Non-Heme Iron Nitrosyls in Biology

Butler, Anthony R.; Megson, Ian L.

doi:10.1021/cr000076d

Cited by 343Metal-Catalyzed Oxygenation MechanismsHemoglobin structure and functionNitric Oxide and Endothelin Effects

Non-Heme Iron Nitrosyls in Biology

Butler, Anthony R., Megson, Ian L.·2002·Chemical Reviews

DOI 10.1021/cr000076d

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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNon-Heme Iron Nitrosyls in BiologyAnthony R. Butler and Ian L. MegsonView Author Information School of Chemistry, Purdie Building, University of St Andrews, Fife KY16 9ST, Scotland Centre for Cardiovascular Science, University of Edinburgh, EH8 9XD Scotland Cite this: Chem. Rev. 2002, 102, 4, 1155–1166Publication Date (Web):March 12, 2002Publication History Received31 May 2001Published online12 March 2002Published inissue 1 April 2002https://pubs.acs.org/doi/10.1021/cr000076dhttps://doi.org/10.1021/cr000076dresearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views2543Altmetric-Citations301LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electron paramagnetic resonance spectroscopy,Iron,Peptides and proteins,Salts,Sodium Get e-Alerts

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NO binding to NHI can result in significant biological effects, including disruption of iron-sulfur centers.
“NO binding to NHI can also result in significant biological effects, including disruption of iron-sulfur centers and also binding to the so-called chelatable iron pool of cells (17).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [17]
NO binding to NHI can result in significant biological effects, including binding to the chelatable iron pool of cells.
“NO binding to NHI can also result in significant biological effects, including disruption of iron-sulfur centers and also binding to the so-called chelatable iron pool of cells (17).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [17]
Prolyl hydroxylases are classic nonheme iron complexes involved in collagen formation and HIF-1α stabilization.
“Another classic example that highlights the diversity and importance of nonheme iron complexes in metabolism [235, 236] is the prolyl hydroxylases, which are involved in collagen formation and stabilization of HIF-1α [237-239].”
From Signaling and stress: The redox landscape in NOS2 biology (2015) · cites this paper as [237]

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A Nitric Oxide–Inducible Lactate Dehydrogenase Enables <i>Staphylococcus aureus</i> to Resist Innate Immunity
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Retracted: Role of nitric oxide in the response of <i>Saccharomyces cerevisiae</i> cells to heat shock and high hydrostatic pressure
Domitrovic, T., Palhano, F. L., Barja-Fidalgo, C., DeFreitas, M., Orlando, M. T. D., & Fernandes, P. M. B. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00039-4 · Cited by 44 · see citing works
Retracted

Authors: Butler, A. R., & Megson, I. L.
Affiliations: University of St Andrews (GB)
University of Edinburgh (GB)
ORCID: Megson, Ian L.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2002-03-12
Volume: 102
Issue: 4
Pages: 1155-1166
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/cr000076d
OpenAlex: W1975739142
Cited by: 343
References: 140
Citations by year: 2026: 5 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 5 · 2017: 10 · 2016: 9 · 2015: 17 · 2014: 24 · 2013: 21 · 2012: 15
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Locations: Chemical Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: non-heme iron, iron nitrosyl, iron-sulfur clusters, nitric oxide, electron spin resonance, iron-containing proteins
MeSH terms: Animals, Ferric Compounds, Humans, Iron, Iron-Sulfur Proteins, Nitric Oxide, Nitroso Compounds, Sulfur, Nonheme Iron Proteins, Nitric Oxide Donors

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Non-Heme Iron Nitrosyls in Biology

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