Alzheimer’s disease: Clinical trials and drug development

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Memantine in Moderate-to-Severe Alzheimer's Disease

Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice

Li, F., & Kim, M. R. (2019) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2019.24.2.165 · Cited by 16

Alzheimer’s Disease: Development of Disease-Modifying Treatments Is the Challenge for Our Generation

Lindsley, C. W. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300190f · Cited by 16

Neuroprotective Effect of Cudrania tricuspidata Fruit Extracts on Scopolamine-Induced Learning and Memory Impairment

Jee, S.-C., Lee, K. M., Kim, M., Lee, Y.-J., Kim, S., Park, J.-O., & Sung, J.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239202 · Cited by 15

AlzheimerRAG: Multimodal Retrieval-Augmented Generation for Clinical Use Cases

Lahiri, A. K., & Hu, Q. (2025) · Machine Learning and Knowledge Extraction · doi:10.3390/make7030089 · Cited by 26

An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease

Ju, Y., Chakravarty, H., & Tam, K. Y. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00464 · Cited by 16

The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model

Mestdagh, C. F. D. V., Koopmans, F., Breiter, J. C., Timmerman, J. A., Vogelaar, P. C., Krenning, G., Mansvelder, H. D., Smit, A. B., Henning, R. H., & van Kesteren, R. E. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01127-z · Cited by 15

Rosiglitazone attenuates amyloid beta and glial fibrillary acidic protein in the hippocampus and neuroinflammation associated learning and memory impairments in rats

Beheshti, F., Hosseini, M., Bakhtiari-Dovvombaygi, H., Salmani, H., Ahmadabady, S., Marefati, N., & Baghcheghi, Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114549 · Cited by 15

Redox Oxygen Species‐Responsive Nanotheranostics with Dual‐Channel Fluorescent Turn‐On for Early Diagnosis and Targeted Therapy of Alzheimer's Disease

Guo, Q., Wang, T., Qian, C., & Wang, X. (2024) · Small · doi:10.1002/smll.202403980 · Cited by 15

Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory

Pooters, T., der Jeugd, A. V., Callaerts‐Vegh, Z., & D’Hooge, R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.015 · Cited by 15

A peptide-based near-infrared fluorescence probe for dynamic monitoring senile plaques in Alzheimer’s disease mouse model

Wang, C.-W., Nan, D., Wang, X.-M., Ke, Z., Chen, G., & Zhou, J. (2017) · 中国科学通报：英文版 · doi:10.1016/j.scib.2017.11.005 · Cited by 16

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World

Nuzziello, N., Ciaccia, L., & Liguori, M. (2019) · Cells · doi:10.3390/cells9010075 · Cited by 15

Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example

Imami, A. S., McCullumsmith, R. E., & O'Donovan, S. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01724-w · Cited by 17

Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease

Wakeman, D. R., Weed, M. R., Perez, S. E., Cline, E. N., Viola, K. L., Wilcox, K. C., Moddrelle, D. S., Nisbett, E. Z., Kurian, A., Bell, A., et al. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12800 · Cited by 18

Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead

Dai, Y., Lei, C., Zhang, Z., Qi, Y., Lao, K., & Gou, X. (2022) · Current Drug Targets · doi:10.2174/1389450123666220421124030 · Cited by 15

From Small Peptides to Large Proteins against Alzheimer’sDisease

Picone, P., Sanfilippo, T., Vasto, S., Baldassano, S., Guggino, R., Nuzzo, D., Bulone, D., Biagio, P. L. S., Muscolino, E., Monastero, R., et al. (2022) · Biomolecules · doi:10.3390/biom12101344 · Cited by 16

Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia

Zeng, P. H., Liu, Y.-C., Wang, X., Ye, C., Sun, Y., Su, H.-F., Qiu, S.-W., Li, Y., Wang, Y., Wang, Y., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1013891 · Cited by 17

From frontotemporal lobar degeneration pathology to frontotemporal lobar degeneration biomarkers

Hales, C. M., & Hu, W. T. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776522 · Cited by 16

For debate: substituting placebo controls in long-term Alzheimer's prevention trials

Spiegel, R., Berres, M., Miserez, A. R., Monsch, A. U., & Initiative, T. A. D. N. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt68 · Cited by 15

Emerging amyloid and tau targeting treatments for Alzheimer’s disease

Khan, A., Corbett, A., & Ballard, C. G. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1326819 · Cited by 16

A critical overview of therapeutic strategy and advancement for Alzheimer's disease treatment

Kuo, Y., & Rajesh, R. (2017) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2017.05.011 · Cited by 15

Enhancement of Visuospatial Working Memory by the Differential Outcomes Procedure in Mild Cognitive Impairment and Alzheimer’s Disease

Vivas, A. B., Ypsilanti, A., Ladas, A. I., Kounti, F., Tsolaki, M., & Estévez, Á. F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00364 · Cited by 15

Voices from the field: Expert reflections on mild cognitive impairment

Peters, K. R., & Katz, S. (2015) · Dementia · doi:10.1177/1471301214562135 · Cited by 16

Isoliensinine ameliorates cognitive dysfunction in AlCl3/D-gal-induced Alzheimer’s disease-like mice by inhibiting the calcium signaling pathway

Li, J.-Q., Ma, X.-H., Dai, H., Wang, C., Zhang, J., & Meng, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119567 · Cited by 15

Engineering exosomes for Alzheimer's disease: Multi‐target therapeutic strategies from pathogenesis to clinical translation

Zhang, Y. C., Li, Z., Guan, H., Qiu, Z., & Zou, C. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70548 · Cited by 17

Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches

Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 20

Assessing the Role of the Generative Pretrained Transformer (GPT) in Alzheimer’s Disease Management: Comparative Study of Neurologist- and Artificial Intelligence–Generated Responses

Zeng, J., Zou, X., Li, S., Tang, Y., Teng, S., Li, H., Wang, C., Wu, Y., Zhang, L., Zhong, Y., et al. (2024) · Journal of Medical Internet Research · doi:10.2196/51095 · Cited by 16

Dextran sulfate sodium inhibits amyloid‐β oligomer binding to cellular prion protein

Aimi, T., Suzuki, K., Hoshino, T., & Mizushima, T. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13166 · Cited by 14

A noninflammatory immune response in aged DNA Aβ42-immunized mice supports its safety for possible use as immunotherapy in AD patients

Lambracht‐Washington, D., & Rosenberg, R. N. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.011 · Cited by 14

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity

Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S. M., Martins, R. N., & Verdile, G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150790 · Cited by 14

Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities

Işık, A., Çevik, U. A., Karayel, A., Celik, I., Erçetin, T., KOÇAK, A. Ö., Özkay, Y., & Kaplancıklı, Z. A. (2022) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2022.2041723 · Cited by 14

Glaucoma and Alzheimer’s Disease in the Elderly

Bizrah, M., Guo, L., & Cordeiro, M. F. (2011) · Aging Health · doi:10.2217/ahe.11.51 · Cited by 14

From the Multifactorial Nature of Alzheimer`s Disease to Multitarget Therapy: The Contribution of the Translational Approach

Calzà, L., Baldassarro, V. A., Giuliani, A., Lorenzini, L., Fernández, M., Mangano, C., Sivilia, S., Alessandri, M., Gusciglio, M., Torricella, R., et al. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113139990140 · Cited by 14

A gold nanoparticle based colorimetric and fluorescent dual-channel probe for acetylcholinesterase detection and inhibitor screening

Lv, J., He, B., Wang, N., Li, M., & Lin, Y. (2018) · RSC Advances · doi:10.1039/c8ra06165c · Cited by 14

Oxidative Stress-Associated Protein Tyrosine Kinases and Phosphatases in Fanconi Anemia

Li, J., & Pang, Q. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5715 · Cited by 14

Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery

Zhang, Y.-B., Liu, M., Wang, Y., Hu, D., Wu, S., Zhao, B., Zhou, B., & Yang, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177958 · Cited by 14

Neuroprotective effect of combined use of nicotine and celecoxib by inhibiting neuroinflammation in ischemic rats

Gou, J., Liang, S., Cheng, W., Wu, S., Ye, Z., Ma, Y., Yin, Y., & Wang, H. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.022 · Cited by 13

GFP-based red-emissive fluorescent probes for dual imaging of β-amyloid plaques and mitochondrial viscosity

Leng, H., Yang, J., Long, L., Yan, Y., Shi, W., Zhang, L., & Yan, J. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106540 · Cited by 13

Alkaloids and Drug Discovery for Neurodegenerative Diseases

Howes, M. R. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_43 · Cited by 13

4,5-Dimethoxy-2-nitrobenzohydrazides and 1-(1-Benzylpiperidin-4-yl)ethan-1-ones as Potential Antioxidant/Cholinergic Endowed Small Molecule Leads

Banu, R., Gerding, J. S., Franklin, C. E., Sikazwe, D., Horton, W., Török, M., Davis, J. M., Cheng, K. H., Nakazwe, M., & Mochona, B. (2017) · Scientia Pharmaceutica · doi:10.3390/scipharm86010002 · Cited by 13

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

Venter, J., Pérez, C., van Otterlo, W. A. L., Martı́nez, A., & Blackie, M. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.04.049 · Cited by 13

Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1

Wang, Y., Zhang, H., Wang, J., Yu, M., Zhang, Q., Yan, S., You, D., Shi, L., Zhang, L., Wang, L., et al. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1900879 · Cited by 12

Plasminogen decreases Aβ42 and Tau deposition, and shows multi-beneficial effects on Alzheimer's disease in mice and humans

Guo, C., Wang, T., Zhang, D., Ge, X., & Li, J. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.078 · Cited by 13

Nanomedicine-Driven Therapeutic Interventions of Autophagy and Stem Cells in The Management of Alzheimer’s Disease

Alhodieb, F. S., Rahman, M. A., Barkat, M. A., Alanezi, A. A., Barkat, H. A., Hadi, H. A., Harwansh, R. K., & Mittal, V. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0108 · Cited by 13

Oxidative stress hypothesis for Alzheimer’s disease and its potential therapeutic implications

Nunomura, A. (2013) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.53.1043 · Cited by 13

An Action Plan to Face the Challenge of Dementia: INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health

Chertkow, H. M. (2018) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2018.27 · Cited by 14

Preclinical and clinical study on [18F]DRKXH1: a novel β-amyloid PET tracer for Alzheimer’s disease

Xu, M., Guo, J., Gu, J., Zhang, L., Liu, Z., Ding, L., Fu, H., Ma, Y., Liang, S., & Wang, H. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05421-0 · Cited by 12

Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components

Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J., & Eckert, G. P. (2015) · Molecules · doi:10.3390/molecules200916524 · Cited by 13

In Silico Insight into Potent of Anthocyanin Regulation of FKBP52 to Prevent Alzheimer’s Disease

Hung, T.-C., Chang, T., Fan, M., Lee, C.-C., & Chen, C. Y. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/450592 · Cited by 13

Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease

Altimiras, F. J., Uszczyńska-Ratajczak, B., Ferreira, F. C., Vlasova, A. V., Palumbo, E., Newhouse, S., Deacon, R. M. J., Farias, L. A. E., Hurley, M. J., Loyola, D. E., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00064 · Cited by 13

A meta-analysis of bulk RNA-seq datasets identifies potential biomarkers and repurposable therapeutics against Alzheimer’s disease

Lamisa, A. B., Ahammad, I., Bhattacharjee, A., Hossain, M. U., Ishtiaque, A., Chowdhury, Z. M., Das, K. C., Salimullah, M., & Keya, C. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-75431-z · Cited by 13

Towards zebrafish model applications in drug discovery targeting central nervous system diseases and neurotoxicity assessment

Li, H., Li, A., Jin, H., & Bian, X. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177776 · Cited by 13

Synthetic efferocytic receptor microglia enhances anti-inflammatory clearance of amyloid-β for AD treatment in mice

Shao, L., Zhang, Y., Yang, Z., Shi, C., Yue, X., Li, C., Liu, Y., Fu, Z., Tang, C., Zhao, X., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads6613 · Cited by 13

Clinical Pharmacology of Novel Anti-Alzheimer Disease Modifying Medications

Caraci, F., Bosco, P., Leggio, G. M., Malaguarnera, M., Drago, F., Bucolo, C., & Salomone, S. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113139990141 · Cited by 12

Could Management of Blood Pressure Prevent Dementia in the elderly?

Mogi, M. (2019) · Clinical Hypertension · doi:10.1186/s40885-019-0135-7 · Cited by 12

Anti-Cholinesterase Potential of Standardized Extract of PHELA a Traditional South African Medicine Formulation

Das, B., Kar, A., Matsabisa, M. G., & Mukherjee, P. K. (2020) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2020.100348 · Cited by 12

MicroRNA-668-3p regulates oxidative stress and cell damage induced by Aβ1-42 by targeting the OXR1/p53-p21 axis

Li, S., Wu, L., Ma, M., Yang, L.-X., & Qin, C. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3598 · Cited by 11

miR ‐6076 targets BCL6 in SH‐SY5Y cells to regulate amyloid‐β‐induced neuronal damage

Lin, Y., Zhang, L., Gao, M., Tang, Z., Cheng, X., Li, H., Qin, J., Tian, M., Jin, G., Zhang, X., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17999 · Cited by 11

Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats

Ni, L., Liu, B., Zhang, J., Long, Y., Dong, G., Jin, H., & Ma, B. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.09.021 · Cited by 12

Research and development of anti-Alzheimer’s disease drugs: an update from the perspective of technology flows

Liu, K., Lin, H.-H., Pi, R., Mak, S., Han, Y., & Yuanjia, H. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1439475 · Cited by 12

Antioxidant and acetylcholinesterase inhibition activity of aliphatic and aromatic edaravone derivatives

Barajas-Carrillo, V. W., Estolano-Cobián, A., Díaz-Rubio, L., Ayllón-Gutiérrez, R., Salazar‐Aranda, R., Díaz-Molina, R. J., García‐González, V., Almanza-Reyes, H. E., Rivero, I. A., Marrero, J. G., et al. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02667-5 · Cited by 12

Flavonoids: An alternative pathway for the treatment of Alzheimer’s disease

Das, P., Preethi, K., Kiruba, A. A., Nikhil, K., & Nayak, A. (2021) · Annals of Phytomedicine An International Journal · doi:10.21276/ap.2021.10.2.33 · Cited by 13

Determining binding sites of polycyclic aromatic small molecule-based amyloid-beta peptide aggregation modulators using sequence-specific antibodies

Irwin, J. A., Wong, H. E., & Kwon, I. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.10.016 · Cited by 12

Analysis of Technological Developments in the Treatment of Alzheimer’s Disease through Patent Documents

Carvalho, K. M., Winter, E., & Antunes, A. M. D. S. (2015) · Intelligent Information Management · doi:10.4236/iim.2015.75022 · Cited by 13

Network Pharmacology and Mechanism Studies of the Protective Effect of Ginseng against Alzheimerʼs Disease Based on Aβ Pathogenesis

Liu, J., Yu, W., Ma, C., Li, T., Liang, Y., Su, S., Zhong, G., Xie, Z., Wu, Q., Chen, J., et al. (2023) · Planta Medica · doi:10.1055/a-2014-6061 · Cited by 13

A light at the end of the tunnel – from mutation identification to a potential treatment for Alzheimer’s disease

Lannfelt, L. (2023) · Upsala Journal of Medical Sciences · doi:10.48101/ujms.v128.10316 · Cited by 12

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500

Lo, A. C., Tesseur, I. C., Scopes, D. I. C., Nerou, E., Callaerts‐Vegh, Z., Vermaercke, B., Treherne, J. M., Strooper, B. D., & D’Hooge, R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.030 · Cited by 11

Insight of the Cytotoxicity of the Aggregates of Peptides or Aberrant Proteins: A Meta-Analysis

Zhou, R., & Xu, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095759 · Cited by 11

Identification and prediction of m7G-related Alzheimer’s disease subtypes: insights from immune infiltration and machine learning models

Ma, C., Li, J., Chi, Y., Sun, X., Yang, M., & Sui, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1161068 · Cited by 12

Alzheimer’s Disease: Differences of Transdermal versus Oral Treatment on Caregiving Time

Riedel, O., Emmrich, A., Klotsche, J., Dodel, R. C., Förstl, H., Maier, W., Reichmann, H., & Wïttchen, H. (2012) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000342929 · Cited by 11

The future of geriatric medicine

Michel, J. (2012) · European Geriatric Medicine · doi:10.1016/j.eurger.2012.06.004 · Cited by 11

Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease

Barilar, J. O., & Šalković‐Petrišić, M. (2016) · Drugs & Aging · doi:10.1007/s40266-016-0407-9 · Cited by 11

Dementia, Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America

Cardona‐Gómez, G. P., & Lopera, F. J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00304 · Cited by 11

Unraveling the Role of Inwardly Rectifying Potassium Channels in the Hippocampus of an Aβ(1–42)-Infused Rat Model of Alzheimer’s Disease

Akyüz, E., Villa, C., Beker, M., & Elibol, B. (2020) · Biomedicines · doi:10.3390/biomedicines8030058 · Cited by 11

Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Pirolla, N. F. F., Batista, V. S., Viegas, F. P. D., Gontijo, V. S., McCarthy, C. R., Viegas, C., & Nascimento-Júnior, N. M. (2020) · Current Drug Targets · doi:10.2174/1389450121999200819144544 · Cited by 11

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

Zhang, G., Wu, J., Huang, C., Cheng, J., Su, Z., Zhu, Z., Yang, X., Guo, B., Wu, L., Zhang, Z., et al. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01762-x · Cited by 11

Adipocytes as a vehicle for ex vivo gene therapy: Novel replacement therapy for diabetes and other metabolic diseases

Kuroda, M., Bujo, H., Aso, M., & Saitō, Y. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2011.00133.x · Cited by 11

Identification of potential bivalent inhibitors from natural compounds for acetylcholinesterase through in silico screening using multiple pharmacophores

Lakshmi, V., Kannan, V. S., & Boopathy, R. (2013) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2012.12.008 · Cited by 11

Hippocampal atrophy but not white-matter changes predicts the long-term cognitive response to cholinesterase inhibitors in Alzheimer’s disease

Cheng, Y., Chen, T., Cheng, T., Lai, Y., Hua, M., Chen, Y., & Chiu, M. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0155-9 · Cited by 10

Receptor Targets in Alzheimer’s Disease Drug Discovery

Wallach, J. V., Colestock, T., & Adejare, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00006-4 · Cited by 11

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

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Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies

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