Alzheimer’s disease: Clinical trials and drug development

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Memantine in Moderate-to-Severe Alzheimer's Disease

Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560

Turning Donepezil into a Multi‐Target‐Directed Ligand through a Merging Strategy

Perone, R. C., Albertini, C., Uliassi, E., Pietri, F. D., Pinheiro, P. D. S. M., Petralla, S., Rizzardi, N., Fato, R., Pulkrabkova, L., Soukup, O., et al. (2020) · ChemMedChem · doi:10.1002/cmdc.202000484 · Cited by 22

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Pauls, E., Bayod, S., Mateo, L., Alcalde, V., Juan-Blanco, T., Sánchez‐Soto, M., Saido, T. C., Saito, T., Berenguer, A., Attolini, C. S., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00983-y · Cited by 23

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

Olloquequi, J., Ettcheto, M., Cano, A. C., Fortuna, A. C., Bicker, J., Sánchez‐López, E., Paz, C., Ureña, J. M., Verdaguer, E., Auladell, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814177 · Cited by 25

Polysaccharides: potential bioactive macromolecules for Alzheimer’s disease

Peng, G., Li, M., & Meng, Z. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1249018 · Cited by 23

The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer’s disease

Angelucci, F., Gelfo, F., Fiore, M., Croce, N., Mathé, A. A., Bernardini, S., & Caltagirone, C. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0099 · Cited by 23

Nanotechnology Building Blocks for Intervention with Alzheimer’s Disease Pathology: Implications in Disease Modifying Strategies

Nazem, A. (2014) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.1000101 · Cited by 20

Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

Tsvetkov, P. O., Cheglakov, I. B., Ovsepyan, A. A., Mediannikov, O., Morozov, A. O., Telegin, G. B., & Kozin, S. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150031 · Cited by 22

Self-Assembly Molecular Chaperone to Concurrently Inhibit the Production and Aggregation of Amyloid β Peptide Associated with Alzheimer’s Disease

Huang, F., Qu, A., Yang, H., Zhu, L., Zhou, H., Liu, J., Long, J., & Shi, L. (2018) · ACS Macro Letters · doi:10.1021/acsmacrolett.8b00495 · Cited by 22

Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality

Rashid, U., & Ansari, F. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50002-7 · Cited by 23

AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer’s disease

Fang, J., Wang, L., Li, Y., Lian, W., Pang, X., Wang, H., Yuan, D., Wang, Q., Liu, A., & Du, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178347 · Cited by 21

Advancements of the sFIDA method for oligomer‐based diagnostics of neurodegenerative diseases

Kulawik, A., Heise, H., Zafiu, C., Willbold, D., & Bannach, O. (2018) · FEBS Letters · doi:10.1002/1873-3468.12983 · Cited by 21

Greenspace Inversely Associated with the Risk of Alzheimer’s Disease in the Mid-Atlantic United States

Wu, J., & Jackson, L. E. (2021) · Earth · doi:10.3390/earth2010009 · Cited by 21

Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice

Bao, J., Liang, Z., Gong, X., Zhao, Y., Wu, M., Liu, W., Tu, C., Wang, X., & Shu, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07241 · Cited by 21

The Potential Role of miRNA-Regulated Autophagy in Alzheimer’s Disease

Zhang, H., Liang, J., & Chen, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147789 · Cited by 22

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Honarnejad, K., Daschner, A., Giese, A., Zall, A., Schmidt, B., Szybińska, A., Kuźnicki, J., & Herms, J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080645 · Cited by 23

CHF 5074 restores visual memory ability and pre‐synaptic cortical acetylcholine release in pre‐plaque Tg2576 mice

Giuliani, A., Beggiato, S., Baldassarro, V. A., Mangano, C., Giardino, L., Imbimbo, B. P., Antonelli, T., Calzà, L., & Ferraro, L. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12136 · Cited by 23

BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR

Makani, V. S., Jang, Y.-G., Christopher, K., Judy, W., Eckstein, J. M., Hensley, K., Chiaia, N. L., Kim, D.-S., & Park, J. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149715 · Cited by 21

Benefits of Deep Transcranial Magnetic Stimulation in Alzheimer Disease

Avirame, K., Stehberg, J., & Todder, D. (2015) · Journal of Ect · doi:10.1097/yct.0000000000000286 · Cited by 24

TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides

Lü, X., Brickson, C., & Murphy, R. M. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00150 · Cited by 21

Anti-Aβ drug candidates in clinical trials and plasmonic nanoparticle-based drug-screen for Alzheimer's disease

Lee, D., Lee, G., & Yoon, D. S. (2018) · The Analyst · doi:10.1039/c7an02013a · Cited by 20

Patients and agents – or why we need a different narrative: a philosophical analysis

Walach, H., & Loughlin, M. (2018) · Philosophy Ethics and Humanities in Medicine · doi:10.1186/s13010-018-0068-x · Cited by 23

Dynamics of Inter-Molecular Interactions Between Single Aβ42 Oligomeric and Aggregate Species by High-Speed Atomic Force Microscopy

Feng, L., Watanabe, H., Molino, P. J., Wallace, G. G., Phung, S. L., Uchihashi, T., & Higgins, M. J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.044 · Cited by 21

Determination and Comparison of Short-Chain Fatty Acids in Serum and Colon Content Samples: Alzheimer’s Disease Rat as a Case Study

Guo, L., Tong, Y., Wang, J., Yin, G., Huang, H.-S., Zeng, L., Wang, P., Li, J., Bi, K., & Wang, T. (2020) · Molecules · doi:10.3390/molecules25235739 · Cited by 21

Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives

Zhao, H., Huang, X., & Tong, Z. (2021) · ChemMedChem · doi:10.1002/cmdc.202100428 · Cited by 21

Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease

Liu, H., & Le, W. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-7 · Cited by 21

New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

Sozio, P., Marinelli, L., Cacciatore, I., Fontana, A., Türkez, H., Giorgioni, G., Ambrosini, D., Barbato, F., Grumetto, L., Pacella, S., et al. (2013) · Molecules · doi:10.3390/molecules180910747 · Cited by 21

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1ΔE9 mice: potential mechanism underlying cognitive impairment

Wang, J., Cheng, X., Zhang, X., Wang, T.-X., Xu, W., Li, F., Liu, F., Cheng, J., Bo, X., Wang, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8453 · Cited by 21

Why are drug trials in Alzheimer's disease failing?

Smith, A. D. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61994-0 · Cited by 21

From Molecules to Medicines: The Role of AI-Driven Drug Discovery Against Alzheimer’s Disease and Other Neurological Disorders

Alghamdi, M. A. (2025) · Pharmaceuticals · doi:10.3390/ph18071041 · Cited by 23

The battle of Alzheimer’s Disease – the beginning of the future Unleashing the potential of academic discoveries

Lundkvist, J., Halldin, M. M., Sandin, J., Nordvall, G., Forsell, P. K. A. L., Svensson, S., Jansson, L., Johansson, G., Winblad, B. G., & Ekstrand, J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00102 · Cited by 21

Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer’s disease model

Pinz, M. P., Vogt, A. G., Rodrigues, K. D. C., dos Reis, A. S., Duarte, L. F. B., Fronza, M. G., Domingues, W. B., Blödorn, E. B., Alves, D. A. C., Campos, V. F., et al. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00703-w · Cited by 21

Ang(1–7) exerts Nrf2-mediated neuroprotection against amyloid beta-induced cognitive deficits in rodents

Varshney, V., & Garabadu, D. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06447-1 · Cited by 20

MiR‐483‐3p improves learning and memory abilities via XPO1 in Alzheimer's disease

Luo, G., Wang, X., & Liu, C. (2022) · Brain and Behavior · doi:10.1002/brb3.2680 · Cited by 20

De Novo Generation and Identification of Novel Compounds with Drug Efficacy Based on Machine Learning

He, D., Liu, Q., Mi, Y., Meng, Q., Xu, L., Hou, C., Wang, J., Li, N., Liu, Y., Chai, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202307245 · Cited by 20

Polyphenols and Their Biogenic Nano‐Formulations Targeting BACE1 as Anti‐Amyloid Therapies; Meeting the Challenges of Bioavailability, Safety, and Specificity for the Treatment of Alzheimer's Disease

Elawad, M. A., Ayaz, M., Mosa, O. F., Usman, A., Hamdoon, A. A. E., Almawash, S., Salim, L. H. M., Ahmed, A., & Elkhalifa, M. E. M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400525 · Cited by 20

Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): A paradigm worth exploring

Stroh, M. A., Swerdlow, R. H., & Zhu, H. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.022 · Cited by 20

Substituent, Charge, and Size Effects on the Fluorogenic Performance of Amyloid Ligands: A Small-Library Screening Study

Donabedian, P. L., Evanoff, M., Monge, F. A., Whitten, D. G., & Chi, E. Y. (2017) · ACS Omega · doi:10.1021/acsomega.7b00231 · Cited by 20

In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer’s disease

Hu, X., Dong, W., Cui, Z.-W., Gao, C., Yu, Z., Yuan, Q., & Min, Z.-L. (2018) · Journal of Molecular Modeling · doi:10.1007/s00894-018-3696-6 · Cited by 20

Memory Function and Brain Functional Connectivity Adaptations Following Multiple-Modality Exercise and Mind–Motor Training in Older Adults at Risk of Dementia: An Exploratory Sub-Study

Silva, N. C. B. S., Nagamatsu, L. S., Gill, D. P., Owen, A. M., & Petrella, R. J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00022 · Cited by 22

Neuroprotective effect of single-wall carbon nanotubes with built-in peroxidase-like activity against β-amyloid-induced neurotoxicity

Shin, J., Lee, S.-J., & Cha, M. (2017) · MedChemComm · doi:10.1039/c6md00716c · Cited by 20

Personalized Gaussian Processes for Future Prediction of Alzheimer's Disease ProgressionPreprint

Peterson, K., Rudovic, O. O., Guerrero, R., & Picard, R. W. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1712.00181 · Cited by 20

Quantum Dots Application in Neurodegenerative Diseases

Hasannejad-Asl, B., Pooresmaeil, F., Choupani, E., Fadaie, M., Hamidinejad, M. A., & Ahmadvand, D. (2021) · Thrita · doi:10.5812/thrita.100105 · Cited by 21

Scopolamine Impairs Spatial Information Recorded With “Miniscope” Calcium Imaging in Hippocampal Place Cells

Sun, D., Unnithan, R. R., & French, C. R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.640350 · Cited by 22

Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders

Dong, X., & Nao, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154501 · Cited by 18

Interactions between Beta-Amyloid and Pericytes in Alzheimer’s Disease

Li, Y.-Y., Guo, D.-D., Duan, R., & Li, Y. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904136 · Cited by 19

A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories

Duchesne, S., Rousseau, L., Belzile, F., Welch, L., Cournoyer, B., Arseneau, M., Lapierre, V., Poulin, S., Potvin, O., & Hudon, C. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230772 · Cited by 24

Cognitive Aging and Early Diagnosis Challenges in Alzheimer's Disease

Britton, G. B., & Rao, K. S. J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110239 · Cited by 21

Activating mitochondrial function and haemoglobin expression with EH‐201, an inducer of erythropoietin in neuronal cells, reverses memory impairment

Horng, L., Hsu, P. S., Chen, L., Tseng, W.-Z., Hsu, K., Wu, C., & Wu, R.-T. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13248 · Cited by 19

When Will Alzheimer's Disease be Cured? A Pharmaceutical Perspective

Townsend, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110020 · Cited by 19

Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations

Xu, J., Kong, X., Qiu, L., Geng, X., Yuanjia, H., & Wang, Y. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.915943 · Cited by 19

Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells

Choi, J., An, X., Lee, B. H., Lee, J. S., Heo, H. J., Kim, T., Ahn, J.-W., & Kim, D. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0296-4 · Cited by 19

β-glucan attenuated scopolamine induced cognitive impairment via hippocampal acetylcholinesterase inhibition in rats

Haider, A., Inam, W., Khan, S. A., Hifza, Mahmood, W., & Abbas, G. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.017 · Cited by 19

Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations

Yu, T., Paudel, P., Seong, S. H., Kim, J. A., Jung, H. A., & Choi, J. S. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.04.008 · Cited by 20

Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions

Mizuki, D., Qi, Z., Tanaka, K., Fujiwara, H., Ishikawa, T., Higuchi, Y., & Matsumoto, K. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13252fp · Cited by 20

Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy

Lambracht‐Washington, D., & Rosenberg, R. N. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.12.007 · Cited by 19

The neuroprotective effects of Chinese bayberry leaves proanthocyanidins

Li, L., Zhang, Y., Sun, B., Zhang, H., Tao, W., Tian, J., Ye, X., & Chen, S. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.031 · Cited by 19

GOOD or BAD Responder? Behavioural and Neuroanatomical Markers of Clinical Response to Donepezil in Dementia

Bottini, G., Berlingeri, M., Basilico, S., Passoni, S., Danelli, L., Colombo, N., Sberna, M., Franceschi, M., Sterzi, R., & Paulesu, E. (2012) · Behavioural Neurology · doi:10.1155/2012/538542 · Cited by 18

Treatment of Alzheimer Disease and Prognosis of Dementia

Yaffe, K. S. (2010) · JAMA · doi:10.1001/jama.2010.1625 · Cited by 19

The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease

Yao, Z., Zhang, L., Liang, L., Liu, Y., Yang, Y., Huang, L., Zhu, H., Ma, C., & Qin, C. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/518421 · Cited by 19

Monodisperse Carboxyl-Functionalized Poly(Ethylene Glycol)-Coated Magnetic Poly(Glycidyl Methacrylate) Microspheres: Application to the Immunocapture of β-Amyloid Peptides

Horák, D., Hlídková, H., Hiraoui, M., Taverna, M., Proks, V., Chánová, E. M., Smadja, C., & Kučerová, Z. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400249 · Cited by 19

Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer’s disease

Sepehri, S., Saeedi, M., Larijani, B. A., & Mahdavi, M. R. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.936240 · Cited by 18

Clinical benefits of green tea consumption for cognitive dysfunction

Ide, K., & Yamada, H. (2015) · PharmaNutrition · doi:10.1016/j.phanu.2015.07.001 · Cited by 19

Decreased Cerebrospinal Fluid Levels of L-Carnitine in Non-Apolipoprotein E4 Carriers at Early Stages of Alzheimer's Disease

Lodeiro, M., Ibáñez, C., Cifuentes, A., Simó, C., & Cedazo-Mı́nguez, Á. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132063 · Cited by 16

The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor

Rojsanga, P., Boonyarat, C., Utsintong, M., Nemecz, Á., Yamauchi, J. G., Talley, T. T., Olson, A. J., Matsumoto, K., & Vajragupta, O. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.06.017 · Cited by 18

Cerebrospinal Fluid Proteins as Regulators of Beta‐amyloid Aggregation and Toxicity

Pate, K. M., & Murphy, R. M. (2017) · Israel Journal of Chemistry · doi:10.1002/ijch.201600078 · Cited by 17

Unlocking Human Brain Metabolism by Genome-Scale and Multiomics Metabolic Models: Relevance for Neurology Research, Health, and Disease

Sertbaş, M., & Ülgen, K. Ö. (2018) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2018.0088 · Cited by 18

Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer’s disease

Zhang, P., Wang, Z., Mou, C., Zou, J., Xie, Y., Liu, Z., Naman, C. B., Mao, Y., Wei, J., Huang, X., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105387 · Cited by 18

Effect of Rheum Ribes Hydro-Alcoholic Extract on Memory Impairments in Rat Model of Alzheimer's Disease.

Zahedi, M., Hojjati, M. R., Fathpour, H., Rabiei, Z., Alibabaei, Z., & Basim, A. (2015) · Europe PMC (PubMed Central) · Cited by 18

Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer’s Disease

Mecocci, P., Polidori, M. C., & Praticò, D. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-62703-598-9_16 · Cited by 18

The Evolution of AChE Inhibitors in Alzheimer's Disease: From Single‐Target to Multi‐Target Ligands

Mehta, N. V., Kapadia, A., Khambete, M., & Abhyankar, A. N. (2025) · ChemBioChem · doi:10.1002/cbic.202500053 · Cited by 20

Advancements in Pharmacological Treatment of Alzheimer’s Disease: The Advent of Disease-Modifying Therapies (DMTs)

Wang, Q., Chen, S., Wang, J., Shang, H., & Chen, X. (2024) · Brain Sciences · doi:10.3390/brainsci14100990 · Cited by 18

Harnessing artificial intelligence in Alzheimer's disease management: navigating ethical challenges in AI

Habibi, F., Ghaderkhani, S., Shokoohi, M., Banari, T., Morsali, M., Abadi, R. N. S., & Kiamehr, H. (2025) · AI and Ethics · doi:10.1007/s43681-025-00673-0 · Cited by 19

The Effects of Bushen Capsule on Episodic Memory in Amnestic Mild Cognitive Impairment Patients: A Pilot Placebo Controlled fMRI Study

Zhang, J., Xu, K., Wei, D., Guo, R., Li, H., Wang, Y., & Zhang, Z. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150004 · Cited by 17

The Recent Updates of Therapeutic Approaches Against Aβ for the Treatment of Alzheimer's Disease

Ling, S., Zhou, J., Rudd, J. A., Hu, Z., & Fang, M. (2011) · The Anatomical Record · doi:10.1002/ar.21425 · Cited by 17

Amyloids of multiple species: are they helpful in survival?

Upadhyay, A., & Mishra, A. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12399 · Cited by 17

Centre- versus home-based exercise among people with mci and mild dementia: study protocol for a randomized parallel-group trial

Middleton, L. E., Black, S. E., Herrmann, N., OH, P. I., Regan, K., & Lanctôt, K. L. (2018) · BMC Geriatrics · doi:10.1186/s12877-017-0684-0 · Cited by 20

Pharmakologische Therapie der Alzheimer-Demenz

Müller, P., Fendt, M., & Müller, N. (2019) · Der Internist · doi:10.1007/s00108-019-0625-4 · Cited by 17

Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway

Qu, X., Guan, P., Han, L., Wang, Z., & Huang, X. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00943-1 · Cited by 18

Reliability of Changes in Brain Volume Determined by Longitudinal Voxel‐Based Morphometry

Takao, H., Amemiya, S., Abe, O., & Initiative, A. D. N. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27568 · Cited by 17

Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway

Park, H., Yoo, J.-S., Kim, J., Hwang, B. Y., Han, J., Yeon, S.-W., & Kang, J. (2014) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2014.01.008 · Cited by 17

Brain investigation and brain conceptualization.

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Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation

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