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Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities

Macrez, Richard, Stys, Peter K, Vivien, Denis, Lipton, Stuart A, Docagne, Fabian·2016·The Lancet Neurology
DOI 10.1016/s1474-4422(16)30165-x
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Abstract

Research advances support the idea that excessive activation of the glutamatergic pathway plays an important part in the pathophysiology of multiple sclerosis. Beyond the well established direct toxic effects on neurons, additional sites of glutamate-induced cell damage have been described, including effects in oligodendrocytes, astrocytes, endothelial cells, and immune cells. Such toxic effects could provide a link between various pathological aspects of multiple sclerosis, such as axonal damage, oligodendrocyte cell death, demyelination, autoimmunity, and blood-brain barrier dysfunction. Understanding of the mechanisms underlying glutamate toxicity in multiple sclerosis could help in the development of new approaches for diagnosis, treatment, and follow-up in patients with this debilitating disease. While several clinical trials of glutamatergic modulators have had disappointing results, our growing understanding suggests that there is reason to remain optimistic about the therapeutic potential of these drugs.

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Metadata

Authors
Macrez, R., Stys, P. K., Vivien, D., Lipton, S. A., & Docagne, F.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2016-09
Volume
15
Issue
10
Pages
1089-1102
ISSN
1474-4422
DOI
10.1016/s1474-4422(16)30165-x
Cited by
127
References
5
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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