Effects of 5-HT on memory and the hippocampus: model and data.
Open accessAbstract
5-Hydroxytryptamine (5-HT) transmission has been implicated in memory and in depression. Both 5-HT depletion and specific 5-HT agonists lower memory performance, while depression is also associated with memory deficits. The precise neuropharmacology and neural mechanisms underlying these effects are unknown. We used neural network simulations to elucidate the neuropharmacology and network mechanisms underlying 5-HT effects on memory. The model predicts that these effects are largely dependent on transmission over the 5-HT1A and 5-HT3 receptors, which regulate the selectivity of retrieval. It also predicts differential memory deficit profiles for 5-HT depletion and overactivation. The latter predictions were confirmed in studies with healthy and depressed participants undergoing acute tryptophan depletion or ipsipirone challenge. The results suggest that the memory impairments in depressed subjects may be related to 5-HT undertransmission, and support the notion that 5-HT1A agonists ameliorate memory deficits in depression.
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5-HT transmission in the hippocampus is disrupted in schizophrenia and MDD, and this dysfunction is likely to contribute to deficits in learning and memory in these disorders.
“5-HT transmission in the hippocampus is disrupted in schizophrenia and MDD (Naughton et al., 2000; Middlemiss et al., 2002) and this 5-HT dysfunction is likely to contribute deficits in learning and memory in these disorders (Meeter et al., 2006; Gray and Roth, 2007).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Meeter et al., 2006
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- Authors
- Meeter, M., Talamini, L., Schmitt, J. A. J., & Riedel, W. J.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Maastricht University (NL)
- Corresponding author
- Meeter, Martijn
- Venue
- Neuropsychopharmacology
- Published
- 2005-08-31
- Volume
- 31
- Issue
- 4
- Pages
- 712-720
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2121297151
- Cited by
- 68
- References
- 60
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Science Foundation
- GlaxoSmithKline
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- serotonin, memory, hippocampus, depression, 5-HT1A receptor, 5-HT3 receptor, tryptophan depletion, neural network model, neuropharmacology
- MeSH terms
- Animals, Computer Simulation, Hippocampus, Humans, Memory, Serotonin, Serotonin Antagonists, Verbal Learning, Neural Networks, Computer, Serotonin Receptor Agonists
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