Alzheimer’s disease: Clinical trials and drug development

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Memantine in Moderate-to-Severe Alzheimer's Disease

Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560

Progress in the development of new drugs in Alzheimer's disease

Piau, A., Nourhashémi, F., Hein, C., Caillaud, C., & Vellas, B. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0012-x · Cited by 32

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

Bahari‐Javan, S., Sananbenesi, F., & Fischer, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00160 · Cited by 40

Passive Immunotherapies Targeting Amyloid Beta and Tau Oligomers in Alzheimer’s Disease

Zanden, C. M. V., & Chi, E. Y. (2019) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2019.10.024 · Cited by 40

Protective effects of vitamin D on learning and memory deficit induced by scopolamine in male rats: the roles of brain-derived neurotrophic factor and oxidative stress

Mansouri, F., Ghanbari, H., Marefati, N., Arab, Z., Salmani, H., Beheshti, F., & Hosseini, M. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02062-w · Cited by 43

Intra- and inter-cortical motor excitability in Alzheimer’s disease

Hoeppner, J., Wegrzyn, M., Thome, J., Bauer, A., Oltmann, I., Buchmann, J., & Teipel, S. (2012) · Journal of neural transmission · doi:10.1007/s00702-011-0738-y · Cited by 37

Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice

Zhang, J., Yue, X., Luo, H., Jiang, W., Mei, Y., Ai, L., Gao, G., Wu, Y., Yang, H. M., An, J., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7520 · Cited by 41

Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer’s disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids

Pan, T., Xie, S., Zhou, Y., Hu, J., Luo, H., Li, X., & Huang, L. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.06.056 · Cited by 40

Commentary on “Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.” A Canadian perspective

Gauthier, S. G., Patterson, C., Gordon, M., Soucy, J., Schubert, F., & Leuzy, A. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.03.006 · Cited by 40

Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases

Wang, H., Liu, S., Sun, Y., Chen, C., Hu, Z., Li, Q., Long, J., Yan, Q., Liang, J., Lin, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102472 · Cited by 39

A Peptide‐Drug Conjugate‐Based Nanoplatform for Immunometabolic Activation and In Situ Nerve Regeneration in Advanced‐Stage Alzheimer's Disease

Liu, P., Zhang, T., Wu, Y., Chen, Q., Sun, T., & Jiang, C. (2024) · Advanced Materials · doi:10.1002/adma.202408729 · Cited by 42

Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons

Chen, B., Teng, Y., Zhang, X., Lv, X., & Yin, Y. (2016) · BioMed Research International · doi:10.1155/2016/1421430 · Cited by 39

Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction

Kiametis, A. S., Silva, M. A., Romeiro, L. A. S., Martins, J. B. L., & Gargano, R. (2017) · Journal of Molecular Modeling · doi:10.1007/s00894-017-3228-9 · Cited by 40

Azure C Targets and Modulates Toxic Tau Oligomers

Cascio, F. L., & Kayed, R. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00501 · Cited by 41

Cyanidin-3- O -glucoside inhibits Aβ40 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity

Liu, F., Zhao, F., Wang, W., Sang, J., Jia, L., Li, L., & Lu, F. (2020) · Food & Function · doi:10.1039/c9fo00316a · Cited by 39

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

Lalut, J., Payan, H., Davis, A., Lecoutey, C., Legay, R., Santos, J. S. O., Claeysen, S., Dallemagne, P., & Rochais, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-59805-7 · Cited by 41

Nanoliposomes as a Therapeutic Tool for Alzheimer’s Disease

Ordóñez‐Gutiérrez, L., & Wandosell, F. G. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00020 · Cited by 40

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

Monge‐Fuentes, V., Gomes, F. M. M., Campos, G. A. A., Silva, J. D. C., Biolchi, A. M., dos Anjos, L. C., Gonçalves, J. C., Lopes, K. S., & Mortari, M. R. (2015) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1186/s40409-015-0031-x · Cited by 41

Vaccination against Alzheimer disease

Fettelschoss‐Gabriel, A., Zabel, F., & Bachmann, M. F. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.28183 · Cited by 39

Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads

Panza, F., Frisardi, V., Imbimbo, B. P., Seripa, D., Solfrizzi, V., & Pilotto, A. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.579099 · Cited by 38

CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer’s disease in the Chinese Han population

Yan, H., Kong, Y., He, B., Huang, M., Li, J., Zheng, J., Liang, L., Bi, J., Zhao, S., & Shi, L. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.024 · Cited by 38

Nucleic Acid-Based Theranostics for Tackling Alzheimer's Disease

Chakravarthy, M., Chen, S., Dodd, P. R., & Veedu, R. N. (2017) · Theranostics · doi:10.7150/thno.21529 · Cited by 39

A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice

Yang, S., Shin, J., Shin, N. N., Hwang, J., Hong, S.-C., Park, K., Lee, J. W., Lee, S., Baek, S., Kim, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40205-5 · Cited by 38

Modulation of Amyloid-β42 Conformation by Small Molecules Through Nonspecific Binding

Liang, C., Savinov, S. N., Fejzo, J., Eyles, S. J., & Chen, J. (2019) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.9b00599 · Cited by 41

Genetics and epigenetics of Alzheimer's disease

Alagiakrishnan, K., Gill, S. S., & Fagarasanu, A. D. (2012) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2011-130363 · Cited by 40

Charting a path toward combination therapy for Alzheimer’s disease

Stephenson, D., Perry, D., Bens, C., Bain, L. J., Berry, D., Krams, M., Sperling, R., Dilts, D., Luthman, J., Hanna, D., et al. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.995168 · Cited by 37

mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases

Shang, D., Huang, M., Wang, B., Yan, X., Wu, Z., & Zhang, X. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220810114644 · Cited by 44

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3

Kang, M. S., Baek, S., Chun, Y. S., Moore, A. Z., Landman, N., Berman, D. E., Yang, H. O., Morishima‐Kawashima, M., Osawa, S., Funamoto, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445734 · Cited by 38

Epigenetics of Alzheimer's Disease and Frontotemporal Dementia

Veerappan, C. S., Sleiman, S. F., & Coppola, G. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0219-0 · Cited by 38

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds

Joseph‐Mathurin, N., Dorieux, O., Trouche, S. G., Boutajangout, A., Kraska, A., Fontès, P., Verdier, J., Sigurdsson, E. M., Mestre‐Francés, N., & Dhénain, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.013 · Cited by 38

The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity in human neuroblastoma SH-SY5Y cells

Xiao, Z., Huang, C., Wu, J., Sun, L., Hao, W., Leung, L. K., & Huang, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.09.023 · Cited by 37

A study on knowledge, attitudes and health behaviours regarding A lzheimer's disease among community residents in T ianjin, C hina

Yang, H., Cong, J. ‐., Zang, X., Jiang, N., & Zhao, Y. (2015) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.12259 · Cited by 38

Recent studies on cellular and molecular mechanisms in Alzheimer’s disease: focus on epigenetic factors and histone deacetylase

Dubey, H., Gulati, K., & Ray, A. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0049 · Cited by 36

Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far

Bazzari, F. H., Abdallah, D. M., & El-Abhar, H. S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190301111120 · Cited by 39

Age‐related neurodegenerative diseases

Duggan, M. R., Torkzaban, B., Ahooyi, T. M., Khalili, K., & Gordon, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29248 · Cited by 40

ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel Drug Targets in Neurodegenerative Disorders

Maqoud, F., Scala, R., Hoxha, M., Zappacosta, B., & Tricarico, D. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210119095626 · Cited by 39

Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β

Chai, A. B., Lam, H. H. J., Kockx, M., & Gelissen, I. C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158980 · Cited by 41

Retinal Imaging Techniques Based on Machine Learning Models in Recognition and Prediction of Mild Cognitive Impairment

Zhang, Q., Li, J., Bian, M., He, Q., Shen, Y., Lan, Y., & Huang, D. F. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s333833 · Cited by 36

Modulating Nitric Oxide Signaling in the Cns for Alzheimer’s Disease Therapy

Zhihui, Q. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.111 · Cited by 37

Design and Synthesis of Neuroprotective Methylthiazoles and Modification as NO-Chimeras for Neurodegenerative Therapy

Qin, Z., Luo, J., VandeVrede, L. A., Tavassoli, E., Fà, M., Teich, A. F., Arancio, O., & Thatcher, G. R. J. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300353r · Cited by 37

Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice

Chen, P., Chen, F., Lei, J., & Zhou, B. (2023) · Phytotherapy Research · doi:10.1002/ptr.7848 · Cited by 38

Impaired retention in AβPP Swedish mice six months after oral exposure to chlorpyrifos

Peris‐Sampedro, F., Salazar, J. G., Cabré, M., Reverte, I., Domingo, J. L., Sánchez-Santed, F., & Colomina, M. T. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.07.036 · Cited by 36

Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease

Svedružić, Ž. M., Popović, K., & Jengić, V. Š. (2013) · PLoS ONE · doi:10.1371/journal.pone.0050759 · Cited by 35

Memory defect induced by beta-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms

Xia, Z., Zhang, R., Wu, P., Xia, Z., & Hu, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.008 · Cited by 36

Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer’s disease: a novel diagnostic marker

Jiao, S.-S., Bu, X., Liu, Y.-H., Wang, Q.-H., Liu, C.-H., Yao, X.-Q., Zhou, X., & Wang, Y.-J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.146 · Cited by 34

Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study

Pan, K., Xu, W., Mangialasche, F., Dekhtyar, S., Fratiglioni, L., & Wang, H. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180870 · Cited by 36

Mindfulness and psychoeducation to manage stress in amnestic mild cognitive impairment: A pilot study

Chouinard, A.-M., Larouche, E., Audet, M.-C., Hudon, C., & Goulet, S. (2019) · Aging & Mental Health · doi:10.1080/13607863.2018.1484890 · Cited by 35

An updated Alzheimer’s disease progression model: incorporating non-linearity, beta regression, and a third-level random effect in NONMEM

Conrado, D. J., Denney, W. S., Chen, D., & Ito, K. (2014) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-014-9375-z · Cited by 35

Coriandrum sativumSuppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation

Liu, Q. F., Jeong, H., Lee, J. H., Hong, Y. K., Oh, Y., Kim, Y., Suh, Y. S., Bang, S. M., Yun, H. S., Lee, K., et al. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500749 · Cited by 34

Benzimidazole-derived Compounds Designed for Different Targets of Alzheimer’s Disease

Gülcan, H. O., Mavideniz, A., Sahin, M. F., & Orhan, İ. E. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190124123208 · Cited by 35

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors

Shi, C., Peng, W., Zhao, J., Yang, H., Qu, L., Wang, C., Kong, L., & Wang, X. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111961 · Cited by 36

Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

Wang, Y., Pan, W., Liang, W.-C., Law, W.-K., Ip, D. T.-M., Ng, T., Waye, M. M. Y., & Wan, D. C. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/937370 · Cited by 35

Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression

Naser, S. S., Singh, D., Preetam, S., Kishore, S., Kumar, L., Nandi, A., Simnani, F. Z., Choudhury, A., Sinha, A., Mishra, Y. K., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100701 · Cited by 37

Latrepirdine for Alzheimer's disease

Chau, S. A., Herrmann, N., Ruthirakuhan, M. T., Chen, J. J., & Lanctôt, K. L. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009524.pub2 · Cited by 34

The human β-amyloid precursor protein: biomolecular and epigenetic aspects

Nguyen, K. V. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2014-0041 · Cited by 39

Fast in vivo imaging of amyloid plaques using μ-MRI Gd-staining combined with ultrasound-induced blood–brain barrier opening

Santin, M. D., Debeir, T., Bridal, S. L., Rooney, T., & Dhénain, M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.106 · Cited by 34

Benzothiazepine CGP37157 and Its Isosteric 2′-Methyl Analogue Provide Neuroprotection and Block Cell Calcium Entry

González‐Lafuente, L., Egea, J., Leon, R. M., Martínez-Sanz, F. J., Monjas, L., Pérez, C., Merino, C., de Diego, A. M. G., Rodrı́guez-Franco, M. I., de Diego, A. M. G., et al. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300009e · Cited by 34

Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease

Jeon, S. G., Kim, Y. J., Kim, K. A., Mook‐Jung, I., & Moon, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0918-y · Cited by 33

Cognitive changes following multiple-modality exercise and mind-motor training in older adults with subjective cognitive complaints: The M4 study

Silva, N. C. B. S., Gill, D. P., Owen, A. M., Liu-Ambrose, T. Y. L., Hachinski, V., Shigematsu, R., & Petrella, R. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196356 · Cited by 37

High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Prefibrillar Amyloid Protein Aggregates

Fanni, A. M., Monge, F. A., Lin, C., Thapa, A., Bhaskar, K., Whitten, D. G., & Chi, E. Y. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00719 · Cited by 35

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Sergeant, N., Vingtdeux, V., Eddarkaoui, S., Gay, M., Evrard, C., Fur, N. L., Laurent, C., Caillierez, R., Obriot, H., Larchanché, P.-E., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.028 · Cited by 36

Tamoxifen for amyotrophic lateral sclerosis

Chen, P.-C., Hsieh, Y., Huang, C., & Hu, C. (2020) · Medicine · doi:10.1097/md.0000000000020423 · Cited by 34

Multifaceted Alzheimer’s Disease: Building a Roadmap for Advancement of Novel Therapies

Kaur, D., Behl, T., Sehgal, A., Singh, S., Sharma, N., & BUNGAU, S. G. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03415-w · Cited by 34

Comparison of the chemical constituents and anti-Alzheimer’s disease effects of Uncaria rhynchophylla and Uncaria tomentosa

Xu, Q., Shaw, P. C., Hu, Z. J., Yang, W., Ip, S., Xian, Y., & Lin, Z. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00514-2 · Cited by 34

β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease

Mohaupt, P., Pons, M., Vialaret, J., Delaby, C., Hirtz, C., & Lehmann, S. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01125-1 · Cited by 34

Beyond Amyloid

Lane, R. F., Shineman, D. W., Steele, J., Lee, L. H., & Fillit, H. M. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-394816-8.00007-6 · Cited by 35

The development of quality indicators to improve psychosocial care in dementia

Vasse, E., Moniz-Cook, E. D., Rikkert, M. G. M. O., Cantegreil, I., Charras, K., Dorenlot, P., Fumero, G., Franco, M., Woods, B. T., & Vernooij-Dassen, M. J. F. J. (2012) · International Psychogeriatrics · doi:10.1017/s1041610211002523 · Cited by 34

Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults

Prehn, K., Stengl, H., Grittner, U., Kosiolek, R., Ölschläger, A., Weidemann, A., & Flöel, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.170 · Cited by 37

Co‐Assembled Nanoparticles toward Multi‐Target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self‐Assembly

Li, W., Xu, L., Wang, S., Wang, Y., Pan, Y., Shi, L., & Guo, D. (2024) · Advanced Materials · doi:10.1002/adma.202401918 · Cited by 35

A Biocompatible Hydrogen‐Bonded Organic Framework (HOF) as Sonosensitizer and Artificial Enzyme for In‐Depth Treatment of Alzheimer's Disease

Ya, J., Zhang, H., Qin, G., Huang, C., Zhao, C., Ren, J., & Qu, X. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402342 · Cited by 33

Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma

Li, Z., Jiang, S., Wang, J., Li, W., Yang, J., Liu, W., Gao, H., Huang, Y., & Ruan, S. (2025) · Science Advances · doi:10.1126/sciadv.adr8841 · Cited by 35

PKCε Deficits in Alzheimer's Disease Brains and Skin Fibroblasts

Khan, T. K., Sen, A., Hongpaisan, J., Lim, C. S., Nelson, T. J., & Alkon, D. L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141221 · Cited by 33

Long non-coding RNAs in Alzheimer's disease

Zhang, Z. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150813142956 · Cited by 33

Dual Histamine H3R/Serotonin 5-HT4R Ligands with Antiamnesic Properties: Pharmacophore-Based Virtual Screening and Polypharmacology

Lepailleur, A., Fréret, T., Lemaître, S., Boulouard, M., Dauphin, F., Hinschberger, A., Dulin, F., Lesnard, A., Bureau, R., & Rault, S. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci500157n · Cited by 33

Somatic comorbidities and Alzheimer’s disease treatment

Clodomiro, A., Gareri, P., Puccio, G., Frangipane, F., Lacava, R. V., Castagna, A., Manfredi, V. G. L., Colao, R., & Bruni, A. C. (2013) · Neurological Sciences · doi:10.1007/s10072-013-1290-3 · Cited by 35

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β

Povellato, G., Tuxworth, R. I., Hanger, D. P., & Tear, G. (2013) · Biology Open · doi:10.1242/bio.20136692 · Cited by 35

Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models

Zhou, W., Zhong, G., Fu, S., Xie, H., Chi, T., Li, L., Rao, X., Zeng, S., Xu, D., Wang, H., et al. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00125 · Cited by 33

Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model

Caillaud, M., Guillard, J., Richard, D., Milin, S., Chassaing, D., Paccalin, M., Page, G., & Bilan, A. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212663 · Cited by 33

In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds

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Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission

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