Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J., & Kuncl, R. W. (1995) · Annals of Neurology · doi:10.1002/ana.410380114 · Cited by 1,471

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341

Astrocytes are active players in cerebral innate immunity

Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304

Mutations of optineurin in amyotrophic lateral sclerosis

Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., Kinoshita, Y., Kamada, M., Nodera, H., Suzuki, H., et al. (2010) · Nature · doi:10.1038/nature08971 · Cited by 1,265

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Johnson, J. O., Mandrioli, J., Benatar, M., Abramzon, Y., Van Deerlin, V. M., Trojanowski, J. Q., Gibbs, J. R., Brunetti, M., Gronka, S., Wuu, J., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.036 · Cited by 1,235

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,197

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,131

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

Howland, D., Liu, J., She, Y., Goad, B., Maragakis, N. J., Kim, B. B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032539299 · Cited by 890

Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells

Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880

Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain

Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874

Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model

Kaspar, B. K., Lladó, J., Sherkat, N., Rothstein, J. D., & Gage, F. H. (2003) · Science · doi:10.1126/science.1086137 · Cited by 872

Prevalence and patterns of cognitive impairment in sporadic ALS

Ringholz, G. M., Appel, S. H., Bradshaw, M. R., Cooke, N., Mosnik, D. M., & Schulz, P. E. (2005) · Neurology · doi:10.1212/01.wnl.0000172911.39167.b6 · Cited by 843

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815

Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T., & Eggan, K. (2007) · Nature Neuroscience · doi:10.1038/nn1885 · Cited by 799

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study

Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.012 · Cited by 737

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

Beers, D. R., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R., & Appel, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607423103 · Cited by 733

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

Li, M., Ona, V. O., Guégan, C., Chen, M., Jackson-Lewis, V. R., Andrews, L. J., Olszewski, A. J., Stieg, P. E., Lee, J.-P., Przedborski, S., et al. (2000) · Science · doi:10.1126/science.288.5464.335 · Cited by 717

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

Wegorzewska, I., Bell, S., Cairns, N. J., Miller, T. M., & Baloh, R. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908767106 · Cited by 706

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

Meletis, K., Barnabé‐Heider, F., Carlén, M., Evergren, E., Tomilin, N. V., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 685

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

Bosco, D. A., Morfini, G. A., Karabacak, M., Song, Y., Gros‐Louis, F., Pasinelli, P., Goolsby, H., Fontaine, B. A., Lemay, N., McKenna-Yasek, D. M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2660 · Cited by 685

Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial

Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

Neumann, M., Kwong, L. K., Lee, E. B., Kremmer, E., Flatley, A., Xu, Y., Forman, M. S., Troost, D., Kretzschmar, H. A., Trojanowski, J. Q., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0477-9 · Cited by 608

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

Azzouz, M., Ralph, G. S., Storkebaum, E., Walmsley, L. E., Mitrophanous, K. A., Kingsman, S. M., Carmeliet, P., & Mazarakis, N. D. (2004) · Nature · doi:10.1038/nature02544 · Cited by 588

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

Henkel-Tigges, J., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R., & Appel, S. H. (2003) · Annals of Neurology · doi:10.1002/ana.10805 · Cited by 576

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

Ralph, G. S., Radcliffe, P. A., Day, D. M., Carthy, J. M., Leroux, M. A., Lee, D. C. P., Wong, L., Bilsland, L. G., Greensmith, L., Kingsman, S. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1205 · Cited by 507

Design, power, and interpretation of studies in the standard murine model of ALS

Scott, S., Kranz, J. E., Cole, J., Lincecum, J. M., Thompson, K., Kelly, N., Bostrom, A., Theodoss, J., Al‐Nakhala, B. M., Vieira, F. G., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701856300 · Cited by 504

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS

Storkebaum, E., Lambrechts, D., Dewerchin, M. A., Moreno-Murciano, P., Appelmans, S., Oh, H., Damme, P. V., Rutten, B. P. F., Man, W. Y., Mol, M. D., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1360 · Cited by 499

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis

Bosch, L. V. D., Damme, P. V., Bogaert, E., & Robberecht, W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.05.002 · Cited by 491

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., & Appel, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807419105 · Cited by 485

Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment

Pramatarova, A., Laganière, J., Roussel, J., Brisebois, K., & Rouleau, G. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03369.2001 · Cited by 482

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Barnabé‐Heider, F., Yeung, M. S. Y., Naldini, L., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2268 · Cited by 463

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2210 · Cited by 441

Immune reactivity in a mouse model of familial ALS correlates with disease progression

Alexianu, M. E., Kozovska, M., & Appel, S. H. (2001) · Neurology · doi:10.1212/wnl.57.7.1282 · Cited by 438

Motoneuron Death Triggered by a Specific Pathway Downstream of Fas

Raoul, C., Estévez, Á. G., Nishimune, H., Cleveland, D. W., deLapeyrière, O., Henderson, C. E., Haase, G., & Pettmann, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00905-4 · Cited by 432

Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease

Lino, M. M., Schneider, C., & Caroni, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04825.2002 · Cited by 424

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Damme, P. V., Hoecke, A. V., Lambrechts, D., Vanacker, P., Bogaert, E., Swieten, J. C. V., Carmeliet, P., Bosch, L. V. D., & Robberecht, W. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712039 · Cited by 421

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R., & Julien, J.-P. (2006) · Nature Neuroscience · doi:10.1038/nn1603 · Cited by 419

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.003 · Cited by 411

Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

Križ, J., Nguyen, M. D., & Julien, J. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0487 · Cited by 411

Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration

Gong, Y. H., Parsadanian, A. S., Andreeva, A., Snider, W. D., & Elliott, J. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00660.2000 · Cited by 387

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

Chiu, I. M., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S. A., Vartanian, T. K., Brown, R. H., & Carroll, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804610105 · Cited by 380

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

Harraz, M. M., Marden, J. J., Zhou, W., Zhang, Y., Williams, A. J., Sharov, V. S., Nelson, K., Luo, M., Paulson, H. L., Schöneich, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34060 · Cited by 375

Microglia in ALS: The Good, The Bad, and The Resting

Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353

Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 332

Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease

Nagai, M., Aoki, M., Miyoshi, I., Kato, M., Pasinelli, P., Kasai, N., Brown, R. H., & Itoyama, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09246.2001 · Cited by 318

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540010026013 · Cited by 318

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

Yamanaka, K., Boillee, S., Roberts, E. A., Garcia, M. L., McAlonis-Downes, M., Mikse, O. R., Cleveland, D. W., & Goldstein, L. S. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802556105 · Cited by 309

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS

Drachman, D. B., Frank, K., Dykes‐Hoberg, M., Teismann, P., Almer, G., Przedborski, S., & Rothstein, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10374 · Cited by 307

Trial of celecoxib in amyotrophic lateral sclerosis

Cudkowicz, M., Shefner, J. M., Schoenfeld, D., Zhang, H., Andreasson, K. I., Rothstein, J. D., & Drachman, D. B. (2006) · Annals of Neurology · doi:10.1002/ana.20903 · Cited by 302

Minocycline delays disease onset and mortality in a transgenic model of ALS

Bosch, L. V. D., Tilkin, P., Lemmens, G., & Robberecht, W. (2002) · Neuroreport · doi:10.1097/00001756-200206120-00018 · Cited by 297

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

Guo, H. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg267 · Cited by 297

A clinical trial of creatine in ALS

Shefner, J. M., Cudkowicz, M., Schoenfeld, D., Conrad, T. M., Taft, J., Chilton, M., Urbinelli, L., Qureshi, M., Zhang, H., Pestronk, A., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000142992.81995.f0 · Cited by 293

Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury

Zhao, W., Beers, D. R., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J., & Appel, S. H. (2010) · Glia · doi:10.1002/glia.20919 · Cited by 288

Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase‐1 transgenic mice: Mechanisms of mitochondriopathy and cell death

Martin, L. J., Liu, Z., Chen, K. Y., Price, A. C., Pan, Y. H., Swaby, J. A., & Golden, W. C. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21160 · Cited by 270

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

Jaarsma, D., Teuling, E., Haasdijk, E. D., Zeeuw, C. I. D., & Hoogenraad, C. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5258-07.2008 · Cited by 260

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

Wu, D., Ré, D. B., Nagai, M., Ischiropoulos, H., & Przedborski, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603670103 · Cited by 258

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

Appel, S. H., Beers, D. R., & Henkel, J. S. (2010) · Trends in Immunology · doi:10.1016/j.it.2009.09.003 · Cited by 256

Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis

Schiffer, D., Cordera, S., Cavalla, P., & Migheli, A. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00073-1 · Cited by 255

Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1

Yang, Y., Gozen, O., Watkins, A., Lorenzini, I., Lepore, A., Gao, Y., Vidensky, S., Brennan, J., Poulsen, D., Won Park, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.010 · Cited by 237

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

Damme, P. V., Bogaert, E., Dewil, M., Hersmus, N., Kiraly, D., Scheveneels, W., Bockx, I., Braeken, D., Verpoorten, N., Verhoeven, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705046104 · Cited by 236

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III

Kaufmann, P., Thompson, J. L. P., Levy, G., Buchsbaum, R., Shefner, J. M., Krivickas, L. S., Katz, J., Rollins, Y. D., Barohn, R. J., Jackson, C. E., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21743 · Cited by 236

IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110068019 · Cited by 221

Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease

Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G., & Rivest, S. (2008) · Brain · doi:10.1093/brain/awn331 · Cited by 221

Transgenic-Mouse Model of Amyotrophic Lateral Sclerosis

Gurney, M. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412223312516 · Cited by 217

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

Wang, L., Gutmann, D. H., & Roos, R. P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq463 · Cited by 214

Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene

Zhou, H., Huang, C., Chen, H., Wang, D., Landel, C. P., Xia, P. Y., Bowser, R. P., Liu, Y.-J., & Xia, X. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000887 · Cited by 209

Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis

Hensley, K., Floyd, R. A., Gordon, B., Mou, S., Pye, Q. N., Stewart, C. A., West, M. S., & Williamson, K. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00968.x · Cited by 205

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

Banerjee, R., Mosley, R. L., Reynolds, A. D., Dhar, A., Jackson-Lewis, V. R., Gordon, P. H., Przedborski, S., & Gendelman, H. E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002740 · Cited by 204

Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis

Poloni, M., Facchetti, D., Mai, R., Micheli, A., Agnoletti, L., Francolini, G., Mora, G., Camana, C., Mazzini, L., & Bachetti, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01177-0 · Cited by 197

Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues

Corti, S. P., Locatelli, F., Donadoni, C., Guglieri, M., Papadimitriou, D. A., Strazzer, S., Bo, R. D., & Comi, G. P. (2004) · Brain · doi:10.1093/brain/awh273 · Cited by 195

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

Chiu, I. M., Phatnani, H. P., Kuligowski, M., Tapia, J. C., Carrasco, M. A., Zhang, M., Maniatis, T., & Carroll, M. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911405106 · Cited by 194

Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Kiaei, M., Petri, S., Kipiani, K., Gardian, G., Choi, D., Chen, J., Calingasan, N. Y., Schafer, P. H., Muller, G. W., Stewart, C. A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5253-05.2006 · Cited by 183

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

Henkel-Tigges, J., Beers, D. R., Siklós, L., & Appel, S. H. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.016 · Cited by 181

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis

Elliott, J. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00242-x · Cited by 181

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Zhong, Z., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38476 · Cited by 176

Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia

Xiao, Q., Zhao, W., Beers, D. R., Yen, A. A., Xie, W., Henkel, J. S., & Appel, S. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04677.x · Cited by 174

NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord.

Zhu, X., Hill, R., & Nishiyama, A. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000015 · Cited by 168

Reactive Astrogliosis is Widespread in the Subcortical White Matter of Amyotrophic Lateral Sclerosis Brain

Kushner, P. D., Stephenson, D. T., & Wright, S. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199105000-00008 · Cited by 166

Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity

Dodge, J. C., Haidet, A. M., Yang, W., Passini, M. A., Hester, M. E., Clarke, J., Roskelley, E. M., Treleaven, C. M., Rizo, L., Martin, H. L., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.60 · Cited by 160

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

Gowing, G., Philips, T., Wijmeersch, B. V., Audet, J., Dewil, M., Bosch, L. V. D., Billiau, A., Robberecht, W., & Julien, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3494-08.2008 · Cited by 159

Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

Zhang, R., Gascon, R., Miller, R. G., Gelinas, D. F., Mass, J., Hadlock, K. G., Jin, X., Reis, J., Narvaez, A., & McGrath, M. S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.009 · Cited by 158

Increased cytotoxic potential of microglia from ALS‐transgenic mice

Weydt, P., Yuen, E., Ransom, B. R., & Möller, T. (2004) · Glia · doi:10.1002/glia.20062 · Cited by 147

Redox modifier genes in amyotrophic lateral sclerosis in mice

Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31265 · Cited by 145

A therapeutic role for cyclooxygenase‐2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

Pompl, P. N., Ho, L., Bianchi, M., McManus, T. E., Qin, W., & Pasinetti, G. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0876fje · Cited by 144

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

Appel, S. H., Engelhardt, J. I., Henkel-Tigges, J., Siklós, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000327668.43541.22 · Cited by 140

Motor Neuron Degeneration Promotes Neural Progenitor Cell Proliferation, Migration, and Neurogenesis in the Spinal Cords of Amyotrophic Lateral Sclerosis Mice

Chi, L.-Y., Ke, Y., Luo, C., Li, B.-L., Gozal, D., Kalyanaraman, B., & Liu, R.-G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0076 · Cited by 134

Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis

Nagy, D., Kato, T., & Kushner, P. D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380312 · Cited by 131

Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin‐1β in neurodegeneration

Nguyen, M. D., Julien, J., & Rivest, S. (2001) · Annals of Neurology · doi:10.1002/ana.1256 · Cited by 129

The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice

West, M. S., Mhatre, M., Ceballos, A., Floyd, R. A., Grammas, P., Gabbita, S. P., Hamdheydari, L., Mai, T., Mou, S., Pye, Q. N., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02700.x · Cited by 121

The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis

Wang, L., Sharma, K., Grisotti, G., & Roos, R. P. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.002 · Cited by 121

Frontotemporal Lobar Degeneration

(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-44781-2.50191-1 · Cited by 120

Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease

Wilkinson, B. L., Cramer, P. E., Varvel, N. H., Reed-Geaghan, E. G., Jiang, Q., Szabo, A., Herrup, K., Lamb, B. T., & Landreth, G. E. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.014 · Cited by 118

Visualization of mitotic radial glial lineage cells in the developing rat brain by Cdc2 kinase-phosphorylated vimentin

Kamei, Y., Inagaki, N., Nishizawa, M., Tsutsumi, O., Taketani, Y., & Inagaki, M. (1998) · Glia · doi:10.1002/(sici)1098-1136(199807)23:3 · Cited by 114

Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis

Solomon, J. N., Lewis, C. B., Ajami, B., Corbel, S. Y., Rossi, F. M. V., & Krieger, C. (2006) · Glia · doi:10.1002/glia.20331 · Cited by 105

Absence of Tumor Necrosis Factor-α Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutations

Gowing, G., Dequen, F., Soucy, G., & Julien, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0602-06.2006 · Cited by 105

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology

Wang, L., Sharma, K., Deng, H., Siddique, T., Grisotti, G., Liu, E., & Roos, R. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.004 · Cited by 101

Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial

Meininger, V., Drory, V. E., Leigh, P. N., Ludolph, A. C., Robberecht, W., & Silani, V. (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960902803432 · Cited by 97

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration

Lepore, A. C., Dejea, C. M., Carmen, J., Rauck, B. M., Kerr, D. A., Sofroniew, M. V., & Maragakis, N. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.020 · Cited by 92

Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice

Park, S., Kim, H.-T., Yun, S., Kim, I., Lee, J., Lee, I.-S., & Park, K. I. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.7.054 · Cited by 90

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

Philips, T., Muynck, L. D., Thu, H. N. T., Weynants, B., Vanacker, P., Dhondt, J., Sleegers, K., Schelhaas, H. J., Verbeek, M. M., Vandenberghe, R. R., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181fc9aea · Cited by 83

Lenalidomide (Revlimid®) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis

Neymotin, A., Petri, S., Calingasan, N. Y., Wille, E. J., Schafer, P. H., Stewart, C. A., Hensley, K., Beal, M. F., & Kiaei, M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.028 · Cited by 80

Recent advances in motor neuron disease

Damme, P. V., & Robberecht, W. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832ffbe3 · Cited by 76

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis

Gros‐Louis, F., Andersen, P. M., Dupré, N., Urushitani, M., Dion, P. A., Souchon, F., D'Amour, M. L., Camu, W., Meininger, V., Bouchard, J.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902174106 · Cited by 58

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase

Gowing, G., Lalancette-Hébert, M., Audet, J.-N., Dequen, F., & Julien, J.-P. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.021 · Cited by 53

Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis

Ohnishi, S., Ito, H., Suzuki, Y., Adachi, Y., Wate, R., Zhang, J., Nakano, S., Kusaka, H., & Ikehara, S. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.012 · Cited by 50

Inducible Nitric Oxide Synthase (iNOS) and Nitrotyrosine Immunoreactivity in the Spinal Cords of Transgenic Mice with a G93A MutantSOD1Gene

Sasaki, S., Warita, H., Abe, K., & Iwata, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.839 · Cited by 46

Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study

Galbussera, A. A., Tremolizzo, L., Brighina, L., Testa, D., Lovati, R., Ferrarese, C., Cavaletti, G., & Filippini, G. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0668-x · Cited by 44

Leech giant glial cell: functional role in a simple nervous system

Deitmer, J. W., Rose, C. R., Munsch, T., Schmidt, J., Nett, W., Schneider, H.-P., & Lohr, C. (1999) · Glia · doi:10.1002/(sici)1098-1136(199912)28:3 · Cited by 43

Bone marrow‐derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX3CR1

Lewis, C. B., Solomon, J. N., Rossi, F. M. V., & Krieger, C. (2009) · Glia · doi:10.1002/glia.20859 · Cited by 40

Neuronal over‐expression of chromogranin A accelerates disease onset in a mouse model of ALS

Ezzi, S. A., Larivière, R., Urushitani, M., & Julien, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06979.x · Cited by 34

Survival in a transgenic model of fals is independent of inos expression

Son, M., Fathallah‐Shaykh, H. M., & Elliott, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.1104 · Cited by 30

P413L CHGB is not associated with ALS susceptibility or age at onset in a Dutch population

van Vught, P. W. J., Veldink, J. H., & van den Berg, L. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002512107 · Cited by 15

Altered immune response to CNS viral infection in mice with a conditional knock‐down of macrophage‐lineage cells

Carmen, J., Gowing, G., Julien, J., & Kerr, D. A. (2006) · Glia · doi:10.1002/glia.20359 · Cited by 15

Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.

van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190

Hallmarks of neurodegenerative diseases

Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789

The changing scene of amyotrophic lateral sclerosis

Robberecht, W., & Philips, T. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3430 · Cited by 957

Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity

Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638

Neuroinflammation in motor neuron disease

Endo, F., Komine, O., & Yamanaka, K. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12309 · Cited by 95

Neuron-Microglia Interactions in Motor Neuron Degeneration. The Inflammatory Hypothesis in Amyotrophic Lateral Sclerosis Revisited

Rodríguez, M. J., & Mahy, N. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867324666161123091314 · Cited by 22

Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis

Weydt, P., & ̈ller, T. M. (2005) · Neuroreport · doi:10.1097/00001756-200504250-00001 · Cited by 84

Neuroinflammation in neurodegenerative disease.

Yamanaka, K. (2023) · PubMed Central · doi:10.18999/nagjms.85.1.30 · Cited by 1

The microglial-motoneuron dialogue in ALS.

Appel, S. H., Zhao, W., Beers, D. R., & Henkel-Tigges, J. (2011) · Europe PMC (PubMed Central) · Cited by 179