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Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling
Open accessAbstract
Notch signaling in Drosophila requires a RING finger (RF) protein encoded by neuralized. Here we show that the Xenopus homolog of neuralized (Xneur) is expressed where Notch signaling controls cell fate choices in early embryos. Overexpressing XNeur or putative dominant-negative forms in embryos inhibits Notch signaling. As expected for a RF protein, we show that XNeur fulfills the biochemical requirements of ubiquitin ligases. We also show that wild-type XNeur decreases the cell surface level of the Notch ligand, XDelta1, while putative inhibitory forms of XNeur increase it. Finally, we provide evidence that XNeur acts as a ubiquitin ligase for XDelta1 in vitro. We propose that XNeur plays a conserved role in Notch activation by regulating the cell surface levels of the Delta ligands, perhaps directly, via ubiquitination.
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Citations
Cited by
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Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
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Bonifacino, J. S., & Traub, L. M. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161800 · Cited by 2,040
Receptor downregulation and multivesicular-body sorting
Katzmann, D. J., Odorizzi, G., & Emr, S. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm973 · Cited by 1,201
Hematopoietic stem cell fate is established by the Notch-Runx pathway
Burns, C. E., Traver, D., Mayhall, E., Shepard, J. L., & Zon, L. I. (2005) · Genes & Development · doi:10.1101/gad.1337005 · Cited by 401
Canonical and Non-Canonical Notch Ligands
D’Souza, B., Meloty-Kapella, L., & Weinmaster, G. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92003-6 · Cited by 362
Metadata
- Authors
- Deblandre, G. A., Lai, E. C., & Kintner, C.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 1
- Issue
- 6
- Pages
- 795-806
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2051944835
- Cited by
- 222
- References
- 0
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deblandre, G. A., Lai, E. C., & Kintner, C. (2001). Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling. Developmental Cell. https://doi.org/10.1016/s1534-5807(01)00091-0
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