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Cited by 677

The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.

Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence

Open access
Kerr, Jacqueline, Anderson, Cheryl, Lippman, Scott M·2017·The Lancet Oncology
DOI 10.1016/s1470-2045(17)30411-4
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Abstract

The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being studied for their associations with cancer. Physical activity is inversely associated with and sedentary behaviour is positively (and independently) associated with an increased risk of more than ten types of cancer, including colorectal cancer (and advanced adenomas), endometrial cancers, and breast cancer. The most consistent dietary risk factor for premalignant and invasive breast cancer is alcohol, whether consumed during early or late adult life, even at low levels. Epidemiological studies show that the inclusion of wholegrain, fibre, fruits, and vegetables within diets are associated with reduced cancer risk, with diet during early life (age <8 years) having the strongest apparent association with cancer incidence. However, randomised controlled trials of diet-related factors have not yet shown any conclusive associations between diet and cancer incidence. Obesity is a key contributory factor associated with cancer risk and mortality, including in dose–response associations in endometrial and post-menopausal breast cancer, and in degree and duration of fatty liver disease-related hepatocellular carcinoma. Obesity produces an inflammatory state, characterised by macrophages clustered around enlarged hypertrophied, dead, and dying adipocytes, forming crown-like structures. Increased concentrations of aromatase and interleukin 6 in inflamed breast tissue and an increased number of macrophages, compared with healthy tissue, are also observed in women with normal body mass index, suggesting a metabolic obesity state. Emerging randomised controlled trials of physical activity and dietary factors and mechanistic studies of immunity, inflammation, extracellular matrix mechanics, epigenetic or transcriptional regulation, protein translation, circadian disruption, and interactions of the multibiome with lifestyle factors will be crucial to advance this field.

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Metadata

Authors
Kerr, J., Anderson, C., & Lippman, S. M.
Venue
The Lancet Oncology
Publisher
Elsevier BV
Published
2017-08
Volume
18
Issue
8
Pages
e457-e471
ISSN
1470-2045 (ISSN-L)
DOI
10.1016/s1470-2045(17)30411-4
OpenAlex
W2736536661
Cited by
677
References
207
FWCI
22.73
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. https://app.cochat.ai/papers/10.1016/s1470-2045(17)30411-4
The paper
Kerr, J., Anderson, C., & Lippman, S. M. (2017). Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(17)30411-4

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.