Serotonergic targets in depression.

A molecular and cellular theory of depression

Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works

The Biochemistry of Affective Disorders

Coppen, A. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1237 · Cited by 1,230 · see citing works

Current advances and trends in the treatment of depression

Blier, P., & de Montigny, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90315-8 · Cited by 1,113 · see citing works

Tryptophan depletion causes a rapid lowering of mood in normal males

Young, S. N., Smith, S. E., Pihl, R. O., & Ervin, F. R. (1985) · Psychopharmacology · doi:10.1007/bf00431803 · Cited by 715 · see citing works

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

Lovenberg, T. W., Baron, B. M., de Lecea, L., Miller, J. D., Prosser, R. A., Rea, M. A., Foye, P. E., Racke, M. M., Slone, A. L., Siegel, B. W., et al. (1993) · Neuron · doi:10.1016/0896-6273(93)90149-l · Cited by 691 · see citing works

Pindolol Induces a Rapid Improvement of Depressed Patients Treated With Serotonin Reuptake Inhibitors

Artigas, F. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030084009 · Cited by 512 · see citing works

A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5‐ht7 receptor in rat brain

Gustafson, E. L., Durkin, M. M., Bard, J., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15241.x · Cited by 295 · see citing works

Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

Hagan, J. J., Price, G. W., Jeffrey, P., Deeks, N. J., Stean, T. O., Piper, D. C., Smith, M. I., Upton, N., Medhurst, A. D., Middlemiss, D. N., et al. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703357 · Cited by 288 · see citing works

A Novel, Potent, and Selective 5-HT7Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Lovell, P. J., Bromidge, S. M., Dabbs, S., Duckworth, D. M., Forbes, I. T., Jennings, A. J., King, F. D., Middlemiss, D. N., Rahman, S. K., Saunders, D. V., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm991151j · Cited by 252 · see citing works

Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder

Du, L., Bakish, D., Lapierre, Y. D., Ravindran, A. V., & Hrdina, P. D. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 229 · see citing works

5-HT 7 receptors: current knowledge and future prospects

Vanhoenacker, P., Haegeman, G., & Leysen, J. E. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01432-7 · Cited by 211 · see citing works

Localization of 5-HT7 receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression

Neumaier, J. F., Sexton, T. J., Yracheta, J., Diaz, A. M., & Brownfield, M. S. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00092-2 · Cited by 205 · see citing works

Effect of Pindolol on the Function of Pre- and Postsynaptic 5-HT1A Receptors: In Vivo Microdialysis and Electrophysiological Studies in the Rat Brain

Romero, L. I. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00240-e · Cited by 185 · see citing works

Effects of Antidepressants on 5-HT7 Receptor Regulation in the Rat Hypothalamus

Mullins, U. L. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00041-x · Cited by 166 · see citing works

Patients With Severe Depression May Benefit From Buspirone Augmentation of Selective Serotonin Reuptake Inhibitors

Appelberg, B., Syvälahti, E. K. G., Koskinen, T., Mehtonen, O. ‐., Muhonen, T. T., & Naukkarinen, H. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0608 · Cited by 156 · see citing works

Control of dorsal raphé 5-HT function by multiple 5-HT1 autoreceptors: parallel purposes or pointless plurality?

Stamford, J. A., Davidson, C., McLaughlin, D. P., & Hopwood, S. E. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01631-3 · Cited by 137 · see citing works

Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5‐HT1Aand 5‐HT1Breceptor agonists 8‐OH‐DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD‐299 and NAS‐181

Hillegaart, V., & Ahlénius, S. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702239 · Cited by 128 · see citing works

SB‐224289–a novel selective (human) 5‐HT1B receptor antagonist with negative intrinsic activity

Selkirk, J. V., Scott, C. M., Ho, M., Burton, M. J., Watson, J. M., Gaster, L. M., Collin, L., Jones, B. J., Middlemiss, D. N., & Price, G. W. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702059 · Cited by 125 · see citing works

Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex

Casanovas, J. M., Hervás, I., & Artigas, F. (1999) · Neuroreport · doi:10.1097/00001756-199905140-00010 · Cited by 118 · see citing works

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

Wood, M. D., Reavill, C., Trail, B. K., et al. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00054-5 · Cited by 101 · see citing works

5-HT7 receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons

Errico, M., Crozier, R. A., Plummer, M. R., & Cowen, D. S. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00460-7 · Cited by 97 · see citing works

Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat

Czachura, J. F., & Rasmussen, K. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000290 · Cited by 97 · see citing works

5‐HT1B Autoreceptors limit the effects of selective serotonin re‐uptake inhibitors in mouse hippocampus and frontal cortex

Malagié, I., Trillat, A., Bourin, M., Jacquot, C., Hen, R., & Gardier, A. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00083.x · Cited by 87 · see citing works

Pindolol augmentation of antidepressant therapy

McAskill, R., Mir, S., & Taylor, D. M. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.3.203 · Cited by 81 · see citing works

β-blocker Binding to Human 5-HT1A Receptors in vivo and in vitro Implications for Antidepressant Therapy

Rabiner, E. A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00109-3 · Cited by 75 · see citing works

Pre‐ and postsynaptic effects of zimelidine and norzimelidine on the serotoninergic system: single cell studies in the rat

de Montigny, C., Blier, P., Caillé, G., & Kouassi, É. (1981) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1981.tb00711.x · Cited by 72 · see citing works

Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism

Dawson, L. A., Nguyen, H. Q., & Geiger, A. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00052-0 · Cited by 70 · see citing works

Drug action at the 5-HT1A receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-11C]WAY-100635

Rabiner, E. A., Gunn, R. N., Wilkins, M. R., Sargent, P. A., Mocaër, E., Sedman, E., Cowen, P. J., & Grasby, P. M. (2000) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(00)00120-7 · Cited by 66 · see citing works

Depression and Sleep Disorders: Clinical Relevance, Economic Burden and Pharmacological Treatment

Brunello, N., Armitage, R., Feinberg, I., Holsboer‐Trachsler, E., Léger, D., Linkowski, P., Mendelson, W. B., Racagni, G., Saletu, B., Sharpley, A. L., et al. (2000) · Neuropsychobiology · doi:10.1159/000026680 · Cited by 65 · see citing works

5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential

Koek, W., Vacher, B., Cosi, C., et al. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01011-1 · Cited by 63 · see citing works

The role of 5-HT1A and 5-HT1B/1D receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (±)pindolol

Dawson, L. A., & Nguyen, H. Q. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00192-6 · Cited by 61 · see citing works

Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or β-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo

Hjorth, S., Bengtsson, H. J., & Milano, S. P. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00779-0 · Cited by 61 · see citing works

Serotonergic Modulation of Photic Entrainment in the Syrian Hamster

Rea, M. A., & Pickard, G. E. (2000) · Biological Rhythm Research · doi:10.1076/0929-1016(200007)31:3;1-k;ft284 · Cited by 58 · see citing works

Decreased plasma tryptophan concentration in major depression: relationship to melancholia and weight loss

Anderson, I. M., Parry‐Billings, M., Newsholme, E. A., Poortmans, J.-R., & Cowen, P. J. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90143-v · Cited by 50 · see citing works

Electrophysiological evidence for postsynaptic 5-HT1A receptor control of dorsal raphe 5-HT neurones

Martín‐Ruiz, R., & Ugedo, L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00050-8 · Cited by 48 · see citing works

Enhancement of 5-HT1B and 5-HT1D receptor antagonist effects on extracellular 5-HT levels in the guinea-pig brain following concurrent 5-HT1A or 5-HT re-uptake site blockade

Roberts, C., Boyd, D. F., Middlemiss, D. N., & Routledge, C. A. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00051-9 · Cited by 46 · see citing works

Latency to paroxetine‐induced anxiolysis in the rat is reduced by co‐administration of the 5‐HT1A receptor antagonist WAY100635

Duxon, M. S., Starr, K. R., & Upton, N. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703496 · Cited by 43 · see citing works

Localization of serotonin5A receptors in discrete regions of the circadian timing system in the Syrian hamster

Duncan, M. J., Jennes, L., Jefferson, J. B., & Brownfield, M. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02383-0 · Cited by 42 · see citing works

SB 242084: A Selective 5‐HT2CReceptor Antagonist

Matteo, V. D., Giovanni, G. D., & Esposito, E. (2000) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2000.tb00147.x · Cited by 41 · see citing works

SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor

Middlemiss, D. N., Göthert, M., Schlicker, E., Scott, C. M., Selkirk, J. V., Watson, J. M., Gaster, L. M., Wyman, P. A., Riley, G. J., & Price, G. W. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00262-9 · Cited by 40 · see citing works

Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study

Roberts, C., & Price, G. W. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01551-8 · Cited by 35 · see citing works

5HT 7 Receptors in the Rodent Suprachiasmatic Nucleus

Gannon, R. L. (2001) · Journal of Biological Rhythms · doi:10.1177/074873040101600103 · Cited by 34 · see citing works

The effect of SB-236057-A, a selective 5-HT 1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig

Roberts, C., Hatcher, P. D., Hagan, J. J., et al. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000276 · Cited by 24 · see citing works

SB‐272183, a selective 5‐HT1A, 5‐HT1B and 5‐HT1D receptor antagonist in native tissue

Watson, J. M., Roberts, C., Scott, C. M., et al. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704133 · Cited by 21 · see citing works

Cholinergic channel activator, ABT-418, enhances delayed-response accuracy in rats

Terry, A. V., Buccafusco, J. J., & Decker, M. W. (1997) · Drug Development Research · doi:10.1002/(sici)1098-2299(199704)40:4 · Cited by 16 · see citing works

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304 · see citing works

In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain

Li, X., Zhu, W., Roh, M.-S., Friedman, A. B., Rosborough, K., & Jope, R. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300439 · Cited by 300 · see citing works

Altered expression of CD4+CD25+ regulatory T cells and its 5-HT1a receptor in patients with major depression disorder

Li, Y., Xiao, B., Qiu, W., Yang, L., Hu, B., Tian, X., & Yang, H. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.018 · Cited by 163 · see citing works

Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment

Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works

Drug targets for cognitive enhancement in neuropsychiatric disorders.

Wallace, T. L., Ballard, T. M., Pouzet, B., Riedel, W. J., & Wettstein, J. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.022 · Cited by 127 · see citing works

Antidepressant-like effect of the organoselenium compound ebselen in mice: Evidence for the involvement of the monoaminergic system

Posser, T., Kaster, M. P., Baraúna, S. C., Rocha, J. B. T., Rodrigues, A. L. S., & Leal, R. B. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.055 · Cited by 86 · see citing works

Effects of 5-HT on memory and the hippocampus: model and data.

Meeter, M., Talamini, L., Schmitt, J. A. J., & Riedel, W. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300869 · Cited by 68 · see citing works

Electrophysiological indication for a link between serotonergic neurotransmission and personality in alcoholism

Herrmann, M. J., Sonnek, G., Weijers, H. ‐., Wiesbeck, G. A., Böning, J., & Fallgatter, A. J. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00241-x · Cited by 13 · see citing works

Headache Induced by Serotonergic Agonists—a Key to the Interpretation of Migraine Pathogenesis?

Panconesi, A., & Sicuteri, R. (1997) · Cephalalgia · doi:10.1046/j.1468-2982.1997.1701003.x · Cited by 52 · see citing works

Different role of spinal 5-HT (hydroxytryptamine) 7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models

(2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev202 · Cited by 1 · see citing works

Partial 5-HT receptor agonist activity by the 5-HT receptor antagonist SB 206,553 is revealed in rats spinalized as neonates

Shumsky, J. S., Kao, T.-C., AMATO, N., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.012 · Cited by 13 · see citing works

Development of norepinephrine transporter reuptake inhibition assays using SK-N-BE(2)C cells

Decker, A. M., & Blough, B. E. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00633 · Cited by 4 · see citing works