakauchi, H., & Ando, M. (2022) · Cells · doi:10.3390/cells11020269 · Cited by 29 · see citing works
Self-citationSynthetic gene circuits and cellular decision-making in human pluripotent stem cells
Prochazka, L., Benenson, Y., & Zandstra, P. W. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.09.003 · Cited by 29 · see citing works
Current Concepts of Stem Cell Therapy for Chronic Spinal Cord Injury
Suzuki, H., & Sakai, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147435 · Cited by 28 · see citing works
Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application
Mahmood, N., Suh, T. C., Ali, K. M., Sefat, E., Jahan, U. M., Huang, Y., Gilger, B. C., & Gluck, J. M. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10435-8 · Cited by 28 · see citing works
Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040810 · Cited by 23 · see citing works
Self-citationCell therapy strategies for COVID-19: Current approaches and potential applications
Zaki, M. M., Lesha, E., Said, K., Kiaee, K., Robinson‐McCarthy, L. R., George, H., Hanna, A., Appleton, E., Liu, S., Ng, A. H. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg5995 · Cited by 25 · see citing works
Clinical Application for Tissue Engineering Focused on Materials
Kitsuka, T., Hama, R., Ulziibayar, A., Matsuzaki, Y., Kelly, J. M., & Shinoka, T. (2022) · Biomedicines · doi:10.3390/biomedicines10061439 · Cited by 25 · see citing works
Challenges and perspectives of heart repair with pluripotent stem cell-derived cardiomyocytes
Eschenhagen, T., & Weinberger, F. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00472-6 · Cited by 24 · see citing works
Movahed, A. Y., Bagheri, R., Savatier, P., Šarić, T., & Moradi, S. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102543 · Cited by 28 · see citing works
Cardiac cell therapy: Current status, challenges and perspectives
Menasché, P. (2020) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2020.01.002 · Cited by 23 · see citing works
Pluripotent Stem Cells for Spinal Cord Injury Repair
Martín-López, M., Fernández‐Muñoz, B., & Cánovas, S. (2021) · Cells · doi:10.3390/cells10123334 · Cited by 22 · see citing works
Frederiksen, H. R. S., Doehn, U., Tveden‐Nyborg, P., & Freude, K. (2021) · Frontiers in Genome Editing · doi:10.3389/fgeed.2020.623717 · Cited by 20 · see citing works
Lipus, A., Janosz, E., Ackermann, M., Hetzel, M., Dahlke, J., Buchegger, T., Wunderlich, S., Martin, U., Cathomen, T., Schambach, A., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072481 · Cited by 19 · see citing works
Beneath the radar: immune-evasive cell sources for stroke therapy.
Buil, B. A., Rentsch, N. H., Weber, R. Z., Rickenbach, C., Halliday, S., Hotta, A., Tackenberg, C., & Rust, R. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.12.004 · Cited by 18 · see citing works
Possible Strategies to Reduce the Tumorigenic Risk of Reprogrammed Normal and Cancer Cells
Lin, Y.-C., Ku, C.-C., Wuputra, K., Liu, C.-J., Wu, D.-C., Satou, M., Mitsui, Y., Saito, S., & Yokoyama, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105177 · Cited by 20 · see citing works
Stem cell-based therapy for hirschsprung disease, do we have the guts to treat?
Alhawaj, A. F. (2021) · Gene Therapy · doi:10.1038/s41434-021-00268-4 · Cited by 18 · see citing works
Liu, Y., Yang, Y., Suo, Y., Li, C., Chen, M., Zheng, S., Li, H., Tang, C., Fan, N.-N., Lan, T., et al. (2022) · Molecular Therapy: Methods & Clinical Development · doi:10.1016/j.omtm.2022.01.014 · Cited by 17 · see citing works
Culturing human pluripotent stem cells for regenerative medicine
Ozawa, H., Matsumoto, T., & Nakagawa, M. (2023) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2023.2225701 · Cited by 16 · see citing works
Petkov, S., Dressel, R., Rodríguez-Polo, I., & Behr, R. (2020) · Cells · doi:10.3390/cells9112422 · Cited by 16 · see citing works
Inoue, M., Yamaguchi, R., He, C. C. J., Ikeda, A., Okano, H., & Kohyama, J. (2023) · Stem Cell Investigation · doi:10.21037/sci-2022-037 · Cited by 15 · see citing works
Self-citationBenefits and Hurdles of Pancreatic β-Cell Replacement
Bolla, A. M., Montefusco, L. B., Pastore, I., Lunati, M. E., Nasr, M. B., & Fiorina, P. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac058 · Cited by 15 · see citing works
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells
Nishimura, T., Xu, H., 岩崎, 正., Karigane, D., Saavedra, B., Takahashi, Y., Suchy, F. P., Monobe, S., Martin, R. M., Ohtaka, M., et al. (2020) · Gene Therapy · doi:10.1038/s41434-020-0179-z · Cited by 14 · see citing works
Self-citationInterconversion of Cancer Cells and Induced Pluripotent Stem Cells
Sarker, D. B., Xue, Y., Mahmud, F., Jocelyn, J. A., & Sang, Q. A. (2024) · Cells · doi:10.3390/cells13020125 · Cited by 13 · see citing works
Mohammadi, A., Maleki-Jamshid, A., Sanooghi, D., Milan, P. B., Rahmani, A., Sefat, F., Shahpasand, K., Soleimani, M., Bakhtiari, M., Belali, R., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0968-1 · Cited by 13 · see citing works
Tynecka, M., Moniuszko, M., & Eljaszewicz, A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10137-7 · Cited by 13 · see citing works
Non-invasive quantification of stem cell-derived islet graft size and composition
Lithovius, V., Lahdenpohja, S., Ibrahim, H., Saarimäki‐Vire, J., Uusitalo, L., Montaser, H., Mikkola, K., Yim, C., Keller, T., Rajander, J., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06194-5 · Cited by 10 · see citing works
Teratoma Formation Assay for Assessing Pluripotency and Tumorigenicity of Pluripotent Stem Cells
Miyawaki, S., Okada, Y., Okano, H., & Miura, K. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2518 · Cited by 11 · see citing works
Self-citationVarrault, A., Journot, L., & Bouschet, T. (2019) · Stem Cells and Development · doi:10.1089/scd.2018.0233 · Cited by 12 · see citing works
Induced Pluripotent Stem Cell-Derived Cardiomyocytes: From Regulatory Status to Clinical Translation
Soares, C. S. P., & Ribeiro, M. H. L. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0080 · Cited by 10 · see citing works
A Guide in Synthetic Biology: Designing Genetic Circuits and Their Applications in Stem Cells
Elnaggar, K. S., Gamal, O., Hesham, N., Ayman, S., Mohamed, N., Moataz, A., Elzayat, E. M., & Hassan, N. (2025) · SynBio · doi:10.3390/synbio3030011 · Cited by 10 · see citing works
Neglected No More: Emerging Cellular Therapies in Traumatic Injury
Lowry, L. E., Herzig, M. C. S., Christy, B. A., Schäfer, R., Pati, S., Cap, A. P., & Bynum, J. A. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10086-7 · Cited by 10 · see citing works
Kitagawa, T., Nagoshi, N., Okano, H., & Nakamura, M. (2022) · Neurospine · doi:10.14245/ns.2244628.314 · Cited by 10 · see citing works
Self-citationBurkert, K., Taheri, H., Hamad, S., Oliverio, M., Peinkofer, G., Kornfeld, J., Harnying, W., Pfannkuche, K., Hescheler, J., Berkessel, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81351-z · Cited by 5 · see citing works
Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids
Gong, S., He, K., Liu, Y., Luo, X., Ashraf, K., He, J., Li, W., Yang, L., Rehman, T. U., Shen, M., et al. (2025) · Cell Proliferation · doi:10.1111/cpr.70033 · Cited by 8 · see citing works
Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care
Jagadeesan, S. K., Sandarage, R. V., Mathiyalagan, S., & Tsai, E. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083874 · Cited by 8 · see citing works
Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?
Shalaby, K. E., & Abdelalim, E. M. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00786-8 · Cited by 10 · see citing works
Ochieng, B. O., Zhao, L., & Ye, Z. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0175 · Cited by 11 · see citing works
Engineering pluripotent stem cells with synthetic biology for regenerative medicine
Mao, Y., Wang, S., Yu, J., & Li, W. (2024) · Medical Review · doi:10.1515/mr-2023-0050 · Cited by 8 · see citing works
Hypoimmunogenic pluripotent stem cells: A game-changer in cell-based regenerative medicine.
Asadi-Sarabi, P., Rismani, E., Shabanpouremam, M., Hendi, Z., Nikoubin, B., Rahimi, S., Taleb, M., Khosravi, A., Zarrabi, A., Hassan, M., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115134 · Cited by 8 · see citing works
Making Skeletal Muscle from Human Pluripotent Stem Cells
Nogami, K., Blanc, M., Takemura, F., Takeda, S., & Miyagoe‐Suzuki, Y. (2018) · InTech eBooks · doi:10.5772/intechopen.77263 · Cited by 7 · see citing works
Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells
Hiura, S., Kuwasaki, Y., Nishikawa, Y., Kimura, T., Yoshida, S., Nakayama, M., Makino, T., & Ueno, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-18394-z · Cited by 7 · see citing works
Induced Pluripotent Stem Cells, a Stepping Stone to In Vitro Human Models of Hearing Loss
Alonso, M. B. D., & Petković, H. (2022) · Cells · doi:10.3390/cells11203331 · Cited by 6 · see citing works
Induced Pluripotent Stem Cells for Clinical Use
Vanneaux, V. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88878 · Cited by 6 · see citing works
Update on Mesenchymal and Induced Pluripotent Stem Cells
Al‐Anazi, K. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77857 · Cited by 5 · see citing works
Improving the safety of iPSC-derived T cell therapy
Ando, M., Kinoshita, S., Furukawa, Y., Ando, J., Nakauchi, H., & Brenner, M. (2022) · Molecular Players in iPSC Technology · doi:10.1016/b978-0-323-90059-1.00010-5 · Cited by 3 · see citing works
Self-citationExtracellular Vesicles and Cellular Ageing
Romero-García, N., Mas‐Bargues, C., Huete-Acevedo, J., & Borrás, C. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_11 · Cited by 4 · see citing works
Microfluidic chip for label-free removal of teratoma-forming cells from therapeutic human stem cells
Wellmerling, K., Lehmann, C., Singh, A. K., & Kirby, B. J. (2020) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2020.100030 · Cited by 4 · see citing works
Stem and progenitor cell-based therapy of myelin disorders
Goldman, S. A., Franklin, R. J. M., & Osório, M. J. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90120-8.00015-0 · Cited by 3 · see citing works
Müller, T. H. (2021) · Biologics · doi:10.2147/btt.s267281 · Cited by 4 · see citing works
Retinal therapy with induced pluripotent stem cells; leading the way to human clinical trials
Yanai, A., McNab, P., & Gregory-Evans, K. (2019) · Expert Review of Ophthalmology · doi:10.1080/17469899.2019.1568872 · Cited by 3 · see citing works
Spinal interneurons and cell transplantation
Tucker, A., Aceves, M., Butts, J. C., & Dulin, J. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819260-3.00003-2 · Cited by 3 · see citing works
Pluripotent stem cell-derived cardiomyocyte transplantation: marching from bench to bedside
Yi, H., Liu, J., Wang, W., Li, H., Kong, W., Li, X., Zhang, W., Pahlavan, S., Tang, Y., Wang, X., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2801-x · Cited by 2 · see citing works
Waris, S., Begam, H. H., Kumar, M. P., Abdulrasool, Z., Avudaiappan, M., Butler, A. E., & Nandakumar, M. (2026) · Cells · doi:10.3390/cells15020191 · Cited by 4 · see citing works
- Authors
- Itakura, G., Kawabata, S., Ando, M., Nishiyama, Y., Sugai, K., Ozaki, M., Iida, T., Ookubo, T., Kojima, K., Kashiwagi, R., Yasutake, K., Nakauchi, H., Miyoshi, H., Nagoshi, N., Kohyama, J., Iwanami, A., Matsumoto, M., Nakamura, M., & Okano, H.
- Affiliations
- Keio University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Nakamura, Masaya
- Okano, Hideyuki
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 8
- Issue
- 3
- Pages
- 673-684
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5355810
- OpenAlex
- W2592109836
- Cited by
- 115
- References
- 54
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 10 · 2017: 5
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- General Insurance Association of Japan (15-2B-13)
- Japan Agency for Medical Research and Development (16bm0204001h0004)
- Research Center Network for Realization of Regenerative Medicine
- Japan Society for the Promotion of Science (15K10422)
- Keio University (253G1, TKDA3-4)
- Japan Science and Technology Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- induced pluripotent stem cells, fail-safe systems, inducible caspase-9, tumorigenicity, teratoma, apoptosis, lentiviral gene delivery, spinal cord injury, cell transplantation, motor recovery, NOD/SCID mice
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Cell Transformation, Neoplastic, Female, Humans, Spinal Cord Injuries, Teratoma, Gene Expression, Apoptosis, Genes, Reporter, Stem Cell Transplantation, Mice, Induced Pluripotent Stem Cells, Clustered Regularly Interspaced Short Palindromic Repeats
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