The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Conserved Organization of Centromeric Chromatin in Flies and Humans
Open accessAbstract
Recent studies have highlighted the importance of centromere-specific histone H3-like (CENP-A) proteins in centromere function. We show that Drosophila CID and human CENP-A appear at metaphase as a three-dimensional structure that lacks histone H3. However, blocks of CID/CENP-A and H3 nucleosomes are linearly interspersed on extended chromatin fibers, and CID is close to H3 nucleosomes in polynucleosomal preparations. When CID is depleted by RNAi, it is replaced by H3, demonstrating flexibility of centromeric chromatin organization. Finally, contrary to models proposing that H3 and CID/CENP-A nucleosomes are replicated at different times in S phase, we show that interspersed H3 and CID/CENP-A chromatin are replicated concurrently during S phase in humans and flies. We propose that the unique structural arrangement of CID/CENP-A and H3 nucleosomes presents centromeric chromatin to the poleward face of the condensing mitotic chromosome.
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Cites
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
Hendzel, M. J., Wei, Y., Mancini, M. A., Van Hooser, A., Ranalli, T., Brinkley, B. R., Bazett-Jones, D. P., & Allis, C. D. (1997) · Chromosoma · doi:10.1007/s004120050256 · Cited by 1,859
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739
The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA
Henikoff, S., Ahmad, K., & Malik, H. S. (2001) · Science · doi:10.1126/science.1062939 · Cited by 1,384
Kanda, T., Sullivan, K. F., & Wahl, G. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70156-3 · Cited by 969
Earnshaw, W. C., & Rothfield, N. (1985) · Chromosoma · doi:10.1007/bf00328227 · Cited by 842
Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries
Noma, K.-I., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1064150 · Cited by 747
Harrington, J. J., Bokkelen, G. V., Mays, R. W., Gustashaw, K., & Willard, H. F. (1997) · Nature Genetics · doi:10.1038/ng0497-345 · Cited by 646
Requirement of Heterochromatin for Cohesion at Centromeres
Bernard, P., Maure, J.-F., Partridge, J. F., Genier, S., Javerzat, J.-P., & Allshire, R. C. (2001) · Science · doi:10.1126/science.1064027 · Cited by 616
Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles
Sunkel, C. E., & Glover, D. M. (1988) · Journal of Cell Science · doi:10.1242/jcs.89.1.25 · Cited by 561
Cited by
Molecular architecture of the kinetochore–microtubule interface
Cheeseman, I. M., & Desai, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2310 · Cited by 915
Histones: annotating chromatin
Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852
The human CENP-A centromeric nucleosome-associated complex
Foltz, D. R., Jansen, L. E. T., Black, B. E., Bailey, A. O., Yates, J. R., & Cleveland, D. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1397 · Cited by 731
The molecular basis for centromere identity and function
McKinley, K. L., & Cheeseman, I. M. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.5 · Cited by 668
Complete genomic and epigenetic maps of human centromeres
Altemose, N., Logsdon, G. A., Bzikadze, A. V., Sidhwani, P., Langley, S. A., Caldas, G. V., Hoyt, S. J., Uralsky, L., Ryabov, F. D., Shew, C. J., et al. (2022) · Science · doi:10.1126/science.abl4178 · Cited by 618
Self-citation
Metadata
- Authors
- Blower, M. D., Sullivan, B. A., & Karpen, G. H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 2
- Issue
- 3
- Pages
- 319-330
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2060073273
- Cited by
- 543
- References
- 51
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Blower, M. D., Sullivan, B. A., & Karpen, G. H. (2002). Conserved Organization of Centromeric Chromatin in Flies and Humans. Developmental Cell. https://doi.org/10.1016/s1534-5807(02)00135-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
