Cited by 152Developmental Biology and Gene RegulationCongenital limb and hand anomaliesHedgehog Signaling Pathway Studies

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Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling

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Suzuki, Takayuki, Takeuchi, Jun, Koshiba-Takeuchi, Kazuko, Ogura, Toshihiko·2004·Developmental Cell

DOI 10.1016/s1534-5807(03)00401-5

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Abstract

Despite extensive studies on the anterior-posterior (AP) axis formation of limb buds, mechanisms that specify digit identities along the AP axis remain obscure. Using the four-digit chick leg as a model, we report here that Tbx2 and Tbx3 specify the digit identities of digits IV and III, respectively. Misexpression of Tbx2 and Tbx3 induced posterior homeotic transformation of digit III to digit IV and digit II to digit III, respectively. Conversely, misexpression of their mutants VP16 Delta Tbx2 and VP16 Delta Tbx3 induced anterior transformation. In both cases, alterations in the expression of several markers (e.g., BMP2, Shh, and HoxD genes) were observed. In addition, Tbx2 and Tbx3 rescued Noggin-mediated inhibition of interdigital BMP signaling, signaling which is pivotal in establishing digit identities. Hence, we conclude that Tbx3 specifies digit III, and the combination of Tbx2 and Tbx3 specifies digit IV, acting together with the interdigital BMP signaling cascade.

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285
In situ Hybridization
Langdale, J. A. (1994) · Springer eBooks · doi:10.1007/978-1-4612-2694-9_18 · Cited by 869
Local application of retinoic acid to the limb bond mimics the action of the polarizing region
Tickle, C. A., Alberts, B., Wolpert, L., & Lee, J. (1982) · Nature · doi:10.1038/296564a0 · Cited by 663
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
Davis, A. P., Witte, D. P., Hsieh‐Li, H. M., Potter, S. S., & Capecchi, M. R. (1995) · Nature · doi:10.1038/375791a0 · Cited by 584
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
Litingtung, Y., Dahn, R. D., Li, Y., Fallon, J. F., & Chiang, C. C. (2002) · Nature · doi:10.1038/nature01033 · Cited by 579
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. S., Krakowiak, P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, L. B., Gebuhr, T. C., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-311 · Cited by 540
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
Lewis, P. M., Dunn, M., McMahon, J. A., Logan, M. P. O., Martin, J. F., St‐Jacques, B., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00369-5 · Cited by 515
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod
Fromental-Ramain, C., Warott, X., Messadecq, N., LeMeur, M., Dollé, P., & Chambon, P. (1995) · Development · doi:10.1242/dev.122.10.2997 · Cited by 435
Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3
Welscher, P. T., Zúñiga, A., Kuijper, S. J. M., Drenth, T., Goedemans, H. J., Meijlink, F. C. P. W., & Zeller, R. (2002) · Science · doi:10.1126/science.1075620 · Cited by 372

Show all 34 references

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“Thus, critical morphogenic and oncogenic signaling pathways, such as BMPs 17 , Shh 18 , TGF-β 19 , FGFs 20 , Wnt/ β -catenin 21 , as well as BRAF/MAPK pathway, participate in TBX3 expression regulation, mostly at the transcriptional level 12,15 .”
Background
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Self-citation
Genomewide analysis of gene expression associated with Tcof1 in mouse neuroblastoma
Mogass, M., York, T. P., Li, L., Rujirabanjerd, S., & Shiang, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.004 · Cited by 13

Authors: Suzuki, T., Takeuchi, J., Koshiba-Takeuchi, K., & Ogura, T.
Affiliations: Nara Institute of Science and Technology (JP)
Tohoku University (JP)
Corresponding author: Ogura, Toshihiko
ORCID: Suzuki, Takayuki
Takeuchi, Jun
Ogura, Toshihiko
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2004-01
Volume: 6
Issue: 1
Pages: 43-53
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(03)00401-5
OpenAlex: W2074557542
Cited by: 148
References: 34
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2022: 3 · 2021: 13 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 10
FWCI: 5.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3485 d)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
Korea Toray Science Foundation
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: TBX2, TBX3, digit identity, Sonic hedgehog signaling, BMP signaling, noggin, homeotic transformation, Hoxd genes, limb bud development
MeSH terms: Animals, Chick Embryo, Genes, Homeobox, Hindlimb, Mutation, Toes, Signal Transduction, Trans-Activators, Transforming Growth Factor beta, Homeodomain Proteins, Gene Expression Regulation, Developmental, Limb Buds, Bone Morphogenetic Proteins, Body Patterning, T-Box Domain Proteins, Models, Animal, Hedgehog Proteins, Bone Morphogenetic Protein 2

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Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling

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