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Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies
Open accessAbstract
The success of potent antiretroviral treatment for HIV infection is primarily determined by adherence. We systematically review the evidence of effectiveness of interventions to increase adherence to antiretroviral treatment in sub-Saharan Africa. We identified 27 relevant reports from 26 studies of behavioural, cognitive, biological, structural, and combination interventions done between 2003 and 2010. Despite study diversity and limitations, evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa. However, some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings. These findings emphasise the need for more research, particularly for randomised controlled trials, to examine the effect of context and specific features of intervention content on effectiveness. Future work should assess intervention targeting and selection of interventions based on behavioural theories relevant to sub-Saharan Africa.
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“A systematic search for mHealth reviews in seven databases found several mHealth reviews that included aspects of monitoring such as adherence studies,17 behaviour change18 and attendance reminders.19 20”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“and messages had more impact when they were linked with patient–health worker interaction.17 27 49 51–53”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“For example, weekly reminders worked better than daily reminders”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
In the citing paper
“Reviews have found variation in effect depending on how mechanisms were operationalised.”
From mHealth text and voice communication for monitoring people with chronic diseases in low-resource settings: a realist review (2018) · cites this paper as [17]
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Cited by
Sorted by citations
Items 101–200 of 246
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“Furthermore, this article adds to existing research on the importance of the social context in HIV care [20,25,63,73–75] and to the limited research carried out to date in countries with high HIV prevalence,”
Strategies for retention of heterosexual men in HIV care in sub-Saharan Africa: A systematic review
Kusemererwa, S., Akena, D. H., Nakanjako, D., Kigozi, J., Nanyunja, R., Nanfuka, M., Kizito, B., Okello, J. M., & Sewankambo, N. K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246471 · Cited by 32
“For adequate viral suppression to be realized, patients need to adhere to ART over their lifetime [6].”
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“• 30 papers are reviews of other studies on medication adherence [1-30].”
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Counseling for improving adherence to antiretroviral treatment: a systematic review
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“Although some counseling guidelines within the reviewed studies are available (30–33), they do not systematically assess their relative efficacy (Bärnighausen et al., 2011).”
BackgroundMasquillier, C., Wouters, E., Mortelmans, D., & Booysen, F. (2014) · Journal of the International AIDS Society · doi:10.7448/ias.17.1.18802 · Cited by 32
“This finding underscores the importance of the social context in explaining the discrepant findings on the effectiveness of the PAS intervention and its widely differing effect sizes [26,27].”
BackgroundSocial exposure to an antiretroviral treatment programme in rural KwaZulu‐Natal
Bor, J. H., Bärnighausen, T., Newell, C., Tanser, F. C., & Newell, M. (2011) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2011.02795.x · Cited by 29
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“Similar researches emphasizing on self-care strategies for acute and chronic conditions have highlighted the importance of improving the lifestyle of self-care programs, which could help to ameliorate their health status and increase their motivation and ability to participate in treatment plans (48,49).”
BackgroundWiens, M. O., MacLeod, S. M., Musiime, V., Ssenyonga, M., Kizza, R. B., Bakeera‐Kitaka, S., Odoi‐Adome, R., & Ssali, F. N. (2012) · Pediatric Drugs · doi:10.1007/bf03262238 · Cited by 29
“A recent systematic review of adherence interventions found that out of 26 studies conducted only one used electronic monitoring for adherence assessment.([12]) It is probable that the effect size of any adherence promoting intervention would be more accurately measured using electronic means than an alternate objecti…”
Nozaki, I., Kuriyama, M., Manyepa, P., Zyambo, M. K., Kakimoto, K., & Bärnighausen, T. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0221-2 · Cited by 29
“ART patients’ behavior, in turn, is likely to depend in part on beliefs about treatment effectiveness, side effects, and the consequences of non-retention and non-adherence [7, 8].”
BackgroundSelf-citationNyoni, T., Sallah, Y. H., Okumu, M., Byansi, W., Lipsey, K. L., & Small, E. (2020) · AIDS Care · doi:10.1080/09540121.2020.1742870 · Cited by 29
“They involve family members, partners of PLWH, and community members such as friends, neighbors, and community health workers, and HIV-infected peers (Bärnighausen et al., 2011; Nachega et al., 2009; Simoni et al., 2008).”
BackgroundZack, R. M., Irema, K., Kazonda, P., Leyna, G. H., Liu, E., Spiegelman, D. L., Fawzi, W. W., Njelekela, M. A., Killewo, J., & Danaei, G. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001117 · Cited by 27
“Randomized trials could be designed to determine whether successful interventions to improve antiretroviral adherence, such as using mobile text messages [39] and financial incentives [40,41], would also improve adherence to antihypertensives.”
BackgroundSun, L., Qu, M.-B., Chen, B.-X., Li, C., Fan, H.-H., & Zhao, Y. (2023) · JMIR mHealth and uHealth · doi:10.2196/42799 · Cited by 25
“The robustness and relevance of results increase with the number of distinct outcome measures that show the same result [20].”
Quintana, Y., Martorell, E., Fahy, D., & Safran, C. (2018) · Applied Clinical Informatics · doi:10.1055/s-0038-1660516 · Cited by 29
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Antiretroviral therapy adherence strategies used by patients of a large HIV clinic in Lesotho
Axelsson, J., Hallager, S., & Barfod, T. S. (2015) · Journal of Health Population and Nutrition · doi:10.1186/s41043-015-0026-9 · Cited by 26
“Other studies have found positive evidence with supportive text messages and other reminder devices [25, 38, 39].”
ResultLippman, S. A., Shade, S. B., Sumitani, J., de Kadt, J., Gilvydis, J. M., Ratlhagana, M. J., Grignon, J. S., Tumbo, J. M., Gilmore, H. J., Agnew, E., et al. (2016) · Trials · doi:10.1186/s13063-016-1190-y · Cited by 24
“Similarly, personal support interventions that focus on professional case management or engaging peers or family networks to provide encouragement and support to remain in care and adhere to medications have demonstrated promise [22].”
BackgroundTreffry-Goatley, A., Lessells, R. J., Pam, S., Bärnighausen, T., de Oliveira, T., Moletsane, R., & Seeley, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148801 · Cited by 24
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Cressey, T. R., Siriprakaisil, O., Klinbuayaem, V., Quame‐Amaglo, J., Kubiak, R. W., Sukrakanchana, P.-O., Than-in-at, K., Baeten, J. M., Sirirungsi, W., Cressey, R., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2593-4 · Cited by 24
“Existing tools to monitor ART and PrEP adherence, such as patient self-reporting [8, 9], pill counting and home-based visits [9–11] have been shown to be ineffective.”
MethodAnalysis of Systematic Reviews of Medication Adherence Interventions for Persons with HIV, 1996–2017
Rooks-Peck, C. R., Wichser, M. E., Adegbite, A. H., DeLuca, J. B., Barham, T., Ross, L. W., Higa, D. H., & Sipe, T. A. (2019) · AIDS Patient Care and STDs · doi:10.1089/apc.2019.0125 · Cited by 23
Determinants of Engagement in HIV Treatment and Care Among Zambians New to Antiretroviral Therapy
Jones, D. L., Zulu, I., Vamos, S., Cook, R., Chitalu, N. W., & Weiss, S. M. (2012) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2012.06.009 · Cited by 23
Kasang, C., Kalluvya, S. E., Majinge, C., Kongola, G. W., Mlewa, M., Massawe, I., Kabyemera, R., Magambo, K. A., Ulmer, A., Klinker, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146678 · Cited by 24
“This drop-out rate (which is equivalent to an annual 12% loss-to follow-up) is comparable to the loss-to-follow-up rates reported in many other clinical trials on HIV drug adherence in Sub-Saharan Africa [29].”
Bangsberg, D., & Mills, E. (2013) · Antiviral Therapy · doi:10.3851/imp2536 · Cited by 25
“Despite the importance of lifelong adherence, there are few interventions that have demonstrated consistent effects in improving adherence in the longer term in resource-limited settings [17].”
BackgroundYbarra, M. L., Agaba, E., Chen, E., & Nyemara, N. (2020) · AIDS and Behavior · doi:10.1007/s10461-020-02795-4 · Cited by 23
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Stuart, R. M., Fraser‐Hurt, N., Kerr, C. C., Mabusela, E., Madi, V., Mkhwanazi, F., Pillay, Y. G., Barron, P., Muzah, B., Matsebula, T. C., et al. (2018) · Journal of the International AIDS Society · doi:10.1002/jia2.25068 · Cited by 19
“Despite the recognition of the importance of cities in achieving the Fast-Track targets, most studies tend to focus on analysing the care and treatment cascade within countries [7,9,11-13] or within clinics[14,15].”
BackgroundNaslund, J. A., Dionne‐Odom, J., Destiné, C. J., Jogerst, K. M., Sénécharles, R. R., Louis, M. J., Desir, J., Ledan, Y. N., Beausejour, J. R., Charles, R., et al. (2014) · AIDS Research and Treatment · doi:10.1155/2014/137545 · Cited by 20
“The clinical effectiveness of ART depends on retention in care and long-term adherence [2].”
BackgroundInfluentialCost Effectiveness of Potential ART Adherence Monitoring Interventions in Sub-Saharan Africa
Phillips, A. N., Cambiano, V., Nakagawa, F., Bansi‐Matharu, L., Sow, P. S., Ehrenkranz, P. D., Ford, D., Mugurungi, O. M., Apollo, T., Murungu, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167654 · Cited by 20
Developing a predictive risk model for first‐line antiretroviral therapy failure in South Africa
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“Practically, the identification of high-risk groups for treatment failure has an important application in clinical settings, where high-risk patients could be monitored more closely and receive treatment adherence counselling or other interventions [31].”
BackgroundCôté, J., Godin, G., Guéhéneuc, Y., Rouleau, G., Ramirez-Garcìa, P., Otis, J., Tremblay, C. L., & Fadel, G. (2012) · Trials · doi:10.1186/1745-6215-13-187 · Cited by 20
“[26] and Horvarth et al.”
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“These are important factors that should be considered when implementing adherence reminder devices in routine settings, emphasising the importance of context, examining specific features of the intervention and rigorous evaluation of implementation impact and performance [14, 15].”
BackgroundCommunity engagement with HIV drug adherence in rural South Africa: a transdisciplinary approach
Treffry-Goatley, A., Lessells, R. J., Moletsane, R., de Oliveira, T., & Gaede, B. M. (2018) · Medical Humanities · doi:10.1136/medhum-2018-011474 · Cited by 19
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“Adherence is therefore of critical importance to individual patient outcomes as well as an overall public health concern [3].”
BackgroundEstimating the range of potential epidemiological impact of pre-exposure prophylaxis
Cremin, Í., & Hallett, T. B. (2015) · AIDS · doi:10.1097/qad.0000000000000591 · Cited by 18
“Furthermore, there is vast experience from research regarding adherence to other forms of prevention such as malaria prophylaxis, prophylaxis for latent tuberculosis, hypertension and oral contraceptives [16], as well as adherence to antiretrovirals for HIV treatment [17], which can be drawn upon.”
BackgroundMcCluskey, S. M., Boum, Y., Musinguzi, N., Haberer, J. E., Martin, J. N., Hunt, P. W., Marconi, V. C., Bangsberg, D. R., & Siedner, M. J. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001479 · Cited by 18
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“Adherence to ART is very important for those living with HIV not just to improve health but also to reduce viral load and therefore decrease the risk of transmission (Bärnighausen et al., 2011; Bezabhe et al., 2014; Chaiyachati et al., 2014).”
Backgroundvan Elsland, S. L., Peters, R. P. H., Kok, M. O., van Toorn, R., Springer, P. E., Cotton, M. F., Grobbelaar, C. J., Aarnoutse, R. E., & van Furth, A. M. (2018) · Tropical Medicine & International Health · doi:10.1111/tmi.13134 · Cited by 17
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A Pilot RCT Evaluating InThistoGether, an mHealth HIV Prevention Program for Ugandan Youth
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“SMS reminders 131 (22) 53 (13) 170 (67)”
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“Beginning in 2004, ART use in sub-Saharan Africa was dramatically expanded using a public health approach, which led to a rapid expansion of access to treatment in resource-limited settings [1, 2, 4].”
BackgroundNiu, X., Kubiak, R. W., Siriprakaisil, O., Klinbuyaem, V., Sukrakanchana, P.-O., Cressey, R., Okochi, H., Gandhi, M., Cressey, T. R., & Drain, P. K. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac405 · Cited by 14
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“There are several studies showing that food transfers have positive effects on promoting ART adherence and retention in care (Barnighausen et al., 2011; Cantrell et al., 2008; Ivers, Chang, Gregory Jerome, & Freedberg, 2010; Van Oosterhout et al., 2010).”
BackgroundAssociation of knowledge on ART line of treatment, scarcity of treatment options and adherence
Ramadhani, H. O., Muiruri, C., Maro, V. P., Omondi, M., Mushi, J. B., Lirhunde, E. S., & Bartlett, J. A. (2016) · BMC Health Services Research · doi:10.1186/s12913-016-1483-6 · Cited by 14
“Interventions to improve adherence to ART are a priority, and numerous interventions have been explored [18, 19].”
BackgroundWachira, J., Genberg, B. L., Mwangi, A., Chemutai, D., Braitstein, P. K. A., Galárraga, O., Siika, A. M., & Wilson, I. B. (2022) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002987 · Cited by 13
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“Interventions that can promote ART adherence vary considerably in cost and complexity [22], resulting in a need for care programs to target interventions selectively.”
BackgroundPurchase, S. E., Cunningham, J., Esser, M., & Skinner, D. G. (2016) · African Journal of AIDS Research · doi:10.2989/16085906.2016.1210656 · Cited by 13
“These include early and complete disclosure to children; child and caregiver belief in the efficacy of treatment; strong child–caregiver relationships and strong family structures; community-based adherence support by patient advocates; medication reminders; early and ongoing education and counselling; and a strong co…”
BackgroundWachira, J., Genberg, B. L., Kafu, C., Braitstein, P. K. A., Laws, M. B., & Wilson, I. B. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s168664 · Cited by 13
MacCarthy, S., Mendoza-Graf, A., Huang, H., Mukasa, B., & Linnemayr, S. (2019) · Children and youth services review · doi:10.1016/j.childyouth.2019.04.007 · Cited by 13
“However, there has been an increasing number of mobile phone-based studies in rural areas in Africa, as well as continuing improvements to mobile phone connectivity in rural areas of Uganda in the last several years (Bärnighausen et al., 2011; Pop-Eleches et al., 2011).”
BackgroundImmunoassay for HIV Drug Metabolites Tenofovir and Tenofovir Diphosphate
Sevenler, D., Bardon, A., Fernández-Suárez, M., Marshall, L. F., Toner, M., Drain, P. K., & Sandlin, R. D. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00010 · Cited by 13
Holmes, C. B., Pillay, Y., Mwango, A., Perriëns, J., Ball, A. L., Barreneche, O., Wignall, S., Hirnschall, G. O., & Doherty, M. C. (2014) · AIDS · doi:10.1097/qad.0000000000000250 · Cited by 11
“At an individual level, substantial evidence has demonstrated the benefits of two-way mobile phone text message systems, and WHO has made a strong recommendation for consideration of this approach [7].”
BackgroundPromoting long term adherence to antiretroviral treatment
Mills, E., Lester, R., & Ford, N. (2012) · British medical journal · doi:10.1136/bmj.e4173 · Cited by 10
Phillips, T. K., Bonnet, K. R., Myer, L., Buthelezi, S., Rini, Z., Bassett, J., Schlundt, D. G., & Clouse, K. (2019) · Maternal and Child Health Journal · doi:10.1007/s10995-019-02766-9 · Cited by 9
Ibeneme, S., Revere, L., Hwang, L., Rajan, S. S., Okeibunor, J., Muneene, D., & Langabeer, J. R. (2020) · Informatics · doi:10.3390/informatics7020011 · Cited by 10
“This mHealth strategy increased medication adherence and follow-up visits that led to overall reductions in patients’ viral load [12].”
BackgroundNdirangu, M., Sztam, K. A., Sheriff, M., Hawken, M. P., Arpadi, S. M., Rashid, J., Deckelbaum, R., & El-Sadr, W. M. (2014) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2014.0153 · Cited by 9
Kemp, C. G., Gerth‐Guyette, E., Dube, L., Andrasik, M. P., & Rao, D. (2016) · AIDS and Behavior · doi:10.1007/s10461-016-1386-x · Cited by 9
“This ‘‘Pre-ART’’ phase is a broken link in many Sub-Saharan African health programs [14, 15].”
BackgroundInfluentialMills, E. J., & Ford, N. P. (2011) · AIDS · doi:10.1097/qad.0b013e32834f3319 · Cited by 9
“received the meticulous attention to improving adherence and retention in care as HIV/AIDS, yet there is still little agreement about which interventions work best to improve adherence in a given setting [17].”
BackgroundLujintanon, S., Eshun‐Wilson, I., Tourneau, N. L., Beres, L. K., Schwartz, S., Baral, S., Thompson, R. R., Underwood, A., Fox, B., Geng, E. H., et al. (2024) · Journal of the International AIDS Society · doi:10.1002/jia2.26263 · Cited by 8
Clinical Features and Management of HIV/AIDS
Wood, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-7020-5101-2.00011-x · Cited by 8
Chebet, J. J., McMahon, S. A., Chase, R. P., Tarumbiswa, T., Maponga, C., Mandara, E., Bärnighausen, T., & Geldsetzer, P. (2023) · PLOS Global Public Health · doi:10.1371/journal.pgph.0001423 · Cited by 9
“Facility-based interventions could include intensive adherence counseling and monitoring and multi-month PrEP prescriptions [37, 53].”
Self-citationPhillips, T. K., & Myer, L. (2019) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2019.1607296 · Cited by 8
“[153,154]; a small pilot study using a mobile phone-based case manager found the approach to be feasible and acceptable for pregnant and postpartum women [155].”
BackgroundThe United States government's response to HIV/AIDS today: ‘Test and treat’ as prevention
Berkelman, R. L. (2012) · Journal of Public Health Policy · doi:10.1057/jphp.2012.21 · Cited by 8
“It is a global issue that those with HIV infection become less adherent to ART over time.(20) The World Health Organization has recognized that poor adherence to treatment of chronic diseases is a worldwide problem of striking magnitude.”
BackgroundART Adherence as a Key Component of Prevention With Persons Living With HIV in Mozambique
Dawson-Rose, C. S., Gutin, S. A., Cummings, B., Jaiantilal, P., Johnson, K. A., & Mbofana, F. (2015) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2015.10.001 · Cited by 8
“Perhaps because of this, treatment side effects as a barrier to PP, as noted in other literature (Barnighausen et al., 2011), did not emerge in patient or health care staff interviews.”
Self-Reported Adherence to Antiretroviral Therapy in HIV+ Colombian Population
Remor, E. (2013) · SAGE Open · doi:10.1177/2158244013497727 · Cited by 8
“Previous work has pointed out the need for more research in theory-based interventions to increase ARV adherence, especially in resource-limited contexts (Bärnighausen et al., 2011).”
BackgroundEffectiveness of Psycho-Educational Intervention in HIV Patients’ Treatment
Ribeiro, C., Castro, R. S. E., Dinis-Ribeiro, M. J., & Fernandes, L. P. N. S. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00198 · Cited by 8
“The literature shows that the rates of adherence to intervention programs continue at a lower level in spite of innovative programs (40, 67).”
BackgroundHIV Treatment for Alcohol and Non-Injection Drug Users in El Salvador
Dickson‐Gómez, J., Bodnar, G., Petroll, A., Johnson, K., & Glasman, L. R. (2015) · Qualitative Health Research · doi:10.1177/1049732314568322 · Cited by 7
Goodman, M. L., Elliott, A., Gitari, S., Keiser, P. H., & Raimer-Goodman, L. A. (2016) · Journal of Water and Health · doi:10.2166/wh.2016.230 · Cited by 7
Implementation and Operational Research
Were, M. C., Kessler, J., Shen, C., Sidle, J. E., Macharia, S. M., Lizcano, J. A., Siika, A. M., Wools‐Kaloustian, K., & Kurth, A. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000666 · Cited by 7
Wouters, E., Booysen, F., & Masquillier, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163963 · Cited by 7
Chas, J., Héma, A., Slama, L., Kaboré, N. F., Lescure, F.-X., Fontaine, C., Pialoux, G., & Sawadogo, A. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125588 · Cited by 7
Mukonda, E. E., Hsiao, M., Vojnov, L., Myer, L., & Lesosky, M. (2020) · BMJ Global Health · doi:10.1136/bmjgh-2020-002522 · Cited by 7
Sabin, L., Gifford, A. L., Haberer, J. E., Harvey, K., Sarkisova, N., Martin, K., West, R. L., Stephens, J., Killian, C., Halim, N., et al. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03623-7 · Cited by 7
Self-citationJennings, L., West, R. L., Halim, N., Kaiser, J. L., Gwadz, M. V., MacLeod, W., Gifford, A. L., Haberer, J. E., Orrell, C., & Sabin, L. (2023) · Trials · doi:10.1186/s13063-023-07322-z · Cited by 7
“Intervention studies provide ample evidence that patients can benefit from support interventions [20], including peer groups [21], motivational interviewing [21–23], and text message reminders [21, 23, 24].”
BackgroundSelf-citationThe uncertain future of lay counsellors: continuation of HIV services in Lesotho under pressure
Bemelmans, M., Goux, D., Baert, S., Cutsem, G. V., Motsamai, M., Philips, M. P., Damme, W. V., Mwale, H., Biot, M., & van den Akker, T. (2015) · Health Policy and Planning · doi:10.1093/heapol/czv106 · Cited by 6
“Lay workers in Mozambique have shown to play a crucial role in the facilitation of community patient groups, creating a link between such groups and the health care system (Hermann et al. 2009; Bärnighausen et al. 2011; Ledikwe et al. 2013; Bemelmans et al. 2014).”
BackgroundFreeman, A., Kiumbu, M., Mwamba, B., Atibu, J., Mukumbi, H., Mwila, L., Cummiskey, C., Stolka, K., Hemingway‐Foday, J., & Newman, J. E. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0761-8 · Cited by 6
From policy to action: how to operationalize the treatment for all agenda
Celletti, F., Cohn, J., Connor, C., Lee, S., Giphart, A., & Montaner, J. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.21185 · Cited by 6
“Homebased visits by community health workers soon after ART initiation can help decrease early loss to follow-up after ART initiation [26].”
BackgroundOptimal timing of HIV home‐based counselling and testing rounds in Western Kenya
Olney, J., Eaton, J. W., Braitstein, P. K. A., Hogan, J. W., & Hallett, T. B. (2018) · Journal of the International AIDS Society · doi:10.1002/jia2.25142 · Cited by 6
Which delivery model innovations can support sustainable HIV treatment?
Bulstra, C. A., Hontelez, J. A. C., Ogbuoji, O., & Bärnighausen, T. (2019) · African Journal of AIDS Research · doi:10.2989/16085906.2019.1686033 · Cited by 6
Self-citationAmeyaw, E. K., Nutor, J. J., Okiring, J., Yeboah, I., Agbadi, P., Getahun, M., Agbadi, W., & Thompson, R. (2024) · BMC Public Health · doi:10.1186/s12889-024-18004-z · Cited by 5
“Through a sub-Saharan African-based systematic review, Bärnighausen et al. [33] noted that rural residents had lower ART adherence compared to urban residents.”
BackgroundMehta, M., Semitala, F. C., Lynen, L., & Colebunders, R. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.129 · Cited by 5
Njau, T., Ngakongwa, F., Sunguya, B. F., Kaaya, S., & Fekadu, A. (2022) · Healthcare · doi:10.3390/healthcare10122491 · Cited by 5
Pascoe, S. J. S., Fox, M. P., Kane, J. C., Mngadi-Ncube, S., Manganye, P., Long, L. C., Metz, K. L., Allen, T., Sardana, S. M., Greener, R., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-065848 · Cited by 5
Posse, M., & Baltussen, R. M. P. M. (2013) · Cost Effectiveness and Resource Allocation · doi:10.1186/1478-7547-11-20 · Cited by 5
“Despite calls for more economic analysis of interventions to improve treatment outcomes [17,28-31], to our knowledge this study is the first to provide a detailed cost estimation of food assistance to HIV/AIDS patients.”
BackgroundLIFE EXPECTANCIES OF HIV-POSITIVE ADULTS RECEIVING ANTIRETROVIRAL TREATMENT IN SOUTH AFRICA
Mossong, J., Dorrington, R., Schomaker, M., Keiser, O., Fox, M. P., Prozesky, H. W., Giddy, J., Garone, D., Cornell, M., Egger, M., et al. (2012) · Cited by 5
HIV Care Continuum in Adults and Children: Cost-Effectiveness Considerations
Harripersaud, K., McNairy, M. L., Ahmed, S., Abrams, E. J., Thirumurthy, H., & El‐Sadr, W. (2017) · World Bank, Washington, DC eBooks · doi:10.1596/978-1-4648-0524-0_ch4 · Cited by 5
Impact à long terme des traitements antirétroviraux en Afrique, état des connaissances
Taverne, B., Desclaux, A., Delaporte, É., & Ndoye, I. (2014) · Bulletin de la Société de pathologie exotique · doi:10.1007/s13149-014-0392-3 · Cited by 5
“De plus, pour un même individu, l’observance est un phénomène dynamique toujours susceptible d’évolution [7].”
Metadata
- Authors
- Bärnighausen, T., Chaiyachati, K., Chimbindi, N., Peoples, A., Haberer, J., & Newell, M.-L.
- Affiliations
- Harvard University (US)
- University of KwaZulu-Natal (ZA)
- University of Michigan (US)
- Massachusetts General Hospital (US)
- University College London (GB)
- Corresponding author
- Bärnighausen, Till
- ORCID
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 11
- Issue
- 12
- Pages
- 942-951
- ISSN
- 1473-3099 (ISSN-L)
- PMC
- PMC4250825
- OpenAlex
- W2098160568
- Cited by
- 246
- References
- 107
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 24 · 2015: 29 · 2014: 33 · 2013: 26 · 2012: 29
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- U.S. Public Health Service (K-23 087228, 1R01MG083539-01)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058482, 1R01-HD058482- 01)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- antiretroviral therapy adherence, HIV, adherence interventions, treatment supporters, directly observed therapy, text messaging, rations, sub-Saharan Africa, behavioral interventions, intervention effectiveness
- MeSH terms
- Assessment of Medication Adherence, Humans, HIV Infections, Drug Monitoring, Outcome Assessment, Health Care, Africa South of the Sahara, Antiretroviral Therapy, Highly Active, Medication Adherence
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