miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Open accessAbstract
Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent therapeutic approaches involving the delivery of miRNA-124 have demonstrated a neuroprotective role, showing promise in treating neurodegenerative disorders and brain traumas.
“Recent therapeutic approaches involving the delivery of miRNA-124 have demonstrated a neuroprotective role, showing promise in treating neurodegenerative disorders and brain traumas [167, 168].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [167]
Cites
5 retracted
MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1
An, F.-M., Gong, G.-H., Wang, Y., Bian, M., Li-jun, Y., & Wei, C. (2017) · Oncotarget · doi:10.18632/oncotarget.23119 · Cited by 129 · see citing works
RetractedSw, W., Lx, D., Hy, C., Zq, S., Sl, Y., & Wy, X. (2018) · PubMed · doi:10.26355/eurrev_201801_14201 · Cited by 23 · see citing works
RetractedMiR-124 regulates osteoblast differentiation through GSK-3β in ankylosing spondylitis.
Sl, T., Qh, H., Lg, W., Liu, C., & Al, C. (2018) · PubMed · doi:10.26355/eurrev_201810_16136 · Cited by 20 · see citing works
RetractedWei, C., Ren, L., Li, K., & Lu, Z. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.051 · Cited by 13 · see citing works
RetractedGong, G., Gu, Y., Zhang, Y., Liu, W., Li, L., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117497 · Cited by 1 · see citing works
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,422 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Ostrom, Q. T., Gittleman, H. R., Farah, P., Ondracek, A., Chen, Y., Wolinsky, Y., Stroup, N. E., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not151 · Cited by 12,049 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works
Oncomirs — microRNAs with a role in cancer
Esquela‐Kerscher, A., & Slack, F. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1840 · Cited by 7,038 · see citing works
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works
Feigin, V. L., Nichols, E., Alam, T., Bannick, M. S., Beghi, E., Blake, N., Culpepper, W. J., Dorsey, E. R., Elbaz, A., Ellenbogen, R. G., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30499-x · Cited by 5,644 · see citing works
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956 · see citing works
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works
Non-coding RNAs and cancer: microRNAs and beyond
Raia, R. M., & Călin, G. A. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.e5 · Cited by 3,394 · see citing works
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
Johnson, D. E., O'Keefe, R. A., & Grandis, J. R. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.8 · Cited by 3,110 · see citing works
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works
Feigin, V. L., Lawes, C. M., Bennett, D. A., Barker-Collo, S. L., & Parag, V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70025-0 · Cited by 2,855 · see citing works
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799 · see citing works
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594 · see citing works
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491 · see citing works
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works
Reactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336 · see citing works
Thijs, R. D., Surges, R., O'Brien, T. J., & Sander, J. W. A. S. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32596-0 · Cited by 2,203 · see citing works
Feigin, V. L., Norrving, B., & Mensah, G. A. (2017) · Circulation Research · doi:10.1161/circresaha.116.308413 · Cited by 2,184 · see citing works
Ostrom, Q. T., Gittleman, H. R., Fulop, J., Liu, M. B., Blanda, R., Kromer, C. M., Wolinsky, Y., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov189 · Cited by 2,142 · see citing works
Microglial <scp>M1/M2</scp> polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
Exosomes as drug delivery vehicles for Parkinson’s disease therapy
Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works
Thompson, A. J., Baranzini, S. E., Geurts, J. J. G., Hemmer, B., & Ciccarelli, O. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30481-1 · Cited by 1,856 · see citing works
Compston, A., & Coles, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08220-x · Cited by 1,743 · see citing works
Identification of Mammalian microRNA Host Genes and Transcription Units
Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L., & Bradley, A. (2004) · Genome Research · doi:10.1101/gr.2722704 · Cited by 1,732 · see citing works
Dolecek, T. A., Propp, J. M., Stroup, N. E., & Kruchko, C. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos218 · Cited by 1,710 · see citing works
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589 · see citing works
Dobson, R., & Giovannoni, G. (2018) · European Journal of Neurology · doi:10.1111/ene.13819 · Cited by 1,571 · see citing works
Qureshi, A. I., Mendelow, A. D., & Hanley, D. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60371-8 · Cited by 1,526 · see citing works
Microglia Biology: One Century of Evolving Concepts
Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525 · see citing works
Unfolding the role of protein misfolding in neurodegenerative diseases
Soto, C. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1007 · Cited by 1,506 · see citing works
Diagnosis and Management of Dementia: Review
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019) · JAMA · doi:10.1001/jama.2019.4782 · Cited by 1,451 · see citing works
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,438 · see citing works
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
Burda, J. E., & Sofroniew, M. V. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.034 · Cited by 1,431 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
Keep, R. F., Hua, Y., & Xi, G. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70104-7 · Cited by 1,308 · see citing works
van Es, M. A., Hardiman, O. M., Chiò, A., Al‐Chalabi, A., Pasterkamp, R. J., Veldink, J. H., & van den Berg, L. H. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31287-4 · Cited by 1,305 · see citing works
Astrocyte barriers to neurotoxic inflammation
Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202 · see citing works
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
Soto, C., & Pritzkow, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0235-9 · Cited by 1,180 · see citing works
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works
Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update
An, S. J., Kim, T. J., & Yoon, B. W. (2017) · Journal of Stroke · doi:10.5853/jos.2016.00864 · Cited by 1,020 · see citing works
Mechanism of Oxidative Stress in Neurodegeneration
Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964 · see citing works
Global prevalence and incidence of traumatic spinal cord injury
Fehlings, M. G., Singh, A., Tetreault, L. A., Kalsi‐Ryan, S., & Nouri, A. (2014) · Clinical Epidemiology · doi:10.2147/clep.s68889 · Cited by 950 · see citing works
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938 · see citing works
Traumatic Spinal Cord Injury—Repair and Regeneration
Ahuja, C. S., Nori, S., Tetreault, L., Wilson, J. R., Kwon, B. K., Harrop, J. S., Choi, D., & Fehlings, M. G. (2017) · Neurosurgery · doi:10.1093/neuros/nyw080 · Cited by 927 · see citing works
Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z. G., & Chopp, M. (2012) · Stem Cells · doi:10.1002/stem.1129 · Cited by 897 · see citing works
Self-citationThe global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate
Lee, B. B., Cripps, R. A., Fitzharris, M., & WING, P. C. (2013) · Spinal Cord · doi:10.1038/sc.2012.158 · Cited by 869 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 865 · see citing works
Antiangiogenic therapy in oncology: current status and future directions
Jayson, G. C., Kerbel, R. S., Ellis, L. M., & Harris, A. L. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01088-0 · Cited by 829 · see citing works
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790 · see citing works
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
Silber, J., Lim, D. A., Petritsch, C., Persson, A. I., Maunakea, A. K., Yu, M., Vandenberg, S. R., Ginzinger, D. G., James, C. D., Costello, J. F., et al. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-14 · Cited by 765 · see citing works
Nucleotide sequence and organization of the adeno-associated virus 2 genome
Srivastava, A., Lusby, E. W., & Berns, K. I. (1983) · Journal of Virology · doi:10.1128/jvi.45.2.555-564.1983 · Cited by 721 · see citing works
Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.018 · Cited by 697 · see citing works
Cell death in the nervous system
Bredesen, D. E., Rao, R. V., & Mehlen, P. (2006) · Nature · doi:10.1038/nature05293 · Cited by 638 · see citing works
Evidence for stroke-induced neurogenesis in the human brain
Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W. P., Wang, Y., Shen, J., Mao, Y. Q., Banwait, S., & Greenberg, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603512103 · Cited by 627 · see citing works
Self-citationSystematic review of incidence studies of Parkinson's disease
Twelves, D., Perkins, K. S. M., & Counsell, C. E. (2002) · Movement Disorders · doi:10.1002/mds.10305 · Cited by 619 · see citing works
Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Laterza, O., Lim, L. P., Garrett-Engele, P. W., Vlasáková, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.131797 · Cited by 618 · see citing works
Essandoh, K., Li, Y., Huo, J., & Fan, G. (2016) · Shock · doi:10.1097/shk.0000000000000604 · Cited by 603 · see citing works
Self-citationExosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia
Yang, J., Zhang, X., Chen, X., Wang, L., & Yang, G. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.010 · Cited by 592 · see citing works
Self-citationChappell, W. H., Steelman, L. S., Long, J. M., Kempf, R. C., Abrams, S. L., Franklin, R. A., Bäsecke, J., Stivala, F., Donia, M., Fagone, P., et al. (2011) · Oncotarget · doi:10.18632/oncotarget.240 · Cited by 587 · see citing works
Jeyaseelan, K., Lim, K. Y., & Armugam, A. (2008) · Stroke · doi:10.1161/strokeaha.107.500736 · Cited by 586 · see citing works
Progressive multiple sclerosis: from pathogenic mechanisms to treatment
Correale, J. D., Gaitán, M. I., Ysrraelit, M. C., & Fiol, M. P. (2016) · Brain · doi:10.1093/brain/aww258 · Cited by 583 · see citing works
Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation
Jha, M. K., Jo, M., Kim, J.-H., & Suk, K. (2019) · The Neuroscientist · doi:10.1177/1073858418783959 · Cited by 579 · see citing works
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky, A. M., Sonntag, K.-C., Isacson, O., & Kosik, K. S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0441 · Cited by 574 · see citing works
Incidence and 10-Year Survival of Intracerebral Hemorrhage in a Population-Based Registry
Sacco, S., Marini, C., Toni, D., Olivieri, L., & Carolei, A. (2009) · Stroke · doi:10.1161/strokeaha.108.523209 · Cited by 538 · see citing works
Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons
Brown, G. C., & Neher, J. J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8105-9 · Cited by 526 · see citing works
Song, Y., Li, Z., He, T., Qu, M., Jiang, L., Li, W., Shi, X., Pan, J., Zhang, L., Wang, Y., et al. (2019) · Theranostics · doi:10.7150/thno.30879 · Cited by 487 · see citing works
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
Jimenez-Mateos, E. M., Engel, T., Merino‐Serrais, P., McKiernan, R. C., Tanaka, K., Mouri, G., Sano, T., O’Tuathaigh, C. M. P., Waddington, J. L., Prenter, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2834 · Cited by 463 · see citing works
Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0035-2 · Cited by 459 · see citing works
MicroRNA delivery through nanoparticles
Lee, S. W. L., Paoletti, C., Campisi, M., Osaki, T., Adriani, G., Kamm, R. D., Mattu, C., & Chiono, V. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.007 · Cited by 443 · see citing works
microRNA dysregulation in neurodegenerative diseases: A systematic review
Juźwik, C. A., Drake, S., Zhang, Y., Paradis-Isler, N., Sylvester, A., Amar‐Zifkin, A., Douglas, C., Morquette, B., Moore, C. S., & Fournier, A. E. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101664 · Cited by 436 · see citing works
HUANG, S. H., Ge, X., Yu, J., Han, Z., Yin, Z., Li, Y., Chen, F., Wang, H., Zhang, J., & Lei, P. (2017) · The FASEB Journal · doi:10.1096/fj.201700673r · Cited by 422 · see citing works
Self-citationJucker, M. (2010) · Nature Medicine · doi:10.1038/nm.2224 · Cited by 401 · see citing works
Postoperative Impairment of Cognitive Function in Rats
Wan, Y., Xu, J., Ma, D., Zeng, Y., Cibelli, M., & Maze, M. (2007) · Anesthesiology · doi:10.1097/00000542-200703000-00007 · Cited by 394 · see citing works
Self-citationBurgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., Villa, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094839 · Cited by 385 · see citing works
Matsubara, H., Takeuchi, T., Nishikawa, E., Yanagisawa, K., Hayashita, Y., Ebi, H., Yamada, H., Suzuki, M., Nagino, M., Nimura, Y., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210425 · Cited by 370 · see citing works
Wang, R., Zhang, S., Chen, X., Li, N., Li, J., Jia, R., Pan, Y., & Liang, H. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0911-0 · Cited by 363 · see citing works
Mikita, J., Dubourdieu-Cassagno, N., Deloire, M. S., Vekris, A., Biran, M., Raffard, G., Brochet, B., Canron, M.-H., Franconi, J.-M., Boiziau, C., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458510379243 · Cited by 358 · see citing works
Treatment of multiple sclerosis — success from bench to bedside
Tintoré, M., Vidal‐Jordana, Á., & Sastre‐Garriga, J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0082-z · Cited by 344 · see citing works
Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here
Tobin, M. K., Bonds, J. A., Minshall, R. D., Pelligrino, D. A., Testai, F. D., & Lazarov, O. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.130 · Cited by 327 · see citing works
Adeno-associated viruses undergo substantial evolution in primates during natural infections
Gao, G., Alvira, M. R., Somanathan, S., Lü, Y., Vandenberghe, L. H., Rux, J. J., Calcedo, R., Sanmiguel, J. C., Abbas, Z., & Wilson, J. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937739100 · Cited by 323 · see citing works
Kim, G., Kim, M., Lee, Y., Byun, J. W., Hwang, D. W., & Lee, M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.11.009 · Cited by 313 · see citing works
Astrocyte reactivity and astrogliosis after spinal cord injury
Okada, S., Hara, M., Kobayakawa, K., Matsumoto, Y., & Nakashima, Y. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.10.004 · Cited by 313 · see citing works
Ponomarev, E. D., Veremeyko, T., & Weiner, H. L. (2012) · Glia · doi:10.1002/glia.22363 · Cited by 311 · see citing works
Spinal Cord Injury (SCI) 2016 Facts and Figures at a Glance
(2016) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2016.1210925 · Cited by 307 · see citing works
Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.110 · Cited by 306 · see citing works
Exosomes/miRNAs as mediating cell-based therapy of stroke
Xin, H., Li, Y., & Chopp, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00377 · Cited by 302 · see citing works
Self-citationMicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice
Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M. J., Feinberg, P. A., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., et al. (2013) · Science · doi:10.1126/science.1244193 · Cited by 301 · see citing works
Exosome nanotechnology: An emerging paradigm shift in drug delivery
Lakhal‐Littleton, S., & Wood, M. J. A. (2011) · BioEssays · doi:10.1002/bies.201100076 · Cited by 299 · see citing works
Intracerebral Hemorrhage Associated With Oral Anticoagulant Therapy
Steiner, T., Rosand, J. M., & Diringer, M. N. (2005) · Stroke · doi:10.1161/01.str.0000196989.09900.f8 · Cited by 294 · see citing works
Mitsumoto, H., Brooks, B. R., & Silani, V. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70129-2 · Cited by 291 · see citing works
Jiang, D., Gong, F., Ge, X., Lv, C., Huang, C., Feng, S., Zhou, Z., Rong, Y., Wang, J., Ji, C., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00665-8 · Cited by 282 · see citing works
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression
Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y., Irie, S., Uneo, S., Koyasu, T., Matsui, R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2897 · Cited by 276 · see citing works
The emerging roles of microRNAs in CNS injuries
Bhalala, O. G., Srikanth, M., & Kessler, J. A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.67 · Cited by 274 · see citing works
Metals and neurodegenerative diseases. A systematic review
Cicero, C. E., Mostile, G., Vasta, R., Rapisarda, V., Signorelli, S. S., Ferrante, M., Zappia, M., & Nicoletti, A. S. Q. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.048 · Cited by 269 · see citing works
Sun, Y., Li, Q., Gui, H., Xu, D.-P., Yang, Y., Su, D., & Liu, X. (2013) · Cell Research · doi:10.1038/cr.2013.116 · Cited by 253 · see citing works
miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma
Wei, J., Wang, F., Kong, L.-Y., Xu, S., Doucette, T. A., Ferguson, S. D., Yang, Y., McEnery, K., Jethwa, K. R., Gjyshi, O., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4318 · Cited by 253 · see citing works
Erratum: Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.158 · Cited by 248 · see citing works
Noninvasive Molecular Imaging of Neuroinflammation
Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245 · see citing works
Ge, X., Guo, M., Hu, T., Li, W., Huang, S., Yin, Z., Li, Y., Chen, F., Zhu, L., Kang, C., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2019.11.017 · Cited by 242 · see citing works
Self-citationPathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
Ciccarelli, O., Barkhof, F., Bodini, B., Stefano, N. D., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler‐Kingshott, C. A. M. G., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70101-2 · Cited by 241 · see citing works
Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients
Ji, Q., Ji, Y., Peng, J., Zhou, X., Chen, X., Zhao, H., Xu, T., Chen, L., & Xu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163645 · Cited by 236 · see citing works
Genetically engineered mouse models of neurodegenerative diseases
Wong, P. C., Cai, H., Borchelt, D., & Price, D. L. (2002) · Nature Neuroscience · doi:10.1038/nn0702-633 · Cited by 232 · see citing works
Molecular subclassification of diffuse gliomas: Seeing order in the chaos
Huse, J. T., PHILLIPS, H. S., & Brennan, C. W. (2011) · Glia · doi:10.1002/glia.21165 · Cited by 231 · see citing works
Respiratory Failure in Amyotrophic Lateral Sclerosis
Niedermeyer, S. E., Murn, M., & Choi, P. J. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.06.035 · Cited by 231 · see citing works
Puyal, J., Ginet, V., & Clarke, P. G. H. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.002 · Cited by 218 · see citing works
Liu, X., Chopp, M., Zhang, R. L., Tao, T., Wang, X. L., Kassis, H., Hozeska‐Solgot, A., Zhang, L., Chen, C., & Zhang, Z. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023461 · Cited by 215 · see citing works
Self-citationWitiw, C. D., & Fehlings, M. G. (2015) · Journal of Spinal Disorders & Techniques · doi:10.1097/bsd.0000000000000287 · Cited by 215 · see citing works
Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM
Florczyk, S. J., Wang, K., Jana, S., Wood, D. L., Sytsma, S. K., Sham, J. G., Kievit, F. M., & Zhang, M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.034 · Cited by 213 · see citing works
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
Smith, P. Y., Hashimi, A. A., Girard, J., Delay, C., & Hébert, S. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 209 · see citing works
Wang, X., Liu, D., Huang, H., Wang, Z., Hou, T., Yang, X., Pang, P., Wei, N., Zhou, Y., Dupras, M.-J., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.023 · Cited by 205 · see citing works
Self-citationMicroRNAs: A new class of gene regulators
Guarnieri, D. J., & Dileone, R. (2008) · Annals of Medicine · doi:10.1080/07853890701771823 · Cited by 202 · see citing works
Microglia centered pathogenesis in ALS: insights in cell interconnectivity
Brites, D. M. T. O., & Vaz, A. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00117 · Cited by 201 · see citing works
Yang, Y., Ye, Y., Kong, C., Su, X., Zhang, X., Bai, W., & He, X. (2019) · Neurochemical Research · doi:10.1007/s11064-018-02714-z · Cited by 199 · see citing works
The role of α-synuclein in neurodegenerative diseases
Bennett, M. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.010 · Cited by 195 · see citing works
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
Taj, S. H., Kho, W., Riou, A., Wiedermann, D., & Hoehn, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.025 · Cited by 191 · see citing works
The benefits of neuroinflammation for the repair of the injured central nervous system
Yong, H. Y. F., Rawji, K. S., Ghorbani, S., Xue, M., & Yong, V. W. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0223-3 · Cited by 190 · see citing works
Wang, H., Ye, Y., Zhu, Z., Mo, L., Lin, C., Wang, Q., Wang, H., Gong, X., He, X., Lu, G., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12267 · Cited by 173 · see citing works
MicroRNAs: Novel Regulators During the Immune Response
Bi, Y., Liu, G., & Yang, R. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21639 · Cited by 172 · see citing works
Loss of Brain-enriched miR-124 MicroRNA Enhances Stem-like Traits and Invasiveness of Glioma Cells
Xia, H., Cheung, W. K. C., Ng, S. S., Jiang, X., Jiang, S., Sze, J., Leung, G., Lü, G., Chan, D. T. M., Bian, X., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.332627 · Cited by 172 · see citing works
Skalsky, R. L., & Cullen, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024248 · Cited by 170 · see citing works
MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease
Saraiva, C., Paiva, J., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.005 · Cited by 169 · see citing works
Kwon, I., & Schaffer, D. V. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9431-0 · Cited by 164 · see citing works
Yao, L., Zhu, Z., Wu, J., Zhang, Y., Zhang, H., Sun, X., Qian, C., Wang, B., Xie, L., Zhang, S., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900363r · Cited by 161 · see citing works
MicroRNA-124 as a novel treatment for persistent hyperalgesia
Willemen, H. L. D. M., Huo, X., Mao‐Ying, Q., Zijlstra, J., Heijnen, C. J., & Kavelaars, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-143 · Cited by 160 · see citing works
Pathophysiology of status epilepticus
Walker, M. C. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.044 · Cited by 160 · see citing works
microRNA and stem cell function
Hatfield, S. D., & Ruohola‐Baker, H. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0530-3 · Cited by 159 · see citing works
Molecular Engineering of Viral Gene Delivery Vehicles
Schaffer, D. V., Koerber, J. T., & Lim, K. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160514 · Cited by 159 · see citing works
Yao, L., Ye, Y., Mao, H., Lu, F., He, X., Lu, G., & Zhang, S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1053-4 · Cited by 159 · see citing works
Li, R., Zhao, K., Ruan, Q., Meng, C., & Yin, F. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-2146-x · Cited by 158 · see citing works
Dutta, R., Chomyk, A. M., Chang, A., Ribaudo, M. V., Deckard, S. A., Doud, M. K., Edberg, D. D., Bai, B., Li, M., Baranzini, S. E., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23860 · Cited by 156 · see citing works
Doeppner, T. R., Doehring, M., Bretschneider, E., Zechariah, A., Kaltwasser, B., Müller, B., Koch, J. C., Bähr, M., Hermann, D. M., & Michel, U. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1142-5 · Cited by 155 · see citing works
Peng, J., Omran, A. G., Ashhab, M. U., Kong, H., Gan, N., He, F. P., & Yin, F. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9953-3 · Cited by 145 · see citing works
MicroRNAs mediating CNS inflammation: Small regulators with powerful potential
Su, W., Aloi, M. S., & Garden, G. A. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.003 · Cited by 139 · see citing works
Adeno-Associated Virus Vectors and Neurological Gene Therapy
Ojala, D. S., Amara, D. P., & Schaffer, D. V. (2014) · The Neuroscientist · doi:10.1177/1073858414521870 · Cited by 137 · see citing works
MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics
Nieto‐Díaz, M., Esteban, F. J., Reigada, D., Muñoz‐Galdeano, T., Yunta, M., Caballero-López, M. J., Navarro-Ruíz, R., del Águila, Á., & Maza, R. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00053 · Cited by 135 · see citing works
Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135 · see citing works
Qian, D., Li, L., Rong, Y., Liu, W., Wang, Q., Zhou, Z., Gu, C., Huang, Y., Zhao, X., Chen, J., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1667189 · Cited by 133 · see citing works
MicroRNAs: 'ribo-regulators' of glucose homeostasis
Gauthier, B. R., & Wollheim, C. B. (2006) · Nature Medicine · doi:10.1038/nm0106-36 · Cited by 132 · see citing works
miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion
Fowler, A., Thomson, D. W., Giles, K. M., Maleki, S., Mreich, E., Wheeler, H. T., Leedman, P. J., Biggs, M. T., Cook, R., Little, N., et al. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.026 · Cited by 132 · see citing works
Shi, Z., Chen, Q., Li, C.-Y., Wang, L., Qian, X., Jiang, C., Liu, X., Wang, X., Hai, L., Kang, C., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou084 · Cited by 131 · see citing works
Self-citationSharif, S., Ghahremani, M. H., & Soleimani, M. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9788-3 · Cited by 130 · see citing works
Plasma miR-124 as a biomarker for cerebral infarction
Weng, H., Shen, C.-S., Hirokawa, G., Ji, X., Takahashi, R., Shimada, K., Kishimoto, C., & Iwai, N. (2011) · Biomedical Research · doi:10.2220/biomedres.32.135 · Cited by 125 · see citing works
Su, Y., Deng, M., Xiong, W., Xie, A., Guo, J., Liang, Z., Hu, B., Chen, J., Zhu, X., Man, H., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.008 · Cited by 123 · see citing works
Role of Exosomes as a Treatment and Potential Biomarker for Stroke
Otero‐Ortega, L., Laso-García, F., Frutos, M. G.-D., Fuentes, B., Diekhorst, L., Díez‐Tejedor, E., & Gutiérrez‐Fernández, M. (2018) · Translational Stroke Research · doi:10.1007/s12975-018-0654-7 · Cited by 122 · see citing works
Yu, A., Zhang, T., Duan, H., Pan, Y., Zhang, X., Yang, G., Wang, J., Deng, Y., & Yang, Z. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.12.003 · Cited by 121 · see citing works
Li, D., Huang, S., Yin, Z., Zhu, J., Ge, X., Han, Z., Tan, J., Zhang, S., Zhao, J., Chen, F., et al. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02825-1 · Cited by 121 · see citing works
RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS
Mishima, T., Mizuguchi, Y., Kawahigashi, Y., Takizawa, T., & Takizawa, T. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.035 · Cited by 120 · see citing works
MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy
Zheng, H., Tang, R., Yao, Y., Ji, Z., Cao, Y., Liu, Z., Peng, F., Wang, W., Can, D., Xing, H., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8981-5 · Cited by 120 · see citing works
Kanagaraj, N., Beiping, H., Dheen, S. T., & Tay, S. S. W. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.039 · Cited by 119 · see citing works
Zhao, M.-Y., Wang, G.-Q., Wang, N.-N., Qiao-yan, Y., Liu, R.-L., & Shi, W. (2019) · Neurological Research · doi:10.1080/01616412.2018.1548747 · Cited by 118 · see citing works
Brennan, G. P., Dey, D., Chen, Y., Patterson, K. P., Magnetta, E., Hall, A. M., Dubé, C. M., Mei, Y., & Baram, T. Z. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.042 · Cited by 114 · see citing works
Survivorship in adults with malignant brain and other central nervous system tumor from 2000–2014
Gittleman, H. R., Boscia, A. L., Ostrom, Q. T., Truitt, G., Fritz, Y., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy090 · Cited by 113 · see citing works
Li, N., Pan, X., Zhang, J., Ma, A., Yang, S., Ma, J., & Xie, A. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2841-9 · Cited by 107 · see citing works
Nanoscale delivery systems for microRNAs in cancer therapy
Boca, S., Gulei, D., Zimța, A., Onaciu, A., Magdo, L., Țigu, A. B., Ionescu, C., Irimie, A., Buiga, R., & Berindan‐Neagoe, I. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03317-9 · Cited by 104 · see citing works
Virtual reality for spinal cord injury-associated neuropathic pain: Systematic review
Chi, B., Chau, B., Yeo, E., & Ta, P. (2019) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2018.09.006 · Cited by 97 · see citing works
Shimada, I. S., Peterson, B. M., & Spees, J. L. (2010) · Stroke · doi:10.1161/strokeaha.110.589010 · Cited by 95 · see citing works
Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
Martier, R., Liefhebber, J. M. P., García‐Osta, A., Miniarikova, J., Cuadrado‐Tejedor, M., Espelosin, M., Ursúa, S., Petry, H., van Deventer, S. J. H., Evers, M. M., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.02.001 · Cited by 89 · see citing works
Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia
Taj, S. H., Kho, W., Aswendt, M., Collmann, F. M., Green, C., Adamczak, J. M., Tennstaedt, A., & Hoehn, M. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9700-y · Cited by 88 · see citing works
Mori, T., Tan, J., Arendash, G. W., Koyama, N., Nojima, Y., & Town, T. (2008) · Stroke · doi:10.1161/strokeaha.107.503821 · Cited by 85 · see citing works
Cunha, C., Santos, C., Gomes, C., Fernandes, A. M. A., Correia, A. M., Sebastião, A. M., Vaz, A. R., & Brites, D. M. T. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0631-2 · Cited by 85 · see citing works
Chen, Y., Sun, J., Chen, W., Wu, G.-C., Wang, Y.-Q., Zhu, K., & Wang, J. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0061-x · Cited by 84 · see citing works
Haston, K. M., & Finkbeiner, S. M. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103548 · Cited by 81 · see citing works
Varley, J. A., Brooks, D. J., & Edison, P. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.08.105 · Cited by 81 · see citing works
Gebauer, K., Peters, I., Dubrowinskaja, N., Hennenlotter, J., Abbas, M., Scherer, R., Tezval, H., Merseburger, A., Stenzl, A., Kuczyk, M., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.537 · Cited by 81 · see citing works
Methamphetamine use and future risk for Parkinson’s disease: Evidence and clinical implications
Lappin, J., Darke, S. G., & Farrell, M. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.02.032 · Cited by 80 · see citing works
Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke
Sørensen, S. S., Nygaard, A., Carlsen, A. L., Heegaard, N. H. H., Bak, M., & Christensen, T. (2017) · Biomarker Research · doi:10.1186/s40364-017-0104-9 · Cited by 78 · see citing works
The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity
Wang, W., Wang, X., Chen, L., Zhang, Y., Xu, Z., Liu, J., Jiang, G., Li, J., Zhang, X., Wang, K., et al. (2016) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2016.3 · Cited by 76 · see citing works
Self-citationComparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke
Leung, L. Y., Chan, C. P.-Y., Leung, Y. K., Jiang, H. L., Abrigo, J., Wang, D. F., Chung, J., Rainer, T. H., & Graham, C. A. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.03.007 · Cited by 72 · see citing works
Zhou, Y., Deng, J., Chu, X., Zhao, Y., & Guo, Y. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-181053 · Cited by 72 · see citing works
Gan, L., Li, Z., Lv, Q.-K., & Huang, W. Y. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118449 · Cited by 72 · see citing works
Chivero, E. T., Liao, K., Niu, F., Tripathi, A., Tian, C., Buch, S., & Hu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00573 · Cited by 69 · see citing works
Dong, R., Zhang, B., Tai, L., Liu, H., Shi, F., & Liu, N. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26170 · Cited by 68 · see citing works
MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases
Saraiva, C., Esteves, M., & Bernardino, L. I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.008 · Cited by 68 · see citing works
Yelick, J., Men, Y., Jin, S., Seo, S., Espejo‐Porras, F., & Yang, Y. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113414 · Cited by 68 · see citing works
miR-124-3p attenuates MPP + -induced neuronal injury by targeting STAT3 in SH-SY5Y cells
Geng, L., Liu, W., & Chen, Y. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217734492 · Cited by 66 · see citing works
miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice
Du, X., Huo, X., Yang, Y., Hu, Z., Botchway, B. O. A., Jiang, Y., & Fang, M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.08.082 · Cited by 63 · see citing works
Human Brain Injury and miRNAs: An Experimental Study
Sessa, F., Maglietta, F., Bertozzi, G., Salerno, M., Mizio, G. D., Messina, G., Montana, A., Ricci, P., & Pomara, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071546 · Cited by 63 · see citing works
Wang, D., Shi, L., Xin, W., Xu, J., Xu, J., Li, Q., Xu, Z. Z., Wang, J., Wang, G., Yao, W., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.03.106 · Cited by 63 · see citing works
Self-citationMicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma
Mucaj, V., Lee, S. S., Skuli, N., Giannoukos, D. N., Qiu, B., Eisinger‐Mathason, T. S. K., Nakazawa, M. S., Shay, J. E. S., Gopal, P. P., Venneti, S., et al. (2014) · Oncogene · doi:10.1038/onc.2014.168 · Cited by 61 · see citing works
Jiang, S., Li, C., McRae, G., Lykken, E. A., Sevilla, J., Liu, S.-Q., Wan, Y., & Li, Q.-J. (2014) · Science Signaling · doi:10.1126/scisignal.2004824 · Cited by 61 · see citing works
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 61 · see citing works
Flagged first, then by citations
1 of the 277 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis
Datta, N., Johnson, C., Kao, D. H., Gurnani, P., Alexander, C., Polytarchou, C., & Monaghan, T. M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106870 · Cited by 39 · see citing works
Biomarkers in neurodegenerative diseases: a broad overview
Sathish, S., & Ayyavoo, V. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00075 · Cited by 38 · see citing works
Li, Y., Peng, B., Li, Y., Huang, A., Peng, Y., Yu, Q., & Li, Y. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109900 · Cited by 33 · see citing works
Self-citationQu, X., Zhang, L., & Wang, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06238 · Cited by 29 · see citing works
Self-citationKim, C., Koo, K., Kim, H. J., & Kim, T. P. (2024) · Biosensors · doi:10.3390/bios14080407 · Cited by 28 · see citing works
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Chen, Y., An, Q., Yang, S., Chen, Y.-L., Tong, L., & Ji, L.-L. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114154 · Cited by 27 · see citing works
Wang, J., Li, S., Lan, Y., Liu, X., & Li, W. (2024) · Current Medicine · doi:10.1007/s44194-024-00031-y · Cited by 23 · see citing works
MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
Yao, T.-T., Chen, L., Du, Y., Jiang, Z., & Cheng, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04582-x · Cited by 21 · see citing works
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
Asl, E. R., Hosseini, S. E., Tahmasebi, F., Bolandi, N., & Barati, S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01578-6 · Cited by 19 · see citing works
Lipid nanoparticle-mediated delivery of microRNA-124 reduces neuroinflammation
Ma, Z., Dang, H. A., Yang, J., Rodella, G., Mwema, A., Lombaerde, E. D., Chen, Y., Geest, B. G. D., Pesch, V. V., Muccioli, G. G., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123589 · Cited by 19 · see citing works
Intramolecular DNA Wheel Construction for Highly Sensitive Electrochemical Detection of miRNA
Qu, X., Han, Y., Huang, Q., & Miao, P. (2025) · Nano Letters · doi:10.1021/acs.nanolett.4c05127 · Cited by 18 · see citing works
Stevanović, M. J., Ninković, D. S., Mojsin, M. M., Drakulić, D., & Schwirtlich, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.338990 · Cited by 17 · see citing works
Shi, L., Ji, C.-H., Tang, W., Liu, Y., Zhang, W., & Guan, W. (2022) · Current Neurovascular Research · doi:10.2174/1567202619666220713105306 · Cited by 17 · see citing works
Self-citationGhosh, M., Bayat, A., & Pearse, D. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157246 · Cited by 17 · see citing works
Regulation of Oxidative Stress by Long Non-coding RNAs in Central Nervous System Disorders
Xu, X., & Zhang, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.931704 · Cited by 15 · see citing works
Yang, J., Dong, J., Li, H., Gong, Z., Wang, B., Du, K., Zhang, C., Bi, H., Wang, J., Tian, X., et al. (2023) · ACS Omega · doi:10.1021/acsomega.3c06679 · Cited by 16 · see citing works
Fang, C., Qian, J., Tu, B., Xia, X., Jia, C.-Y., & Shen, C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04755-2 · Cited by 9 · see citing works
Zhang, X., Cai, Y., Sit, B. H. M., Jian, R. X., Malki, Y., Zhang, Y., Ong, C. C. Y., Li, Q., Lam, R. P. K., & Rainer, T. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041530 · Cited by 8 · see citing works
Anjum, A., Chan, A., Hussain, H. B., & Lokanathan, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s522028 · Cited by 8 · see citing works
MicroRNA-Based Delivery Systems for Chronic Neuropathic Pain Treatment in Dorsal Root Ganglion
Jackson, S., Gigliobianco, M. R., Casadidio, C., Martino, P. D., & Censi, R. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070930 · Cited by 7 · see citing works
Extracellular vesicle-based therapies for neurodegenerative diseases
Hu, G., Gogzheyan, C., Panja, S., Sil, S., & Gendelman, H. E. (2025) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2025-0016 · Cited by 6 · see citing works
Research progress of miRNA in post-stroke cognitive impairment
Weng, Y., Xue, C., Guo, H., Zhang, L., & Tang, X. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111796 · Cited by 7 · see citing works
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Tahmasebi, F., Asl, E. R., Vahidinia, Z., & Barati, S. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01478-1 · Cited by 5 · see citing works
Guo, L., Liu, C., Jiang, C., Dong, Y., Aung, L. H. H., Ding, H., & Gao, Y. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13031 · Cited by 5 · see citing works
miR-124 and VAMP3 Act Antagonistically in Human Neuroblastoma
Zhang, X., Yang, C., Meng, Z., Zhong, H., Hou, X., Wang, F., Lu, Y., Guo, J., & Zeng, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914877 · Cited by 5 · see citing works
miR-124 in Neuroblastoma: Mechanistic Insights, Biomarker Potential, and Therapeutic Prospects
Monisha, K. M., Shivakumar, D. A., Mutthuraj, D., Nandini, G., Muthusami, S., & Basalingappa, K. M. (2024) · Current Proteomics · doi:10.2174/0115701646331003240821061517 · Cited by 4 · see citing works
Ion channel and biophysical properties of extracellular vesicles
Sanghvi, S. K., & Singh, H. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111364 · Cited by 3 · see citing works
Dual Roles of Exosomes in Tumor Progression and Their Bioengineering as Targeted Drug Carriers
Wu, J., Zhou, Y., Jiang, Y., Xu, W., Yan, T. X., & Ma, S. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c07735 · Cited by 4 · see citing works
Geng, Y., Lv, H., Liu, Y., Guo, D., Zheng, J., Li, Y., Jiang, H., & Chen, D. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14971 · Cited by 3 · see citing works
Self-citationPal, P., Sharma, M., Gupta, S. K., Potdar, M. B., & Belgamwar, A. V. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150778 · Cited by 2 · see citing works
Zhu, Y., Tong, J., Jiang, J., Shi, K., Xie, J., Zhu, Y., Li, Y., & Xu, Y. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01572-3 · Cited by 3 · see citing works
Self-citationLiu, C., Chen, J., Xu, G., & Ma, L. (2025) · Neurological Research · doi:10.1080/01616412.2025.2571981 · Cited by 2 · see citing works
Gupta, R. V., Begum, M. Y., Kumar, R., Gupta, J., Nagraik, R., Panda, S. P., Abomughaid, M. M., Lakhanpal, S., Avinash, D., Osmani, R. A. M., et al. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10258-7 · Cited by 4 · see citing works
JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention
Zhang, X., Li, P., Ma, F., Wang, T., Chu, Q., Wei, S., Xue, C., Wang, Z., & Lu, J. J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02692-9 · Cited by 3 · see citing works
Yadav, B., Gangwar, P., Kumari, K., Yadav, A., Rao, R., Kumar, K., Verma, H., Dhiman, M., & Mantha, A. K. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1835778 · Cited by 2 · see citing works
Mengel‐From, J., Nielsen, K. E., Clemmensen, S. B., Feddersen, S., Christensen, K., Hjelmborg, J., Tan, Q., & Nygaard, M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111980 · Cited by 1 · see citing works
Correlation of miRNA-124-3p and SP1 expression levels in spinal cord injury
Zand, M., Sadegh, M., Khansarinejad, B., & Mondanizadeh, M. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102231 · Cited by 1 · see citing works
miR-124 acts During Drosophila Development to Determine the Phase of Adult Circadian Behavior
Xia, Y., Chen, C., & Emery, P. (2025) · Journal of Biological Rhythms · doi:10.1177/07487304251361579 · Cited by 1 · see citing works
Aljabali, A. A. A., Alkaraki, A. K., Gammoh, O., Qnais, E. Y., Alqudah, A. M., Alshaer, W., Mishra, V. K., Mishra, Y., & El‐Tanani, M. (2025) · Current Clinical Pharmacology · doi:10.2174/0127724328381443250825092900 · Cited by 1 · see citing works
Pachauri, P. K., & Panda, S. P. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02121-9 · Cited by 1 · see citing works
Wang, R., Feng, Y., Zhou, Z., Jiang, J., Zhang, R., Zou, W., Yang, H., Lv, W., & Shen, Y. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1748418 · Cited by 2 · see citing works
Li, Y.-J., Chen, X., Luo, Y., Chang, J., Liu, S.-Z., Shan, X., Song, J.-J., Hao, N., Yan, X.-H., Gao, W.-L., et al. (2026) · World Journal of Stem Cells · doi:10.4252/wjsc.v18.i3.114929 · Cited by 1 · see citing works
Self-citationmicroRNA-124 in Alzheimer’s Disease: Bridging Neuro-regulation and Emerging Therapeutic Strategies
Mandal, S., Singh, G., Banga, A., Maparu, K., & Aran, K. R. (2026) · Current Pharmacology Reports · doi:10.1007/s40495-026-00454-1 · Cited by 1 · see citing works
Fuso, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21863-7.00016-0 · Cited by 1 · see citing works
Shahkileh, S. S. V., Ghaderian, S. M. H., Sheikhha, M. H., Mohammadpour, H., Rakhshan, A., Bastami, M., & Vojdani, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1566888/v1
Noble, F., & Marie, N. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77934-3.00005-6
Towards an armed oncolytic virus approach to glioblastoma treatmentPreprint
Calistri, A., Reale, A., Fornaini, M. V., Donati, V., Rego, A. G. D. O. D., Panarelli, M., Rossetto, A., Pietro, C. D., Trevisan, M., Persano, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.07.641877
Calistri, A., Rossetto, A., Reale, A., Fornaini, M. V., Panarelli, M., Persano, L., Rampazzo, E., Parolin, C., Donati, V., do Rêgo, A. G. D. O., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08329-1
Acupuncture in neural stem cell-based therapy for cognitive impairment
Chang, H.-C. (2026) · World Journal of Stem Cells · doi:10.4252/wjsc.119872
Chen, Y., Tang, F., & Li, X. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05198-9
Lin, Y.-L., Chen, Y., Ji, X.-Y., Zhang, Z.-H., Piao, C., Tong, L., & Ji, L. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110994
Soltani, S., Zandi, M., Mirzaei, H., Ebrahimi, S., Zaheri, H. R., & Abbasi, S. (2026) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/cjid/5657680
- Authors
- Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G.
- Affiliations
- Jilin University (CN)
- Corresponding author
- Li, Yulin
- Chi, Guangfan
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2021-04-22
- Volume
- 42
- Issue
- 7
- Pages
- 2031-2053
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11421642
- OpenAlex
- W3155646278
- Cited by
- 55
- References
- 277
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 9 · 2023: 7 · 2022: 7
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571199, 81870974)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- miR-124, microRNA, central nervous system injury, ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, neuroinflammation, post-transcriptional regulation, microRNA delivery, therapeutic target
- MeSH terms
- Central Nervous System, Central Nervous System Diseases, Humans, Spinal Cord Injuries, Neurodegenerative Diseases, Trauma, Nervous System, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review