The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study
Open accessAbstract
BACKGROUND: Alcohol use is causally linked to multiple cancers. We present global, regional, and national estimates of alcohol-attributable cancer burden in 2020 to inform alcohol policy and cancer control across different settings globally. METHODS: In this population-based study, population attributable fractions (PAFs) calculated using a theoretical minimum-risk exposure of lifetime abstention and 2010 alcohol consumption estimates from the Global Information System on Alcohol and Health (assuming a 10-year latency period between alcohol consumption and cancer diagnosis), combined with corresponding relative risk estimates from systematic literature reviews as part of the WCRF Continuous Update Project, were applied to cancer incidence data from GLOBOCAN 2020 to estimate new cancer cases attributable to alcohol. We also calculated the contribution of moderate (<20 g per day), risky (20-60 g per day), and heavy (>60 g per day) drinking to the total alcohol-attributable cancer burden, as well as the contribution by 10 g per day increment (up to a maximum of 150 g). 95% uncertainty intervals (UIs) were estimated using a Monte Carlo-like approach. FINDINGS: Globally, an estimated 741 300 (95% UI 558 500-951 200), or 4·1% (3·1-5·3), of all new cases of cancer in 2020 were attributable to alcohol consumption. Males accounted for 568 700 (76·7%; 95% UI 422 500-731 100) of total alcohol-attributable cancer cases, and cancers of the oesophagus (189 700 cases [110 900-274 600]), liver (154 700 cases [43 700-281 500]), and breast (98 300 cases [68 200-130 500]) contributed the most cases. PAFs were lowest in northern Africa (0·3% [95% UI 0·1-3·3]) and western Asia (0·7% [0·5-1·2]), and highest in eastern Asia (5·7% [3·6-7·9]) and central and eastern Europe (5·6% [4·6-6·6]). The largest burden of alcohol-attributable cancers was represented by heavy drinking (346 400 [46·7%; 95% UI 227 900-489 400] cases) and risky drinking (291 800 [39·4%; 227 700-333 100] cases), whereas moderate drinking contributed 103 100 (13·9%; 82 600-207 200) cases, and drinking up to 10 g per day contributed 41 300 (35 400-145 800) cases. INTERPRETATION: Our findings highlight the need for effective policy and interventions to increase awareness of cancer risks associated with alcohol use and decrease overall alcohol consumption to prevent the burden of alcohol-attributable cancers. FUNDING: None.
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Murray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30752-2 · Cited by 9,854
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Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
Self-citationBoffetta, P., & Hashibe, M. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70577-0 · Cited by 877
Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands
Dinmohamed, A. G., Visser, O., Verhoeven, R. H. A., Louwman, M. W. J., van Nederveen, F. H., Willems, S. M., Merkx, M. A. W., Lemmens, V. E. P. P., Nagtegaal, I. D., & Siesling, S. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30265-5 · Cited by 699
Self-citationNiedzwiedz, C. L., Green, M. J., Benzeval, M., Campbell, D., Craig, P., Demou, E., Leyland, A., Pearce, A., Thomson, R., Whitley, E., et al. (2021) · Journal of Epidemiology and Community Health · doi:10.1136/jech-2020-215060 · Cited by 525
Cancer incidence and mortality attributable to alcohol consumption
Praud, D., Rota, M., Rehm, J., Shield, K., Zatoński, W., Hashibe, M., La Vecchia, C., & Boffetta, P. (2016) · International Journal of Cancer · doi:10.1002/ijc.29890 · Cited by 218
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Global burden of primary liver cancer in 2020 and predictions to 2040
Rumgay, H., Arnold, M., Ferlay, J., Lesi, O., Cabasag, C. J., Vignat, J., Laversanne, M., McGlynn, K. A., & Soerjomataram, I. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.021 · Cited by 2,197
Self-citationAASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
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“Lifestyle factors, such as alcohol and tobacco use, increase risk of many cancers, including HCC. [15] Smoking is associated with a 20% – 86% increased risk of HCC, which can return nearly to baseline after 30 years of smoking cessation.”
Global, regional and national burden of primary liver cancer by subtype
Rumgay, H., Ferlay, J., de Martel, C., Georges, D., Ibrahim, A. S., Zheng, R., Wei, W., Lemmens, V. E. P. P., & Soerjomataram, I. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2021.11.023 · Cited by 615
Self-citationDominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433
Force, L. M., Kocarnik, J. M., May, M. L., Bhangdia, K., Crist, A., Penberthy, L., Pritchett, N., Acheson, A., Deitesfeld, L., A, B., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01635-6 · Cited by 494
Metadata
- Authors
- Rumgay, H., Shield, K., Charvat, H., Ferrari, P., Sornpaisarn, B., Obot, I., Islami, F., Lemmens, V. E. P. P., Rehm, J., & Soerjomataram, I.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 22
- Issue
- 8
- Pages
- 1071-1080
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W3183035192
- Cited by
- 683
- References
- 6
- FWCI
- 62.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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