The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The proteasome in brain aging
Abstract
The proteasome is a large intracellular protease, present in all cells of the central nervous system (CNS), that is responsible for the majority of intracellular protein degradation. In particular, the proteasome is responsible for the degradation of most oxidized, aggregated, and misfolded proteins. The importance of proteasome activity to neuronal homeostasis is highlighted by previous studies demonstrating that proteasome inhibition alone is sufficient to induce neuron death in vitro. Recent studies indicate that alterations in proteasome activity may occur during, and possibly contribute to, the aging process. These data raise the possibility that alterations in the proteasome proteolytic pathway may contribute to the elevations in protein oxidation, protein aggregation, and neurodegeneration evident in the aging CNS. The focus of this review is to describe what is currently known about the proteasome in the CNS, describe established age-related alterations in proteasome biology, and to discuss how such alterations in proteasome biology may ultimately contribute to the aging of the CNS.
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“Similar to age-dependent reduction of autophagy, evidence of impaired UPS in the aging brain arises from studies showing age-dependent accumulation of polyubiquitinated proteins in neurons and a brain region-specific reduction of age-dependent proteasome activity in the hippocampus and cerebral cortex (Keller et al., 2002; Mattson and Arumugam, 2018).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Keller et al., 2002
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
Ageing and neuronal vulnerability
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The Ubiquitin Proteasome System in Neurodegenerative Diseases
Ciechanover, A. J., & Brundin, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00606-8 · Cited by 1,000
NAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790
Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786
Metadata
- Authors
- Keller, J.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Keller, J
- ORCID
- Keller, J
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 1
- Issue
- 2
- Pages
- 279-293
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W1983882750
- Cited by
- 247
- References
- 82
- Citations by year
- 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 13 · 2013: 8 · 2012: 15
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG018437, AG18437)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- proteasome, brain aging, protein degradation, protein oxidation, protein aggregation, protein misfolding, neurodegeneration, neuronal homeostasis, proteasome inhibition, central nervous system
- MeSH terms
- Aging, Brain, Cysteine Endopeptidases, Humans, Multienzyme Complexes, Oxidative Stress, Proteasome Endopeptidase Complex
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