Cited by 387Per- and polyfluoroalkyl substances researchCarcinogens and Genotoxicity AssessmentFluoride Effects and Removal

Carcinogenicity of Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid

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Zahm, Shelia, Bonde, Jens Peter, Chiu, Weihsueh A, Hoppin, Jane, Kanno, Jun, Abdallah, Mohamed, Blystone, Chad R, Calkins, Miriam M +39 more·2024·The Lancet Oncology

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Registry

Crossref · 10.1016/s1470-2045(23)00622-8

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9 of 9 references verified0 citation errors · 0 not checkable

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  • Proposed carcinogenic mechanisms include activation of PPAR-α, genotoxic effects, endocrine disruption, and epigenetic alterations.

    “Proposed carcinogenic mechanisms include activation of peroxisome proliferator-activated receptor alpha (PPAR-α), which influences lipid metabolism, cell proliferation, and inflammation—pathways that may contribute to tumor development, B genotoxic effects, endocrine disruption, and epigenetic alterations [101].”

    From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [101]

    The mechanistic-evidence passages (page not provided) report epigenetic alterations, PPARα-mediated effects, altered cell proliferation, and PFOS effects on thyroid- and androgen-mediated pathways. They do not report genotoxic effects or specifically establish PPARα activation and its claimed effects on inflammation and lipid metabolism; searches for genotoxicity and those pathway details found no supporting passage. (LLM, conf=0.86)

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1 of the 10 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [1]International Agency for Research on Cancer. Volume 135: Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). Lyon, France; Nov 7–14, 2023. IARC Monogr Identif Carcinog Hazards Hum (in press). 40489584
  2. [3]National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of perfluorooctanoic acid (CASRN 335-67-1) administered in feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) rats (revised). Research Triangle Park (NC): National Toxicology Program, 2023. PMC8039881 33556048

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Authors
Zahm, S., Bonde, J. P., Chiu, W. A., Hoppin, J., Kanno, J., Abdallah, M., Blystone, C. R., Calkins, M. M., Dong, G.-H., Dorman, D. C., Fry, R., Guo, H., Haug, L. S., Hofmann, J. N., Iwasaki, M., Machala, M., Mancini, F. R., Maria-Engler, S. S., Møller, P., Ng, J. C., Pallardy, M., Post, G. B., Salihovic, S., Schlezinger, J., Soshilov, A., Steenland, K., Steffensen, I.-L., Tryndyak, V., White, A., Woskie, S., Fletcher, T., Ahmadi, A., Ahmadi, N., Benbrahim-Tallaa, L., Bijoux, W., Chittiboyina, S., de Conti, A., Facchin, C., Madia, F., Mattock, H., Merdas, M., Pasqual, E., Suonio, E., Viegas, S., Zupunski, L., Wedekind, R., & Schubauer-Berigan, M. K.
Affiliations
Centre international de recherche sur le cancer (FR)
Venue
The Lancet Oncology
Publisher
Elsevier BV
Published
2024-01
Volume
25
Issue
1
Pages
16-17
ISSN
1470-2045 (ISSN-L)
OpenAlex
W4389208799
Cited by
387
References
10
Citations by year
2026: 136 · 2025: 149 · 2024: 100 · 2023: 2
FWCI
32.23
Type
journal article
Language
en
Locations
  • The Lancet Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
  • World Health Organization
  • National Cancer Institute (U01CA033193, R01CA033193)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
Keywords
perfluorooctanoic acid, PFOS, carcinogenicity, perfluorinated compounds, isomers, salt, cancer risk assessment
MeSH terms
Caprylates, Fluorocarbons, Humans, Alkanesulfonic Acids

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