Cited by 651Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury Research

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Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

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Philips, Thomas, Robberecht, Wim·2011·The Lancet Neurology

DOI 10.1016/s1474-4422(11)70015-1

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Abstract

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of motor neurons. The biological processes that drive this glial reaction are complex and have both beneficial and deleterious effects on motor neurons. Therapeutic interventions targeting these cells are being explored. An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction.

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Authors: Philips, T., & Robberecht, W.
Affiliations: KU Leuven (BE)
Corresponding author: Robberecht, Wim
ORCID: Philips, Thomas
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2011-03
Volume: 10
Issue: 3
Pages: 253-263
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(11)70015-1
OpenAlex: W2144507462
Cited by: 646
References: 133
Citations by year: 2026: 25 · 2025: 24 · 2024: 39 · 2023: 45 · 2022: 38 · 2021: 44 · 2020: 45 · 2019: 41 · 2018: 43 · 2017: 58 · 2016: 44 · 2015: 41 · 2014: 52 · 2013: 53 · 2012: 40
FWCI: 6.36
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: amyotrophic lateral sclerosis, neuroinflammation, glial activation, microglia, astrocytes, motor neuron degeneration, neurodegeneration
MeSH terms: Amyotrophic Lateral Sclerosis, Animals, Humans, Inflammation, Neuroglia, T-Lymphocytes, Signal Transduction, Motor Neuron Disease

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Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

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