Alzheimer’s disease: Clinical trials and drug development

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.118 · Cited by 4,622

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275

Memantine in Moderate-to-Severe Alzheimer's Disease

Reisberg, B., Doody, R., Stöffler, A., Schmitt, F., Ferris, S., & Möbius, H. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa013128 · Cited by 2,043

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560

40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment

Carstensen, M. S., Lindén, J., Nguyen, N., Hansen, H. E., Carrillo, G. M. F., Hansen, L. S., Corell, D. D., Broeng, J., Kriegsfeld, L. J., & Petersen, P. M. (2020) · doi:10.1117/12.2544338 · Cited by 9

Effects of Morning Blue-Green 500 nm Light Therapy on Cognition and Biomarkers in Middle-Aged and Older Adults with Subjective Cognitive Decline and Mild Cognitive Impairment: Study Protocol for a Randomized Controlled Trial

Wang, Z., Zhang, Y., Dong, L., Zheng, Z., Zhong, D., Long, X., Cai, Q., Jian, W., Zhang, S., Wu, W., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201560 · Cited by 11

Purine adducts as a presumable missing link for aristolochic acid nephropathy‐related cellular energy crisis, potential anti‐fibrotic prevention and treatment

Kocic, G. M., Gajić, M., Tomović, K., Hadži-Djokić, J., Anderluh, M., & Šmelcerović, A. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15618 · Cited by 10

Automated brain volumetric program measuring regional brain atrophy in diagnosis of mild cognitive impairment and Alzheimer’s disease dementia

Ryu, D.-W., Hong, Y. J., Cho, J. H., Kwak, K., Lee, J. M., Shim, Y. S., Youn, Y. C., & Yang, D. W. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00678-x · Cited by 10

ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild‐Type Mice and Modifiers of a Pre‐Existing Motor Phenotype in Tau Mutant Mice

Liu, X., Dobbie, M. S., Tunningley, R., Whittle, B., Zhang, Y., Ittner, L. M., & Götz, J. (2011) · BioMed Research International · doi:10.1155/2011/130947 · Cited by 11

Screening for Alzheimer’s Disease

Lundquist, T. S., & Ready, R. E. (2013) · Journal of Applied Gerontology · doi:10.1177/0733464813500711 · Cited by 10

Neuritogenic Monoglyceride Derived from the Constituent of a Marine Fish for Activating the PI3K/ERK/CREB Signalling Pathways in PC12 Cells

Yang, W., Luo, Y., Tang, R., Zhang, H., Ye, Y., Xiang, L., & Qi, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224200 · Cited by 10

N‐Stearoyl‐L‐Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ1–42 via the CB2 Receptor

Li, W., Wang, Z., Liu, S., Hu, Y., Yin, M., & Yang, L. (2016) · Stem Cells International · doi:10.1155/2016/7419389 · Cited by 10

Prevention Studies in Alzheimer’s Disease: Progress Towards the Development of New Therapeutics

Coley, N., Gallini, A., & Andrieu, S. (2015) · CNS Drugs · doi:10.1007/s40263-015-0256-9 · Cited by 11

Statins and therapy of Alzheimer's disease: questions of efficacy versus trial design

Wolozin, B. L. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt101 · Cited by 10

Dementia: is the biopsychosocial model vindicated?

Iliffe, S., & Manthorpe, J. (2017) · British Journal of General Practice · doi:10.3399/bjgp17x691781 · Cited by 10

Phytocompounds of Senecio candicans as potential acetylcholinesterase inhibitors targeting Alzheimer's disease: A structure-based virtual screening and molecular dynamics simulation study

Periyasamy, T. S., Chandrasekar, A. K., Roy, G., Sekar, N., & Lakshmanan, H. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108396 · Cited by 9

Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein

Liang, J., Li, R., Wong, G., & Huang, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00879-0 · Cited by 13

Scaffold hopping strategy toward novel Pyrazolo[3,4-d]pyrimidine-based thiazole frameworks as potential cholinesterase inhibitors for treating Alzheimer’s disease: insight into in vitro and in silico approaches

Al‐Joufi, F. A., Alwethaynani, M. S., Sarfraz, H., Asif, F., Hussain, R., Sardar, A., Khan, Y., Hassan, F., Binsaleh, A. Y., Al‐Hoshani, N., et al. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.145424 · Cited by 9

Present Status and Road Map to Achieve Inclusive and Holistic Care for Dementia in a Japanese Community: Analysis Using the Delphi Method

Takechi, H., Mori, T., Hashimoto, T., & Nakamura, S. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000358821 · Cited by 9

Correlations between Alzheimer’s Disease Cerebrospinal Fluid Biomarkers and Cerebral Glucose Metabolism after 12 Months of Phenserine Treatment

Nordberg, A. K., Kadir, A., Andreasen, N., Almkvist, O., Wall, A. E., Blennow, K., Långström, B., & Zetterberg, H. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-132474 · Cited by 10

Gene Therapy Strategies: Gene Augmentation

Nóbrega, C., Mendonça, L. S., & Matos, C. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-41333-0_6 · Cited by 9

An Overview of Existing Publications and Most Relevant Projects/Platforms on the Use of Blockchain in Medicine and Neurology

Hort, J., Vališ, M., Zhang, B., Kuča, K., & Angelucci, F. (2021) · Frontiers in Blockchain · doi:10.3389/fbloc.2021.580227 · Cited by 9

Multicomponent Training Prevents Memory Deficit Related to Amyloid-β Protein-Induced Neurotoxicity

Soares, C. B., Daré, L. R., Lima, K. R., Lopes, L. F., dos Santos, A. G., Schimidt, H. L., Carpes, F. P., Lloret, A., Viña, J., & Mello‐Carpes, P. B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210424 · Cited by 11

A new quinolone and acetylcholinesterase inhibitors from a sponge-associated fungusPenicilliumsp. SCSIO41033

Xu, F., Chen, W., Ye, Y., Qi, X., Zhao, K. X., Long, J., Pang, X., Liu, Y., & Wang, J. (2022) · Natural Product Research · doi:10.1080/14786419.2022.2139694 · Cited by 9

Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy

Gella, A., & Bole, I. (2011) · InTech eBooks · doi:10.5772/16683 · Cited by 9

CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice

Beggiato, S., Giuliani, A., Sivilia, S., Lorenzini, L., Antonelli, T., Imbimbo, B. P., Giardino, L., Calzà, L., & Ferraro, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.065 · Cited by 10

Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease

Ortiz, C. J. C., Silva, M. D. F., Gontijo, V. S., Viegas, F. P. D., Dias, K. S. T., & Viegas, C. (2018) · Methods in pharmacology and toxicology · doi:10.1007/7653_2018_2 · Cited by 10

Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

Suh, M., & Lee, D. S. (2018) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-018-0550-9 · Cited by 8

Natural Modulators of Amyloid-Beta Precursor Protein Processing.

Zhang, C., & Tanzi, R. E. (2012) · PubMed · Cited by 9

Human Handedness: Genetics, Microtubules, Neuropsychiatric Diseases and Brain Language AreasPreprint

Wiberg, A., Douaud, G., Ng, M., Omran, Y. A., Alfaro‐Almagro, F., Marchini, J., Bennett, D., Smith, S. M., & Furniss, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/454660 · Cited by 9

Integrated Bioinformatic Analysis and Validation Identifies Immune Microenvironment-Related Potential Biomarkers in Alzheimer's Disease

Yang, F., Zhang, N., Ou, G., & Xu, S.-W. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.5 · Cited by 11

XJB-5-131 Is a Mild Uncoupler of Oxidative Phosphorylation

Xun, Z., Wipf, P., & McMurray, C. T. (2022) · Journal of Huntington s Disease · doi:10.3233/jhd-220539 · Cited by 8

Forest Biomass as a Promising Source of Bioactive Essential Oil and Phenolic Compounds for Alzheimer’s Disease Therapy

Moreira, P., Matos, P., Figueirinha, A., Salgueiro, L., Batista, M. T., Branco, P. C., Cruz, M. T., & Pereira, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158812 · Cited by 10

Luteoloside inhibits Aβ1–42 fibrillogenesis, disintegrates preformed fibrils, and alleviates amyloid-induced cytotoxicity

Zhang, D., Zhang, J., Ma, Z., Wu, Q., Liu, M., Fan, T., Ding, L., Ren, D., Wen, A., & Wang, J. (2024) · Biophysical Chemistry · doi:10.1016/j.bpc.2023.107171 · Cited by 8

Dissecting the shared genetic architecture between Alzheimer’s disease and frailty: a cross-trait meta-analyses of genome-wide association studies

Enduru, N., Fernandes, B. S., & Zhao, Z. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1376050 · Cited by 9

Diagnostic misconceptions? A closer look at clinical research on Alzheimer's disease

Kutschenko, L. K. (2011) · Journal of Medical Ethics · doi:10.1136/medethics-2011-100026 · Cited by 8

The memory ameliorating effects of DHP1402, an herbal mixture, on cholinergic blockade-induced cognitive dysfunction in mice

Kim, H., Lee, H. E., Jung, I. H., Jeon, S. J., Zhang, J., Kwon, Y., Jang, D. S., & Ryu, J. H. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.09.013 · Cited by 8

Surface Enhanced Raman Spectroscopy for Medical Diagnostics

Jahn, M., Radu, A. I., Weber, K., Cialla‐May, D., & Popp, J. (2018) · Springer eBooks · doi:10.1007/978-3-662-56333-5_1 · Cited by 8

Determination of donepezil in human plasma using ultra performance liquid chromatography-tandem mass spectrometry

Jeong, H. C., Park, J.-E., Hyun, J.-Y., Park, M.-K., Shin, D., & Shin, K. (2018) · Translational and Clinical Pharmacology · doi:10.12793/tcp.2018.26.2.64 · Cited by 8

The Role of Cilostazol and Inflammation in Cognitive Impairment After Ischemic Stroke

Huang, L., Hsieh, S., Tsai, C.-C., Chen, C., & Yang, Y. (2021) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175211016185 · Cited by 8

Highlights on Synthetic, Natural, and Hybrid Cholinesterase Inhibitors for Effective Treatment of Alzheimer’s Disease: A Review

Danao, K. R., Kodape, Y., Mahapatra, D. K., Borikar, S. P., & Karande, N. A. (2021) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2021.131107 · Cited by 8

Plasma MMP-9 Levels as the Future Risk of Conversion to Dementia in ApoE4-Positive MCI Patients: Investigation Based on the Alzheimer's Disease Neuroimaging Initiative Database

Abe, K., Chiba, Y., Ide, K., Yoshimi, A., Asami, T., Suda, A., Odawara, T., & Hishimoto, A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.19 · Cited by 9

DMTHB ameliorates memory impairment in Alzheimer's disease mice through regulation of neuroinflammation

Zhang, Y., Liu, D., Yao, X., Wen, J., Wang, Y., & Zhang, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136770 · Cited by 9

Nucleosome assembly protein 1-like 5 alleviates Alzheimer’s disease-like pathological characteristics in a cell model

Wang, B. J., Liu, W., & Sun, F.-X. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1034766 · Cited by 8

Anti-Aβ42 Aggregative Polyketides from the Antarctic Psychrophilic Fungus Pseudogymnoascus sp. OUCMDZ-3578

Han, X., Gao, H., Lai, H., Zhu, W., & Wang, Y. (2023) · Journal of Natural Products · doi:10.1021/acs.jnatprod.2c01101 · Cited by 8

Enzyme Inhibitors Involved in the Treatment of Alzheimer’s Disease

Revadigar, V., Ghalib, R. M., Murugaiyah, V., Embaby, M. A., Jawad, A. H., Mehdi, S. H., Hashim, R., & Sulaiman, O. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-803959-5.50003-9 · Cited by 9

Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies

Ren, Y., Kunze, A., & Renaud, P. (2015) · Neuromethods · doi:10.1007/978-1-4939-2510-0_12 · Cited by 8

8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease

Domínguez, J. L., Fernández‐Nieto, F., Brea, J. M., Catto, M., Paleo, M. R., Porto, S., Sardina, F. J., Castro, M., Pisani, L., Carotti, A., et al. (2016) · ChemistrySelect · doi:10.1002/slct.201600735 · Cited by 8

Strategies Targeting Soluble β-Amyloid Oligomers and their Application to Early Diagnosis of Alzheimer’s Disease

Zeng, F., Li, Y., Xu, Y., Yang, J., Liu, Z., Li, X., & Ren, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191031163504 · Cited by 8

Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms?

Corbett, A., & Ballard, C. G. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.815723 · Cited by 8

Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins

Zhang, Y., Deng, L., Wei, J., Huang, L., Gao, F., Yu, L., Zhu, F., Mi, J., Wu, J., Ren, F., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00721 · Cited by 8

Soluble epoxide hydrolase: Mechanisms and therapeutic potential in psychiatric and neurological disorders

Zhao, M., Yang, J., & Hashimoto, K. (2024) · Advances in pharmacology · doi:10.1016/bs.apha.2024.10.007 · Cited by 7

Phenotypic Assays for β-Amyloid in Mouse Embryonic Stem Cell-Derived Neurons

McIntire, L. B., Landman, N., Kang, M. S., Finan, G. M., Hwang, J. C., Moore, A. Z., Park, L., Lin, C., & Kim, T. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.06.005 · Cited by 7

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols

Wei, H., Lu, D., Sun, V., Zhang, J., Gu, Y., Osenkowski, P., Ye, W., Selkoe, D. J., Wolfe, M. S., & Augelli‐Szafran, C. E. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.03.042 · Cited by 7

Citrus and Health

Marhuenda, J., Cerdá, B., Villaño, D., Galindo, A., & Zafrilla, P. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79283 · Cited by 7

Amyloid fibrils from organic solutions of an amphiphilic dipeptide

Casanovas, J., Mayans, E., Díaz, A., Gil, A. M., Jiménez, A. I., Cativiela, C., Puiggalı́, J., & Alemán, C. (2019) · Chemical Communications · doi:10.1039/c9cc04139g · Cited by 7

Spatial Training Attenuates Long-Term Alzheimer’s Disease-Related Pathogenic Processes in APP/PS1 Mice

Zhao, Y., Bao, J., Liu, W., Gong, X., Liang, Z., Li, W., Wu, M., Xiao, Y., Sun, B., Wang, X., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215016 · Cited by 6

Design, reformulation, and standardization of a traditional-based memory enhancer herbal preparation originated from Persian medicine

Dabaghian, F., Azadi, A., & Zarshenas, M. M. (2022) · Journal of Medicinal Plants · doi:10.52547/jmp.21.82.93 · Cited by 7

Insights into the mechanisms of non-coding RNAs’ implication in the pathogenesis of Alzheimer’s disease

Khodayi-Shahrak, M., Khalaj‐Kondori, M., Feizi, M. A. H., & Talebi, M. (2022) · EXCLI journal · doi:10.17179/excli2022-5006 · Cited by 8

A selective degeneration of cholinergic neurons mediated by NRADD in an Alzheimer's disease mouse model

Li, L., Zhang, B., Tang, X., Yu, Q., He, A., Lu, Y., & Li, X. (2022) · Cell Insight · doi:10.1016/j.cellin.2022.100060 · Cited by 7

Intranasal delivery of stem cells labeled by nanoparticles in neurodegenerative disorders: Challenges and opportunities

Alizadeh, R., Asghari, A., Taghizadeh‐Hesary, F., Moradi, S., Farhadi, M. R., Mehdizadeh, M., Simorgh, S., Nourazarian, A., Shademan, B., Susanabadi, A., et al. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1915 · Cited by 7

Prevention of Alzheimer’s Disease: Intervention Studies

Mangialasche, F., Xu, W., & Kivipelto, M. (2013) · InTech eBooks · doi:10.5772/55034 · Cited by 7

A brief update on dementia prevention

Polidori, M. C., & Pientka, L. (2012) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-011-0263-5 · Cited by 8

Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax.

Zhang, L., & Zhang, Y. (2013) · Europe PMC (PubMed Central) · Cited by 7

Can we reduce the risk of dementia?: Table 1

Robertson, M., Seaton, A., & Whalley, L. J. (2014) · QJM · doi:10.1093/qjmed/hcu072 · Cited by 7

Drug Development for Alzheimer's Disease: Recent Progress

Ji, W., & Ha, I. (2010) · Experimental Neurobiology · doi:10.5607/en.2010.19.3.120 · Cited by 7

Early multidomain intervention to stave off Alzheimer’s disease

He, R.-Q. (2016) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-00100 · Cited by 6

Influence of the γ-carboline and carbazole pharmacophore moieties on anticholinesterase and antiradical activity of multifunctional agents for the treatment of neurodegenerative diseases

Махаева, Г. Ф., Boltneva, N. P., Ковалева, Н. В., Рудакова, Е. В., Lushchekina, S. V., Aksinenko, A. Y., & Sokolov, V. B. (2018) · Russian Chemical Bulletin · doi:10.1007/s11172-018-2282-5 · Cited by 7

From the nose to the brain, nanomedicine drug delivery

Zeeshan, F., Mishra, D. K., & Kesharwani, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820466-5.00008-9 · Cited by 7

Positron emission tomography imaging of the P2X7 receptor with a novel tracer, [18F]GSK1482160, in a transgenic mouse model of Alzheimer's disease and healthy non‐human primates

Qiu, Y., Bi, L., Huang, G., Li, Z., Wei, H., Li, G., Wei, J., Liao, K., Yang, M., Ye, P., et al. (2024) · Brain‐X · doi:10.1002/brx2.55 · Cited by 6

Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer’s disease

Kim, E. J., Park, S., Schuessler, B. P., Boo, H., Cho, J., & Kim, J. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116081 · Cited by 10

Advances in the use of structural and diffusion magnetic resonance imaging for characterizing SCD and MCI due to Alzheimer’s disease

Yang, H. J., Dong, C., Cai, Y., Zhao, M., Liu, J., Bian, S., & Ding, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1596459 · Cited by 6

Tailored brain metastatic tumor cells-derived apoptotic bodies ameliorate Alzheimer’s disease by promoting microglia efferocytosis and neuroinflammation mitigation

Mu, Z., Chen, Y., Hu, Y., Wang, H., & Li, J. H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03750-y · Cited by 7

Imbalance, compensation, and rigidity in brain functional connectivity and microstates among older adults with cognitive impairment

Ding, F., Jia, S., Xin, X., Li, S., Liu, C., Guo, Z., Liu, Q., Ma, X., Chen, W., & Wang, X. (2025) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-025-01803-9 · Cited by 6

Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study

Ravanelli, F., Musazzi, L., Barbieri, S. S., Rovati, G. E., Popoli, M., Barbon, A., & Ieraci, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713084 · Cited by 6

Epigenetics and Down syndrome

González-Molina, L. A., Dekker, A. D., Deyn, P. P. D., Dolga, A. M., & Rots, M. G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18516-8.00014-4 · Cited by 7

Does Physical Exercise Modify the Pathophysiology of Alzheimer's Disease in Older Persons?

Raffin, J. (2024) · Journal of Aging Research and Lifestyle · doi:10.14283/jarlife.2024.11 · Cited by 6

The active components of Erzhi wan and their anti-Alzheimer's disease mechanisms determined by an integrative approach of network pharmacology, bioinformatics, molecular docking, and molecular dynamics simulation

Yu, M., Shen, Z., Zhang, S., Zhang, Y., Zhao, H., & Zhang, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33761 · Cited by 6

Polypharmacological Drug Design Guided by Integrating Phenotypic and Restricted Fragment Docking Strategies

Li, S., Li, X., Ma, L., Luo, Z., Yin, F., Zhang, Y., Chen, Y., Wan, S., Zhou, H., Wang, X., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01731 · Cited by 7

Correlation between potentially inappropriate medication and Alzheimer's disease among the elderly.

Tao, P., Chen, P.-E., Tao, J., Yang, S.-N., Tung, T.-H., & Chien, C.-W. (2020) · Archives of gerontology and geriatrics (Print) · doi:10.1016/j.archger.2019.03.010 · Cited by 6

Evolution of the Research Literature and the Scientific Community of Alzheimer’s Disease from 1983-2017: A 35-Year Survey

Robert, C., Wilson, C. S., Lipton, R. B., & Arreto, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191281 · Cited by 8

Neurodegeneration and the pharmacotherapeutic aspect of Alzheimer's disease

Binert-Kusztal, Ż., Starek, M., & Dąbrowska, M. (2021) · Farmacja Polska · doi:10.32383/farmpol/142108 · Cited by 6

Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer’s Disease

Liu, Q. F., Choi, H., Son, T., Kim, Y.-M., Kanmani, S., Chin, Y., Kim, S.-N., Kim, K. K., Kim, K., & Koo, B. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220413082130 · Cited by 5

CHEMICAL COMPOSITION AND THERAPEUTIC ACTIVITY OF LEBANESE ROSE GERANIUM (PELARGONIUM HYBRID) EXTRACTS

Fayoumi, L. (2022) · FARMACIA · doi:10.31925/farmacia.2022.3.13 · Cited by 6

Historical perspectives on the discovery and development of drugs to treat neurological disorders

Williams, M. J., & COYLE, J. T. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511980053.008 · Cited by 6

Accelerating Regulatory Science Initiatives for the Development of Drugs for Alzheimer’s Disease in Japan

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