The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation
Abstract
Creutzfeldt-Jakob disease (CJD) is a fatal disease presenting with rapidly progressive dementia, and most patients die within a year of clinical onset. CJD poses a potential risk of iatrogenic transmission, as it can incubate asymptomatically in humans for decades before becoming clinically apparent. In this Review, we sought evidence to understand the current iatrogenic risk of CJD to public health by examining global evidence on all forms of CJD, including clinical incidence and prevalence of subclinical disease. We found that although CJD, particularly iatrogenic CJD, is rare, the incidence of sporadic CJD is increasing. Incubation periods as long as 40 years have been observed, and all genotypes have now been shown to be susceptible to CJD. Clinicians and surveillance programmes should maintain awareness of CJD to mitigate future incidences of its transmission. Awareness is particularly relevant for sporadic CJD, which occurs in older people in whom clinical presentation could resemble rapidly developing dementia.
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient
Peden, A. H., Head, M. W., Diane, L. R., Jeanne, E. B., & James, W. I. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16811-6 · Cited by 858
Wadsworth, J., Joiner, S., Hill, A., Campbell, T., Desbruslais, M., Luthert, P., & Collinge, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05403-4 · Cited by 693
Preclinical variant CJD after blood transfusion in a PRNP codon 129 heterozygous patient
Peden, A., Head, M. W., Ritchie, D. L., et al. (2004) · Cited by 486
Prevalence of lymphoreticular prion protein accumulation in UK tissue samples
Hilton, D. A., Ghani, A. C., Conyers, L., Edwards, P., McCardle, L., Ritchie, D., Penney, M., Hegazy, D., & Ironside, J. W. (2004) · The Journal of Pathology · doi:10.1002/path.1580 · Cited by 444
Self-citationKuru in the 21st century—an acquired human prion disease with very long incubation periods
Collinge, J., Whitfield, J., McKintosh, E., Beck, J., Mead, S., Thomas, D. J., & Alpers, M. P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68930-7 · Cited by 427
Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment
Brown, P., Brandel, J.-P., Sato, T., Nakamura, Y., MacKenzie, J., Will, R. G., Ladogana, A., Pocchiari, M., Leschek, E. W., & Schonberger, L. B. (2012) · Emerging Infectious Diseases · doi:10.3201/eid1806.120116 · Cited by 361
Gill, O. N., Spencer, Y., Richard-Loendt, A., Kelly, C., Dabaghian, R., Boyes, L., Linehan, J., Simmons, M., Webb, P., Bellerby, P., et al. (2013) · BMJ · doi:10.1136/bmj.f5675 · Cited by 300
Self-citationDetection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues
Bruce, M., McConnell, I., Will, R., & Ironside, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05411-3 · Cited by 255
Metadata
- Authors
- Uttley, L., Carroll, C., Wong, R., Hilton, D. A., & Stevenson, M.
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 20
- Issue
- 1
- Pages
- e2-e10
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2995523476
- Cited by
- 258
- References
- 44
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation. https://app.cochat.ai/papers/10.1016/s1473-3099(19)30615-2
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- Uttley, L., Carroll, C., Wong, R., Hilton, D. A., & Stevenson, M. (2020). Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(19)30615-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
