The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Frontotemporal dementia and its subtypes: a genome-wide association study
Open accessAbstract
Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72--have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. Methods We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. To reduce genetic heterogeneity, all participants were of European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10(-8)) single-nucleotide polymorphisms. Findings We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10(-8)). Combined (joint) analyses of discovery and replication phases showed genome-wide significant association at 6p21.3, HLA locus (immune system), for rs9268877 (p=1·05 × 10(-8); odds ratio=1·204 [95% CI 1·11-1·30]), rs9268856 (p=5·51 × 10(-9); 0·809 [0·76-0·86]) and rs1980493 (p value=1·57 × 10(-8), 0·775 [0·69-0·86]) in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC (the transcripts of which are related to lysosomal biology), for the behavioural FTD subtype for which joint analyses showed suggestive association for rs302668 (p=2·44 × 10(-7); 0·814 [0·71-0·92]). Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation in cis. Interpretation Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and to shed light on the pathomechanisms contributing to FTD. Funding The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/MRC Centre on Parkinson's disease, Alzheimer's Research UK, and Texas Tech University Health Sciences Center.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“MAPT mutations drive tau pathology”
From The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders (2024) · cites this paper as Ferrari et al. 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Age-dependent neurodegenerative disorders are clinically diverse but exhibit significant comorbidity and heterogeneous pathology both within and across disorders”
From The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders (2024) · cites this paper as Ferrari et al. 2014
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Self-citationClassification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Self-citationFrontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Self-citationDeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936
Self-citationA Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409
Self-citationMeta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citation
Cited by
Sorted by citations
Items 101–200 of 386
Neuroinflammation — using big data to inform clinical practice
Dendrou, C. A., McVean, G., & Fugger, L. H. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.171 · Cited by 43
Mukherjee, S., Russell, J. C., Carr, D. T., Burgess, J. D., Allen, M., Serie, D. J., Boehme, K. L., Kauwe, J. S. K., Naj, A. C., Fardo, D. W., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.01.016 · Cited by 39
Self-citationGlial cells and adaptive immunity in frontotemporal dementia with tau pathology
Hartnell, I. J., Blum, D. L., Nicoll, J. A. R., Dorothée, G., & Boche, D. (2020) · Brain · doi:10.1093/brain/awaa457 · Cited by 41
Uncovering the impact of noncoding variants in neurodegenerative brain diseases
Frydas, A., Wauters, E., van der Zee, J., & Broeckhoven, C. V. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.08.010 · Cited by 44
Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A. E., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.08.007 · Cited by 40
Self-citationDistinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies
Kohl, Z., Schlachetzki, J. C. M., Stemick, J., Hornauer, P., Münch, M., Adame, A., Riemenschneider, M. J., Winkler, J., & Masliah, E. (2017) · Neural Plasticity · doi:10.1155/2017/3851262 · Cited by 39
Self-citationPalluzzi, F., Ferrari, R., Graziano, F., Novelli, V., Rossi, G., Galimberti, D., Rainero, I., Benussi, L., Nacmias, B., Bruni, A. C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185797 · Cited by 38
Self-citationOverlapping genetic architecture between Parkinson disease and melanoma
Dube, U., Ibáñez, L., Budde, J., Benítez, B. A., Davis, A. A., Harari, O., Iles, M. M., Law, M. H., Brown, K. M., & Cruchaga, C. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02110-z · Cited by 40
Self-citationXu, W., Han, S., Zhang, C. M., Li, J., Wang, Y., Tan, C., Li, H.-Q., Dong, Q., Mei, C., Tan, L., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb3063 · Cited by 39
Moguilner, S., Whelan, R., Adams, H., Valcour, V., Tagliazucchi, E., & Ibáñez, A. (2023) · eBioMedicine · doi:10.1016/j.ebiom.2023.104540 · Cited by 39
Multi-functional role of apolipoprotein E in neurodegenerative diseases
Islam, S., Noorani, A. A., Sun, Y., Michikawa, M., & Zou, K. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1535280 · Cited by 43
Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia
Kreisl, W. C., Henter, I. D., & Innis, R. B. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.004 · Cited by 41
Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning
Koutsouleris, N., Pantelis, C., Velakoulis, D., McGuire, P. K., Dwyer, D., Urquijo-Castro, M. F., Paul, R., Dong, S., Popovic, D., Oeztuerk, O. F., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.2075 · Cited by 42
Self-citationFernández, M. V., Liu, M., Beric, A., Johnson, M., Cetin, A., Patel, M. R., Budde, J., Kohlfeld, P., Bergmann, K., Lowery, J., et al. (2024) · Scientific Data · doi:10.1038/s41597-024-03485-9 · Cited by 41
Self-citationRecent advances in the molecular genetics of frontotemporal lobar degeneration
Rainero, I. (2017) · Functional Neurology · doi:10.11138/fneur/2017.32.1.007 · Cited by 34
Self-citationExamining the Lancet Commission risk factors for dementia using Mendelian randomisation
Desai, R., John, A., Saunders, R., Marchant, N. L., Buckman, J. E. J., Charlesworth, G. M., Zuber, V., & Stott, J. C. H. (2023) · BMJ Mental Health · doi:10.1136/bmjment-2022-300555 · Cited by 35
Genetic risk factor clustering within and across neurodegenerative diseases
Koretsky, M. J., Alvarado, C. X., Makarious, M. B., Vitale, D., Levine, K. S., Bandrés‐Ciga, S., Dadu, A., Scholz, S. W., Sargent, L. J., Faghri, F., et al. (2023) · Brain · doi:10.1093/brain/awad161 · Cited by 31
Self-citationDifferences in Sex Distribution Between Genetic and Sporadic Frontotemporal Dementia
de Boer, S. C. M., Riedl, L., van der Lee, S. J., Otto, M., Anderl‐Straub, S., Landín-Romero, R., Sorrentino, F., Fieldhouse, J. L. P., Reus, L. M., Vacaflor, B., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210688 · Cited by 35
Self-citationGluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
Italia, M., Ferrari, E. S., Luca, M. D., & Gardoni, F. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105539 · Cited by 32
Unlocking the Therapeutic Potential of Natural Products for Alzheimer’s Disease
Li, Z., Zhang, Z., & Yu, B. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c03049 · Cited by 33
Technological readiness and implementation of genomic‐driven precision medicine for complex diseases
Franks, P. W., Melén, E., Friedman, M., Sundström, J., Kockum, I. S., Klareskog, L., Almqvist, C., Bergen, S. E., Czene, K., Hägg, S., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13330 · Cited by 34
Modifiers of GRN -Associated Frontotemporal Lobar Degeneration
Wauters, E., Mossevelde, S. V., van der Zee, J., Cruts, M., & Broeckhoven, C. V. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.004 · Cited by 33
Self-citationMusa, G., Lillo, P., van der Hiele, K., Méndez‐Orellana, C., Ibáñez, A. M., & Slachevsky, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.734251 · Cited by 31
Artificial intelligence for dementia genetics and omics
Bettencourt, C., Skene, N., Bandres‐Ciga, S., Anderson, E., Winchester, L. M., Foote, I. F., Schwartzentruber, J., Botia, J. A., Nalls, M., Singleton, A., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13427 · Cited by 30
Self-citationJiang, D., Hou, J., Nan, H., Yue, A., Chu, M. K., Wang, Y., Wang, Y., & Wu, L. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01586-6 · Cited by 34
Ciani, M., Benussi, L., Bonvicini, C., & Ghidoni, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00506 · Cited by 32
Self-citationOverlapping Genetic Architecture Between Schizophrenia and Neurodegenerative Disorders
Li, C., Yang, T., Ou, R., & Shang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.797072 · Cited by 33
Miedema, S. S. M., Mol, M. O., Koopmans, F., Hondius, D., van Nierop, P., Menden, K., Mestdagh, C. F. D. V., van Rooij, J., Ganz, A. B., Paliukhovich, I., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01387-8 · Cited by 27
Self-citationConserved gene signatures shared among MAPT mutations reveal defects in calcium signaling
Minaya, M., Mahali, S. K., Iyer, A. K., Eteleeb, A. M., Martinez, R. J., Huang, G., Budde, J., Temple, S., Nana, A. L., Seeley, W. W., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1051494 · Cited by 29
Self-citationGenetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease
Nott, A., & Holtman, I. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168539 · Cited by 33
Yang, C., Farias, F. G., Ibáñez, L., Sadler, B. E., Fernández, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., Budde, J., et al. (2020) · medRxiv · doi:10.1101/2020.06.25.20140277 · Cited by 29
Self-citationLi, M., Jiang, C., Lai, Y., Wang, Y., Zhao, M., Li, S., Peng, X., He, L., Guo, X., Li, S., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029623 · Cited by 29
Genetic Diversity in Frontotemporal Dementia
Shpilyukova, Y. A., Fedotova, E. Y., & Illarioshkin, S. N. (2020) · Molecular Biology · doi:10.1134/s0026893320010136 · Cited by 28
Rodríguez‐Fernández, B., Gispert, J. D., Guigó, R., Navarro, A., Vilor‐Tejedor, N., & Crous‐Bou, M. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.006 · Cited by 30
Shared genetic links between frontotemporal dementia and psychiatric disorders
Li, C., Pang, D., Lin, J., Yang, T., & Shang, H. (2022) · BMC Medicine · doi:10.1186/s12916-022-02335-y · Cited by 28
Review: Molecular pathology of frontotemporal lobar degenerations
Borroni, B., Alberici, A., & Buratti, E. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12534 · Cited by 26
Self-citationNascimento, C. F., Nunes, P. V., Rodriguez, R. D., Takada, L. T., Suemoto, C. K., Grinberg, L. T., Nitríni, R., & Lafer, B. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.04.008 · Cited by 26
Valentino, R. R., Scotton, W. J., Roemer, S. F., Lashley, T., Heckman, M. G., Shoai, M., Martínez-Carrasco, A., Tamvaka, N., Walton, R. L., Baker, M., et al. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00083-8 · Cited by 25
Self-citationTherapeutic and diagnostic challenges for frontotemporal dementia
Dâ€TMAlton, S., & Lewis, J. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00204 · Cited by 26
Jonson, C., Levine, K. S., Lake, J., Hertslet, L., Jones, L., Patel, D., Kim, J., Bandrés‐Ciga, S., Terry, N. L., Mata, I. F., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13873 · Cited by 24
Self-citationGenome-wide association study unravels mechanisms of brain glymphatic activity
Huang, S., Ge, Y., Ren, P., Wu, B., Gong, W., Du, J., Chen, S.-D., Kang, J., Ma, Q., Bokde, A. L. W., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55706-9 · Cited by 30
Pottier, C. P., Küçükali, F., Baker, M. C., Batzler, A. J., Jenkins, G. D., van Blitterswijk, M., Vicente, C. T., Coster, W. D., Wynants, S., de Walle, P. V., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59216-0 · Cited by 28
Self-citationSLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degeneration
Barbier, M., Camuzat, A., Hachimi, K. H. E., Guégan, J., Rinaldi, D., Lattante, S., Houot, M., Sánchez‐Valle, R., Sabatelli, M., Antonell, A., et al. (2021) · Brain · doi:10.1093/brain/awab171 · Cited by 26
Self-citationDíaz‐Torres, S., He, W., Thorp, J. G., Seddighi, S., Mullany, S., Hammond, C. J., Hysi, P. G., Pasquale, L. R., Khawaja, A. P., Hewitt, A. W., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104615 · Cited by 24
Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum
Vilor‐Tejedor, N., Genius, P., Rodríguez‐Fernández, B., Minguillón, C., Sadeghi, I., González‐Escalante, A., Crous‐Bou, M., Suárez‐Calvet, M., Grau‐Rivera, O., Brugulat‐Serrat, A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13537 · Cited by 21
Yang, X., Zheng, J., Tian, S., Chen, Y., An, R., Zhao, Q., & Xu, Y. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.12.055 · Cited by 24
Epigenetic Mechanisms Underlying the Pathogenesis of Neurogenetic Diseases
Qureshi, I., & Mehler, M. F. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0302-1 · Cited by 23
Che, X., Zhao, Q., Huang, Y. M., Li, X., Ren, R., Chen, S., Guo, Q., & Wang, G. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170692 · Cited by 23
Wang, J. C., Ramaswami, G., & Geschwind, D. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-85061-4 · Cited by 21
Manzoni, C., Kia, D. A., Ferrari, R., Leonenko, G., Costa, B., Saba, V., Jabbari, E., Tan, M. M. X., Albani, D., Álvarez, V., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.05.017 · Cited by 24
Self-citationWingo, A. P., Liu, Y., Vattathil, S. M., Gerasimov, E. S., Mei, Z., Ravindran, S. P., Liu, J., Shantaraman, A., Seifar, F., Wang, E., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02291-2 · Cited by 21
Genetic testing in dementia‐A medical genetics perspective
Huq, A. J., Sexton, A., Lacaze, P. A., Masters, C. L., Storey, E., Velakoulis, D., James, P. A., & Winship, I. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5535 · Cited by 23
Cerami, C., Marcone, A., Crespi, C., Iannaccone, S., Marangoni, C., Dodich, A., Giusti, M. C., Zamboni, M. M., Golzi, V., & Cappa, S. F. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.02.039 · Cited by 21
Self-citationMata-Garrido, J., Tapia, O., Casafont, Í., Berciano, M. T., Cuadrado, A., & Lafarga, M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0573-6 · Cited by 24
Reus, L. M., Paşaniuc, B., Posthuma, D., Boltz, T. A., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.023 · Cited by 21
Self-citationImpact of APOE genotype on prion-type propagation of tauopathy
Williams, T., Ruiz, A. J., Ruiz, A. M., Vo, Q., Tsering, W., Xu, G. M., McFarland, K. N., Giasson, B. I., Sullivan, P. M., Borchelt, D., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01359-y · Cited by 21
Self-citationFUS gene mutation in amyotrophic lateral sclerosis: a new case report and systematic review
Xiao, X., Li, M., Ye, Z., He, X., Wei, J. S., & Zha, Y. (2023) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2023.2272170 · Cited by 21
Ehtewish, H., Mesleh, A. G., Ponirakis, G., Lennard, K. S., Hamad, H. K. A., Chandran, M., Parray, A., Abdesselem, H., Wijten, P., Decock, J. V., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1256745 · Cited by 20
Chalitsios, C. V., Ley, H., Gao, J., Turner, M. R., & Thompson, A. G. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12665-x · Cited by 20
Katisko, K., Solje, E., Koivisto, A. M., Krüger, J., Kinnunen, T. T., Hartikainen, P. H., Helisalmi, S., Korhonen, V. E., Herukka, S., Haapasalo, A., et al. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.05.011 · Cited by 22
Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations
Pottier, C. P., Mateiu, L. M., Baker, M., DeJesus‐Hernandez, M., Vicente, C. T., Finch, N. A., Tian, S., van Blitterswijk, M., Murray, M. E., Ren, Y., et al. (2021) · Brain · doi:10.1093/brain/awab437 · Cited by 20
Self-citationMultimodal mapping of regional brain vulnerability to focal cortical dysplasia
Lee, H. M., Hong, S., Gill, R. S., Caldairou, B., Wang, Z. I., Zhang, J., Deleo, F., Schrader, D. V., Bartoloméi, F., Guye, M., et al. (2023) · Brain · doi:10.1093/brain/awad060 · Cited by 20
Hagenaars, S. P., Radaković, R., Crockford, C., Fawns‐Ritchie, C., Harris, S. E., Galé, C. R., & Deary, I. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198187 · Cited by 21
Metabolomic changes associated with frontotemporal lobar degeneration syndromes
Murley, A. G., Jones, P. S., Coyle Gilchrist, I., Bowns, L., Wiggins, J., Tsvetanov, K. A., & Rowe, J. B. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09824-1 · Cited by 18
Self-citationWest, R. J. H., Ugbode, C., Gao, F., & Sweeney, S. T. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy048 · Cited by 19
Pharmacotherapy for Frontotemporal Dementia
Khoury, R., Liu, Y., Sheheryar, Q., & Grossberg, G. T. (2021) · CNS Drugs · doi:10.1007/s40263-021-00813-0 · Cited by 22
Evaluating the association between genetically proxied ACE inhibition and dementias
Nassan, M. M., Daghlas, I., Piras, I. S., Rogalski, E. J., Reus, L. M., Pijnenburg, Y. A. L., Cuddy, L. K., Saxena, R., Mesulam, M. M., & Huentelman, M. J. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13062 · Cited by 17
Self-citationFodder, K., Murthy, M. N., Rizzu, P., Toomey, C. E., Hasan, R., Humphrey, J., Raj, T., Lunnon, K., Mill, J. S., Heutink, P., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02583-z · Cited by 17
Self-citationTargeting Progranulin as an Immuno-Neurology Therapeutic Approach
Boylan, M. A., Pincetic, A., Romano, G. J., Tatton, N. A., Kenkare-Mitra, S., & Rosenthal, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115946 · Cited by 19
A polygenic score method boosted by non-additive models
Ohta, R., Tanigawa, Y., Suzuki, Y., Kellis, M., & Morishita, S. (2024) · Nature Communications · doi:10.1038/s41467-024-48654-x · Cited by 19
Llibre‐Guerra, J. J., Lee, S. E., Suemoto, C. K., Ehrenberg, A. J., Kovács, G. G., Karydas, A., Staffaroni, A. M., Resende, E. D. P. F., Kim, E., Hwang, J., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12924 · Cited by 18
Self-citationThe behavioral variant of frontotemporal dementia: An analysis of the literature and a case report.
Birkhoff, J. M., Garberi, C., & Re, L. (2016) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2016.04.001 · Cited by 19
Wang, H., Lv, J., Zhao, Y., Wei, H., Zhang, T., Yang, H., Chen, Z., & Jiang, J. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13659 · Cited by 17
Lucchese, G. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00060 · Cited by 17
Rab38 Mutation and the Lung Phenotype
Osanai, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082203 · Cited by 17
Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?
Cavazzana, I., Alberici, A., Bonomi, E., Ottaviani, R., Kumar, R., Archetti, S., Manes, M. A., Cosseddu, M., Buratti, E., Padovani, A., et al. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.10.006 · Cited by 20
Self-citationJääskeläinen, O., Solje, E., Hall, A., Katisko, K., Korhonen, V. E., Tiainen, M., Kangas, A. J., Helisalmi, S., Pikkarainen, M., Koivisto, A. M., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190132 · Cited by 17
Benussi, L., Longobardi, A., Koçoğlu, C., Carrara, M., Bellini, S., Ferrari, C., Nicsanu, R., Saraceno, C., Bonvicini, C., Fostinelli, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413633 · Cited by 17
Self-citationKatisko, K., Solje, E., Korhonen, P., Jääskeläinen, O., Loppi, S. H., Hartikainen, P. H., Koivisto, A. M., Kontkanen, A., Korhonen, V. E., Helisalmi, S., et al. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09552-1 · Cited by 20
Zhao, L., Tang, Y., Tu, Y., & Cao, J. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01801-7 · Cited by 17
Yap, Y. W., Llanos, R. M., Fontaine, S. L., Cater, M. A., Beart, P. M., & Cheung, N. S. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1666-2 · Cited by 16
Frontotemporal Lobar Degeneration: Mechanisms and Therapeutic Strategies
Li, Y., Tan, M., Yu, J., & Tan, L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9507-5 · Cited by 17
Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases
Hardy, J. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150287 · Cited by 15
Self-citationProtein network analysis reveals selectively vulnerable regions and biological processes in FTD
Bonham, L. W., Steele, N. Z. R., Karch, C. M. M., Manzoni, C., Geier, E. G., Wen, N., Ofori-Kuragu, A., Momeni, P., Hardy, J., Miller, Z., et al. (2018) · Neurology Genetics · doi:10.1212/nxg.0000000000000266 · Cited by 16
Self-citationPervasive biases in proxy GWAS based on parental history of Alzheimer’s diseasePreprint
Wu, Y., Sun, Z., Zheng, Q., Miao, J., Dorn, S., Mukherjee, S., Fletcher, J. M., & Lu, Q. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.13.562272 · Cited by 16
Chen, K., Gao, T., Liu, Y., Zhu, K., Wang, T., & Zeng, P. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.017 · Cited by 15
PET Imaging to Measure Neuroinflammation In Vivo
Malpetti, M., Franzmeier, N., & Brendel, M. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3774-6_12 · Cited by 14
Bonham, L. W., Steele, N. Z. R., Karch, C. M. M., Broce, I., Geier, E. G., Wen, N., Momeni, P., Hardy, J., Miller, Z., Gorno‐Tempini, M. L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46415-1 · Cited by 15
Self-citationNeuroimaging of Diseases Causing Dementia
Masdeu, J. C. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.08.003 · Cited by 16
Modelling the functional genomics of Parkinson’s disease inCaenorhabditis elegans:LRRK2and beyond
Chandler, R. J., Cogo, S., Lewis, P. A., & Kevei, É. (2021) · Bioscience Reports · doi:10.1042/bsr20203672 · Cited by 16
Chen, H., Qiao, J., Wang, T., Shao, Z., Huang, S., & Zeng, P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.680104 · Cited by 14
Kwon, S. H., Parthiban, S., Tippani, M., Divecha, H. R., Eagles, N. J., Lobana, J. S., Williams, S. R., Mak, M., Bharadwaj, R. A., Kleinman, J. E., et al. (2023) · GEN Biotechnology · doi:10.1089/genbio.2023.0019 · Cited by 14
Broce, I., Castruita, P. A., & Yokoyama, J. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.639078 · Cited by 14
GBA ‐associated parkinsonism and dementia: beyond α‐synucleinopathies?
Pilotto, A., Schulte, C., Hauser, A., Biskup, S., Munz, M., Brockmann, K., Schaeffer, E., Synofzik, M., Maetzler, W., Suenkel, U., et al. (2015) · European Journal of Neurology · doi:10.1111/ene.12894 · Cited by 14
Vattathil, S. M., Gerasimov, E. S., Canon, S. M., Lori, A., Tan, S. S. M., Kim, P. J., Liu, Y., Lai, E. C., Bennett, D. A., Wingo, T. S., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00778-x · Cited by 14
Role of Autoantibodies in Neurodegenerative Dementia: An Emerging Association
Arshad, F., Varghese, F. A., Paplikar, A., Gangadhar, Y., Ramakrishnan, S., Chaudhuri, J. R., Mahadevan, A., & Alladi, S. (2021) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000517238 · Cited by 13
Cheng, J., Deng, Y., & Yu, J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15937 · Cited by 12
Yin, K., Chen, T., Gu, X., Jiang, Z., Su, W., Duan, Q., Wen, X.-J., Cao, B., Li, J.-R., Chi, L., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04528-3 · Cited by 13
Strauss, A., Swann, P., Kigar, S. L., Christou, R., Yarkoni, N. S., Turner, L., Murley, A. G., Chouliaras, L., Shapiro, N. L., Ashton, N. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02809-w · Cited by 16
Self-citationGenetics and Neuropathology of Neurodegenerative Dementias
Scholz, S. W., & Cobos, I. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001505 · Cited by 13
Metadata
- Authors
- Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Brooks, W. S., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Waldö, M. L., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G.-Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Deschamps, W., Van Langenhove, T., Cruts, M., Van Broeckhoven, C., Cappa, S. F., Le Ber, I., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Heutink, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Rademakers, R., Baker, M., Dickson, D. W., Graff-Radford, N. R., Petersen, R. C., Knopman, D., Josephs, K. A., Boeve, B. F., Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., van Swieten, J. C., Dopper, E. G. P., Seelaar, H., Pijnenburg, Y. A. L., Scheltens, P., Logroscino, G., Capozzo, R., Novelli, V., Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H.-H., Graff, C., Pasquier, F., Rollin, A., Deramecourt, V., Lebert, F., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J., & Momeni, P.
- Affiliations
- Texas Tech University (US)
- National Institutes of Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Guy's Hospital (GB)
- UNSW Sydney (AU)
- Neuroscience Research Australia (AU)
- South Australia Pathology (AU)
- Fundació ACE (ES)
- University of Brescia (IT)
- Washington University in St. Louis (US)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Milan (IT)
- Universitat Autònoma de Barcelona (ES)
- Lund University (SE)
- University of British Columbia (CA)
- University of Manchester (GB)
- Northwestern University (US)
- Newcastle University (GB)
- University of Pisa (IT)
- Columbia University (US)
- Walton Centre (GB)
- Royal Victoria Infirmary (GB)
- Centro de Investigación Médica Aplicada (ES)
- West London Mental Health NHS Trust (GB)
- Technical University of Munich (DE)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Toronto (CA)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Freiburg (DE)
- MRC Prion Unit (GB)
- German Center for Neurodegenerative Diseases (DE)
- University of Pennsylvania (US)
- University of Antwerp (BE)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Centre Hospitalier de Saint-Brieuc (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Florence (IT)
- University of Copenhagen (DK)
- Saarland University (DE)
- University of Regensburg (DE)
- University of Luxembourg (LU)
- University of Cambridge (GB)
- Cardiff University (GB)
- Presidio Ospedaliero Lamezia Terme (IT)
- Mayo Clinic (US)
- University of California, San Francisco (US)
- Erasmus MC (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of Bari Aldo Moro (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- University of Salerno (IT)
- MultiMedica (IT)
- Federico II University Hospital (IT)
- University College London (GB)
- Karolinska University Hospital (SE)
- Université Lille Nord de France (FR)
- National Institute on Aging (US)
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Hardy, John
- ORCID
- Ferrari, Raffaele
- Hernandez, Dena G
- Rohrer, Jonathan D
- Ramasamy, Adaikalavan
- Kwok, John B J
- Brooks, William S
- Schofield, Peter R
- Halliday, Glenda M
- Hodges, John R
- Piguet, Olivier
- Haan, Eric
- Borroni, Barbara
- Padovani, Alessandro
- Cruchaga, Carlos
- Cairns, Nigel J
- Benussi, Luisa
- Binetti, Giuliano
- Ghidoni, Roberta
- Forloni, Gianluigi
- Galimberti, Daniela
- Fenoglio, Chiara
- Scarpini, Elio
- Clarimón, Jordi
- Lleó, Alberto
- Blesa, Rafael
- Waldö, Maria Landqvist
- Nilsson, Karin
- Nilsson, Christer
- Mackenzie, Ian R A
- Hsiung, Ging-Yuek R
- Mann, David M A
- Grafman, Jordan
- Morris, Christopher M
- Attems, Johannes
- Griffiths, Timothy D
- McKeith, Ian G
- Thomas, Alan J
- Pietrini, P
- Huey, Edward D
- Wassermann, Eric M
- Perneczky, Robert
- Alexopoulos, Panagiotis
- Kurz, Alexander
- Rainero, Innocenzo
- Rubino, Elisa
- Pinessi, Lorenzo
- Rogaeva, Ekaterina
- Rossi, Giacomina
- Tagliavini, Fabrizio
- Giaccone, Giorgio
- Rowe, James B
- Schlachetzki, Johannes C M
- Collinge, John
- Mead, Simon
- Danek, Adrian
- Grossman, Murray
- Trojanowski, John Q
- van der Zee, Julie
- Cruts, Marc
- Cappa, Stefano F
- Hannequin, Didier
- Brice, Alexis
- Nacmias, Benedetta
- Sorbi, Sandro
- Bagnoli, Silvia
- Piaceri, Irene
- Nielsen, Jørgen E
- Hjermind, Lena E
- Gasparoni, Gilles
- Gu, Wei
- Rossor, Martin N
- Fox, Nick C
- Warren, Jason D
- Spillantini, Maria Grazia
- Morris, Huw R
- Rizzu, Patrizia
- Heutink, Peter
- Snowden, Julie S
- Rollinson, Sara
- Richardson, Anna
- Gerhard, Alexander
- Bruni, Amalia C
- Maletta, Raffaele
- Cupidi, Chiara
- Bernardi, Livia
- Anfossi, Maria
- Gallo, Maura
- Smirne, Nicoletta
- Rademakers, Rosa
- Baker, Matt
- Dickson, Dennis W
- Petersen, Ronald C
- Knopman, David
- Josephs, Keith A
- Boeve, Bradley F
- Seeley, William W
- Miller, Bruce L
- Dopper, Elise G P
- Seelaar, Harro
- Pijnenburg, Yolande A L
- Scheltens, Philip
- Logroscino, Giancarlo
- Capozzo, Rosa
- Novelli, Valeria
- Puca, Annibale A
- Franceschi, Massimo
- Milan, Graziella
- Pasquier, Florence
- Deramecourt, Vincent
- Lebert, Florence
- Kapogiannis, Dimitrios
- Ferrucci, Luigi
- Pickering-Brown, Stuart
- Singleton, Andrew B
- Hardy, John
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 13
- Issue
- 7
- Pages
- 686-699
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC4112126
- OpenAlex
- W2152748843
- Cited by
- 383
- References
- 61
- Citations by year
- 2026: 17 · 2025: 29 · 2024: 48 · 2023: 44 · 2022: 32 · 2021: 39 · 2020: 32 · 2019: 28 · 2018: 33 · 2017: 27 · 2016: 26 · 2015: 19 · 2014: 8
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- IMT Institutional Repository (IMT School for Advanced Studies Lucca) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- DZNE Pub (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- ARUK (ARUK-PG2012-18)
- MRC Sudden Death Brain Bank (CS) (G0901254 to JH and MW)
- Fellowship award (G0802462 to MR)
- National Health and Medical Resarch Council (NHMRC), Australia (510217 and 1005769)
- NHMRC (630428 and 1005769, 510217 and 1005769, 1029538, 1037746)
- NHMRC Enabling (401184)
- NHMRC Research Fellowship 630434 (1029538, and Program Grant 1037746)
- NHMRC Career Development Fellowship 1022684 (1003139)
- NIH (P50 AG05681, P01 AG03991, and P01 AG026276, AG023501, AG019724)
- Fondazione CARIPLO (2009-2633, 2009–2633)
- CIHR (74580)
- PARF (C06-01)
- Newcastle Brain Tissue Resource (G0400074 and G1100540)
- BMBF (FKZ 01GI1007A)
- Cambridge NIHR Biomedical Research Centre and Wellcome Trust (088324)
- VMVD and JQT (AG032953, AG017586 and AG010124)
- MG (AG032953, AG017586, AG010124, and NS044266)
- German Ministry for Education and Research (01GS0465)
- MRC (G0301152)
- Motor Neuron Disease Association (6057)
- RR (P50 AG016574, R01 NS080882, R01 NS065782, P50 NS72187)
- DWD (P50NS072187, P50AG016574)
- State of Florida Alzheimer Disease Initiative, and CurePSP Inc. NRGR, JEP, RCP, DK, and BFB (P50 AG016574)
- KAJ (R01 AG037491)
- BLM (P50AG023501, P01AG019724)
- HR (AG032306)
- Stichting Dioraphte Foundation (11 02 03 00)
- Nuts Ohra Foundation (0801-69)
- Hersenstichting Nederland (BG 2010-02)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, genetic susceptibility loci, semantic dementia, progressive nonfluent aphasia, HLA, 6p21.3, MAPT, gene regulatory networks, C9orf72, methylation quantitative trait loci
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged, Genome-Wide Association Study, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
