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Cited by 2,807Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 138 of the 140 references it cites were found in a registry or an index.

Non-motor symptoms of Parkinson's disease: diagnosis and management

Chaudhuri, K Ray, Healy, Daniel G, Schapira, Anthony HV·2006·The Lancet Neurology
DOI 10.1016/s1474-4422(06)70373-8
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Abstract

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics related to dopamine deficiency that are a consequence of degeneration of the substantia nigra pars compacta. However, non-dopaminergic and non-motor symptoms are sometimes present before diagnosis and almost inevitably emerge with disease progression. Indeed, non-motor symptoms dominate the clinical picture of advanced Parkinson's disease and contribute to severe disability, impaired quality of life, and shortened life expectancy. By contrast with the dopaminergic symptoms of the disease, for which treatment is available, non-motor symptoms are often poorly recognised and inadequately treated. However, attention is now being focused on the recognition and quantitation of non-motor symptoms, which will form the basis of improved treatments. Some non-motor symptoms, including depression, constipation, pain, genitourinary problems, and sleep disorders, can be improved with available treatments. Other non-motor symptoms can be more refractory and need the introduction of novel non-dopaminergic drugs. Inevitably, the development of treatments that can slow or prevent the progression of Parkinson's disease and its multicentric neurodegeneration provides the best hope of curing non-motor symptoms.

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Crossref · 10.1016/s1474-4422(06)70373-8

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Citations

Cites

Show all 140 references

Research works printed but not linked: 7

  1. Chaudhuri, 2004, The holistic management of Parkinson's using a novel non-motor symptom scale and questionnaire, Adv Clin Neurosci Rehab, 4, 20
  2. Gulati, 2004, A clinical observational study of the pattern and occurrence of non-motor symptoms in Parkinson's disease ranging from early to advanced disease, Mov Disord, 19, S406
  3. Abbott, 2005, Excessive daytime sleepiness and the future risk of Parkinson's disease, Mov Disord, 20, S101
  4. Doder, 2000, Brain serotonin 5HT1A receptors in Parkinson's disease with and without depression measured by positron emission tomography with 11C-WAY 10635, Mov Disord, 15, 213
  5. Diederich, 2005, Repeated visual hallucinations in Parkisnon's disease as disturbed external/internal perceptions: focused review and a new integrative model, Mov Disord, 20, 130, 10.1002/mds.20308 · DOI
  6. Tyvaert, 2005, Sexual dysfunction and sub-thalamic stimulation in Parkinson's disease, Park Related Disord, 11, 116
  7. Isaacson, 2005, Non-motor symptoms frequently herald end-of-dose wearing off in Parkinson's disease, Mov Disord, 20, S52

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Metadata

Authors
Chaudhuri, K. R., Healy, D. G., & Schapira, A. H.
Affiliations
  • Guy's and St Thomas' NHS Foundation Trust (GB)
  • The Royal Free Hospital (GB)
ORCID
Schapira, Anthony HV
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2006-03
Volume
5
Issue
3
Pages
235-245
ISSN
1474-4422 (ISSN-L)
DOI
10.1016/s1474-4422(06)70373-8
OpenAlex
W1982535961
Cited by
2,807
References
140
Citations by year
2026: 184 · 2025: 170 · 2024: 143 · 2023: 159 · 2022: 168 · 2021: 165 · 2020: 197 · 2019: 168 · 2018: 161 · 2017: 174 · 2016: 152 · 2015: 156 · 2014: 130 · 2013: 130 · 2012: 129
FWCI
9.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, non-motor symptoms, depression, constipation, pain, genitourinary dysfunction, sleep disorders, substantia nigra pars compacta, neurodegeneration, quality of life, disability
MeSH terms
Autonomic Nervous System Diseases, Humans, Pain, Parkinson Disease, Psychotic Disorders, Sleep Wake Disorders, Disease Progression, Pain Management

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