Advances in Alzheimer's disease research over the past two decades

NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537 · see citing works

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01024-z · Cited by 2,498 · see citing works

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279 · see citing works

Donanemab in Early Alzheimer’s Disease

Mintun, M. A., Lo, A. C., Duggan Evans, C., Wessels, A. M., Ardayfio, P. A., Andersen, S. W., Shcherbinin, S., Sparks, J., Sims, J. R., Brys, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100708 · Cited by 1,728 · see citing works

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

Budd Haeberlein, S., Aisen, P. S., Barkhof, F., Chalkias, S., Chen, T., Cohen, S., Dent, G., Hansson, O., Harrison, K., von Hehn, C., et al. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2022.30 · Cited by 1,367 · see citing works

CSF markers for incipient Alzheimer's disease

Blennow, K., & Hampel, H. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00530-1 · Cited by 1,291 · see citing works

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

Janelidze, S., Mattsson, N., Palmqvist, S., Smith, R., Beach, T. G., Serrano, G. E., Chai, X., Proctor, N. K., Eichenlaub, U., Zetterberg, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0755-1 · Cited by 1,247 · see citing works

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

Ossenkoppele, R., Schonhaut, D. R., Schöll, M., Lockhart, S. N., Ayakta, N., Baker, S. L., O’Neil, J. P., Janabi, M., Lazaris, A., Cantwell, A., et al. (2016) · Brain · doi:10.1093/brain/aww027 · Cited by 1,185 · see citing works

Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group

Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00066-1 · Cited by 1,051 · see citing works

The A4 Study: Stopping AD Before Symptoms Begin?

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 756 · see citing works

Alzheimer’s disease drug development pipeline: 2024

Cummings, J., Zhou, Y., Lee, G., Zhong, K., Fonseca, J., & Cheng, F. (2024) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12465 · Cited by 702 · see citing works

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Barthélemy, N. R., Li, Y., Joseph-Mathurin, N., Gordon, B. A., Hassenstab, J., Benzinger, T. L. S., Buckles, V., Fagan, A. M., Perrin, R. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0781-z · Cited by 651 · see citing works

[ ¹⁸ F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

Xia, C., Arteaga, J., Chen, G., Gangadharmath, U., Gomez, L. F., Kasi, D., Lam, C., Liang, Q., Liu, C., Mocharla, V. P., et al. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.008 · Cited by 605 · see citing works

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

Weiner, M. W., Veitch, D. P., Aisen, P. S. S., Beckett, L. A., Cairns, N. J., Green, R. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Morris, J. C., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.10.006 · Cited by 499 · see citing works

Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease

Janelidze, S., Teunissen, C. E., Zetterberg, H., Allué, J. A., Sarasa, L., Eichenlaub, U., Bittner, T., Ovod, V., Verberk, I. M. W., Toba, K., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.3180 · Cited by 494 · see citing works

Combined neuropathological pathways account for age‐related risk of dementia

Power, M. C., Mormino, E. C., Soldan, A., James, B. D., Yu, L., Armstrong, N. M., Bangen, K. J., Delano‐Wood, L., Lamar, M., Lim, Y. Y., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25246 · Cited by 215 · see citing works

Alzheimer's Disease Drug Development Pipeline 2020

Sabbagh, M. N. (2020) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.12 · Cited by 66 · see citing works

Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future

Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01484-7 · Cited by 988 · see citing works

Biomarker Changes during 20 Years Preceding Alzheimer’s Disease

Jia, J., Ning, Y., Chen, M., Wang, S., Yang, H., Li, F., Ding, J., Li, Y., Zhao, B., Lyu, J., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2310168 · Cited by 455 · see citing works

Characterization of Brain Volume Changes in Aging Individuals With Normal Cognition Using Serial Magnetic Resonance Imaging

Fujita, S., Mori, S., Onda, K., Hanaoka, S., Nomura, Y., Nakao, T., Yoshikawa, T., Takao, H., Hayashi, N., & Abe, O. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.18153 · Cited by 169 · see citing works

Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy

Quan, M., Cao, S., Wang, Q., Wang, S., & Jia, J. (2023) · Phenomics · doi:10.1007/s43657-023-00098-x · Cited by 60 · see citing works

Artificial Intelligence-Enabled End-To-End Detection and Assessment of Alzheimer’s Disease Using Voice

Agbavor, F., & Liang, H. (2022) · Brain Sciences · doi:10.3390/brainsci13010028 · Cited by 47 · see citing works

Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia

van der Gaag, B., Deshayes, N. A. C., Brevé, J. J. P., Bol, J. G. J. M., Jonker, A. J., Hoozemans, J. J. M., Courade, J., & van de Berg, W. D. J. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02657-y · Cited by 45 · see citing works

Lysosome‐Targeting Protein Degradation Through Endocytosis Pathway Triggered by Polyvalent Nano‐Chimera for AD Therapy

Wang, X., Chen, S., Xia, X., Du, Y., Wei, Y., Yang, W., Zhang, Y., Song, Y., Lei, T., Huang, Q., et al. (2024) · Advanced Materials · doi:10.1002/adma.202411061 · Cited by 40 · see citing works

Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases

Zhang, X., Fu, M., Wang, Y., & Wu, T. S. (2025) · Frontiers in Drug Delivery · doi:10.3389/fddev.2025.1644633 · Cited by 30 · see citing works

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, G., To, X. V., Bodea, L., Yousef, J. M., Richter-Stretton, G. L., Palliyaguru, T., Chicoteau, A., Dagley, L. F., Nasrallah, F. A., & Götz, J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02509-5 · Cited by 27 · see citing works

Effect of Exercise and Oral Niacinamide Mononucleotide on Improving Mitochondrial Autophagy in Alzheimer’s Disease

Wu, W., Yuan, S., Tang, Y., Meng, X., Peng, M., Hu, Z., & Liu, W. (2023) · Nutrients · doi:10.3390/nu15132851 · Cited by 26 · see citing works

Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia

Chauveau, L., Landeau, B., Dautricourt, S., Turpin, A., Delarue, M., Hébert, O., Sayette, V. D. L., Chételat, G., & de Florès, R. (2025) · Brain · doi:10.1093/brain/awaf008 · Cited by 27 · see citing works

Differences between ante mortem Alzheimer's disease biomarkers in predicting neuropathology at autopsy

Wang, Z., Tan, L., Wang, H.-F., Chen, S., Fu, Y., Gao, P., Ma, Y., Guo, Y., Hou, J., Zhang, D., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12997 · Cited by 19 · see citing works

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer’s disease

Penny, L. K., Lofthouse, R. A., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., & Wischik, C. M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00417-w · Cited by 20 · see citing works

Clinical trajectories preceding incident dementia up to 15 years before diagnosis: a large prospective cohort study

You, J., Guo, Y., Wang, Y., Zhang, Y., Wang, H.-F., Wang, L., Kang, J., Feng, J., Yu, J., & Cheng, W. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02570-0 · Cited by 18 · see citing works

Predicting changes in brain metabolism and progression from mild cognitive impairment to dementia using multitask Deep Learning models and explainable AI

García‐Gutiérrez, F., Hernández-Lorenzo, L., Cabrera‐Martín, M. N., Matías‐Guiu, J. A., & Ayala, J. L. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120695 · Cited by 18 · see citing works

Bone Marrow‐Derived GCA+ Immune Cells Drive Alzheimer's Disease Progression

Zhou, R., Wang, L., Chen, L., Xu, F., Zhou, R., Peng, X. F., Wen, J., Huang, Y., & Zhou, H. (2023) · Advanced Science · doi:10.1002/advs.202303402 · Cited by 16 · see citing works

Alkaloids in Uncaria rhynchophylla improves AD pathology by restraining CD4+ T cell-mediated neuroinflammation via inhibition of glycolysis in APP/PS1 mice

Kuang, Y., Zhu, M., Gu, H., Tao, Y., Huang, H., & Chen, L. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118273 · Cited by 16 · see citing works

Public perceptions related to healthcare preparedness to anti-amyloid therapies for Alzheimer’s Disease in Japan

Sato, K., Niimi, Y., Ihara, R., Iwata, A., Suzuki, K., Nemoto, K., Arai, T., Higashi, S., Igarashi, A., Kasuga, K., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01568-8 · Cited by 16 · see citing works

Integrating plasma p‐tau217 and digital cognitive assessments for early detection in Alzheimer's disease

Vanderlip, C. R., & Stark, C. E. L. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70355 · Cited by 15 · see citing works

Chronic kidney disease and dementia: an epidemiological perspective

Ikram, M. A. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00967-w · Cited by 17 · see citing works

Regional attention-enhanced vision transformer for accurate Alzheimer's disease classification using sMRI data

Jomeiri, A., Navin, A. H., & Shamsi, M. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.111065 · Cited by 16 · see citing works

Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study

Nair, A. K., Adluru, N., Finley, A. J., Gresham, L. K., Skinner, S. E., Alexander, A. L., Davidson, R. J., Ryff, C. D., & Schaefer, S. M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1355998 · Cited by 14 · see citing works

Exosomal Non-Coding RNAs as Potential Biomarkers for Alzheimer’s Disease: Advances and Perspectives in Translational Research

Titze-de-Almeida, S. S., Marina, C. L., Ramos, M. V., Silva, L. D. D. S., Brandão, P. R. D. P., Bispo, D. D. D. C., von Glehn, F., & Titze‐de‐Almeida, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178246 · Cited by 13 · see citing works

Dynamic prediction of goal location by coordinated representation of prefrontal-hippocampal theta sequences

Wang, Y., Wang, X., Wang, L., Li, Z., Meng, S., Zhu, N., An, X., Wang, L., Yang, J., Zheng, C., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.03.032 · Cited by 16 · see citing works

Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer′s Disease Neurodegeneration

Bartra, C., Irisarri, A., Villoslada, A., Corpas, R., Aguirre, S., García-Lara, E., Sunol, C. E., Pallàs, M., Griñán‐Ferré, C., & Sanfeliu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315151 · Cited by 12 · see citing works

Selective autophagy in type 2 diabetes-associated cognitive dysfunction: Insightful mechanisms and therapies

Luo, L., Que, M., Zeng, L., Wang, X., Sun, T., Zhou, Z., Zhao, Y., Li, S., & Luo, A. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107947 · Cited by 11 · see citing works

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Iwatsubo, T., Sperling, R. A., Algeciras‐Schimnich, A., Arai, H., Barron, A. M., Benzinger, T. L. S., Carrillo, M. C., Chen, C., Choi, S. H., Fontana, I. C., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70536 · Cited by 10 · see citing works

Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies

Jiang, J., Jiang, T., Wang, X., Zhao, M., Shi, H., Zhang, H., Li, W., Jiang, S., Zhang, X., Zhou, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14506 · Cited by 9 · see citing works

Advances in nanoprobes for molecular MRI of Alzheimer's disease

Parekh, P. A., Badachhape, A., Tanifum, E. A., Annapragada, A., & Ghaghada, K. B. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1946 · Cited by 9 · see citing works

CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

del Campo, M., Quesada, C., Vermunt, L., Peeters, C. F. W., Hok‐A‐Hin, Y. S., Trieu, C., den Braber, A., Verberk, I. M. W., Visser, P. J., Tijms, B. M., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00767-z · Cited by 9 · see citing works

Towards Better and More Valid Zebrafish Models of Alzheimer's Disease: A Scientific Tribute to Prof. Mikhail I. Aghajanov

Kotova, M. M., Stewart, A., Grigoryan, A., Shariff, S., Mirzaei, F., Kantawala, B., Dilbaryan, K., de Abreu, M. S., Galstryan, D. S., Cui, J., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70090 · Cited by 7 · see citing works

Sex differences in Alzheimer’s disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals

Milà‐Alomà, M., Hulle, C. V., Brugulat‐Serrat, A., Brodu, M. M. C., González‐Escalante, A., Sánchez‐Benavides, G., Shekari, M., Castro‐Aldrete, L., Minguillón, C., Martínková, J., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01844-1 · Cited by 7 · see citing works

Reactive Oxygen Species‐Associated Chiral Nanoarchitectures for Bioscience

Yu, G., Qu, A., Wu, Z., Xu, L., Xu, C., & Kuang, H. (2023) · Small Science · doi:10.1002/smsc.202300123 · Cited by 7 · see citing works

Atractylenolide III Mitigates Alzheimer's Disease by Enhancing Autophagy via the YY1 ‐ TFEB Pathway

Zhang, X., Chu, S., Huang, Y., Li, Z., Song, J., Wang, P., Su, Y., Zhang, Z., & Xie, Z. (2025) · Phytotherapy Research · doi:10.1002/ptr.70069 · Cited by 6 · see citing works

Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer’s trials

Vanderlip, C. R., Gillen, D. L., Grill, J. D., & Stark, C. E. L. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100503 · Cited by 6 · see citing works

How calcineurin inhibitors affect cognition

Thiankhaw, K., Chattipakorn, N., & Chattipakorn, S. C. (2024) · Acta Physiologica · doi:10.1111/apha.14161 · Cited by 6 · see citing works

Physical activity modifies associations between cerebrospinal fluid tau measures and executive function

Dougherty, R. J., Soldan, A., Pettigrew, C. A., Greenberg, B., Spira, A. P., Moghekar, A., & Albert, M. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70085 · Cited by 5 · see citing works

Cognitive function instrument-based anosognosia to predict amyloid status

Furuya, Y., Sato, K., Niimi, Y., Ihara, R., Suzuki, K., Iwata, A., & Iwatsubo, T. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251317508 · Cited by 5 · see citing works

The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease

Zeiss, C. J., Huttner, A. J., Nairn, A. C., Arnsten, A. F. T., Datta, D., Strittmatter, S. M., Wyk, B. V., & Duque, A. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251323787 · Cited by 5 · see citing works

Radiolabeled imaging agents for Alzheimer's disease

Wu, J., Li, K., Yang, J., Mao, M., & Cheng, Y. (2023) · iRadiology · doi:10.1002/ird3.35 · Cited by 5 · see citing works

Omega‐3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia

Lázaro, I., Grau‐Rivera, O., Suárez‐Calvet, M., Fauria, K., Minguillón, C., Shekari, M., Falcón, C., García-Prat, M., Huguet, J., Molinuevo, J. L., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12596 · Cited by 5 · see citing works

Clinical utility of diffusion MRI ‐derived measures of cortical microstructure in a real‐world memory clinic setting

Torso, M., Fumagalli, G., Ridgway, G. R., Contarino, V. E., Hardingham, I., Scarpini, E. A., Galimberti, D., Chance, S. A., & Arighi, A. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52097 · Cited by 5 · see citing works

Pathological Markers of Alzheimer’s Disease and Related Dementia in the Rhesus Macaque Amygdala

Thomas, J. L., Nilaver, B. I., Lomniczi, A., Brown, D. I., Appleman, M., Kohama, S. G., & Urbanski, H. F. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230184 · Cited by 5 · see citing works

Proteome Profiling of Cerebrospinal Fluid and Machine Learning Reveal Protein Classifiers of Two Forms of Alzheimer’s Disease Characterized by Increased or Not Altered Levels of Tau

Scalia, E., Calligaris, M., Pinto, M. L., Castelbuono, S., Iemmolo, M., Re, V. L., Bivona, G., Piccoli, T., Ghersi, G., & Scilabra, S. D. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.101025 · Cited by 4 · see citing works

Scaffold-client behavior and structural organization in multicomponent protein condensates as revealed by studying tau/TDP-43 droplets

Monnaka, V. U., Shipley, B., Boyko, S., Aguiar, P. M. D. C., Hinczewski, M., & Surewicz, W. K. (2026) · Communications Chemistry · doi:10.1038/s42004-026-01933-8 · Cited by 4 · see citing works

Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure

Mulet‐Pons, L., Solé‐Padullés, C., Cabello‐Toscano, M. R., Abellaneda‐Pérez, K., Perellón‐Alfonso, R., Cattaneo, G., Sánchez, J. S., Alviarez‐Schulze, V., Bargalló, N., Tormos, J. M., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1441359 · Cited by 4 · see citing works

Daily activities and suspected dementia among community-dwelling older adults: a cross-sectional study

Yan, S., Geng, Z., Zhang, J., Liu, H., Chen, Z., Shi, Y., & Zhang, F. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05648-0 · Cited by 3 · see citing works

Proteomics and its application in the research of acupuncture: An updated review

Zhong, Z., Sun, M., He, M., Huang, H., Hu, G., Ma, S., Zheng, H., Li, M., Yao, L., Cong, D., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33233 · Cited by 3 · see citing works

CDI-Unet:3D Image Segmentation of Hippocampus Based on Hybrid Attention Mechanism with Cross-Dimensional Interaction

Wang, Z., & Yu, L. (2025) · Arabian Journal for Science and Engineering · doi:10.1007/s13369-025-10286-8 · Cited by 3 · see citing works

Multi-omics integration reveals key miRNAs, immune inflammation, and signaling pathways in Alzheimer's disease: Implications for targeted therapy

Wang, G., Duan, J., Sun, L., Pan, S., Liu, Q., Fu, K., Zhang, D., Yuan, X., Fan, B., Hu, B., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147874 · Cited by 3 · see citing works

Classification of Alzheimer’s Disease Stages using Weighted Brain Connectivity based Graph Convolutional Neural Network

Sounthararajah, J., Kumaralingam, L., Jegatheeswaran, T., Srivishagan, S., Thanikasalam, K., & Ratnarajah, N. (2025) · International Conference on Advanced Research in Computing (ICARC) · doi:10.1109/icarc64760.2025.10963110 · Cited by 3 · see citing works

White matter hyperintensity modulates the amyloid‐tau‐cognition association and anti‐amyloid treatment efficacy in asymptomatic older adults

Lin, Z., Hong, Y., Hu, Y., Xiao, Q., Peng, S., Wu, D., Guo, T., & Jiang, D. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70990 · Cited by 2 · see citing works

Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology

Ma, H., Yu, Z., Qiao, Q., Wang, W., Li, Z., Wang, P., Song, J., Zhang, X., Su, Y., Sun, Y., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112817 · Cited by 2 · see citing works

Scorpion venom heat-resistant synthetic peptide regulates Nrf-2 to alleviate neuronal pyroptosis in an AD model induced by endoplasmic reticulum stress under PM2.5 exposure

Duan, K., Qin, C., Zhang, Y., Li, D., Zhang, J., & Li, F. (2025) · Toxicon · doi:10.1016/j.toxicon.2025.108504 · Cited by 2 · see citing works

Cognitive co-ageing with inequitable political ecologies: Deconditioning & urban public transport

Fletcher, J. R. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.118727 · Cited by 2 · see citing works

Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing

Makridis, A., Kazeli, K., Katsipis, G., Tzekaki, E. E., Pantazaki, Α. A., Bosch, C., Carbajo, R. S., & Angelakeris, M. (2026) · Nanoscale Advances · doi:10.1039/d6na00021e · Cited by 2 · see citing works

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Graff‐Radford, J., Karliner, L., Barnes, D. E., Frisoni, G. B., Sperling, R. A., Villain, N., Benzinger, T. L. S., Teunissen, C. E., & Jack, C. R. (2026) · The Lancet Neurology · doi:10.1016/s1474-4422(26)00248-6 · Cited by 2 · see citing works

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Huang, T., Gong, X., Liang, Z., Yang, R., Wu, L., Yang, C., Wu, M., Wang, X., Shu, X., & Bao, J. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167197 · Cited by 2 · see citing works

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Oyadeyi, A., Smith, C., Willeford, B. V., Grissett-Hardwick, G., Fizzano, K. M., Ws, R., Sorace, A. G., Osborne, A., Samuel, S., Campbell, I., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.26.734585 · Cited by 1 · see citing works

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Yan, M. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3012816

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Huang, P., Tang, H., Feng, Z., Stergiakouli, E., Gaunt, T. R., Zheng, J., & Lu, Y. (2024) · medRxiv · doi:10.1101/2024.09.09.24313366

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Li, C., & Lin, J. (2025) · Wiley eBooks · doi:10.1002/9783527845347.ch1

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Barrett-Young, A., Cawston, E. E., Ryan, B., Abraham, W. C., Ambler, A. P., Anderson, T., Cheyne, K. R., Goodin, E. A., Hogan, S., Houts, R., et al. (2025) · medRxiv · doi:10.1101/2025.04.09.25325556

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Yu, L., & Wang, Z. (2025) · Journal of Electronic Imaging · doi:10.1117/1.jei.34.2.023043

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Liu, Q. L., Chu, Z., Hu, Z., Long, C., Zhu, B., He, Z., Wang, Y., Cao, F., Lin, Q., Zhou, Y., et al. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.10.008

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Wang, W., Hou, S., Wang, B., Sun, D., Liu, H., Zhao, T., Wang, Q., Xu, S., Li, T., & Quan, M. (2025) · iScience · doi:10.1016/j.isci.2025.113895

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Kim, N., Jeon, J. Y., Seo, J., Lee, Y., Kim, H.-J., & Kim, J. S. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121674

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Yuan, M., Gu, C., Nguyen, T. T. T., Xu, L., Chen, X., Sun, J., Zhong, L., Zheng, Y., Zhang, L., Lu, Q., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121644

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Horowitz, R. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261445434

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Sato, K., Niimi, Y., Ihara, R., Suzuki, K., Iwata, A., & Iwatsubo, T. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261464182 · Cited by 1 · see citing works

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Nakashima, S., Sato, K., Niimi, Y., Ihara, R., Iwata, A., Nemoto, K., Arai, T., Higashi, S., Igarashi, A., Kasuga, K., et al. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261470054

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Waly, O. M., El‐Sayed, S. M., Ghaly, M. A., & El‐Subbagh, H. I. (2026) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-026-01006-6

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Ai, P., Wang, X., Shi, H., Wu, A., & Wang, J. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.10.008

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Neurology, T. L. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00402-1 · Cited by 8 · see citing works

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Samarasekera, U. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00403-3 · Cited by 1 · see citing works

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Shimura, N., Pozenato, C. G. D. A., Silva, W. B., & Rodrigues, J. R. G. [. (2026) · doi:10.66396/sec.c11

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