Cited by 455Migraine and Headache StudiesTraumatic Brain Injury ResearchPharmaceutical Practices and Patient Outcomes

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Medication-overuse headache: a worldwide problem

Diener, Hans-Christoph, Limmroth, Volker·2004·The Lancet Neurology

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Abstract

Medication overuse and subsequent medication-overuse headache (MOH) is a growing problem worldwide. Epidemiological data suggest that up to 4% of the population overuse analgesics and other drugs for the treatment of pain conditions such as migraine and that about 1% of the general population in Europe, North America, and Asia have MOH. Recent clinical studies gave further insights in clinical and pharmacological features, such as critical monthly doses and frequencies. These features seem to vary significantly and depend on the primary headache disorder and the type of drug that is overused. Along with these findings the new international classification of headache disorders has now incorporated additional criteria and new headache entities that will facilitate the diagnosis of MOH. Withdrawal therapy is the only treatment for this disorder and clear restriction of monthly doses is the central requirement for successful prevention.

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Authors: Diener, H.-C., & Limmroth, V.
Affiliations: Essen University Hospital (DE)
Corresponding author: Diener, Hans-Christoph
ORCID: Limmroth, Volker
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2004-08
Volume: 3
Issue: 8
Pages: 475-483
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(04)00824-5
OpenAlex: W2115215127
Cited by: 455
References: 82
Citations by year: 2026: 6 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 16 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 15 · 2016: 19 · 2015: 20 · 2014: 23 · 2013: 26 · 2012: 26
FWCI: 2.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords: medication overuse headache, analgesic overuse, migraine, headache frequency, International Classification of Headache Disorders, withdrawal therapy, headache prevention
MeSH terms: Diagnosis, Differential, Headache, Humans, Prognosis, Outcome Assessment, Health Care, Headache Disorders, Drug-Related Side Effects and Adverse Reactions

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Medication-overuse headache: a worldwide problem

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