The DOI matches its Crossref record; 130 of the 133 references it cites were found in a registry or an index.
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
Open accessAbstract
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of motor neurons. The biological processes that drive this glial reaction are complex and have both beneficial and deleterious effects on motor neurons. Therapeutic interventions targeting these cells are being explored. An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction.
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“Activation of microglia through genetic, infectious, inflammatory, or physical stimuli, leads to stereotypical changes in their morphology, accompanied by proliferation, migration, and the release of proinflammatory cytokines and chemokines [417–419].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [419]
Citations
Cites
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Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
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Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
The changing scene of amyotrophic lateral sclerosis
Robberecht, W., & Philips, T. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3430 · Cited by 957
Self-citationTumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638
Metadata
- Authors
- Philips, T., & Robberecht, W.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Robberecht, Wim
- ORCID
- Philips, Thomas
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 10
- Issue
- 3
- Pages
- 253-263
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2144507462
- Cited by
- 646
- References
- 133
- Citations by year
- 2026: 25 · 2025: 24 · 2024: 39 · 2023: 45 · 2022: 38 · 2021: 44 · 2020: 45 · 2019: 41 · 2018: 43 · 2017: 58 · 2016: 44 · 2015: 41 · 2014: 52 · 2013: 53 · 2012: 40
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- amyotrophic lateral sclerosis, neuroinflammation, glial activation, microglia, astrocytes, motor neuron degeneration, neurodegeneration
- MeSH terms
- Amyotrophic Lateral Sclerosis, Animals, Humans, Inflammation, Neuroglia, T-Lymphocytes, Signal Transduction, Motor Neuron Disease
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