Cited by 55MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases

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Xu, Jinying, Zheng, Yangyang, Wang, Liangjia, Liu, Yining, Wang, Xishu, Li, Yulin, Chi, Guangfan·2022·Cellular and Molecular Neurobiology

Abstract

Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.

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Crossref · 10.1007/s10571-021-01091-6

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276 of 276 references verified0 citation errors · 0 not checkable

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  • Recent therapeutic approaches involving the delivery of miRNA-124 have demonstrated a neuroprotective role, showing promise in treating neurodegenerative disorders and brain traumas.

    “Recent therapeutic approaches involving the delivery of miRNA-124 have demonstrated a neuroprotective role, showing promise in treating neurodegenerative disorders and brain traumas [167, 168].”

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Authors
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G.
Affiliations
Jilin University (CN)
Corresponding author
  • Li, Yulin
  • Chi, Guangfan
Venue
Cellular and Molecular Neurobiology
Published
2021-04-22
Volume
42
Issue
7
Pages
2031-2053
ISSN
  • 0272-4340 (ISSN-L)
  • 1573-6830
OpenAlex
W3155646278
Cited by
55
References
277
Citations by year
2026: 14 · 2025: 18 · 2024: 9 · 2023: 7 · 2022: 7
FWCI
0.70
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Neurobiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81571199, 81870974)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
miR-124, microRNA, central nervous system injury, ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, neuroinflammation, post-transcriptional regulation, microRNA delivery, therapeutic target
MeSH terms
Central Nervous System, Central Nervous System Diseases, Humans, Spinal Cord Injuries, Neurodegenerative Diseases, Trauma, Nervous System, MicroRNAs

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