The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Abstract
Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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“Macrophages, like the monocytes from which they derive, are a heterogeneous cell population each with different markers and functions [1,8–12].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [9]
In the citing paper
“and contribute to macrophage and neutrophil polarization towards a regenerative rather than inflammatory cell state58,63,82,145,172,173,218,219.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [172]
Citations
Cites
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Lee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.809 · Cited by 940
Menetrier-Caux, C., Montmain, G., Dieu, M. C., Bain, C., Favrot, M. C., Caux, C., & Blay, J. Y. (1998) · Blood · doi:10.1182/blood.v92.12.4778 · Cited by 590
Vicari, A. P., & Caux, C. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00033-8 · Cited by 351
Cited by
Sorted by citations
Items 201–201 of 201
ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages
Yang, N., Xiong, Y., Wang, Y., Yi, Y., Zhu, J., Ma, F., Li, J., & Liu, H. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000569 · Cited by 11
Metadata
- Authors
- MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A.
- Affiliations
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Corresponding author
- MANTOVANI, A
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2002-11-01
- Volume
- 23
- Issue
- 11
- Pages
- 549-555
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2001717792
- Cited by
- 5,528
- References
- 4
- Citations by year
- 2026: 153 · 2025: 257 · 2024: 341 · 2023: 312 · 2022: 393 · 2021: 392 · 2020: 355 · 2019: 286 · 2018: 281 · 2017: 332 · 2016: 301 · 2015: 291 · 2014: 307 · 2013: 268 · 2012: 265
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- macrophage polarization, tumor-associated macrophages, M2 macrophages, M1 macrophages, mononuclear phagocytes, tumor microenvironment, dendritic cells, immune evasion, tumor growth and progression, cytokines
- MeSH terms
- Animals, Cell Differentiation, Humans, Macrophage Activation, Macrophages, Neoplasms, Phagocytes, Signal Transduction, Cytokines, Models, Immunological, Chemokines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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