Retracted: Role of nitric oxide in the response of Saccharomyces cerevisiae cells to heat shock and high hydrostatic pressure
Open accessAbstract
Nitric oxide (NO) is a simple and unique molecule that has diverse functions in organisms, including intracellular and intercellular messenger. The influence of NO on cell growth of Saccharomyces cerevisiae and as a signal molecule in stress response was evaluated. Respiring cells were more sensitive to an increase in intracellular NO concentration than fermentatively growing cells. Low levels of NO demonstrated a cytoprotective effect during stress from heat-shock or high hydrostatic pressure. Induction of NO synthase was isoform-specific and dependent on the metabolic state of the cells and the stress response pathway. These results support the hypothesis that an increase in intracellular NO concentration leads to stress protection.
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Low levels of NO exhibit a cytoprotective effect during stress from heat-shock or high hydrostatic pressure in S. cerevisiae.
“Moreover, Domitrovic et al. [23] reported that low levels of NO exhibited a cytoprotective effect during stress from heat-shock or high hydrostatic pressure in S. cerevisiae.”
From Effect of Nitric Oxide on the Antifungal Activity of Oxidative Stress and Azoles Against Candida albicans (2016) · cites this paper as [23]
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(2003) · Yeast · doi:10.1002/yea.949
- Authors
- Domitrovic, T., Palhano, F. L., Barja-Fidalgo, C., DeFreitas, M., Orlando, M. T. D., & Fernandes, P. M. B.
- Affiliations
- Universidade Federal do Espírito Santo (BR)
- Dept. Farmacologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ 20.551-030, Brazil
- Universidade do Estado do Rio de Janeiro (BR)
- Dept. C. Fisiológicas/CBM/UFES Av. Marechal Campos, 1468 Maruípe 29040-090 Vitória, ES, Brazil
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06-01
- Volume
- 3
- Issue
- 4
- Pages
- 341-346
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- OpenAlex
- W2155672783
- Cited by
- 44
- References
- 28
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2022-03-20)
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide, Saccharomyces cerevisiae, heat shock, high hydrostatic pressure, stress response, cytoprotection, nitric oxide synthase, intracellular signaling
- MeSH terms
- Fungal Proteins, Hydrostatic Pressure, Isoenzymes, Nitric Oxide, Nitroprusside, Saccharomyces cerevisiae, Blotting, Western, Signal Transduction, Heat-Shock Response, Nitric Oxide Synthase, Nitric Oxide Donors, S-Nitroso-N-Acetylpenicillamine
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