Cited by 560Vagus Nerve Stimulation ResearchEpilepsy research and treatmentDeep Brain Stimulation and Movement Disorders

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Vagus-nerve stimulation for the treatment of epilepsy

Ben-Menachem, Elinor·2002·The Lancet Neurology

DOI 10.1016/s1474-4422(02)00220-x

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Abstract

Vagus-nerve stimulation (VNS) is now an accepted treatment for patients with refractory epilepsy. There have been many studies suggesting that VNS affects the brain in such areas as the thalamus and other limbic structures. In addition, there is some evidence that norepinephrine is important in the prophylactic antiseizure effects of VNS. The efficacy of VNS has been established for partial seizure types, even in refractory patients who did not respond to surgical treatment for epilepsy. There are also data, from open-label studies, that suggest efficacy in other seizure types. Therefore, VNS seems to be a broad-spectrum treatment for epilepsy. Improvement is not immediate but increases over 18-24 months of treatment. Most studies report subjective improvements in various quality-of-life measurements during treatment with VNS--objective trials have confirmed this observation. Side-effects are mainly stimulation related and reversible and they tend to decrease over time. They are generally mild to moderate and seldom necessitate the removal of the device. No idiosyncratic side-effects have been reported in 12 years of experience, and VNS does not interact with antiepileptic drugs. Most adverse events are predictable and related to the specific stimulation regimen. VNS does not have cognitive and systemic side-effects and can, therefore, be a valuable treatment approach even for patients who have poor tolerance of antiepileptic drugs.

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Vagus nerve stimulation therapy for partial-onset seizures
Handforth, A., DeGiorgio, C. M., Schachter, S. C., Uthman, B. M., Naritoku, D. K., Tecoma, E. S., Henry, T. R., Collins, S. D., Vaughn, B. V., Gilmartin, R. C., et al. (1998) · Neurology · doi:10.1212/wnl.51.1.48 · Cited by 1,107
Cardiac electrophysiology and arrhythmias
Zipes, D. P., Jalife, J., & Moe, G. K. (1985) · Grune & Stratton eBooks · Cited by 944
Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy
Morris, G. L., Mueller, W. M., & The Vagus Nerve Stimulation Study Group E–E (1999) · Neurology · doi:10.1212/wnl.53.8.1731 · Cited by 727
Vagus Nerve Stimulation for Treatment of Partial Seizures: 1. A Controlled Study of Effect on Seizures
Ben‐Menachem, E., Mañon‐Espaillat, R., Ristanovic, R., Wilder, B. J., Stefan, H., Mirza, W., Tarver, W. B., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02482.x · Cited by 683
Self-citation
Enhanced recognition memory following vagus nerve stimulation in human subjects
Clark, K., Naritoku, D., Smith, D. C., Browning, R., & Jensen, R. A. (1999) · Nature Neuroscience · doi:10.1038/4600 · Cited by 575
Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation
Krahl, S. E., Clark, K. B., Smith, D. C., & Browning, R. A. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01155.x · Cited by 556
Prospective Long‐Term Study of Vagus Nerve Stimulation for the Treatment of Refractory Seizures
DeGiorgio, C. M., Schachter, S. C., Handforth, A., Salinsky, M., Thompson, J., Uthman, B., Reed, R., Collin, S., Tecoma, E., Morris, G. L., et al. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00325.x · Cited by 479
Prevention of Intractable Partial Seizures by Intermittent Vagal Stimulation in Humans: Preliminary Results
Penry, J. K., & Dean, J. C. (1990) · Epilepsia · doi:10.1111/j.1528-1157.1990.tb05848.x · Cited by 474
Inhibition of Experimental Seizures in Canines by Repetitive Vagal Stimulation
Zabara, J. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb01751.x · Cited by 398
Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures
Ben‐Menachem, E., Hamberger, A., Hedner, T., Hammond, E. J., Uthman, B. M., Slater, J. D., Treig, T., Stefan, H., Ramsay, R. E., Wernicke, J. F., et al. (1995) · Epilepsy Research · doi:10.1016/0920-1211(94)00083-9 · Cited by 377
Self-citation

Show all 60 references

Research works printed but not linked: 4

Zabara, 1985, Time course of seizure control to brief repetitive stimuli, Epilepsia, 26, 518
Stoica, 1967, Effects of vagus afferents on strychnine focus of coronal gyrus, Rev Roum Neurol, 4, 287
Stoica, 1968, Vagal trunk stimulation influences on epileptic spiking focus, Rev Roum Neurol, 5, 203
Wheless, 2002, Interim results of a prospective study of early adjunctive vagus nerve stimulation (VNS) therapy, Neurology, 58, 1

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Mertens, A., Carrette, S., Klooster, D., Lescrauwaet, E., Delbeke, J., Wadman, W. J., Carrette, E., Raedt, R., Boon, P., & Vonck, K. E. J. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13488 · Cited by 33
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Authors: Ben-Menachem, E.
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2002-12
Volume: 1
Issue: 8
Pages: 477-482
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(02)00220-x
OpenAlex: W1971482087
Cited by: 560
References: 60
Citations by year: 2026: 28 · 2025: 34 · 2024: 36 · 2023: 39 · 2022: 42 · 2021: 30 · 2020: 38 · 2019: 23 · 2018: 20 · 2017: 19 · 2016: 24 · 2015: 34 · 2014: 22 · 2013: 23 · 2012: 30
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: vagus nerve stimulation, drug-resistant epilepsy, norepinephrine, focal seizures, thalamus, limbic structures, quality of life, adverse effects, seizure types
MeSH terms: Adolescent, Animals, Child, Child, Preschool, Clinical Trials as Topic, Electrodes, Implanted, Electric Stimulation Therapy, Epilepsy, Humans, Quality of Life, Vagus Nerve

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Vagus-nerve stimulation for the treatment of epilepsy

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