The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Gluten sensitivity: from gut to brain
Abstract
Gluten sensitivity is a systemic autoimmune disease with diverse manifestations. This disorder is characterised by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals. Coeliac disease, or gluten-sensitive enteropathy, is only one aspect of a range of possible manifestations of gluten sensitivity. Although neurological manifestations in patients with established coeliac disease have been reported since 1966, it was not until 30 years later that, in some individuals, gluten sensitivity was shown to manifest solely with neurological dysfunction. Furthermore, the concept of extraintestinal presentations without enteropathy has only recently become accepted. In this Personal View, we review the range of neurological manifestations of gluten sensitivity and discuss recent advances in the diagnosis and understanding of the pathophysiological mechanisms underlying neurological dysfunction related to gluten sensitivity.
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“The autoimmune target in neurologic gluten sensitivity is TG6 rather than TG2, which is the target for autoantibodies measured in commercial tests.47”
From The Gut Microbiome and the Brain (2014) · cites this paper as [47]
Citations
Cites
Identification of tissue transglutaminase as the autoantigen of celiac disease
Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997) · Nature Medicine · doi:10.1038/nm0797-797 · Cited by 2,021
Marsh, M. N. (1992) · PubMed · Cited by 1,985
Gluten, major histocompatibility complex, and the small intestine
Marsh, M. N. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91819-p · Cited by 1,692
Molberg, Ø., McAdam, S. N., Körner, R., Quarsten, H., Kristiansen, C., Madsen, L. S., Fugger, L. H., Scott, H., Norén, O., Roepstorff, P., et al. (1998) · Nature Medicine · doi:10.1038/nm0698-713 · Cited by 1,166
Autoimmune T cell responses in the central nervous system
Goverman, J. M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2550 · Cited by 1,057
Newly identified genetic risk variants for celiac disease related to the immune response
Hunt, K. A., Zhernakova, A., Turner, G., Heap, G., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., et al. (2008) · Nature Genetics · doi:10.1038/ng.102 · Cited by 685
Self-citationvan Heel, D. A., Franke, L., Hunt, K. A., Gwilliam, R., Zhernakova, A., Inouye, M., Wapenaar, M. C., Barnardo, M., Bethel, G., Holmes, G. K. T., et al. (2007) · Nature Genetics · doi:10.1038/ng2058 · Cited by 662
Self-citationFollicular B helper T cells in antibody responses and autoimmunity
Vinuesa, C. G., Tangye, S. G., Moser, B., & Mackay, C. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1714 · Cited by 646
Karell, K., Louka, A. S., Moodie, S. J., Ascher, H., Clot, F., Greco, L., Ciclitira, P. J., Sollid, L. M., & Partanen, J. (2003) · Human Immunology · doi:10.1016/s0198-8859(03)00027-2 · Cited by 612
Epidermal Transglutaminase (TGase 3) Is the Autoantigen of Dermatitis Herpetiformis
Sárdy, M., Kárpáti, S., Merkl, B., Paulsson, M., & Smyth, N. R. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011299 · Cited by 515
Research works printed but not linked: 4
- Gee, 1888, On the coeliac affection, St Bartholomews Hosp Rep, 24, 17
- Hadjivassiliou M, Aeschlimann P, Sanders DS, et al. Antibodies against TG6 as the only serological marker of gluten ataxia. Proceedings of the 13th International Coeliac Disease Symposium. Amsterdam; April 6–8, 2009. 09.1.
- Rao, 2007, Sensory neuronopathy due to gluten sensitivity, Ann Indian Acad Neurol, 10, 16
- Hadjivassiliou, 2005, Glutamic acid decarboxylase as a target antigen in gluten sensitivity: the link to neurological manifestations?, J Neurol Neurosurg Psychiatry Proceedings of the Association of British Neurologists Meeting, 76, 150
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Sorted by citations
Items 401–403 of 403
Prevalência de doença celíaca em pacientes com doenças desmielinizantes do sistema nervoso central
de Oliveira, P. (2014) · Americanae (AECID Library)
Impact of Whole Grain Consumption Compliance on Gluten Sensitivity and Bowel Health
Roberts, S. (2015) · ScholarWorks (Walden University) · doi:10.13140/rg.2.1.2016.7849
Estudo da possível associação entre a doença celíaca e as desordens do espectro autista
Batista, I. C. (2011) · Americanae (AECID Library)
Metadata
- Authors
- Hadjivassiliou, M., Sanders, D. S., Grünewald, R. A., Woodroofe, N., Boscolo, S., & Aeschlimann, D.
- Affiliations
- Royal Hallamshire Hospital (GB)
- University of Trieste (IT)
- Cardiff University (GB)
- Corresponding author
- Hadjivassiliou, Marios
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 9
- Issue
- 3
- Pages
- 318-330
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W1992303087
- Cited by
- 404
- References
- 137
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 16 · 2023: 15 · 2022: 15 · 2021: 24 · 2020: 21 · 2019: 21 · 2018: 17 · 2017: 29 · 2016: 23 · 2015: 37 · 2014: 39 · 2013: 30 · 2012: 36
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (submittedVersion)
- Funders
- Ryder Briggs Neuroscience Research Fund
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- gluten sensitivity, celiac disease, neurological symptoms, autoimmune disease, pathophysiology, diagnosis
- MeSH terms
- Animals, Brain Diseases, Celiac Disease, Gastrointestinal Diseases, Glutens, Humans, Nervous System Diseases, Diet, Gluten-Free
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