The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Medication-overuse headache: a worldwide problem
Abstract
Medication overuse and subsequent medication-overuse headache (MOH) is a growing problem worldwide. Epidemiological data suggest that up to 4% of the population overuse analgesics and other drugs for the treatment of pain conditions such as migraine and that about 1% of the general population in Europe, North America, and Asia have MOH. Recent clinical studies gave further insights in clinical and pharmacological features, such as critical monthly doses and frequencies. These features seem to vary significantly and depend on the primary headache disorder and the type of drug that is overused. Along with these findings the new international classification of headache disorders has now incorporated additional criteria and new headache entities that will facilitate the diagnosis of MOH. Withdrawal therapy is the only treatment for this disorder and clear restriction of monthly doses is the central requirement for successful prevention.
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“Medication overuse headache (MOH) is a severe burden to sufferers and its treatment has few evidence-based indications.”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [6]
In the citing paper
“In these patients, the main unresolved problem is the excessive use of drugs for the acute treatment and the overall deterioration experienced in their quality of life, so the headache symptoms should be considered as part of the issue as a whole [2, 6, 7].”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [6]
Citations
Cites
The International Classification of Headache Disorders: 2nd edition
Olesen, J., Goadsby, P. J., & Steiner, T. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00590-8 · Cited by 5,046
Sorge, F., Simone, R. D., Marano, E., Nolano, M., Orefice, G., & Carrieri, P. B. (1988) · Cephalalgia · doi:10.1046/j.1468-2982.1988.0801001.x · Cited by 3,464
Goadsby, P. J. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00711.x · Cited by 2,381
Epidemiology of Tension-Type Headache
Schwartz, B. S. (1998) · JAMA · doi:10.1001/jama.279.5.381 · Cited by 762
Scher, I., Stewart, F. W., Rícci, A., & Lipton, B. R. (2003) · Pain · doi:10.1016/s0304-3959(03)00293-8 · Cited by 714
Epidemiology of Chronic Daily Headache in the General Population
Castillo, J., Muñoz, P., Guitera, V., & Pascual, J. (1999) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1999.3903190.x · Cited by 711
Silberstein, S., Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., et al. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00878.x · Cited by 517
Self-citationFeatures of medication overuse headache following overuse of different acute headache drugs
Limmroth, V., Katsarava, Z., Fritsche, G., Przywara, S., & Diener, H. (2002) · Neurology · doi:10.1212/wnl.59.7.1011 · Cited by 391
Self-citationWithdrawal Syndrome after the Double-Blind Cessation of Caffeine Consumption
Silverman, K., Evans, S. M., Strain, E. C., & Griffiths, R. R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210153271601 · Cited by 380
Incidence and predictors for chronicity of headache in patients with episodic migraine
Katsarava, Z., Schneeweiß, S., Kurth, T., Kroener, U., Fritsche, G., Eikermann, A., Diener, H., & Limmroth, V. (2004) · Neurology · doi:10.1212/01.wnl.0000113747.18760.d2 · Cited by 375
Self-citation
Research works printed but not linked: 5
- Moeschlin, 1957, Phenacetinsucht und Schäden, Schweiz Med Wochenschr, 87, 123
- 1988, . Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain, Cephalalgia, 8, 1
- Diener, 1988, Analgetikainduzierter Dauerkopfschmerz. Existiert eine kritische Dosis?, Arzneimitteltherapie, 6, 156
- Newman, 1993, Hemicrania continua: 7 new cases and a literature review, Headache, 32, 267
- Z Katsarava, M Müssig, A Dzagniza, G Fritsche, HC Diener, V Limmroth, Rate and predictors for relapses in medication overuse headache: a four year prospective study. Cephalalgia (in press).
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Waldman, S. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-3792-9.00026-6
Mintz, B. L. (2013) · doi:10.1002/9781118618189.ch21
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Genc, H., Baykan, B., Bolay, H., Uluduz, D., Ünal-Çevik, I., Kissani, N., Luvsannorov, O., Togha, M., Ozdemir, A. A., & Ozge, A. (2024) · Figshare · doi:10.6084/m9.figshare.26574895
Rix, M. G., & Harvey, M. S. (2010) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.194374
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Maamar, M. B. (2015) · theses.fr (ABES) · doi:10.70675/6f5660fezb572z4da4z937dz709fdaabc1db
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Masson, R. (2020) · theses.fr (ABES) · doi:10.70675/3bb511a1za582z4458za9d7z2bda595f8108
Sudibyo, D. A., Widjiati, W., Hidayati, H. B., Sulaiman, W. A. W., & Rattanawong, W. (2026) · Romanian Journal of Neurology · doi:10.37897/rjn.2026.2.8
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Green, M. W. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-95313-9.00023-x
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Metadata
- Authors
- Diener, H.-C., & Limmroth, V.
- Affiliations
- Essen University Hospital (DE)
- Corresponding author
- Diener, Hans-Christoph
- ORCID
- Limmroth, Volker
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 3
- Issue
- 8
- Pages
- 475-483
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2115215127
- Cited by
- 455
- References
- 82
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 16 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 15 · 2016: 19 · 2015: 20 · 2014: 23 · 2013: 26 · 2012: 26
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- medication overuse headache, analgesic overuse, migraine, headache frequency, International Classification of Headache Disorders, withdrawal therapy, headache prevention
- MeSH terms
- Diagnosis, Differential, Headache, Humans, Prognosis, Outcome Assessment, Health Care, Headache Disorders, Drug-Related Side Effects and Adverse Reactions
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