The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Treatment advances in neonatal neuroprotection and neurointensive care
Open accessAbstract
Knowledge of the nature, prognosis, and ways to treat brain lesions in neonatal infants has increased remarkably. Neonatal hypoxic-ischaemic encephalopathy (HIE) in term infants, mirrors a progressive cascade of excito-oxidative events that unfold in the brain after an asphyxial insult. In the laboratory, this cascade can be blocked to protect brain tissue through the process of neuroprotection. However, proof of a clinical effect was lacking until the publication of three positive randomised controlled trials of moderate hypothermia for term infants with HIE. These results have greatly improved treatment prospects for babies with asphyxia and altered understanding of the theory of neuroprotection. The studies show that moderate hypothermia within 6 h of asphyxia improves survival without cerebral palsy or other disability by about 40% and reduces death or neurological disability by nearly 30%. The search is on to discover adjuvant treatments that can further enhance the effects of hypothermia.
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Cites
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Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
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Self-citation
Cited by
Hypoxic-Ischemic Encephalopathy: A Review for the Clinician
Douglas-Escobar, M., & Weiss, M. D. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2014.3269 · Cited by 778
Cerebral plasticity: windows of opportunity in the developing brain
Ismail, F. Y., Fatemi, A., & Johnston, M. V. (2017) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2016.07.007 · Cited by 572
Self-citationColver, A., Fairhurst, C., & Pharoah, P. O. D. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61835-8 · Cited by 577
Attention-deficit/hyperactivity disorder and very preterm/very low birth weight: a meta-analysis
Franz, A. P., Bolat, G. U., Bolat, H., Matijasevich, A., Santos, I. S., Silveira, R. C., Procianoy, R. S., Rohde, L. A., & Moreira-Maia, C. R. (2018) · Pediatrics · doi:10.1542/peds.2017-1645 · Cited by 317
Panigrahy, A., Schmithorst, V. J., Wisnowski, J. L., Watson, C. G., Bellinger, D. C., Newburger, J. W., & Rivkin, M. J. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.01.013 · Cited by 86
Metadata
- Authors
- Johnston, M. V., Fatemi, A., Wilson, M. A., & Northington, F.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 10
- Issue
- 4
- Pages
- 372-382
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2098603695
- Cited by
- 278
- References
- 142
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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