Cited by 5,528Immune cells in cancerImmunotherapy and Immune ResponsesAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A, SOZZANI, S, LOCATI, M, ALLAVENA, P, SICA, A·2002·Trends in Immunology

Open this paper in CoChat — free account

Abstract

Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.

Integrity signals

Registry

Crossref · 10.1016/s1471-4906(02)02302-5

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Lee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.809 · Cited by 940
Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor
Menetrier-Caux, C., Montmain, G., Dieu, M. C., Bain, C., Favrot, M. C., Caux, C., & Blay, J. Y. (1998) · Blood · doi:10.1182/blood.v92.12.4778 · Cited by 590
Chemokines in cancer
Vicari, A. P., & Caux, C. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00033-8 · Cited by 351

Show all 4 references

Sorted by citations

Items 101–200 of 201

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression
Saleh, R., & Elkord, E. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.017 · Cited by 292
Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells
Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6561 · Cited by 302
Colorectal liver metastasis: molecular mechanism and interventional therapy
Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00922-2 · Cited by 298
The functional crosstalk between myeloid-derived suppressor cells and regulatory T cells within the immunosuppressive tumor microenvironment
Haist, M., Stege, H., Grabbe, S., & Bros, M. (2021) · Cancers · doi:10.3390/cancers13020210 · Cited by 295
Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy
Cersosimo, F., Lonardi, S., Bernardini, G., Telfer, B., Mandelli, G. E., Santucci, A., Vermi, W., & Giurisato, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155207 · Cited by 280
Cellular and molecular pathways of renal repair after acute kidney injury
Kumar, S. (2018) · Kidney International · doi:10.1016/j.kint.2017.07.030 · Cited by 271
Mechanically-compliant intracortical implants reduce the neuroinflammatory response
Nguyen, J. K., Park, D. J., Skousen, J. L., Hess-Dunning, A. E., Tyler, D. J., Rowan, S. J., Weder, C., & Capadona, J. R. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/5/056014 · Cited by 274
Liver fibrosis: cellular mechanisms of progression and resolution
Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science · doi:10.1042/cs20060242 · Cited by 270
Heme oxygenase-1 in tumor biology and therapy
Was, H., Dulak, J., & Jozkowicz, A. (2010) · Current Drug Targets · doi:10.2174/1389450111009011551 · Cited by 259
The promotion of a constructive macrophage phenotype by solubilized extracellular matrix
Sicari, B. M., Dziki, J. L., Siu, B. F., Medberry, C. J., Dearth, C. L., & Badylak, S. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.060 · Cited by 255
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
Raes, G., Brys, L., Dahal, B. K., Brandt, J., Grooten, J., Brombacher, F., Vanham, G., Noël, W., Bogaert, P., Boonefaes, T., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0304212 · Cited by 246
Gene expression profiling of cutaneous wound healing
Deonarine, K., Panelli, M. C., Stashower, M. E., Jin, P., Smith, K., Slade, H. B., Norwood, C., Wang, E., Marincola, F. M., & Stroncek, D. F. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-11 · Cited by 229
Metabolic reprogramming in triple-negative breast cancer
Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243
Call off the dog(ma): M1/M2 polarization is concurrent following traumatic brain injury
Morganti, J. M., Riparip, L.-K., & Rosi, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148001 · Cited by 229
CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization
Li, M., Sun, X., Zhao, J., Xia, L., Li, J., Xu, M., Wang, B., Guo, H., Yu, C., Gao, Y., et al. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0279-0 · Cited by 225
Non-genetic engineering of cells for drug delivery and cell-based therapy
Wang, Q., Cheng, H., Peng, H., Zhou, H., Li, P. Y., & Langer, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.003 · Cited by 225
Tumor microenvironment in ovarian cancer: function and therapeutic strategy
Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218
Examination of the foreign body response to biomaterials by nonlinear intravital microscopy
Dondossola, E., Holzapfel, B. M., Alexander, S., Filippini, S., Hutmacher, D. W., & Friedl, P. (2016) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0007 · Cited by 215
Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
Lee, C., Jeong, H., Bae, Y., Shin, K., Kang, S., Kim, H., Oh, J., & Bae, H. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0610-4 · Cited by 211
Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes
Gallagher, K. A., Joshi, A., Carson, W. F., Schaller, M., Allen, R., Mukerjee, S., Kittan, N., Feldman, E. L., Henke, P. K., Hogaboam, C., et al. (2015) · Diabetes · doi:10.2337/db14-0872 · Cited by 206
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma
Antonios, J. P., Soto, H., Everson, R. G., Moughon, D., Orpilla, J. R., Shin, N. P., Sedighim, S., Treger, J., Odesa, S., Tucker, A., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/now287 · Cited by 206
Immune system: a double-edged sword in cancer
Lakshmi Narendra, B., Eshvendar Reddy, K., Shantikumar, S., & Ramakrishna, S. (2013) · Inflammation Research · doi:10.1007/s00011-013-0645-9 · Cited by 206
Diverse functional roles of lipocalin-2 in the central nervous system
Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195
Secreted protein lipocalin‐2 promotes microglial M1 polarization
Jang, E., Lee, S., Kim, J., Kim, J., Seo, J., Lee, W., Mori, K., Nakao, K., & Suk, K. (2013) · The FASEB Journal · doi:10.1096/fj.12-222257 · Cited by 198
Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue
ZHANG, J.-Z., LIU, Z., LIU, J., REN, J.-X., & SUN, T.-S. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1650 · Cited by 194
Retracted
Effects of Microglia on Neurogenesis
Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187
Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model
Kuen, J., Darowski, D., Kluge, T., & Majety, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182039 · Cited by 192
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188
Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer: A NTI-C ANCER S TRATEGIESTO T ARGET TAMs IN B REAST C ANCER
Tariq, M., Zhang, J., Liang, G., Ding, L., He, Q., & Yang, B. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25895 · Cited by 178
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer
Hollmén, M., Karaman, S., Schwager, S., Lisibach, A., Christiansen, A. J., Maksimow, M., Varga, Z., Jalkanen, S., & Detmar, M. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1115177 · Cited by 185
Molecular pathways in cancer-related inflammation
Del Prete, A., Allavena, P., Santoro, G., Fumarulo, R., Corsi, M. M., & Mantovani, A. (2011) · Biochemia Medica · doi:10.11613/bm.2011.036 · Cited by 181
Self-citation
Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles
Hall, B., Dembinski, J., Sasser, A., Studeny, M., Andreeff, M., & Marini, F. (2007) · International Journal of Hematology · doi:10.1532/ijh97.06230 · Cited by 171
Iron induces anti-tumor activity in tumor-associated macrophages
Costa da Silva, M., Breckwoldt, M. O., Vinchi, F., Correia, M. P., Stojanovic, A., Thielmann, C. M., Meister, M., Muley, T., Warth, A., Platten, M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01479 · Cited by 164
Macrophagic and microglial responses after focal traumatic brain injury in the female rat
Turtzo, L., Lescher, J., Janes, L., Dean, D. D., Budde, M. D., & Frank, J. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-82 · Cited by 167
APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective
Tai, L. M., Ghura, S., Koster, K. P., Liakaite, V., Maienschein‐Cline, M., Kanabar, P., Collins, N., Ben‐Aissa, M., Lei, A. Z., Bahroos, N., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13072 · Cited by 165
Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy
Zhan, X., Jia, L., Niu, Y., Qi, H., Chen, X., Zhang, Q., Zhang, J., Wang, Y., Dong, L., & Wang, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.09.007 · Cited by 161
Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia
Freilich, R. W., Woodbury, M. E., & Ikezu, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079416 · Cited by 160
MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages
Huang, C., Liu, X.-J., QunZhou, Xie, J., Ma, T.-T., Meng, X.-M., & Li, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.009 · Cited by 160
Interleukin-1α
Rider, P., Carmi, Y., Voronov, E., & Apte, R. N. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.005 · Cited by 155
Features of skin-coincubated macrophages that promote recovery from spinal cord injury
Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00260-1 · Cited by 155
Neuroinflammation, gut microbiome, and Alzheimer's disease
Lin, L., Zheng, L. J., & Zhang, L. J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0983-2 · Cited by 147
TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth
Standiford, T. J., Kuick, R., Bhan, U., Chen, J., Newstead, M., & Keshamouni, V. G. (2011) · Oncogene · doi:10.1038/onc.2010.619 · Cited by 151
Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt’s Lymphoma
Ogden, C. A., Pound, J. D., Batth, B. K., Owens, S., Johannessen, I., Wood, K., & Gregory, C. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.3015 · Cited by 147
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67911 · Cited by 148
Iron levels in polarized macrophages: regulation of immunity and autoimmunity
Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150
Self-citation
The importance of the macrophage within the human endometrium
Thiruchelvam, U., Dransfield, I., Saunders, P. T. K., & Critchley, H. O. D. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0712327 · Cited by 140
IL-4-Induced Selective Clearance of Oligomeric β-Amyloid Peptide1–42 by Rat Primary Type 2 Microglia
Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., & Nakayama, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6503 · Cited by 143
The Multifaceted Role of Heme in Cancer
Fiorito, V., Chiabrando, D., Petrillo, S., Bertino, F., & Tolosano, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01540 · Cited by 129
Biologic Scaffolds
Costa, A., Naranjo, J. D., Londono, R., & Badylak, S. F. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025676 · Cited by 135
Intermittent hypoxia induces a metastatic phenotype in breast cancer
Chen, A., Sceneay, J., Gödde, N., Kinwel, T., Ham, S., Thompson, E. W., Humbert, P. O., & Möller, A. (2018) · Oncogene · doi:10.1038/s41388-018-0259-3 · Cited by 133
Gene regulatory network modeling of macrophage differentiation corroborates the continuum hypothesis of polarization states
Palma, A., Jarrah, A. S., Tieri, P., Cesareni, G., & Castiglione, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01659 · Cited by 122
Immune-Based Therapy for Spinal Cord Repair: Autologous Macrophages and Beyond
Schwartz, M., & Yoles, E. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.360 · Cited by 131
Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues
Castriconi, R., Carrega, P., Dondero, A., Bellora, F., Casu, B., Regis, S., Ferlazzo, G., & Bottino, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02324 · Cited by 125
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
Joshi, S., Singh, A. R., Zulcic, M., Bao, L., Messer, K., Ideker, T., Dutkowski, J., & Durden, D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095893 · Cited by 128
“We first curated M1 and M2 driver lists based on support in literature [19,33,59] and our experimental multiple-omic data.”
Method
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
Sleeboom, J. J. F., Eslami Amirabadi, H., Nair, P., Sahlgren, C. M., & den Toonder, J. M. J. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.033100 · Cited by 122
The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy
Policastro, L. L., Ibañez, I. L., Notcovich, C., Duran, H. A., & Podhajcer, O. L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4367 · Cited by 120
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
Arnold, S. A., Rivera, L. B., Miller, A. F., Carbon, J. G., Dineen, S. P., Xie, Y., Castrillon, D. H., Sage, E. H., Puolakkainen, P., Bradshaw, A. D., et al. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003228 · Cited by 118
Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis
Bellón, T., Martínez, V., Lucendo, B., del Peso, G., Castro, M. J., Aroeira, L. S., Rodríguez-Sanz, A., Ossorio, M., Sánchez-Villanueva, R., Selgas, R., et al. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq771 · Cited by 114
Altered Phenotype and Functionality of Circulating Immune Cells Characterize Adult Patients With Nonalcoholic Steatohepatitis
Inzaugarat, M. E., Ferreyra Solari, N. E., Billordo, L. A., Abecasis, R., Gadano, A. C., & Cherñavsky, A. C. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9571-1 · Cited by 115
Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
Kawahara, K., Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., & Nakayama, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.049 · Cited by 113
Nanoparticle Interactions with the Tumor Microenvironment
Huai, Y., Hossen, M. N., Wilhelm, S., Bhattacharya, R., & Mukherjee, P. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00448 · Cited by 113
Phenotypic dichotomies in the foreign body reaction
Anderson, J. M., & Jones, J. A. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.010 · Cited by 110
Metabolic reprogramming of the tumour microenvironment
Xing, Y., Zhao, S., Zhou, B. P., & Mi, J. (2015) · The FEBS Journal · doi:10.1111/febs.13402 · Cited by 108
Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing
Rodero, M. P., Hodgson, S. S., Hollier, B., Combadiere, C., & Khosrotehrani, K. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.368 · Cited by 104
Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment
Li, Q., Ma, L., Shen, S., Guo, Y., Cao, Q., Cai, X., Feng, J., Yan, Y., Hu, T., Luo, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1271-3 · Cited by 104
Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Li, R., Hebert, J. D., Lee, T. A., Xing, H., Boussommier-Calleja, A., Hynes, R. O., Lauffenburger, D. A., & Kamm, R. D. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-0442 · Cited by 100
PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease
Fernandez-Boyanapalli, R., Frasch, S. C., Riches, D. W. H., Vandivier, R. W., Henson, P. M., & Bratton, D. L. (2010) · Blood · doi:10.1182/blood-2010-02-272005 · Cited by 98
Bimodal CD40/Fas-Dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression
Cortesi, F., Delfanti, G., Grilli, A., Calcinotto, A., Gorini, F., Pucci, F., Lucianò, R., Grioni, M., Recchia, A., Benigni, F., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.058 · Cited by 100
Tumor‐infiltrating M2 macrophage in pretreatment biopsy sample predicts response to chemotherapy and survival in esophageal cancer
Yamamoto, K., Makino, T., Sato, E., Noma, T., Urakawa, S., Takeoka, T., Yamashita, K., Saito, T., Tanaka, K., Takahashi, T., et al. (2020) · Cancer Science · doi:10.1111/cas.14328 · Cited by 85
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis
Wagner, M., Bjerkvig, R., Wiig, H., Melero-Martin, J. M., Lin, R.-Z., Klagsbrun, M., & Dudley, A. C. (2012) · Angiogenesis · doi:10.1007/s10456-012-9276-y · Cited by 91
Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia
Brambilla, P., Bellani, M., Isola, M., Bergami, A., Marinelli, V, Dusi, N., Rambaldelli, G., Tansella, M., Maria Finardi, A., Martino, G., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.46 · Cited by 86
Kras and tumor immunity: friend or foe?
Cullis, J., Das, S., & Bar-Sagi, D. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031849 · Cited by 85
Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages
Chéné, A.-L., d’Almeida, S., Blondy, T., Tabiasco, J., Deshayes, S., Fonteneau, J.-F., Cellerin, L., Delneste, Y., Grégoire, M., & Blanquart, C. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.06.022 · Cited by 84
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2017.1408751 · Cited by 85
Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties
Novitskiy, S. V., Pickup, M. W., Chytil, A., Polosukhina, D., Owens, P., & Moses, H. L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211639 · Cited by 79
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment
Olsson, A., Nakhlé, J., Sundstedt, A., Plas, P., Bauchet, A.-L., Pierron, V., Bruetschy, L., Deronic, A., Törngren, M., Liberg, D., et al. (2015) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-015-0098-5 · Cited by 78
Transcription Factor Tfec Contributes to the IL-4-Inducible Expression of a Small Group of Genes in Mouse Macrophages Including the Granulocyte Colony-Stimulating Factor Receptor
Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C. A., Heinz, S., Söllner, L., El Chartouni, C., Krause, S. W., Steingrimsson, E., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7111 · Cited by 75
Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model
Roda, J. M., Wang, Y., Sumner, L. A., Phillips, G. S., Marsh, C. B., & Eubank, T. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103817 · Cited by 71
Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids
Tada, M., Konno, T., Tada, M., Tezuka, T., Miura, T., Mezaki, N., Okazaki, K., Arakawa, M., Itoh, K., Yamamoto, T., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24754 · Cited by 70
Tumor‑associated macrophages in lung cancer: Friendly or evil? (Review)
Xu, F., Wei, Y., Tang, Z., Liu, B., & Dong, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11518 · Cited by 67
Clinical perspectives on the age-related increase of immunosuppressive activity
Salminen, A. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02193-4 · Cited by 57
Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo
Elsum, I. A., Yates, L. L., Pearson, H. B., Phesse, T. J., Long, F., O'Donoghue, R., Ernst, M., Cullinane, C., & Humbert, P. O. (2014) · Oncogene · doi:10.1038/onc.2013.498 · Cited by 60
Hypoxia-inducible factors as key regulators of tumor inflammation
Mamlouk, S., & Wielockx, B. (2013) · International Journal of Cancer · doi:10.1002/ijc.27901 · Cited by 61
The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles
Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60
Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model
Gröger, M., Rennert, K., Giszas, B., Weiß, E., Dinger, J., Funke, H., Kiehntopf, M., Peters, F. T., Lupp, A., Bauer, M., et al. (2016) · Scientific Reports · doi:10.1038/srep21868 · Cited by 60
Macrophage diversity in cardiac inflammation: A review
Barin, J. G., Rose, N. R., & Čiháková, D. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.06.009 · Cited by 56
“The evasive, immunosuppressive tumor microenvironment is associated with the production of IL10, TGFβ, glucocorticoids, and vitamin D3, which in turn elicit a poorly activated macrophage phenotype in situ, characterized by expression of Mφ-MR and diminished acquisition of a dendritic cell-like antigen-presenting pheno…”
Background
Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials
Anderson, J. M., & Jiang, S. (2017) · The Immune Response to Implanted Materials and Devices · doi:10.1007/978-3-319-45433-7_2 · Cited by 55
Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model
Jetten, N., Donners, M. M. P. C., Wagenaar, A., Cleutjens, J. P. M., van Rooijen, N., de Winther, M. P. J., & Post, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068811 · Cited by 47
Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma
Ciznadija, D., Liu, Y., Pyonteck, S. M., Holland, E. C., & Koff, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1031 · Cited by 44
Lipid profiling of polarized human monocyte-derived macrophages
Montenegro-Burke, J. R., Sutton, J. A., Rogers, L. M., Milne, G. L., McLean, J. A., & Aronoff, D. M. (2016) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2016.11.002 · Cited by 44
Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis
Zhao, X. N., Li, Y. N., & Wang, Y. T. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15017348 · Cited by 44
Collagen Turnover in Wound Repair––A Macrophage Connection
Nissinen, L. M., & Kähäri, V.-M. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.246 · Cited by 37
Iron imaging reveals tumor and metastasis macrophage hemosiderin deposits in breast cancer
Leftin, A., Ben-Chetrit, N., Klemm, F., Joyce, J. A., & Koutcher, J. A. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184765 · Cited by 36
Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs
Brady, R. V., & Thamm, D. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176807 · Cited by 35
Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation
Khokhar, E. S., Borikar, S., Eudy, E., Stearns, T., Young, K., & Trowbridge, J. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.014 · Cited by 26
ApAGP-fabricated silver nanoparticles induce amendment of murine macrophage polarization
Raja, M. R. C., Vinod Kumar, V., Srinivasan, V., Selvaraj, S., Radhakrishnan, N., Mukundan, R., Raghunandan, S., Anthony, S. P., & Kar Mahapatra, S. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb02095j · Cited by 23
The GLP-1 receptor agonist exenatide improves recovery from spinal cord injury by inducing macrophage polarization toward the M2 phenotype
Noguchi, T., Katoh, H., Nomura, S., Okada, K., & Watanabe, M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1342944 · Cited by 20

Authors: MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A.
Affiliations: University of Milan (IT)
Mario Negri Institute for Pharmacological Research (IT)
Corresponding author: MANTOVANI, A
ORCID: MANTOVANI, A
SOZZANI, S
LOCATI, M
ALLAVENA, P
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2002-11-01
Volume: 23
Issue: 11
Pages: 549-555
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/s1471-4906(02)02302-5
OpenAlex: W2001717792
Cited by: 5,528
References: 4
Citations by year: 2026: 153 · 2025: 257 · 2024: 341 · 2023: 312 · 2022: 393 · 2021: 392 · 2020: 355 · 2019: 286 · 2018: 281 · 2017: 332 · 2016: 301 · 2015: 291 · 2014: 307 · 2013: 268 · 2012: 265
FWCI: 17.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: macrophage polarization, tumor-associated macrophages, M2 macrophages, M1 macrophages, mononuclear phagocytes, tumor microenvironment, dendritic cells, immune evasion, tumor growth and progression, cytokines
MeSH terms: Animals, Cell Differentiation, Humans, Macrophage Activation, Macrophages, Neoplasms, Phagocytes, Signal Transduction, Cytokines, Models, Immunological, Chemokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks