Herpes viruses and Alzheimer's disease: new evidence in the debate

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060 · see citing works

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971 · see citing works

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

Readhead, B., Haure-Mirande, J.-V., Funk, C. C., Richards, M. A., Shannon, P., Haroutunian, V., Sano, M., Liang, W. S., Beckmann, N. D., Price, N. D., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.023 · Cited by 708 · see citing works

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.030 · Cited by 674 · see citing works

Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

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Microbes and Alzheimer’s Disease

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Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain

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Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

Wozniak, M., Mee, A., & Itzhaki, R. (2009) · The Journal of Pathology · doi:10.1002/path.2449 · Cited by 464 · see citing works

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

Tzeng, N.-S., Chung, C.-H., Lin, F.-H., Chiang, C.-P., Yeh, C.-B., Huang, S.-Y., Lu, R.-B., Chang, H.-A., Kao, Y.-C., Yeh, H.-W., et al. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0611-x · Cited by 356 · see citing works

<i>Chlamydophila (Chlamydia) pneumoniae</i>in the Alzheimer's brain

Gérard, H. C., Dreses-Werringloer, U., Wildt, K. S., Deka, S., Oszust, C., Balin, B. J., Frey, W. H., Bordayo, E. Z., Whittum-Hudson, J. A., & Hudson, A. P. (2006) · FEMS Immunology &amp; Medical Microbiology · doi:10.1111/j.1574-695x.2006.00154.x · Cited by 186 · see citing works

Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study

Chen, V. C.-H., Wu, S.-I., Huang, K.-Y., Yang, Y.-H., Kuo, T.-Y., Liang, H.-Y., Huang, K.-L., & Gossop, M. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m11312 · Cited by 142 · see citing works

Increased risk of dementia following herpes zoster ophthalmicus

Tsai, M.-C., Cheng, W.-L., Sheu, J.-J., Huang, C.-C., Shia, B.-C., Kao, L.-T., & Lin, H.-C. (2017) · PLOS ONE · doi:10.1371/journal.pone.0188490 · Cited by 107 · see citing works

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

Little, C. S., Joyce, T. A., Hammond, C. J., Matta, H., Cahn, D., Appelt, D. M., & Balin, B. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00304 · Cited by 71 · see citing works

Smell dysfunction: a biomarker for COVID‐19

Moein, S. T., Hashemian, S. M. R., Mansourafshar, B., Khorram‐Tousi, A., Tabarsi, P., & Doty, R. L. (2020) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22587 · Cited by 793 · see citing works

Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Wan, Q., Song, D., Li, H., & He, M. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00233-4 · Cited by 166 · see citing works

Time to test antibacterial therapy in Alzheimer’s disease

Panza, F., Lozupone, M., Solfrizzi, V., Watling, M., & Imbimbo, B. P. (2019) · Brain · doi:10.1093/brain/awz244 · Cited by 161 · see citing works

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works

Design and Development of Nanomaterial-Based Drug Carriers to Overcome the Blood–Brain Barrier by Using Different Transport Mechanisms

Song, J., Lu, C. T., Leszek, J., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810118 · Cited by 95 · see citing works

Environmental toxins and Alzheimer's disease progression

Vasefi, M., Ghaboolian-Zare, E., Abedelwahab, H., & Osu, A. I. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104852 · Cited by 69 · see citing works

Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations

Maes, T., Mascaró, C., Rotllant, D., Lufino, M. M., Estiarte, A., Guibourt, N., Cavalcanti, F., Griñán‐Ferré, C., Pallàs, M., Nadal, R. A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233468 · Cited by 66 · see citing works

A mechanistic survey of Alzheimer's disease

Tang, Y., Zhang, D., Gong, X., & Zheng, J. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106735 · Cited by 65 · see citing works

Antimicrobial α-defensins as multi-target inhibitors against amyloid formation and microbial infection

Zhang, Y., Liu, Y., Tang, Y., Zhang, D., He, H., Wu, J., & Zheng, J. (2021) · Chemical Science · doi:10.1039/d1sc01133b · Cited by 46 · see citing works

Immunosenescence as a convergence pathway in neurodegeneration

Mohapatra, L., Mishra, D. K., Tripathi, A. S., & Parida, S. K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110521 · Cited by 36 · see citing works

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 33 · see citing works

Viral Infections, Are They a Trigger and Risk Factor of Alzheimer’s Disease?

Rippee‐Brooks, M. D., Wu, W., Dong, J., Pappolla, M. A., Fang, X., & Bao, X. (2024) · Pathogens · doi:10.3390/pathogens13030240 · Cited by 31 · see citing works

“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

Reis, R. J. S., Atluri, R., Balasubramaniam, M., Johnson, J. E., Ganne, A., & Ayyadevara, S. (2021) · Aging Cell · doi:10.1111/acel.13326 · Cited by 32 · see citing works

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis

Madrid, L., Initiative, A. D. N., Moreno–Grau, S., Ahmad, S., González-Pérez, A., de Rojas, I., Xia, R., Adami, P. V. M., García‐González, P., Kleineidam, L., et al. (2021) · Aging · doi:10.18632/aging.202950 · Cited by 33 · see citing works

Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer’s Disease

Liu, C., & Yu, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00297 · Cited by 27 · see citing works

A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer’s Disease

Mitra, S., Gera, R., Linderoth, B., Lind, G., Wahlberg, L. U., Almqvist, P. M., Behbahani, H., & Eriksdotter, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-74046-7_11 · Cited by 25 · see citing works

Alzheimer's disease – the ‘microbial hypothesis’ from a clinical and neuroimaging perspective

Frölich, L. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111181 · Cited by 24 · see citing works

The elusive role of herpesviruses in Alzheimer’s disease: current evidence and future directions

Piotrowski, S. L., Tucker, A., & Jacobson, S. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0011 · Cited by 25 · see citing works

A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease

Zhao, Y. G., Zhan, J., & Liu, Y. (2020) · Aging and Disease · doi:10.14336/ad.2020.0205 · Cited by 23 · see citing works

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

Zhou, X., Fu, A. K. Y., & Ip, N. Y. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.02.001 · Cited by 22 · see citing works

Latent pseudorabies virus infection in medulla oblongata from quarantined pigs

Lu, J., Yuan, W., Zhu, Y., Hou, S., & Wang, X. (2020) · Transboundary and Emerging Diseases · doi:10.1111/tbed.13712 · Cited by 21 · see citing works

Dysregulation of cofilin-1 activity—the missing link between herpes simplex virus type-1 infection and Alzheimer’s disease

Wang, Y., Song, X., Wang, Y., Huang, L., Luo, W., Li, F., Qin, S., Wang, Y., Xiao, J., Wu, Y., et al. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1794789 · Cited by 21 · see citing works

Role of the gut microbiome in Alzheimer’s disease

Chok, K. C., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0122 · Cited by 21 · see citing works

Dementia identified as a risk factor for infection-related hospital contacts in a national, population-based and longitudinal matched-cohort study

Janbek, J., Frimodt‐Møller, N., Laursen, T. M., & Waldemar, G. (2021) · Nature Aging · doi:10.1038/s43587-020-00024-0 · Cited by 21 · see citing works

The challenges of the COVID‐19 pandemic: Approaches for the elderly and those with Alzheimer's disease

Zhang, Q., & Song, W. (2020) · MedComm · doi:10.1002/mco2.4 · Cited by 17 · see citing works

MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection

Wang, Y., Luo, W., Wang, X., Ma, Y., Huang, L., & Wang, Y. (2022) · Journal of Infection · doi:10.1016/j.jinf.2021.12.004 · Cited by 17 · see citing works

Cross-seeding between Aβ and SEVI indicates a pathogenic link and gender difference between alzheimer diseases and AIDS

Tang, Y., Zhang, D., Zhang, Y., Liu, Y., Miller, Y., Gong, K., & Zheng, J. (2022) · Communications Biology · doi:10.1038/s42003-022-03343-7 · Cited by 16 · see citing works

Hsp90 Inhibitors Inhibit the Entry of Herpes Simplex Virus 1 Into Neuron Cells by Regulating Cofilin-Mediated F-Actin Reorganization

Song, X., Wang, Y., Li, F., Cao, W., Zeng, Q., Qin, S., Wang, Z., Jia, J., Xiao, J., Hu, X., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.799890 · Cited by 11 · see citing works

Nucleocapsid proteins from human coronaviruses possess phase separation capabilities and promote FUS pathological aggregation

Dong, H., Zhang, H., Jalin, J., He, Z., Wang, R., Huang, L., Liu, Z., Zhang, S., Dai, B., & Li, D. (2023) · Protein Science · doi:10.1002/pro.4826 · Cited by 8 · see citing works

The presence of herpes simplex-1 and varicella zoster viruses is not related with clinical outcome of Bell's Palsy

Ordóñez, G., Vales, O., Pineda, B., Rodríguez-Jiménez, K., Pianese, C. P., & Sotelo, J. (2020) · Virology · doi:10.1016/j.virol.2020.07.020 · Cited by 6 · see citing works

The cerebrospinal fluid virome in people with HIV: links to neuroinflammation and cognition

Trunfio, M., Scutari, R., Fox, V., Vuaran, E., Dastgheyb, R. M., Fini, V., Granaglia, A., Balbo, F., Tortarolo, D., Bonora, S., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1704392 · Cited by 3 · see citing works

Multiple Causes of Dementia as Engineered Senescence

Garrett, M. D. (2020) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2020.2.2.227 · Cited by 3 · see citing works

Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection

Berger, J. N., Rosales, A., Heiden, D. L., Merrick, C., Monogue, B., Beckham, J. D., & Berg, L. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag102 · Cited by 1 · see citing works

Stress Proteins: Biological Functions, Human Diseases, and Virus Infections

He, M., Wan, Q., Song, D., & He, B. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_4

Olfactory Dysfunction: A Diagnostic Symptom of COVID-19

Kabir, S., Hossain, A. B. M. T., Parash, M. T. H., Lin, C. L. S., Murugaiah, C., Delwar, A. H. M., & Chowdhury, M. A. (2021) · Borneo Journal of Medical Sciences (BJMS) · doi:10.51200/bjms.vi.2637

Análise molecular de DNA viral na parede de aneurismas intracranianos rotos e não rotos

Rabelo, N. N. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-11112021-140139

Manifestações psicopatológicas e cognitivas associadas à infecção pelo vírus SARS-CoV-2

Damiano, R. F. (2023) · doi:10.11606/t.5.2023.tde-29082023-114208

Herpesvirus genome integration in whole‐genome sequences of dementia and control cohorts

Piotrowski, S. L., Allnutt, M. A., Johnson, K., Tanaka, T., Ferrucci, L., Morris, H. R., Hardy, J., Ryten, M., Logroscino, G., Troncoso, J. C., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71047

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.030 · Cited by 674 · see citing works

Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment

Qin, Q., & Li, Y. (2019) · Journal of Medical Virology · doi:10.1002/jmv.25481 · Cited by 26 · see citing works

Alzheimerrs Disease-Associated -amyloid Is Rapidly Seeded by herpesviridae to Protect Against Brain InfectionPreprint

Eimer, W. A., Kumar, D. K. V., Shanmugam, N. K. N., Washicosky, K. J., Rodriguez, A. S., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3155923 · Cited by 3 · see citing works

Controversial role of herpesviruses in Alzheimer’s disease

Rizzo, R. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008575 · Cited by 45 · see citing works

The elusive role of herpesviruses in Alzheimer’s disease: current evidence and future directions

Piotrowski, S. L., Tucker, A., & Jacobson, S. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0011 · Cited by 25 · see citing works