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Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid
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“Proposed carcinogenic mechanisms include activation of peroxisome proliferator-activated receptor alpha (PPAR-α), which influences lipid metabolism, cell proliferation, and inflammation—pathways that may contribute to tumor development, B genotoxic effects, endocrine disruption, and epigenetic alterations [101].”
From Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights (2025) · cites this paper as [101]
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Metadata
- Authors
- Zahm, S., Bonde, J. P., Chiu, W. A., Hoppin, J., Kanno, J., Abdallah, M., Blystone, C. R., Calkins, M. M., Dong, G.-H., Dorman, D. C., Fry, R., Guo, H., Haug, L. S., Hofmann, J. N., Iwasaki, M., Machala, M., Mancini, F. R., Maria-Engler, S. S., Møller, P., Ng, J. C., Pallardy, M., Post, G. B., Salihovic, S., Schlezinger, J., Soshilov, A., Steenland, K., Steffensen, I.-L., Tryndyak, V., White, A., Woskie, S., Fletcher, T., Ahmadi, A., Ahmadi, N., Benbrahim-Tallaa, L., Bijoux, W., Chittiboyina, S., de Conti, A., Facchin, C., Madia, F., Mattock, H., Merdas, M., Pasqual, E., Suonio, E., Viegas, S., Zupunski, L., Wedekind, R., & Schubauer-Berigan, M. K.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- ORCID
- Zahm, Shelia
- Bonde, Jens Peter
- Chiu, Weihsueh A
- Hoppin, Jane
- Kanno, Jun
- Abdallah, Mohamed
- Calkins, Miriam M
- Dong, Guang-Hui
- Dorman, David C
- Fry, Rebecca
- Guo, Huan
- Haug, Line S
- Hofmann, Jonathan N
- Iwasaki, Motoki
- Machala, Miroslav
- Mancini, Francesca R
- Ng, Jack C
- Pallardy, Marc
- Post, Gloria B
- Schlezinger, Jennifer
- Soshilov, Anatoly
- Steenland, Kyle
- Steffensen, Inger-Lise
- Tryndyak, Volodymyr
- Woskie, Susan
- Fletcher, Tony
- Ahmadi, Ayat
- Bijoux, Wendy
- Facchin, Caterina
- Madia, Federica
- Merdas, Mira
- Pasqual, Elisa
- Wedekind, Roland
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2024-01
- Volume
- 25
- Issue
- 1
- Pages
- 16-17
- ISSN
- 1470-2045 (ISSN-L)
- PMC
- PMC12183505
- OpenAlex
- W4389208799
- Cited by
- 387
- References
- 10
- Citations by year
- 2026: 136 · 2025: 149 · 2024: 100
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- World Health Organization
- National Cancer Institute (U01CA033193, R01CA033193)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Keywords
- perfluorooctanoic acid, PFOS, carcinogenicity, perfluorinated compounds, isomers, salt, cancer risk assessment
- MeSH terms
- Caprylates, Fluorocarbons, Humans, Alkanesulfonic Acids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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